US7863444B2
(en)
|
1997-03-19 |
2011-01-04 |
Abbott Laboratories |
4-aminopyrrolopyrimidines as kinase inhibitors
|
WO2000012089A1
(en)
*
|
1998-08-31 |
2000-03-09 |
Merck & Co., Inc. |
Novel angiogenesis inhibitors
|
BR9913887A
(pt)
*
|
1998-09-18 |
2001-10-23 |
Basf Ag |
Composto, e, métodos de inibir a atividade de proteìna quinase, de tratar um paciente que tenha uma condição que seja mediada pela atividade da proteìna quinase e de diminuir a fertilidade em um paciente
|
US6713474B2
(en)
|
1998-09-18 |
2004-03-30 |
Abbott Gmbh & Co. Kg |
Pyrrolopyrimidines as therapeutic agents
|
US6265403B1
(en)
*
|
1999-01-20 |
2001-07-24 |
Merck & Co., Inc. |
Angiogenesis inhibitors
|
US6432979B1
(en)
|
1999-08-12 |
2002-08-13 |
American Cyanamid Company |
Method of treating or inhibiting colonic polyps and colorectal cancer
|
CA2385747A1
(en)
|
1999-09-17 |
2001-03-22 |
Gavin C. Hirst |
Pyrazolopyrimidines as therapeutic agents
|
EP1268481B1
(en)
*
|
1999-09-17 |
2007-12-12 |
Abbott GmbH & Co. KG |
Kinase inhibitors as therapeutic agents
|
US7071199B1
(en)
|
1999-09-17 |
2006-07-04 |
Abbott Gmbh & Cco. Kg |
Kinase inhibitors as therapeutic agents
|
US7101869B2
(en)
|
1999-11-30 |
2006-09-05 |
Pfizer Inc. |
2,4-diaminopyrimidine compounds useful as immunosuppressants
|
AU2001287268A1
(en)
*
|
2000-03-29 |
2001-10-08 |
Knoll Gesellschaft Mit Beschraenkter Haftung |
Method of identifying inhibitors of tie-2
|
WO2001072751A1
(en)
*
|
2000-03-29 |
2001-10-04 |
Knoll Gesellschaft Mit Beschraenkter Haftung |
Pyrrolopyrimidines as tyrosine kinase inhibitors
|
US7369946B2
(en)
|
2000-03-29 |
2008-05-06 |
Abbott Gmbh & Co. Kg |
Method of identifying inhibitors of Tie-2
|
KR100403860B1
(ko)
*
|
2000-12-27 |
2003-11-01 |
엘지전자 주식회사 |
차세대 이동통신 시스템의 접속시도시의 충돌감소를 위한알에이씨에이치 선택방법
|
US7091353B2
(en)
|
2000-12-27 |
2006-08-15 |
Celgene Corporation |
Isoindole-imide compounds, compositions, and uses thereof
|
AR035885A1
(es)
*
|
2001-05-14 |
2004-07-21 |
Novartis Ag |
Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica
|
KR100875380B1
(ko)
*
|
2001-06-23 |
2008-12-23 |
아벤티스 파마슈티칼스 인크. |
단백질 키나제 억제제로서의 피롤로피리미딘
|
CA2452368A1
(en)
|
2001-06-29 |
2003-01-09 |
Ab Science |
New potent, selective and non toxic c-kit inhibitors
|
WO2003002108A2
(en)
|
2001-06-29 |
2003-01-09 |
Ab Science |
Use of tyrosine kinase inhibitors for treating inflammatory diseases
|
CA2452167A1
(en)
*
|
2001-06-29 |
2003-01-09 |
Ab Science |
Use of tyrosine kinase inhibitors for treating multiple sclerosis (ms)
|
WO2003002105A2
(en)
*
|
2001-06-29 |
2003-01-09 |
Ab Science |
Use of tyrosine kinase inhibitors for treating bone loss
|
EP1401413B1
(en)
|
2001-06-29 |
2006-11-22 |
AB Science |
Use of tyrosine kinase inhibitions for treating allergic diseases
|
PT1401416E
(pt)
*
|
2001-06-29 |
2007-02-28 |
Ab Science |
Utilização de inibidores de c-kit para tratar doenças inflamatórias intestinais (dii)
|
JP2004536097A
(ja)
*
|
2001-06-29 |
2004-12-02 |
アブ サイエンス |
自己免疫疾患を治療するためのチロシンキナーゼ阻害剤の使用法
|
GB0121033D0
(en)
*
|
2001-08-30 |
2001-10-24 |
Novartis Ag |
Organic compounds
|
JP2005508904A
(ja)
*
|
2001-09-11 |
2005-04-07 |
スミスクライン ビーチャム コーポレーション |
血管新生阻害剤としてのフロ−及びチエノピリミジン誘導体
|
US20030199525A1
(en)
*
|
2002-03-21 |
2003-10-23 |
