ATE323702T1 - Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität - Google Patents
Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivitätInfo
- Publication number
- ATE323702T1 ATE323702T1 AT03766443T AT03766443T ATE323702T1 AT E323702 T1 ATE323702 T1 AT E323702T1 AT 03766443 T AT03766443 T AT 03766443T AT 03766443 T AT03766443 T AT 03766443T AT E323702 T1 ATE323702 T1 AT E323702T1
- Authority
- AT
- Austria
- Prior art keywords
- tie2
- tek
- pyrimidines
- activity
- condensed pyridines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0218168A GB0218168D0 (en) | 2002-08-06 | 2002-08-06 | Compounds |
GB0312356A GB0312356D0 (en) | 2003-05-30 | 2003-05-30 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE323702T1 true ATE323702T1 (de) | 2006-05-15 |
Family
ID=31497259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03766443T ATE323702T1 (de) | 2002-08-06 | 2003-08-01 | Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität |
Country Status (15)
Country | Link |
---|---|
US (1) | US7427616B2 (de) |
EP (1) | EP1537112B1 (de) |
JP (1) | JP2005538118A (de) |
KR (1) | KR20050067383A (de) |
AR (1) | AR041189A1 (de) |
AT (1) | ATE323702T1 (de) |
AU (1) | AU2003246972A1 (de) |
BR (1) | BR0313078A (de) |
CA (1) | CA2494421A1 (de) |
DE (1) | DE60304718T2 (de) |
IL (1) | IL166521A0 (de) |
MX (1) | MXPA05001389A (de) |
NO (1) | NO20050418L (de) |
TW (1) | TW200407116A (de) |
WO (1) | WO2004013141A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0230089D0 (en) * | 2002-12-24 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
EP1687309A1 (de) | 2003-11-17 | 2006-08-09 | Pfizer Products Inc. | Pyrrolopyrimidinverbindungen, die sich zur behandlung von krebs eignen |
TWI332003B (en) | 2004-01-30 | 2010-10-21 | Lilly Co Eli | Kinase inhibitors |
GB0402518D0 (en) * | 2004-02-05 | 2004-03-10 | Astrazeneca Ab | Therapeutic agents |
NZ548208A (en) * | 2004-02-12 | 2010-09-30 | Transtech Pharma Inc | Substituted azole derivatives, compositions, and methods of use |
US7517888B2 (en) | 2004-04-28 | 2009-04-14 | Cv Therapeutics, Inc. | A1 adenosine receptor antagonists |
CA2566160C (en) * | 2004-05-27 | 2011-01-18 | Pfizer Products Inc. | Pyrrolopyrimidine derivatives useful in cancer treatment |
CA2569887A1 (en) | 2004-06-09 | 2005-12-22 | Glaxo Group Limited | Pyrrolopyridine derivatives |
WO2006019965A2 (en) * | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
TW200615268A (en) * | 2004-08-02 | 2006-05-16 | Osi Pharm Inc | Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds |
KR20070049655A (ko) | 2004-08-13 | 2007-05-11 | 제넨테크, 인크. | Atp-이용 효소 억제 활성을 나타내는2-아미도-티아졸-기재 화합물과 조성물 및 이들의 용도 |
ES2465469T3 (es) | 2005-01-14 | 2014-06-05 | Gilead Connecticut, Inc. | Diaril ureas 1,3-sustituidas como moduladores de la actividad quinasa |
AU2006330587B2 (en) * | 2005-12-23 | 2012-12-13 | Glaxosmithkline Llc | Azaindole inhibitors of aurora kinases |
AU2007240568A1 (en) * | 2006-04-21 | 2007-11-01 | Amgen Inc. | Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use |
US8236823B2 (en) | 2006-10-27 | 2012-08-07 | Amgen Inc. | Multi-cyclic compounds and methods of use |
CN101965350A (zh) | 2008-01-11 | 2011-02-02 | 纳科法尔马有限公司 | 作为抗癌剂的新的吡唑并[3,4-d]嘧啶衍生物 |
