DE60323946D1 - Bicyclische pyridin- und pyrimidininhibitoren von p38-kinase - Google Patents
Bicyclische pyridin- und pyrimidininhibitoren von p38-kinaseInfo
- Publication number
- DE60323946D1 DE60323946D1 DE60323946T DE60323946T DE60323946D1 DE 60323946 D1 DE60323946 D1 DE 60323946D1 DE 60323946 T DE60323946 T DE 60323946T DE 60323946 T DE60323946 T DE 60323946T DE 60323946 D1 DE60323946 D1 DE 60323946D1
- Authority
- DE
- Germany
- Prior art keywords
- pyrimidininhibitors
- kinase
- bicyclic pyridine
- bicyclic
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36237302P | 2002-03-07 | 2002-03-07 | |
US43050802P | 2002-12-03 | 2002-12-03 | |
PCT/EP2003/002090 WO2003074530A1 (en) | 2002-03-07 | 2003-02-28 | Bicyclic pyridine and pyrimidine p38 kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60323946D1 true DE60323946D1 (de) | 2008-11-20 |
Family
ID=27791709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60323946T Expired - Fee Related DE60323946D1 (de) | 2002-03-07 | 2003-02-28 | Bicyclische pyridin- und pyrimidininhibitoren von p38-kinase |
Country Status (19)
Country | Link |
---|---|
US (3) | US7091347B2 (de) |
EP (1) | EP1485390B1 (de) |
JP (1) | JP4187657B2 (de) |
KR (1) | KR100714519B1 (de) |
CN (1) | CN100386328C (de) |
AR (1) | AR038864A1 (de) |
AT (1) | ATE410429T1 (de) |
AU (1) | AU2003210388B2 (de) |
BR (1) | BR0308232A (de) |
CA (1) | CA2477721A1 (de) |
DE (1) | DE60323946D1 (de) |
ES (1) | ES2314224T3 (de) |
MX (1) | MXPA04008592A (de) |
PA (1) | PA8568401A1 (de) |
PE (1) | PE20040189A1 (de) |
PL (1) | PL372886A1 (de) |
RU (1) | RU2301233C2 (de) |
TW (1) | TW200306194A (de) |
WO (1) | WO2003074530A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0313078A (pt) | 2002-08-06 | 2005-07-12 | Astrazeneca Ab | Composto ou um sal deste farmaceuticamente aceitável, composição farmacêutica, e, uso do composto ou de um sal deste farmaceuticamente aceitável |
US7319102B1 (en) | 2003-12-09 | 2008-01-15 | The Procter & Gamble Company | Pyrrolo[2,3-d]pyrimidine cytokine inhibitors |
PL1699800T3 (pl) * | 2003-12-23 | 2010-07-30 | Novartis Ag | Bicykliczne heterocykliczne inhibitory kinazy p-38 |
PL1713806T3 (pl) * | 2004-02-14 | 2013-09-30 | Irm Llc | Związki i kompozycje jako inhibitory kinaz białkowych |
RU2006134021A (ru) * | 2004-02-27 | 2008-04-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные гетероарил-конденсированного пиразола |
AU2005219525B2 (en) * | 2004-02-27 | 2011-08-18 | F. Hoffmann-La Roche Ag | Fused derivatives of pyrazole |
KR20060114022A (ko) | 2004-02-27 | 2006-11-03 | 에프. 호프만-라 로슈 아게 | 인다졸 유도체 및 그들을 함유하는 약학 조성물 |
WO2005107760A1 (en) * | 2004-04-30 | 2005-11-17 | Irm Llc | Compounds and compositions as inducers of keratinocyte differentiation |
MX2007005159A (es) | 2004-10-29 | 2007-06-26 | Tibotec Pharm Ltd | Derivados de pirimidina biciclicos inhibidores del vih. |
GB0427604D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
CN101243088B (zh) * | 2005-08-25 | 2011-06-29 | 霍夫曼-拉罗奇有限公司 | p38 MAP激酶抑制剂及使用它的方法 |
CA2649543A1 (en) * | 2006-04-21 | 2007-11-01 | Amgen Inc. | Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use |
JO3235B1 (ar) | 2006-05-26 | 2018-03-08 | Astex Therapeutics Ltd | مركبات بيررولوبيريميدين و استعمالاتها |
RU2540074C2 (ru) * | 2007-06-21 | 2015-01-27 | Кара Терапеутикс, Инк | Производные имидазопиразина или имидазодиазепина, активные в отношении рецептора св2 |
