BR0308232A - Inibidores de cinase p38 de piridina e pirimidina bicìclicas - Google Patents

Inibidores de cinase p38 de piridina e pirimidina bicìclicas

Info

Publication number
BR0308232A
BR0308232A BR0308232-6A BR0308232A BR0308232A BR 0308232 A BR0308232 A BR 0308232A BR 0308232 A BR0308232 A BR 0308232A BR 0308232 A BR0308232 A BR 0308232A
Authority
BR
Brazil
Prior art keywords
pyrimidine
kinase inhibitors
bicyclic pyridine
pyridine
bicyclic
Prior art date
Application number
BR0308232-6A
Other languages
English (en)
Inventor
Jian Jeffrey Chen
Nolan James Dewdney
Christoph Martin Stahl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0308232A publication Critical patent/BR0308232A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"INIBIDORES DE CINASE P38 DE PIRIDINA E PIRIMIDINA BICìCLICAS". A presente invenção refere-se a compostos que correspem quem à fórmula (I) em que A, R, X, Y, R, R^ 1^ R^ 2^ são conforme definidos, formulações farmacêuticas, processos para fabricação e usos da mesma no tratamento de doenças mediadas por cinase p38.
BR0308232-6A 2002-03-07 2003-02-28 Inibidores de cinase p38 de piridina e pirimidina bicìclicas BR0308232A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36237302P 2002-03-07 2002-03-07
US43050802P 2002-12-03 2002-12-03
PCT/EP2003/002090 WO2003074530A1 (en) 2002-03-07 2003-02-28 Bicyclic pyridine and pyrimidine p38 kinase inhibitors

Publications (1)

Publication Number Publication Date
BR0308232A true BR0308232A (pt) 2004-12-28

Family

ID=27791709

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308232-6A BR0308232A (pt) 2002-03-07 2003-02-28 Inibidores de cinase p38 de piridina e pirimidina bicìclicas

Country Status (19)

Country Link
US (3) US7091347B2 (pt)
EP (1) EP1485390B1 (pt)
JP (1) JP4187657B2 (pt)
KR (1) KR100714519B1 (pt)
CN (1) CN100386328C (pt)
AR (1) AR038864A1 (pt)
AT (1) ATE410429T1 (pt)
AU (1) AU2003210388B2 (pt)
BR (1) BR0308232A (pt)
CA (1) CA2477721A1 (pt)
DE (1) DE60323946D1 (pt)
ES (1) ES2314224T3 (pt)
MX (1) MXPA04008592A (pt)
PA (1) PA8568401A1 (pt)
PE (1) PE20040189A1 (pt)
PL (1) PL372886A1 (pt)
RU (1) RU2301233C2 (pt)
TW (1) TW200306194A (pt)
WO (1) WO2003074530A1 (pt)