CA2729012A1 (en) | 2008-06-27 | 2009-12-30 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
CA2731228A1 (en) | 2008-07-22 | 2010-01-28 | Biocryst Pharmaceuticals, Inc. | Synthetic intermediates and processes |
JOP20190231A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
WO2011018894A1 (en) * | 2009-08-10 | 2011-02-17 | Raqualia Pharma Inc. | Pyrrolopyrimidine derivatives as potassium channel modulators |
SI2540728T1 (sl) | 2010-02-17 | 2019-06-28 | Takeda Pharmaceutical Company Limited | Heterociklična spojina |
EP2603216A4 (de) * | 2010-08-11 | 2013-12-18 | Millennium Pharm Inc | Heteroaryle und verwendungen davon |
US8362004B2 (en) | 2010-09-08 | 2013-01-29 | Bristol-Myers Squibb Company | Piperazine analogs as broad-spectrum influenza antivirals |
EA201390476A1 (ru) | 2010-09-28 | 2013-08-30 | Бристол-Майерс Сквибб Компани | Новые пиперазиновые аналоги с замещенными гетероарильными группами в качестве противовирусных средств широкого применения против гриппа |
EP2733146A1 (de) * | 2012-11-20 | 2014-05-21 | KTB Tumorforschungsgesellschaft mbH | Thioetherderivate als Proteinkinase-Inhibitoren |
CN104936963B (zh) * | 2012-11-20 | 2017-11-28 | 普罗齐纳斯有限公司 | 作为蛋白激酶抑制剂的硫醚衍生物 |
KR20160030565A (ko) | 2013-07-15 | 2016-03-18 | 바스프 에스이 | 살충제 화합물 |
CA2921199A1 (en) * | 2013-08-27 | 2015-03-05 | Bristol-Myers Squibb Company | Ido inhibitors |
WO2016100495A1 (en) * | 2014-12-17 | 2016-06-23 | Duquesne University Of The Holy Spirit | CONFORMATIONALLY RESTRICTED 4-SUBSTITUTED-2,6-DIMETHYLFURO[2,3-d]PYRIMIDINES AS ANTITUMOR AGENTS |
EP3632908A1 (de) | 2018-10-02 | 2020-04-08 | Inventiva | Inhibitoren der yap / taz-tead-interaktion und ihre verwendung bei der behandlung von krebs |
CN113272308A (zh) * | 2018-11-20 | 2021-08-17 | 乔治敦大学 | 用于治疗神经退行性、肌退行性和溶酶体贮积病症的组合物和方法 |
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DD287503A5 (de) | 1988-06-13 | 1991-02-28 | Karl-Marx-Universitaet Leipzig,De | Verfahren zur herstellung von 4-amino-2-mercapto-thieno-/2,3-d/pyrimidinen bzw. 4-amino-2-alkylthio-thieno/2,3-d/-pyrimidinen |
DE4008726A1 (de) | 1990-03-19 | 1991-09-26 | Basf Ag | Thieno(2,3-d)pyrimidinderivate |
US5958930A (en) | 1991-04-08 | 1999-09-28 | Duquesne University Of The Holy Ghost | Pyrrolo pyrimidine and furo pyrimidine derivatives |
US6756388B1 (en) | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
US5589482A (en) | 1994-12-14 | 1996-12-31 | Pfizer Inc. | Benzo-thiophene estrogen agonists to treat prostatic hyperplasia |
AU6966696A (en) | 1995-10-05 | 1997-04-28 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
WO1997049706A1 (en) | 1996-06-25 | 1997-12-31 | Novartis Ag | SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF |
CA2263838A1 (en) | 1996-08-21 | 1998-02-26 | Sugen, Inc. | Crystal structures of a protein tyrosine kinase |
DE69815317T2 (de) | 1997-03-19 | 2005-04-07 | Abbott Gmbh & Co. Kg | Pyrrolo[2,3-d]pyrimidine und ihre verwendung als tyrosinkinase-inhibitoren |
CN1280580A (zh) | 1997-11-11 | 2001-01-17 | 辉瑞产品公司 | 用作抗癌药的噻吩并嘧啶和噻吩并吡啶衍生物 |
AU3859999A (en) | 1998-05-14 | 1999-11-29 | G.D. Searle & Co. | 1,5-diaryl substituted pyrazoles as p38 kinase inhibitors |
