PA8568401A1 - Inhibidores pirimidina y piridina biciclicos de la p38 quinasa - Google Patents
Inhibidores pirimidina y piridina biciclicos de la p38 quinasaInfo
- Publication number
- PA8568401A1 PA8568401A1 PA20038568401A PA8568401A PA8568401A1 PA 8568401 A1 PA8568401 A1 PA 8568401A1 PA 20038568401 A PA20038568401 A PA 20038568401A PA 8568401 A PA8568401 A PA 8568401A PA 8568401 A1 PA8568401 A1 PA 8568401A1
- Authority
- PA
- Panama
- Prior art keywords
- quinasa
- pyrimidine
- bicycle
- pyridine inhibitors
- pyridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
LA PRESENTE INVENCION REVELA COMPUESTOS CORRESPONDIENTES A LA FORMULA, EN DONDE A,R,X,Y,R,R1, Y R2 SON TAL COMO SE DEFINEN, FORMULACIONES FARMACEUTICAS, METODOS DE FABRICACION Y USOS DE LOS MISMOS EN EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR LA QUINASA P38.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36237302P | 2002-03-07 | 2002-03-07 | |
US43050802P | 2002-12-03 | 2002-12-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8568401A1 true PA8568401A1 (es) | 2003-12-10 |
Family
ID=27791709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20038568401A PA8568401A1 (es) | 2002-03-07 | 2003-03-06 | Inhibidores pirimidina y piridina biciclicos de la p38 quinasa |
Country Status (19)
Country | Link |
---|---|
US (3) | US7091347B2 (es) |
EP (1) | EP1485390B1 (es) |
JP (1) | JP4187657B2 (es) |
KR (1) | KR100714519B1 (es) |
CN (1) | CN100386328C (es) |
AR (1) | AR038864A1 (es) |
AT (1) | ATE410429T1 (es) |
AU (1) | AU2003210388B2 (es) |
BR (1) | BR0308232A (es) |
CA (1) | CA2477721A1 (es) |
DE (1) | DE60323946D1 (es) |
ES (1) | ES2314224T3 (es) |
MX (1) | MXPA04008592A (es) |
PA (1) | PA8568401A1 (es) |
PE (1) | PE20040189A1 (es) |
PL (1) | PL372886A1 (es) |
RU (1) | RU2301233C2 (es) |
TW (1) | TW200306194A (es) |
WO (1) | WO2003074530A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE323702T1 (de) | 2002-08-06 | 2006-05-15 | Astrazeneca Ab | Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität |
US7319102B1 (en) * | 2003-12-09 | 2008-01-15 | The Procter & Gamble Company | Pyrrolo[2,3-d]pyrimidine cytokine inhibitors |
AU2004309420B2 (en) * | 2003-12-23 | 2008-10-30 | Novartis Ag | Bicyclic heterocyclic p-38 kinase inhibitors |
PL1713806T3 (pl) * | 2004-02-14 | 2013-09-30 | Irm Llc | Związki i kompozycje jako inhibitory kinaz białkowych |
WO2005085248A1 (en) * | 2004-02-27 | 2005-09-15 | F.Hoffmann-La Roche Ag | Heteroaryl-fused pyrazolo derivatives |
RU2006134022A (ru) | 2004-02-27 | 2008-04-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные индазола и содержащие их фармацевтические композиции |
RU2006134020A (ru) * | 2004-02-27 | 2008-04-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Конденсированные производные пиразола |
WO2005107760A1 (en) * | 2004-04-30 | 2005-11-17 | Irm Llc | Compounds and compositions as inducers of keratinocyte differentiation |
CN101048410B (zh) | 2004-10-29 | 2010-06-23 | 泰博特克药品有限公司 | 抑制hiv的双环嘧啶衍生物 |
GB0427604D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
MX2008002588A (es) * | 2005-08-25 | 2008-03-18 | Hoffmann La Roche | Inhibidores de p38-map-cinasa y los metodos para utilizarlos. |
EP2038289A2 (en) * | 2006-04-21 | 2009-03-25 | Amgen Inc. | Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use |
TWI398252B (zh) * | 2006-05-26 | 2013-06-11 | Novartis Ag | 吡咯并嘧啶化合物及其用途 |
RU2540074C2 (ru) * | 2007-06-21 | 2015-01-27 | Кара Терапеутикс, Инк | Производные имидазопиразина или имидазодиазепина, активные в отношении рецептора св2 |