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US7319102B1 (en) 2003-12-09 2008-01-15 The Procter & Gamble Company Pyrrolo[2,3-d]pyrimidine cytokine inhibitors
PL1699800T3 (pl) * 2003-12-23 2010-07-30 Novartis Ag Bicykliczne heterocykliczne inhibitory kinazy p-38
PL1713806T3 (pl) * 2004-02-14 2013-09-30 Irm Llc Związki i kompozycje jako inhibitory kinaz białkowych
RU2006134021A (ru) * 2004-02-27 2008-04-10 Ф.Хоффманн-Ля Рош Аг (Ch) Производные гетероарил-конденсированного пиразола
AU2005219525B2 (en) * 2004-02-27 2011-08-18 F. Hoffmann-La Roche Ag Fused derivatives of pyrazole
KR20060114022A (ko) 2004-02-27 2006-11-03 에프. 호프만-라 로슈 아게 인다졸 유도체 및 그들을 함유하는 약학 조성물
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GB0427604D0 (en) * 2004-12-16 2005-01-19 Novartis Ag Organic compounds
CN101243088B (zh) * 2005-08-25 2011-06-29 霍夫曼-拉罗奇有限公司 p38 MAP激酶抑制剂及使用它的方法
CA2649543A1 (en) * 2006-04-21 2007-11-01 Amgen Inc. Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use
JO3235B1 (ar) 2006-05-26 2018-03-08 Astex Therapeutics Ltd مركبات بيررولوبيريميدين و استعمالاتها
RU2540074C2 (ru) * 2007-06-21 2015-01-27 Кара Терапеутикс, Инк Производные имидазопиразина или имидазодиазепина, активные в отношении рецептора св2
RU2345996C1 (ru) * 2007-07-17 2009-02-10 Андрей Александрович Иващенко Аннелированные азагетероциклические амиды, включающие пиримидиновый фрагмент, способ их получения и применения
RU2341527C1 (ru) * 2007-07-17 2008-12-20 Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" Аннелированные азагетероциклы, включающие пиримидиновый фрагмент, способ их получения и ингибиторы pi3k киназ
WO2009098236A1 (en) 2008-02-06 2009-08-13 Novartis Ag Pyrrolo [2, 3-d] pyridines and use thereof as tyrosine kinase inhibitors
TW201002713A (en) 2008-04-09 2010-01-16 Organon Nv Pyrrolo[2,3-d]pyrimidin-2-yl-amine derivatives as PKC-theta inhibitors
JO2924B1 (en) 2008-08-22 2015-09-15 نوفارتيس ايه جي Pyroloperimidine compounds and their uses
JP5654469B2 (ja) 2008-10-01 2015-01-14 アーケマ・インコーポレイテッド オンラインの近赤外線分析を使用する、（メタ）アクリル酸を精製するためのプロセスの制御
UY33227A (es) 2010-02-19 2011-09-30 Novartis Ag Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
GB201104267D0 (en) 2011-03-14 2011-04-27 Cancer Rec Tech Ltd Pyrrolopyridineamino derivatives
US20130102601A1 (en) * 2011-10-21 2013-04-25 F. Hoffmann-La Roche Ltd Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease
GB201216017D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Inhibitor compounds
GB201216018D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Pharmacologically active compounds
CN103254194B (zh) * 2013-05-17 2015-07-08 浙江师范大学 一种8-硫杂黄嘌呤化合物的制备方法
GB201403536D0 (en) 2014-02-28 2014-04-16 Cancer Rec Tech Ltd Inhibitor compounds
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Also Published As

Publication number Publication date
ES2314224T3 (es) 2009-03-16
US7449472B2 (en) 2008-11-11
TW200306194A (en) 2003-11-16
US20060084803A1 (en) 2006-04-20
US20050288312A1 (en) 2005-12-29
US7091347B2 (en) 2006-08-15
AR038864A1 (es) 2005-02-02
EP1485390B1 (en) 2008-10-08
US7439247B2 (en) 2008-10-21
JP4187657B2 (ja) 2008-11-26
RU2004129768A (ru) 2005-08-27
PL372886A1 (en) 2005-08-08
CN100386328C (zh) 2008-05-07
RU2301233C2 (ru) 2007-06-20
KR100714519B1 (ko) 2007-05-07
AU2003210388A1 (en) 2003-09-16
ATE410429T1 (de) 2008-10-15
JP2005526057A (ja) 2005-09-02
MXPA04008592A (es) 2004-12-06
US20030207900A1 (en) 2003-11-06
KR20040091084A (ko) 2004-10-27
CA2477721A1 (en) 2003-09-12
AU2003210388B2 (en) 2007-05-17
WO2003074530A1 (en) 2003-09-12
PA8568401A1 (es) 2003-12-10
DE60323946D1 (de) 2008-11-20
PE20040189A1 (es) 2004-05-01
CN1639168A (zh) 2005-07-13
EP1485390A1 (en) 2004-12-15

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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