RU2345996C1 (ru) * | 2007-07-17 | 2009-02-10 | Андрей Александрович Иващенко | Аннелированные азагетероциклические амиды, включающие пиримидиновый фрагмент, способ их получения и применения |
RU2341527C1 (ru) * | 2007-07-17 | 2008-12-20 | Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" | Аннелированные азагетероциклы, включающие пиримидиновый фрагмент, способ их получения и ингибиторы pi3k киназ |
WO2009098236A1 (en) | 2008-02-06 | 2009-08-13 | Novartis Ag | Pyrrolo [2, 3-d] pyridines and use thereof as tyrosine kinase inhibitors |
TW201002713A (en) | 2008-04-09 | 2010-01-16 | Organon Nv | Pyrrolo[2,3-d]pyrimidin-2-yl-amine derivatives as PKC-theta inhibitors |
JO2924B1 (en) | 2008-08-22 | 2015-09-15 | نوفارتيس ايه جي | Pyroloperimidine compounds and their uses |
JP5654469B2 (ja) | 2008-10-01 | 2015-01-14 | アーケマ・インコーポレイテッド | オンラインの近赤外線分析を使用する、(メタ)アクリル酸を精製するためのプロセスの制御 |
UY33227A (es) | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de la cdk4/6 |
GB201104267D0 (en) | 2011-03-14 | 2011-04-27 | Cancer Rec Tech Ltd | Pyrrolopyridineamino derivatives |
US20130102601A1 (en) * | 2011-10-21 | 2013-04-25 | F. Hoffmann-La Roche Ltd | Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease |
GB201216017D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Inhibitor compounds |
GB201216018D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Pharmacologically active compounds |
CN103254194B (zh) * | 2013-05-17 | 2015-07-08 | 浙江师范大学 | 一种8-硫杂黄嘌呤化合物的制备方法 |
GB201403536D0 (en) | 2014-02-28 | 2014-04-16 | Cancer Rec Tech Ltd | Inhibitor compounds |
WO2016169504A1 (zh) * | 2015-04-24 | 2016-10-27 | 广州再极医药科技有限公司 | 稠环嘧啶氨基衍生物﹑其制备方法、中间体、药物组合物及应用 |
WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
GB201709840D0 (en) | 2017-06-20 | 2017-08-02 | Inst Of Cancer Research: Royal Cancer Hospital | Methods and medical uses |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
SG10202110259QA (en) | 2017-10-05 | 2021-10-28 | Fulcrum Therapeutics Inc | Use of p38 inhibitors to reduce expression of dux4 |
WO2019123375A1 (en) * | 2017-12-21 | 2019-06-27 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising motor neuron diseases |
CA3083368A1 (en) * | 2017-12-21 | 2019-06-27 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising a dementia |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4835157A (en) * | 1988-03-15 | 1989-05-30 | Ortho Pharmaceutical Corporation | Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents |
WO1995029897A1 (en) | 1994-04-29 | 1995-11-09 | G.D. Searle & Co. | METHOD OF USING (H+/K+) ATPase INHIBITORS AS ANTIVIRAL AGENTS |
EP0766684A4 (de) | 1994-06-09 | 1997-07-16 | Smithkline Beecham Corp | Endothelin-rezeptor antagonisten |
US6075037A (en) | 1994-06-09 | 2000-06-13 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
NZ333696A (en) | 1996-07-08 | 2000-06-23 | Du Pont Pharm Co | Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of trypsin like protease enzymes like thrombin and Xa factor |
WO1998006715A1 (en) * | 1996-08-09 | 1998-02-19 | Smithkline Beecham Corporation | Novel piperazine containing compounds |
AU4163197A (en) | 1996-08-30 | 1998-03-19 | Eli Lilly And Company | Nonclassical pyrrolo{2,3-d}pyrimidine antifolates |
CN1279682A (zh) * | 1997-10-20 | 2001-01-10 | 霍夫曼-拉罗奇有限公司 | 双环激酶抑制剂 |