RU2341527C1 (ru) * | 2007-07-17 | 2008-12-20 | Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" | Аннелированные азагетероциклы, включающие пиримидиновый фрагмент, способ их получения и ингибиторы pi3k киназ |
RU2345996C1 (ru) * | 2007-07-17 | 2009-02-10 | Андрей Александрович Иващенко | Аннелированные азагетероциклические амиды, включающие пиримидиновый фрагмент, способ их получения и применения |
NZ587271A (en) | 2008-02-06 | 2012-03-30 | Novartis Ag | Pyrrolo[2,3-d]pyrimidines containing a 7h-pyrrolo[2,3-d]pyrimidin-2-yl core and use thereof as tyrosine kinase inhibitors |
TW201002713A (en) * | 2008-04-09 | 2010-01-16 | Organon Nv | Pyrrolo[2,3-d]pyrimidin-2-yl-amine derivatives as PKC-theta inhibitors |
CA2734802C (en) | 2008-08-22 | 2016-05-31 | Novartis Ag | Pyrrolopyrimidine compounds as cdk inhibitors |
KR20170113690A (ko) | 2008-10-01 | 2017-10-12 | 알케마 인코포레이티드 | 온라인 근적외선 분석을 이용한 (메트)아크릴산 정제 방법의 제어 |
UY33227A (es) | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de la cdk4/6 |
GB201104267D0 (en) | 2011-03-14 | 2011-04-27 | Cancer Rec Tech Ltd | Pyrrolopyridineamino derivatives |
US20130102601A1 (en) * | 2011-10-21 | 2013-04-25 | F. Hoffmann-La Roche Ltd | Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease |
GB201216018D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Pharmacologically active compounds |
GB201216017D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Inhibitor compounds |
CN103254194B (zh) * | 2013-05-17 | 2015-07-08 | 浙江师范大学 | 一种8-硫杂黄嘌呤化合物的制备方法 |
GB201403536D0 (en) | 2014-02-28 | 2014-04-16 | Cancer Rec Tech Ltd | Inhibitor compounds |
US10259816B2 (en) * | 2015-04-24 | 2019-04-16 | Guangzhou Maxinovel Pharmaceuticals Co., Ltd. | Condensed-ring pyrimidylamino derivative, preparation method therefor, and intermediate, pharmaceutical composition and applications thereof |
US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
GB201709840D0 (en) | 2017-06-20 | 2017-08-02 | Inst Of Cancer Research: Royal Cancer Hospital | Methods and medical uses |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
ES2927715T3 (es) | 2017-10-05 | 2022-11-10 | Fulcrum Therapeutics Inc | Inhibidores de la quinasa p38 reducen la expresión de dux4 y de los genes que le siguen para el tratamiento de la FSHD |
MX2020006385A (es) * | 2017-12-21 | 2020-12-07 | Gliapharm Sa | Composiciones y metodos para el tratamiento de trastornos neurologicos que comprenden una demencia. |
AU2018392985A1 (en) * | 2017-12-21 | 2020-06-04 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising motor neuron diseases |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4835157A (en) * | 1988-03-15 | 1989-05-30 | Ortho Pharmaceutical Corporation | Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents |
WO1995029897A1 (en) | 1994-04-29 | 1995-11-09 | G.D. Searle & Co. | METHOD OF USING (H+/K+) ATPase INHIBITORS AS ANTIVIRAL AGENTS |
JPH10501532A (ja) | 1994-06-09 | 1998-02-10 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体拮抗物質 |
US6075037A (en) | 1994-06-09 | 2000-06-13 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
NZ333696A (en) | 1996-07-08 | 2000-06-23 | Du Pont Pharm Co | Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of trypsin like protease enzymes like thrombin and Xa factor |
WO1998006715A1 (en) * | 1996-08-09 | 1998-02-19 | Smithkline Beecham Corporation | Novel piperazine containing compounds |
JP2000516961A (ja) | 1996-08-30 | 2000-12-19 | イーライ・リリー・アンド・カンパニー | 非古典的ピロロ[2,3―d]ピリミジン抗葉酸物質 |
