BRPI0418112A - inibidores de p-38 quinase bicìclico heterocìclicos - Google Patents
inibidores de p-38 quinase bicìclico heterocìclicosInfo
- Publication number
- BRPI0418112A BRPI0418112A BRPI0418112-3A BRPI0418112A BRPI0418112A BR PI0418112 A BRPI0418112 A BR PI0418112A BR PI0418112 A BRPI0418112 A BR PI0418112A BR PI0418112 A BRPI0418112 A BR PI0418112A
- Authority
- BR
- Brazil
- Prior art keywords
- kinase inhibitors
- heterocyclic bicyclic
- kinase
- compounds
- disorders
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 3
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract 3
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- -1 methods of treating Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A61P11/00—Drugs for disorders of the respiratory system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
"INIBIDORES DE P-38 QUINASE BICìCLICOS HETEROCìCLICOS". Providenciam-se inibidores de p38 quinase com base em bicíclicos heterocicios, incluindo p38<244> e p38<225> quinase. Também são providenciadas composições farmacêuticas contendo os compostos. São também providenciados métodos de uso dos compostos e composições, incluindo métodos de tratamento, prevenção ou melhora de um ou mais sintomas de doenças e distúrbios medíados por p38 quínase incluindo, sem limitação, doenças e distúrbios inflamatórios.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53252903P | 2003-12-23 | 2003-12-23 | |
US57511304P | 2004-05-28 | 2004-05-28 | |
PCT/US2004/043682 WO2005063766A2 (en) | 2003-12-23 | 2004-12-23 | Bicyclic heterocyclic p-38 kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0418112A true BRPI0418112A (pt) | 2007-04-17 |
Family
ID=34743022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0418112-3A BRPI0418112A (pt) | 2003-12-23 | 2004-12-23 | inibidores de p-38 quinase bicìclico heterocìclicos |
Country Status (14)
Country | Link |
---|---|
US (2) | US7569571B2 (pt) |
EP (1) | EP1699800B1 (pt) |
JP (1) | JP2007517052A (pt) |
KR (1) | KR100899245B1 (pt) |
AT (1) | ATE457313T1 (pt) |
AU (1) | AU2004309420B2 (pt) |
BR (1) | BRPI0418112A (pt) |
CA (1) | CA2548326A1 (pt) |
DE (1) | DE602004025504D1 (pt) |
ES (1) | ES2339670T3 (pt) |
PL (1) | PL1699800T3 (pt) |
PT (1) | PT1699800E (pt) |
RU (1) | RU2006126791A (pt) |
WO (1) | WO2005063766A2 (pt) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004259662B2 (en) | 2003-06-26 | 2008-08-07 | Mereo Biopharma 1 Limited | 5-membered heterocycle-based p38 kinase inhibitors |
BRPI0412689A (pt) | 2003-07-14 | 2006-10-03 | Arena Pharm Inc | derivados de heteroarila e arila fundida como moduladores de metabolismo e a profilaxia e tratamento de distúrbios relacionados a ele |
CA2557667A1 (en) * | 2004-03-02 | 2005-09-15 | Neurogen Corporation | Aryl substituted purine analogues |
WO2006068760A2 (en) | 2004-11-19 | 2006-06-29 | The Regents Of The University Of California | Anti-inflammatory pyrazolopyrimidines |
BRPI0614884A2 (pt) | 2005-08-25 | 2011-04-19 | Hoffmann La Roche | inibidores de p38 map cinase e métodos para uso dos mesmos |
BRPI0615442A2 (pt) * | 2005-08-25 | 2011-05-17 | Hoffmann La Roche | inibidores de p38 map cinase e métodos para uso dos mesmos |
TWI403320B (zh) * | 2005-12-16 | 2013-08-01 | Infinity Discovery Inc | 用於抑制bcl蛋白和結合夥伴間之交互作用的化合物及方法 |
US7465795B2 (en) | 2005-12-20 | 2008-12-16 | Astrazeneca Ab | Compounds and uses thereof |
MX2008012928A (es) | 2006-04-04 | 2009-03-06 | Univ California | Antagonistas de pi3-cinasa. |
WO2008074676A1 (en) | 2006-12-19 | 2008-06-26 | F. Hoffmann-La Roche Ag | Pyrazolo [3, 4 -d] pyrimidine p38 map kinase inhibitors |