US6232320B1 (en) * | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
AU3127900A (en) | 1998-12-23 | 2000-07-31 | Du Pont Pharmaceuticals Company | Thrombin or factor xa inhibitors |
CZ27399A3 (cs) | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
CZ20022353A3 (cs) | 2000-01-07 | 2003-02-12 | Universitaire Instelling Antwerpen | Deriváty purinu, způsob jejich přípravy a jejich použití |
US6635633B2 (en) * | 2000-08-14 | 2003-10-21 | Ortho-Pharmaceutical, Inc. | Substituted pyrazoles |
US7427623B2 (en) * | 2001-09-11 | 2008-09-23 | Smithkline Beecham Corporation | 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof |
-
2003
- 2003-02-28 JP JP2003572998A patent/JP4187657B2/ja not_active Expired - Fee Related
- 2003-02-28 ES ES03743361T patent/ES2314224T3/es not_active Expired - Lifetime
- 2003-02-28 KR KR1020047013677A patent/KR100714519B1/ko not_active IP Right Cessation
- 2003-02-28 AT AT03743361T patent/ATE410429T1/de not_active IP Right Cessation
- 2003-02-28 MX MXPA04008592A patent/MXPA04008592A/es active IP Right Grant
- 2003-02-28 AU AU2003210388A patent/AU2003210388B2/en not_active Ceased
- 2003-02-28 DE DE60323946T patent/DE60323946D1/de not_active Expired - Fee Related
- 2003-02-28 CN CNB038054191A patent/CN100386328C/zh not_active Expired - Fee Related
- 2003-02-28 WO PCT/EP2003/002090 patent/WO2003074530A1/en active IP Right Grant
- 2003-02-28 CA CA002477721A patent/CA2477721A1/en not_active Abandoned
- 2003-02-28 RU RU2004129768/04A patent/RU2301233C2/ru active
- 2003-02-28 EP EP03743361A patent/EP1485390B1/de not_active Expired - Lifetime
- 2003-02-28 PL PL03372886A patent/PL372886A1/xx not_active Application Discontinuation
- 2003-02-28 BR BR0308232-6A patent/BR0308232A/pt not_active IP Right Cessation
- 2003-03-04 PE PE2003000209A patent/PE20040189A1/es not_active Application Discontinuation
- 2003-03-04 TW TW092104537A patent/TW200306194A/zh unknown
- 2003-03-04 AR ARP030100718A patent/AR038864A1/es not_active Application Discontinuation
- 2003-03-06 PA PA20038568401A patent/PA8568401A1/es unknown
- 2003-03-06 US US10/383,392 patent/US7091347B2/en not_active Expired - Fee Related
-
2005
- 2005-08-12 US US11/202,611 patent/US7449472B2/en not_active Expired - Fee Related
- 2005-11-30 US US11/292,217 patent/US7439247B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2314224T3 (es) | 2009-03-16 |
US7449472B2 (en) | 2008-11-11 |
TW200306194A (en) | 2003-11-16 |
US20060084803A1 (en) | 2006-04-20 |
US20050288312A1 (en) | 2005-12-29 |
US7091347B2 (en) | 2006-08-15 |
AR038864A1 (es) | 2005-02-02 |
EP1485390B1 (de) | 2008-10-08 |
US7439247B2 (en) | 2008-10-21 |
JP4187657B2 (ja) | 2008-11-26 |
RU2004129768A (ru) | 2005-08-27 |
PL372886A1 (en) | 2005-08-08 |
CN100386328C (zh) | 2008-05-07 |
RU2301233C2 (ru) | 2007-06-20 |
KR100714519B1 (ko) | 2007-05-07 |
AU2003210388A1 (en) | 2003-09-16 |
ATE410429T1 (de) | 2008-10-15 |
BR0308232A (pt) | 2004-12-28 |
JP2005526057A (ja) | 2005-09-02 |
MXPA04008592A (es) | 2004-12-06 |
US20030207900A1 (en) | 2003-11-06 |
KR20040091084A (ko) | 2004-10-27 |
CA2477721A1 (en) | 2003-09-12 |
AU2003210388B2 (en) | 2007-05-17 |
WO2003074530A1 (en) | 2003-09-12 |
PA8568401A1 (es) | 2003-12-10 |
PE20040189A1 (es) | 2004-05-01 |
CN1639168A (zh) | 2005-07-13 |
EP1485390A1 (de) | 2004-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |