BR0308739A - Tratamentos em combinação para doenças mediadas por quimiocina - Google Patents
Tratamentos em combinação para doenças mediadas por quimiocinaInfo
- Publication number
- BR0308739A BR0308739A BR0308739-5A BR0308739A BR0308739A BR 0308739 A BR0308739 A BR 0308739A BR 0308739 A BR0308739 A BR 0308739A BR 0308739 A BR0308739 A BR 0308739A
- Authority
- BR
- Brazil
- Prior art keywords
- mediated diseases
- chemokine mediated
- combination treatments
- chemokine
- formula
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
"TRATAMENTOS EM COMBINAçãO PARA DOENçAS MEDIADAS POR QUIMIOCINA". A presente invenção refere-se a 88 processos de tratamento de doenças mediadas por quimiocina. Os processos compreendem a administração de antagonistas de receptor de quimiocina-CXC da fórmula ou seus sais ou solvatos farmaceuticamente aceitáveis, em combinação com outras classes de compostos farmacêuticos. As doenças mediadas por quimiocina incluem distúrbios inflamatórios agudos e crónicos, psoríase, fibrose cística, asma e câncer. São também mostrados novos compostos de fórmula (I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36531402P | 2002-03-18 | 2002-03-18 | |
PCT/US2003/008287 WO2003080053A1 (en) | 2002-03-18 | 2003-03-17 | Combination treatments for chemokine-mediated diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0308739A true BR0308739A (pt) | 2005-01-11 |
Family
ID=28454639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0308739-5A BR0308739A (pt) | 2002-03-18 | 2003-03-17 | Tratamentos em combinação para doenças mediadas por quimiocina |
Country Status (14)
Country | Link |
---|---|
US (2) | US20040053953A1 (pt) |
EP (1) | EP1485089B1 (pt) |
JP (1) | JP4733350B2 (pt) |
CN (1) | CN100444839C (pt) |
AR (1) | AR040400A1 (pt) |
AU (1) | AU2003220384B2 (pt) |
BR (1) | BR0308739A (pt) |
CA (1) | CA2479126C (pt) |
MX (1) | MXPA04009127A (pt) |
NO (1) | NO20044402L (pt) |
NZ (1) | NZ535314A (pt) |
TW (2) | TW200304811A (pt) |
WO (1) | WO2003080053A1 (pt) |
ZA (1) | ZA200407339B (pt) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040106794A1 (en) | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
US7132445B2 (en) | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
ATE365154T1 (de) * | 2001-04-16 | 2007-07-15 | Schering Corp | 3,4-disubstituierte cyclobuten-1,2-dione als cxc- chemokinrezeptorliganden |
JP2005505595A (ja) | 2001-10-12 | 2005-02-24 | シェーリング コーポレイション | Cxc−ケモカインレセプターアンタゴニストとしての3,4−二置換マレイミド化合物 |
US6878709B2 (en) | 2002-01-04 | 2005-04-12 | Schering Corporation | 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists |
ATE422203T1 (de) * | 2002-10-09 | 2009-02-15 | Schering Corp | Thiadiazoldioxide und thiadiazoloxide als cxc- und cc-chemokinrezeptor liganden |
US8221495B2 (en) * | 2002-11-07 | 2012-07-17 | Abbott Laboratories | Integration of therapeutic agent into a bioerodible medical device |
US8524148B2 (en) * | 2002-11-07 | 2013-09-03 | Abbott Laboratories | Method of integrating therapeutic agent into a bioerodible medical device |
ATE461673T1 (de) * | 2002-11-07 | 2010-04-15 | Abbott Lab | Verfahren zum anbringen eines medikaments auf eine prothese mittels eines flüssigstrahls |
AR044027A1 (es) | 2003-04-18 | 2005-08-24 | Schering Corp | Sintesis de 2-hidroxi-n,n-dimetil-3-[[2-[1(r) - (5-metil-2-furanil)propil]amino]- 3,4-dioxo-1-ciclobuten-1-il]amino]benzamida |
US7338968B2 (en) * | 2003-12-19 | 2008-03-04 | Schering Corporation | Thiadiazoles AS CXC- and CC- chemokine receptor ligands |
CA2550540A1 (en) | 2003-12-22 | 2005-07-28 | Schering Corporation | Isothiazole dioxides as cxc- and cc- chemokine receptor ligands |
JP2007519751A (ja) * | 2004-01-30 | 2007-07-19 | シェーリング コーポレイション | Cxc−ケモカインレセプターリガンドの結晶多形 |
DE102004016179A1 (de) * | 2004-03-30 | 2005-10-20 | Boehringer Ingelheim Pharma | Verbindungen zur Behandlung von proliferativen Prozessen |
MXPA06011824A (es) * | 2004-04-16 | 2006-12-15 | Genentech Inc | Ensayo para anticuerpos. |
EP1745032B1 (en) | 2004-05-12 | 2013-07-31 | Merck Sharp & Dohme Corp. | CXCR1 and CXCR2 chemokine antagonists |
AR049384A1 (es) * | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
ES2353401T3 (es) | 2005-06-29 | 2011-03-01 | Schering Corporation | Oxidiazolopirazinas y tiadiazolopirazinas 5,6-di-sustituidas como ligandos del receptor de cxc-quimiocina. |
JP2009500334A (ja) | 2005-06-29 | 2009-01-08 | シェーリング コーポレイション | Cxc−ケモカインレセプターリガンドとしてのジ置換オキサジアゾール |
GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
AR061448A1 (es) | 2006-06-12 | 2008-08-27 | Schering Corp | Formulaciones y compuestos farmaceuticos de un antagonista selectivo ya sea del receptor cxcr2, y los metodos para utilizar el mismo en el tratamiento de enfermedades inflamatorias |
CA2657051A1 (en) * | 2006-07-07 | 2008-01-10 | Schering Corporation | 3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands |
US8450348B2 (en) * | 2007-02-21 | 2013-05-28 | Forma Tm, Llc | Derivatives of squaric acid with anti-proliferative activity |
US8183281B2 (en) | 2007-06-06 | 2012-05-22 | Novartis Ag | CXC-chemokine receptor ligands |
US8519168B2 (en) * | 2007-07-03 | 2013-08-27 | Merck Sharp & Dohme Corp. | Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds |
UA103198C2 (en) | 2008-08-04 | 2013-09-25 | Новартис Аг | Squaramide derivatives as cxcr2 antagonists |
WO2010131147A1 (en) * | 2009-05-12 | 2010-11-18 | Pfizer Limited | Cyclobutenedione derivatives |
FR2961695B1 (fr) * | 2010-06-29 | 2012-07-06 | Galderma Res & Dev | Utilisation de composes dans le traitement ou la prevention de troubles cutanes |
WO2012125413A2 (en) * | 2011-03-12 | 2012-09-20 | Vicus Therapeutics, Llc | Compositions for ameliorating systemic inflammation and methods for making and using them |
BR112014004963A2 (pt) | 2011-09-02 | 2017-03-21 | Novartis Ag | sal de colina do composto anti-inflamatório ciclobutanodiona substituído |
FR2981934B1 (fr) * | 2011-10-28 | 2013-12-20 | Galderma Res & Dev | Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines. |
KR101306199B1 (ko) * | 2012-01-31 | 2013-09-09 | 부산대학교 산학협력단 | 포스포리파아제 d 억제제를 유효성분으로 포함하는 골다공증 예방 및 치료용 약학적 조성물 |
US8865723B2 (en) | 2012-10-25 | 2014-10-21 | Tetra Discovery Partners Llc | Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury |
US9763992B2 (en) | 2014-02-13 | 2017-09-19 | Father Flanagan's Boys' Home | Treatment of noise induced hearing loss |
TWI734715B (zh) | 2015-11-19 | 2021-08-01 | 美商卡默森屈有限公司 | 趨化因子受體調節劑 |
TWI724056B (zh) | 2015-11-19 | 2021-04-11 | 美商卡默森屈有限公司 | Cxcr2抑制劑 |
KR20200037857A (ko) * | 2017-08-14 | 2020-04-09 | 알러간, 인코포레이티드 | 3,4-이치환된 3-시클로부텐-1,2-디온 및 그의 용도 |
TWI802591B (zh) | 2017-09-14 | 2023-05-21 | 日商第一三共股份有限公司 | 具有環狀構造的化合物 |
IL275839B2 (en) | 2018-01-08 | 2024-02-01 | Chemocentryx Inc | Methods for the treatment of generalized abscess psoriasis using a CCR6 or CXCR2 antagonist |
GEP20237476B (en) | 2018-09-21 | 2023-03-27 | Pfizer | N-substituted-dioxocyclobutenylamino-3-hydroxypicolinamides useful as ccr6 inhibitors |
CN112851635B (zh) * | 2019-11-28 | 2022-09-16 | 中国医学科学院药物研究所 | 环状砜类化合物及其制备方法、用途和药物组合物 |
EP3868368A1 (en) * | 2020-02-21 | 2021-08-25 | Dompe' Farmaceutici S.P.A. | Cxcl8 (interleukin-8) activity inhibitor and corticosteroid combination and pharmaceutical composition and use thereof |
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-
2003
- 2003-03-17 BR BR0308739-5A patent/BR0308739A/pt not_active IP Right Cessation
- 2003-03-17 NZ NZ535314A patent/NZ535314A/en not_active IP Right Cessation
- 2003-03-17 AU AU2003220384A patent/AU2003220384B2/en not_active Ceased
- 2003-03-17 MX MXPA04009127A patent/MXPA04009127A/es unknown
- 2003-03-17 JP JP2003577881A patent/JP4733350B2/ja not_active Expired - Fee Related
- 2003-03-17 US US10/390,078 patent/US20040053953A1/en not_active Abandoned
- 2003-03-17 CN CNB038106183A patent/CN100444839C/zh not_active Expired - Fee Related
- 2003-03-17 CA CA2479126A patent/CA2479126C/en not_active Expired - Fee Related
- 2003-03-17 WO PCT/US2003/008287 patent/WO2003080053A1/en active IP Right Grant
- 2003-03-17 EP EP03716685.7A patent/EP1485089B1/en not_active Expired - Lifetime
- 2003-03-18 TW TW092105892A patent/TW200304811A/zh unknown
- 2003-03-18 AR AR20030100943A patent/AR040400A1/es not_active Application Discontinuation
- 2003-03-18 TW TW096114061A patent/TW200808314A/zh unknown
-
2004
- 2004-09-13 ZA ZA200407339A patent/ZA200407339B/en unknown
- 2004-10-15 NO NO20044402A patent/NO20044402L/no not_active Application Discontinuation
-
2007
- 2007-02-14 US US11/705,929 patent/US7960433B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
MXPA04009127A (es) | 2005-01-25 |
US20040053953A1 (en) | 2004-03-18 |
NZ535314A (en) | 2007-08-31 |
JP2005533005A (ja) | 2005-11-04 |
EP1485089A1 (en) | 2004-12-15 |
AU2003220384A1 (en) | 2003-10-08 |
CA2479126C (en) | 2011-11-15 |
CN1652779A (zh) | 2005-08-10 |
AR040400A1 (es) | 2005-04-06 |
JP4733350B2 (ja) | 2011-07-27 |
EP1485089B1 (en) | 2013-04-17 |
AU2003220384B2 (en) | 2007-05-10 |
CN100444839C (zh) | 2008-12-24 |
US20070155756A1 (en) | 2007-07-05 |
ZA200407339B (en) | 2005-10-06 |
TW200304811A (en) | 2003-10-16 |
CA2479126A1 (en) | 2003-10-02 |
US7960433B2 (en) | 2011-06-14 |
TW200808314A (en) | 2008-02-16 |
WO2003080053A1 (en) | 2003-10-02 |
NO20044402L (no) | 2004-12-17 |
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