Hirst Gavin C. |
Kinase inhibitors
|
US20030225273A1
(en)
*
|
2002-03-21 |
2003-12-04 |
Michaelides Michael R. |
Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
|
EP1537112B1
(en)
|
2002-08-06 |
2006-04-19 |
Astrazeneca AB |
Condensed pyridines and pyrimidines with tie2 (tek) activity
|
UA80171C2
(en)
*
|
2002-12-19 |
2007-08-27 |
Pfizer Prod Inc |
Pyrrolopyrimidine derivatives
|
US20050008640A1
(en)
*
|
2003-04-23 |
2005-01-13 |
Wendy Waegell |
Method of treating transplant rejection
|
US7592352B2
(en)
*
|
2003-05-06 |
2009-09-22 |
Smithkline Beecham Corporation |
Substituted thieno and furo-pyridines
|
US7429596B2
(en)
*
|
2003-06-20 |
2008-09-30 |
The Regents Of The University Of California |
1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof
|
AR045037A1
(es)
|
2003-07-10 |
2005-10-12 |
Aventis Pharma Sa |
Tetrahidro-1h-pirazolo [3,4-c] piridinas sustituidas, composiciones que las contienen y su utilizacion.
|
JP2007511596A
(ja)
*
|
2003-11-17 |
2007-05-10 |
ファイザー・プロダクツ・インク |
癌の治療において有用なピロロピリミジン化合物
|
CA2553724A1
(en)
*
|
2004-02-03 |
2005-08-18 |
Abbott Laboratories |
Aminobenzoxazoles as therapeutic agents
|
GB0403606D0
(en)
*
|
2004-02-18 |
2004-03-24 |
Novartis Ag |
Organic compounds
|
BRPI0511512A
(pt)
*
|
2004-05-27 |
2007-12-26 |
Pfizer Prod Inc |
derivados pirrolpirimidina úteis no tratamento do cáncer
|
US9512125B2
(en)
|
2004-11-19 |
2016-12-06 |
The Regents Of The University Of California |
Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
|
MX2007011435A
(es)
*
|
2005-03-17 |
2007-12-05 |
Novartis Ag |
N-[3-(1-amino-5,6,7,8-tetrahidro-2,4,4b-triazafluoren-9-il)-fenil ]-benzamidas como inhibidores de cinasa de tirosina/treonina, en particular de cinasa b-raf.
|
CA2623032A1
(en)
*
|
2005-09-30 |
2007-04-12 |
Vertex Pharmaceuticals Incorporated |
Deazapurines useful as inhibitors of janus kinases
|
BRPI0618622A2
(pt)
|
2005-11-17 |
2011-09-06 |
Osi Pharm Inc |
composto, composição, e, uso de um composto
|
CA2631664C
(en)
*
|
2005-12-08 |
2012-05-08 |
Abbott Laboratories |
9-membered heterobicyclic compounds as inhibitors of protein kinases
|
WO2007087395A2
(en)
*
|
2006-01-25 |
2007-08-02 |
Osi Pharmaceuticals, Inc. |
UNSATURATED mTOR INHIBITORS
|
TW200806641A
(en)
*
|
2006-01-25 |
2008-02-01 |
Synta Pharmaceuticals Corp |
Substituted aromatic compounds for inflammation and immune-related uses
|
US20080032960A1
(en)
*
|
2006-04-04 |
2008-02-07 |
Regents Of The University Of California |
PI3 kinase antagonists
|
CL2007002617A1
(es)
|
2006-09-11 |
2008-05-16 |
Sanofi Aventis |
Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
|
DK2081435T3
(da)
|
2006-09-22 |
2016-08-15 |
Pharmacyclics Llc |
Inhibitorer af bruton's tyrosinkinase
|
EP1969934A1
(de)
*
|
2007-03-12 |
2008-09-17 |
Bayer CropScience AG |
4-Cycloalkyl-oder 4-arylsubstituierte Phenoxyphenylamidine und deren Verwendung als Fungizide
|
SG10202107066WA
(en)
*
|
2007-03-28 |
2021-07-29 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
US20120101113A1
(en)
|
2007-03-28 |
2012-04-26 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
WO2009046448A1
(en)
|
2007-10-04 |
2009-04-09 |
Intellikine, Inc. |
Chemical entities and therapeutic uses thereof