EP2152706A1 (en) | 2007-05-07 | 2010-02-17 | Amgen Inc. | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as p38 modulators, process for their preparation, and their pharmaceutical use |
EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
GB2467670B (en) | 2007-10-04 | 2012-08-01 | Intellikine Inc | Chemical entities and therapeutic uses thereof |
US8080546B2 (en) | 2007-10-26 | 2011-12-20 | Amgen Inc. | Pyrazolo-pyridinone derivatives and methods of use |
CN101965336B (zh) | 2008-01-04 | 2015-06-17 | 英特利凯恩有限责任公司 | 某些化学实体、组合物和方法 |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
WO2009114870A2 (en) | 2008-03-14 | 2009-09-17 | Intellikine, Inc. | Kinase inhibitors and methods of use |
US8367671B2 (en) | 2008-03-21 | 2013-02-05 | Amgen Inc. | Pyrazolo[3.4-B]pyrazine compounds as p38 modulators and methods of use as anti-inflamatory agents |
CA2730106A1 (en) | 2008-07-08 | 2010-01-14 | Intellikine, Inc. | Kinase inhibitors and methods of use |
US20110224223A1 (en) | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
JP5731978B2 (ja) | 2008-09-26 | 2015-06-10 | インテリカイン, エルエルシー | 複素環キナーゼ阻害剤 |
ES2570429T3 (es) | 2008-10-16 | 2016-05-18 | Univ California | Inhibidores de heteroaril quinasa de anillo condensado |
US8476431B2 (en) | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
CA2760791C (en) | 2009-05-07 | 2017-06-20 | Intellikine, Inc. | Heterocyclic compounds and uses thereof |
WO2011047384A2 (en) | 2009-10-16 | 2011-04-21 | The Regents Of The University Of California | Methods of inhibiting ire1 |
ES2593256T3 (es) | 2010-05-21 | 2016-12-07 | Infinity Pharmaceuticals, Inc. | Compuestos químicos, composiciones y métodos para las modulaciones de cinasas |
EA022046B1 (ru) | 2010-07-14 | 2015-10-30 | Новартис Аг | Гетероциклические соединения, агонисты рецептора ip |
US9512111B2 (en) | 2010-11-08 | 2016-12-06 | Lycera Corporation | N-sulfonylated tetrahydroquinolines and related bicyclic compounds for inhibition of RORγ activity and the treatment of disease |
CA2817577A1 (en) | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
DK2663309T3 (en) | 2011-01-10 | 2017-06-19 | Infinity Pharmaceuticals Inc | METHODS FOR PRODUCING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES |
TWI592411B (zh) | 2011-02-23 | 2017-07-21 | 英特爾立秦有限責任公司 | 激酶抑制劑之組合及其用途 |
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MX2014000648A (es) | 2011-07-19 | 2014-09-25 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y sus usos. |
KR20140075693A (ko) | 2011-08-29 | 2014-06-19 | 인피니티 파마슈티칼스, 인코포레이티드 | 헤테로사이클릭 화합물 및 그의 용도 |
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- 2004-12-23 DE DE602004025504T patent/DE602004025504D1/de active Active
- 2004-12-23 CA CA002548326A patent/CA2548326A1/en not_active Abandoned
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- 2004-12-23 JP JP2006547489A patent/JP2007517052A/ja active Pending
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US20090264409A1 (en) | 2009-10-22 |
KR100899245B1 (ko) | 2009-05-26 |
DE602004025504D1 (de) | 2010-03-25 |
RU2006126791A (ru) | 2008-01-27 |
CA2548326A1 (en) | 2005-07-14 |
US7569571B2 (en) | 2009-08-04 |
JP2007517052A (ja) | 2007-06-28 |
AU2004309420A1 (en) | 2005-07-14 |
AU2004309420B2 (en) | 2008-10-30 |
EP1699800A2 (en) | 2006-09-13 |
PT1699800E (pt) | 2010-04-12 |
KR20060103272A (ko) | 2006-09-28 |
ATE457313T1 (de) | 2010-02-15 |
EP1699800B1 (en) | 2010-02-10 |
US20070142405A1 (en) | 2007-06-21 |
PL1699800T3 (pl) | 2010-07-30 |
WO2005063766A2 (en) | 2005-07-14 |
ES2339670T3 (es) | 2010-05-24 |
WO2005063766A3 (en) | 2005-09-09 |
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