DK0841344T3 - 1-(2-Desoxy-2-fluor-4-thio-Beta-D-arabinofuranosyl)cytosiner - Google Patents

1-(2-Desoxy-2-fluor-4-thio-Beta-D-arabinofuranosyl)cytosiner

Info

Publication number
DK0841344T3
DK0841344T3 DK97916633T DK97916633T DK0841344T3 DK 0841344 T3 DK0841344 T3 DK 0841344T3 DK 97916633 T DK97916633 T DK 97916633T DK 97916633 T DK97916633 T DK 97916633T DK 0841344 T3 DK0841344 T3 DK 0841344T3
Authority
DK
Denmark
Prior art keywords
arabinofuranosyl
cytosines
deoxy
thio
fluoro
Prior art date
Application number
DK97916633T
Other languages
Danish (da)
English (en)
Inventor
Yuichi Yoshimura
Kenji Kitano
Shinji Miura
Haruhiko Machida
Mikari Watanabe
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Application granted granted Critical
Publication of DK0841344T3 publication Critical patent/DK0841344T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK97916633T 1996-04-09 1997-04-09 1-(2-Desoxy-2-fluor-4-thio-Beta-D-arabinofuranosyl)cytosiner DK0841344T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP11196896 1996-04-09
JP21508296 1996-07-26
JP27863196 1996-09-30
PCT/JP1997/001206 WO1997038001A1 (fr) 1996-04-09 1997-04-09 1-(2-DESOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINES

Publications (1)

Publication Number Publication Date
DK0841344T3 true DK0841344T3 (da) 2002-12-23

Family

ID=27312140

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97916633T DK0841344T3 (da) 1996-04-09 1997-04-09 1-(2-Desoxy-2-fluor-4-thio-Beta-D-arabinofuranosyl)cytosiner

Country Status (10)

Country Link
US (1) US6147058A (de)
EP (1) EP0841344B1 (de)
JP (1) JP3657008B2 (de)
AT (1) ATE224909T1 (de)
CA (1) CA2224155C (de)
DE (1) DE69715774T2 (de)
DK (1) DK0841344T3 (de)
ES (1) ES2182061T3 (de)
PT (1) PT841344E (de)
WO (1) WO1997038001A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138384B1 (en) 1997-08-29 2006-11-21 The Regents Of The University Of California Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
KR100954390B1 (ko) * 1998-02-25 2010-04-26 에모리 유니버시티 2'-플루오로뉴클레오사이드
WO2005027962A1 (en) * 2003-09-18 2005-03-31 Isis Pharmaceuticals, Inc. 4’-thionucleosides and oligomeric compounds
US7524831B2 (en) * 2005-03-02 2009-04-28 Schering Corporation Treatments for Flaviviridae virus infection
EP2388257A1 (de) 2010-05-20 2011-11-23 LibraMedicina, Inc. Verfahren zur Herstellung von substituierten 1-O-acyl-2-deoxy-2-fluor-4-thio-ß-D-Arabinfuranosen
RU2559364C2 (ru) * 2009-12-18 2015-08-10 Либрамедисина, Инк. СПОСОБ ПОЛУЧЕНИЯ ЗАМЕЩЕННЫХ 1-О-АЦИЛ-2-ДЕЗОКСИ-2-ФТОР-4-ТИО-β-D-АРАБИНОФУРАНОЗ
SG11201406080VA (en) * 2012-03-28 2014-11-27 Fujifilm Corp SALT OF 1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINE
RU2633355C2 (ru) * 2012-08-13 2017-10-12 Фуджифилм Корпорэйшн СИНТЕТИЧЕСКОЕ ПРОМЕЖУТОЧНОЕ СОЕДИНЕНИЕ 1-(2-ДЕЗОКСИ-2-ФТОР-4-ТИО-β-D-АРАБИНОФУРАНОЗИЛ)ЦИТОЗИНА, СИНТЕТИЧЕСКОЕ ПРОМЕЖУТОЧНОЕ СОЕДИНЕНИЕ ТИОНУКЛЕОЗИДА И СПОСОБ ИХ ПОЛУЧЕНИЯ
WO2014197578A1 (en) * 2013-06-05 2014-12-11 Idenix Pharmaceuticals, Inc. 1',4'-thio nucleosides for the treatment of hcv
CN106061959B (zh) 2014-02-18 2018-11-09 富士胶片株式会社 四氢噻吩骨架型糖化合物的制造方法及四氢噻吩骨架型糖化合物
JP6351107B2 (ja) * 2014-02-18 2018-07-04 富士フイルム株式会社 チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja) 2014-02-19 2017-09-27 富士フイルム株式会社 チオピラノース化合物等の製造方法
TWI678373B (zh) * 2014-10-31 2019-12-01 日商富士軟片股份有限公司 硫代核苷衍生物或其鹽及醫藥組合物
AU2016240117C1 (en) * 2015-04-03 2020-11-26 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Novel compound of 4'-thionucleoside, as well as preparation method therefor, pharmaceutical composition thereof and application thereof
JP6450356B2 (ja) * 2016-02-29 2019-01-09 富士フイルム株式会社 液状医薬製剤
WO2018043530A1 (ja) 2016-08-31 2018-03-08 富士フイルム株式会社 抗腫瘍剤、抗腫瘍効果増強剤及び抗腫瘍用キット
EA201990780A1 (ru) 2016-12-22 2019-11-29 Твердая форма соединения 4'-тио-2'-фторнуклеозид фосфамида и способ его получения и применения
US11266674B2 (en) 2017-09-01 2022-03-08 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Pharmaceutical composition for tumor treatment or prevention, method, and use thereof
TW201932120A (zh) * 2018-01-29 2019-08-16 日商富士軟片股份有限公司 用於具有異檸檬酸脫氫酶突變的腫瘤的藥物組成物與抗腫瘤劑及其應用
CA3089728C (en) 2018-01-29 2023-01-10 Fujifilm Corporation Antitumor agent for biliary tract cancer and method for treating biliary tract cancer
WO2019164010A1 (ja) * 2018-02-26 2019-08-29 富士フイルム株式会社 膀胱がん用抗腫瘍剤および膀胱がんの処置方法
CN111836628A (zh) 2018-03-13 2020-10-27 富士胶片株式会社 抗肿瘤剂、抗肿瘤效果增强剂及抗肿瘤用试剂盒
WO2020108343A1 (zh) * 2018-11-28 2020-06-04 四川科伦博泰生物医药股份有限公司 以4'-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途
CA3148866A1 (en) * 2019-07-30 2021-02-04 Pinotbio, Inc. Dinucleotide compounds for treating cancers and medical uses thereof
EP4378466A1 (de) 2021-07-29 2024-06-05 FUJIFILM Corporation Pharmazeutische zusammensetzung und antitumormittel für tumore mit mindestens einer beeinträchtigten bap1- oder pbrm1-funktion

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE74701B1 (en) * 1989-10-04 1997-07-30 Univ Birmingham Further antiviral pyrimidine nucleosides
US5811408A (en) * 1994-07-12 1998-09-22 Yamasa Corporation 2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides
JPH0853490A (ja) * 1994-08-09 1996-02-27 Yamasa Shoyu Co Ltd ２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド

Also Published As

Publication number Publication date
PT841344E (pt) 2003-02-28
CA2224155C (en) 2004-10-26
DE69715774D1 (de) 2002-10-31
EP0841344A1 (de) 1998-05-13
WO1997038001A1 (fr) 1997-10-16
EP0841344A4 (de) 1998-05-13
ES2182061T3 (es) 2003-03-01
ATE224909T1 (de) 2002-10-15
CA2224155A1 (en) 1997-10-16
US6147058A (en) 2000-11-14
EP0841344B1 (de) 2002-09-25
JP3657008B2 (ja) 2005-06-08
DE69715774T2 (de) 2003-05-15

Similar Documents

Publication Publication Date Title
ES2182061T3 (es) 1 - (2 - desoxi - 2 - fluor-4- tio-beta-d arabinofuranosil)citosina.
AU5211686A (en) Pyrazolesulfonamide derivative, process for its production and herbicide containing it
ATE201195T1 (de) Tricyclische verbindungen
EP1385518A4 (de) Benzimidazolon-verbindungen
EP0807630A4 (de) Heterozyklische verbindungen
ES2192852T3 (es) Proceso de obtencion de 3-aril-benzofuranonas.
EP0714900A3 (de) Alkylhydrogenchlorsilane, Verfahren zu deren Herstellung und deren Verwendung
BG103778A (en) Process for preparing pyrazole derivatives
FI955954A (fi) Thiolyhdisteitä
AU2001282297A1 (en) Catalysts
GR3029836T3 (en) Process for producing n-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same
ATE223414T1 (de) Prozess zur herstellung von zwischebprodukten für imidazodeazepinen
EP0747350A4 (de) Verfahren zur herstellung von bis(4-alkylthiophenyl)disulfid
DE69706950D1 (de) Furoindolizine
EP0978281A4 (de) Augentropfen
EP0551632A3 (en) Process for the preparation of halogenoanthranilic acid
ATE176242T1 (de) Uck14-verbindungen
DE69615814T2 (de) Uch-15-verbindungen
BR0016521B1 (pt) processo para produÇço de 2-nitroguanidinas 1,3-dissubstituÍdas.
FI904981A0 (fi) Nya inosin/guanosinderivat.
ATE244217T1 (de) Herstellung von beta-mehtylcarbapenem- zwischenprodukten