JP2002517396A (ja) | 1998-06-04 | 2002-06-18 | アボット・ラボラトリーズ | 細胞接着阻害抗炎症性化合物 |
SE9802729D0 (sv) | 1998-08-13 | 1998-08-13 | Astra Pharma Prod | Novel Compounds |
HUP0200355A3 (en) | 1998-09-18 | 2004-07-28 | Abbott Gmbh & Co Kg | 4-aminopyrrolopyrimidines as kinase inhibitors, pharmaceutical compositions containing them and their use |
ID29028A (id) | 1998-09-18 | 2001-07-26 | Basf Ag | Pirolopirimidina sebagai penghambat protein kinase |
UA71945C2 (en) | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
EP1175419B1 (de) | 1999-04-02 | 2003-05-28 | Bristol-Myers Squibb Pharma Company | Arylsulfonyle als faktor xa inhibitoren |
AR029347A1 (es) | 1999-04-02 | 2003-06-25 | Euro Celtique Sa | Compuesto de adenina, compuesto de isognanina y 2,6-ditioxantina como precursor del mismo, uso de dichos compuestos para preparar una composicion farmaceutica y dicha composicion farmaceutica |
US6930101B1 (en) | 1999-05-17 | 2005-08-16 | The Regents Of The University Of California | Thiazolopyrimidines useful as TNFα inhibitors |
EP1181296A1 (de) | 1999-06-03 | 2002-02-27 | Abbott Laboratories | Zelladhäsionshemmende entzündungshemmende verbindungen |
DE60037455T2 (de) | 1999-09-17 | 2008-11-27 | Abbott Gmbh & Co. Kg | Kinaseinhibitoren als arzneimittel |
RU2002110295A (ru) | 1999-09-17 | 2003-12-10 | Милленниум Фармасьютикалс, Инк. (Us) | Ингибиторы фактора Ха |
US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
AU780052B2 (en) | 1999-09-17 | 2005-02-24 | Abbott Gmbh & Co. Kg | Pyrazolopyrimidines as therapeutic agents |
US6632815B2 (en) | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
SE9903544D0 (sv) | 1999-10-01 | 1999-10-01 | Astra Pharma Prod | Novel compounds |
CA2395564A1 (en) | 1999-11-22 | 2001-05-31 | Smithkline Beecham Plc | Novel compounds |
US7115589B2 (en) | 1999-12-17 | 2006-10-03 | Ariad Pharmaceuticals, Inc. | Purine derivatives |
WO2001044259A1 (en) | 1999-12-17 | 2001-06-21 | Ariad Pharmaceuticals, Inc. | Purine derivatives |
CA2363274A1 (en) | 1999-12-27 | 2001-07-05 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs for hepatitis c |
US20030187261A1 (en) | 2000-01-07 | 2003-10-02 | Libor Havlicek | Purine derivatives, process for their preparation and use thereof |
GB2359081A (en) | 2000-02-11 | 2001-08-15 | Astrazeneca Uk Ltd | Pharmaceutically active thiazolopyrimidines |
JP2004514405A (ja) | 2000-03-29 | 2004-05-20 | アボット ゲーエムベーハー ウント カンパニー カーゲー | Tie−2阻害薬の特定方法 |
WO2001072751A1 (en) | 2000-03-29 | 2001-10-04 | Knoll Gesellschaft Mit Beschraenkter Haftung | Pyrrolopyrimidines as tyrosine kinase inhibitors |
AU2001273040A1 (en) | 2000-06-27 | 2002-01-08 | Du Pont Pharmaceuticals Company | Factor xa inhibitors |
JP2002105081A (ja) | 2000-07-28 | 2002-04-10 | Nikken Chem Co Ltd | 新規チオフェンニ環化合物 |
EP1345966A2 (de) | 2000-09-08 | 2003-09-24 | Glaxo Group Limited | Kristallisierte zytoplasmatische tie2 rezeptor-tyrosinkinase domäne und verfahren zur feststellung und zum design ihrer modulatoren |
US20020146472A1 (en) | 2000-11-15 | 2002-10-10 | Chen Kuang Yu | Black tea extract for prevention of disease |
WO2002044156A2 (en) | 2000-11-29 | 2002-06-06 | Glaxo Group Limited | Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors |
MXPA03008560A (es) | 2001-03-22 | 2004-06-30 | Abbot Gmbh & Co Kg | Pirazolopirimidinas como agentes terapeuticos. |
SE0101322D0 (sv) | 2001-04-12 | 2001-04-12 | Astrazeneca Ab | Novel compounds |
AU2002305205A1 (en) | 2001-04-20 | 2002-11-05 | Jingrong Cao | 9-deazaguanine derivatives as inhibitors of gsk-3 |
AU2002315389A1 (en) | 2001-06-21 | 2003-01-08 | Ariad Pharmaceuticals, Inc. | Novel pyrazolo-and pyrrolo-pyrimidines and uses thereof |
WO2003000194A2 (en) | 2001-06-21 | 2003-01-03 | Pfizer Inc. | Thienopyridine and thienopyrimidine anticancer agents |
GB0118479D0 (en) | 2001-07-28 | 2001-09-19 | Astrazeneca Ab | Novel compounds |
US7427623B2 (en) | 2001-09-11 | 2008-09-23 | Smithkline Beecham Corporation | 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof |
DE60228295D1 (de) | 2001-09-21 | 2008-09-25 | Smithkline Beecham Corp | Chemische verbindungen |
JP5039268B2 (ja) | 2001-10-26 | 2012-10-03 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | ベンゾイミダゾールおよび類縁体および蛋白キナーゼ阻害剤としてのその使用 |
AU2002356301A1 (en) | 2001-12-21 | 2003-07-15 | Cancer Research Technology Ltd. | 3,4-diarylpyrazoles and their use in the therapy of cancer |
TW200306191A (en) | 2002-02-22 | 2003-11-16 | Teijin Ltd | Pyrrolopyrimidine derivatives |
CN100386328C (zh) | 2002-03-07 | 2008-05-07 | 霍夫曼-拉罗奇有限公司 | 双环吡啶和嘧啶p38激酶抑制剂 |
-
2003
- 2003-08-01 AT AT03766443T patent/ATE323702T1/de not_active IP Right Cessation
- 2003-08-01 CA CA002494421A patent/CA2494421A1/en not_active Abandoned
- 2003-08-01 WO PCT/GB2003/003275 patent/WO2004013141A1/en active IP Right Grant
- 2003-08-01 AU AU2003246972A patent/AU2003246972A1/en not_active Abandoned
- 2003-08-01 EP EP03766443A patent/EP1537112B1/de not_active Expired - Lifetime
- 2003-08-01 MX MXPA05001389A patent/MXPA05001389A/es unknown
- 2003-08-01 KR KR1020057002193A patent/KR20050067383A/ko not_active Application Discontinuation
- 2003-08-01 DE DE60304718T patent/DE60304718T2/de not_active Expired - Fee Related
- 2003-08-01 BR BR0313078-9A patent/BR0313078A/pt not_active Application Discontinuation
- 2003-08-01 JP JP2004525533A patent/JP2005538118A/ja active Pending
- 2003-08-01 US US10/523,401 patent/US7427616B2/en not_active Expired - Fee Related
- 2003-08-06 AR ARP030102827A patent/AR041189A1/es not_active Application Discontinuation
- 2003-08-06 TW TW092121536A patent/TW200407116A/zh unknown
-
2005
- 2005-01-25 NO NO20050418A patent/NO20050418L/no not_active Application Discontinuation
- 2005-01-26 IL IL16652105A patent/IL166521A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DE60304718T2 (de) | 2007-04-26 |
JP2005538118A (ja) | 2005-12-15 |
US20050256140A1 (en) | 2005-11-17 |
DE60304718D1 (de) | 2006-05-24 |
CA2494421A1 (en) | 2004-02-12 |
US7427616B2 (en) | 2008-09-23 |
BR0313078A (pt) | 2005-07-12 |
AU2003246972A1 (en) | 2004-02-23 |
KR20050067383A (ko) | 2005-07-01 |
TW200407116A (en) | 2004-05-16 |
EP1537112B1 (de) | 2006-04-19 |
EP1537112A1 (de) | 2005-06-08 |
IL166521A0 (en) | 2006-01-15 |
WO2004013141A1 (en) | 2004-02-12 |
NO20050418L (no) | 2005-04-28 |
MXPA05001389A (es) | 2005-04-28 |
AR041189A1 (es) | 2005-05-04 |
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