EP1025102B1 (en) * | 1997-10-20 | 2004-05-19 | F. Hoffmann-La Roche Ag | Bicyclic kinase inhibitors |
US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
AU2381600A (en) | 1998-12-23 | 2000-07-31 | Du Pont Pharmaceuticals Company | Thrombin or factor xa inhibitors |
CZ27399A3 (cs) | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
IL150594A0 (en) | 2000-01-07 | 2003-02-12 | Ustav Ex Botan Adademie Ved Ce | Purine derivatives, process for their preparation and use |
EP1309592B9 (en) * | 2000-08-14 | 2007-02-28 | Ortho-McNeil Pharmaceutical, Inc. | Substituted pyrazoles |
EP1425284A2 (en) * | 2001-09-11 | 2004-06-09 | Smithkline Beecham Corporation | Furo- and thienopyrimidine derivatives as angiogenesis inhibitors |
-
2003
- 2003-02-28 EP EP03743361A patent/EP1485390B1/en not_active Expired - Lifetime
- 2003-02-28 AU AU2003210388A patent/AU2003210388B2/en not_active Ceased
- 2003-02-28 KR KR1020047013677A patent/KR100714519B1/ko not_active IP Right Cessation
- 2003-02-28 PL PL03372886A patent/PL372886A1/xx not_active Application Discontinuation
- 2003-02-28 BR BR0308232-6A patent/BR0308232A/pt not_active IP Right Cessation
- 2003-02-28 CA CA002477721A patent/CA2477721A1/en not_active Abandoned
- 2003-02-28 MX MXPA04008592A patent/MXPA04008592A/es active IP Right Grant
- 2003-02-28 AT AT03743361T patent/ATE410429T1/de not_active IP Right Cessation
- 2003-02-28 RU RU2004129768/04A patent/RU2301233C2/ru active
- 2003-02-28 CN CNB038054191A patent/CN100386328C/zh not_active Expired - Fee Related
- 2003-02-28 JP JP2003572998A patent/JP4187657B2/ja not_active Expired - Fee Related
- 2003-02-28 DE DE60323946T patent/DE60323946D1/de not_active Expired - Fee Related
- 2003-02-28 WO PCT/EP2003/002090 patent/WO2003074530A1/en active IP Right Grant
- 2003-02-28 ES ES03743361T patent/ES2314224T3/es not_active Expired - Lifetime
- 2003-03-04 AR ARP030100718A patent/AR038864A1/es not_active Application Discontinuation
- 2003-03-04 TW TW092104537A patent/TW200306194A/zh unknown
- 2003-03-04 PE PE2003000209A patent/PE20040189A1/es not_active Application Discontinuation
- 2003-03-06 PA PA20038568401A patent/PA8568401A1/es unknown
- 2003-03-06 US US10/383,392 patent/US7091347B2/en not_active Expired - Fee Related
-
2005
- 2005-08-12 US US11/202,611 patent/US7449472B2/en not_active Expired - Fee Related
- 2005-11-30 US US11/292,217 patent/US7439247B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7091347B2 (en) | 2006-08-15 |
EP1485390A1 (en) | 2004-12-15 |
TW200306194A (en) | 2003-11-16 |
MXPA04008592A (es) | 2004-12-06 |
US20050288312A1 (en) | 2005-12-29 |
DE60323946D1 (de) | 2008-11-20 |
PE20040189A1 (es) | 2004-05-01 |
AR038864A1 (es) | 2005-02-02 |
AU2003210388A1 (en) | 2003-09-16 |
US7449472B2 (en) | 2008-11-11 |
RU2004129768A (ru) | 2005-08-27 |
ES2314224T3 (es) | 2009-03-16 |
KR20040091084A (ko) | 2004-10-27 |
CA2477721A1 (en) | 2003-09-12 |
US20030207900A1 (en) | 2003-11-06 |
AU2003210388B2 (en) | 2007-05-17 |
ATE410429T1 (de) | 2008-10-15 |
US7439247B2 (en) | 2008-10-21 |
RU2301233C2 (ru) | 2007-06-20 |
US20060084803A1 (en) | 2006-04-20 |
JP2005526057A (ja) | 2005-09-02 |
CN1639168A (zh) | 2005-07-13 |
CN100386328C (zh) | 2008-05-07 |
KR100714519B1 (ko) | 2007-05-07 |
JP4187657B2 (ja) | 2008-11-26 |
WO2003074530A1 (en) | 2003-09-12 |
BR0308232A (pt) | 2004-12-28 |
EP1485390B1 (en) | 2008-10-08 |
PL372886A1 (en) | 2005-08-08 |
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