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
NZ613219A
(en)
|
2008-01-04 |
2014-11-28 |
Intellikine Llc |
Heterocyclic containing entities, compositions and methods
|
JP5547099B2
(ja)
|
2008-03-14 |
2014-07-09 |
インテリカイン, エルエルシー |
キナーゼ阻害剤および使用方法
|
WO2009114874A2
(en)
|
2008-03-14 |
2009-09-17 |
Intellikine, Inc. |
Benzothiazole kinase inhibitors and methods of use
|
US8557814B2
(en)
*
|
2008-03-19 |
2013-10-15 |
OSI Pharmaceuticals, LLC |
mTOR inhibitor salt forms
|
US20110224223A1
(en)
|
2008-07-08 |
2011-09-15 |
The Regents Of The University Of California, A California Corporation |
MTOR Modulators and Uses Thereof
|
CN102124009B
(zh)
|
2008-07-08 |
2014-07-23 |
因特利凯公司 |
激酶抑制剂及其使用方法
|
WO2010036380A1
(en)
|
2008-09-26 |
2010-04-01 |
Intellikine, Inc. |
Heterocyclic kinase inhibitors
|
AU2009305669A1
(en)
|
2008-10-16 |
2010-04-22 |
The Regents Of The University Of California |
Fused ring heteroaryl kinase inhibitors
|
US8476431B2
(en)
|
2008-11-03 |
2013-07-02 |
Itellikine LLC |
Benzoxazole kinase inhibitors and methods of use
|
EP2427195B1
(en)
|
2009-05-07 |
2019-05-01 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
US7741330B1
(en)
*
|
2009-10-12 |
2010-06-22 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
|
US8980899B2
(en)
|
2009-10-16 |
2015-03-17 |
The Regents Of The University Of California |
Methods of inhibiting Ire1
|
ES2593256T3
(es)
|
2010-05-21 |
2016-12-07 |
Infinity Pharmaceuticals, Inc. |
Compuestos químicos, composiciones y métodos para las modulaciones de cinasas
|
KR101580714B1
(ko)
|
2010-06-03 |
2016-01-04 |
파마싸이클릭스 엘엘씨 |
브루톤 티로신 인산화효소(btk)의 억제제의 용도
|
CA2817577A1
(en)
|
2010-11-10 |
2012-05-18 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
UA115767C2
(uk)
|
2011-01-10 |
2017-12-26 |
Інфініті Фармасьютікалз, Інк. |
Способи отримання ізохінолінонів і тверді форми ізохінолінонів
|
FR2970967B1
(fr)
*
|
2011-01-27 |
2013-02-15 |
Pf Medicament |
Derives de type azaindazole ou diazaindazole comme medicament
|
CN106619647A
(zh)
|
2011-02-23 |
2017-05-10 |
因特利凯有限责任公司 |
激酶抑制剂的组合及其用途
|
MA35024B1
(fr)
*
|
2011-04-05 |
2014-04-03 |
Pfizer Ltd |
Dérivés de pyrrolo-[2,3-d]pyrimidine servant d'inhibiteurs des kinases apparentés à la tropomyosine
|
JP2014520863A
(ja)
|
2011-07-13 |
2014-08-25 |
ファーマサイクリックス,インク. |
Bruton型チロシンキナーゼの阻害剤
|
US8969363B2
(en)
|
2011-07-19 |
2015-03-03 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
US9056877B2
(en)
|
2011-07-19 |
2015-06-16 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
PE20141371A1
(es)
|
2011-08-29 |
2014-10-13 |
Infinity Pharmaceuticals Inc |
Compuestos heterociclicos y usos de los mismos
|
EP2751112B1
(en)
|
2011-09-02 |
2019-10-09 |
The Regents of The University of California |
Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
US8940742B2
(en)
|
2012-04-10 |
2015-01-27 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
US9687488B2
(en)
|
2012-05-03 |
2017-06-27 |
St. Louis College Of Pharmacy |
Compositions and methods for increasing neurotrophic peptides
|
CA3218491A1
(en)
|
2012-06-04 |
2013-12-12 |
Pharmacyclics Llc |
Crystalline forms of a bruton's tyrosine kinase inhibitor
|
US8828998B2
(en)
|
2012-06-25 |
2014-09-09 |
Infinity Pharmaceuticals, Inc. |
Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
|
CN104704129A
(zh)
|
2012-07-24 |
2015-06-10 |
药品循环公司 |
与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变
|
EP2689778A1
(en)
*
|
2012-07-27 |
2014-01-29 |
Pierre Fabre Medicament |
Derivatives of azaindoles or diazaindoles for treating pain
|
JP2015532287A
(ja)
|
2012-09-26 |
2015-11-09 |
ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア |
Ire1の調節
|
AU2013344656A1
(en)
|
2012-11-15 |
2015-06-04 |
Pharmacyclics Llc |
Pyrrolopyrimidine compounds as kinase inhibitors
|
US9481667B2
(en)
|
2013-03-15 |
2016-11-01 |
Infinity Pharmaceuticals, Inc. |
Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
|
CN103333096A
(zh)
*
|
2013-06-25 |
2013-10-02 |
苏州大学 |
一种化学选择性制备多功能吡咯衍生物的新方法
|
PE20160560A1
(es)
|
2013-09-30 |
2016-06-09 |
Pharmacyclics Llc |
DERIVADOS DE PIRAZOLO[3,4-d]PIRIMIDIN COMO INHIBIDORES IRREVERSIBLES DE LA TIROSINA CINASA DE BRUTON (BTK)
|
WO2015051241A1
(en)
|
2013-10-04 |
2015-04-09 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
EA201690713A1
(ru)
|
2013-10-04 |
2016-08-31 |
Инфинити Фармасьютикалз, Инк. |
Гетероциклические соединения и их применения
|
DK3119397T3
(da)
|
2014-03-19 |
2022-03-28 |
Infinity Pharmaceuticals Inc |
Heterocykliske forbindelser til anvendelse i behandling af PI3K-gamma-medierede lidelser
|
US9885086B2
(en)
|
2014-03-20 |
2018-02-06 |
Pharmacyclics Llc |
Phospholipase C gamma 2 and resistance associated mutations
|
WO2015160975A2
(en)
|
2014-04-16 |
2015-10-22 |
Infinity Pharmaceuticals, Inc. |
Combination therapies
|
WO2016019233A1
(en)
|
2014-08-01 |
2016-02-04 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
MX2017001671A
(es)
|
2014-08-07 |
2017-07-04 |
Pharmacyclics Llc |
Formulaciones novedosas de un inhibidor de la tirosina cinasa de bruton.
|
US9708348B2
(en)
|
2014-10-03 |
2017-07-18 |
Infinity Pharmaceuticals, Inc. |
Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
|
BR122023020985A2
(pt)
|
2015-03-03 |
2023-12-26 |
Pharmacyclics Llc |
Formulação de comprimido sólido de um inibidor de tirosina quinase de bruton
|
WO2017027883A1
(en)
|
2015-08-13 |
2017-02-16 |
San Diego State University Research Foundation |
Atropisomerism for increased kinase inhibitor selectivity
|
AU2016322552B2
(en)
|
2015-09-14 |
2021-03-25 |
Infinity Pharmaceuticals, Inc. |
Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
|
WO2017161116A1
(en)
|
2016-03-17 |
2017-09-21 |
Infinity Pharmaceuticals, Inc. |
Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
|
WO2017214269A1
(en)
|
2016-06-08 |
2017-12-14 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
FI3472165T3
(fi)
*
|
2016-06-21 |
2023-12-11 |
Nerviano Medical Sciences Srl |
N-(substituoidun fenyyli-)sulfoniamidin johdannaiset kinaasi-inhibiittoreina
|
KR20190033526A
(ko)
|
2016-06-24 |
2019-03-29 |
인피니티 파마슈티칼스, 인코포레이티드 |
병용 요법
|
SG11201909680UA
(en)
|
2017-04-18 |
2019-11-28 |
Lilly Co Eli |
Phenyl-2-hydroxy-acetylamino-2-methyl-phenyl compounds
|
JP2021535113A
(ja)
*
|
2018-08-22 |
2021-12-16 |
江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司Jiangsu Hengrui Medicine Co., Ltd. |
ピロロ−アミノ−ピリダジノン化合物およびその中間体の調製方法
|
US20220169642A1
(en)
*
|
2019-04-10 |
2022-06-02 |
Cellestia Biotech Ag |
Compounds for the treatment of oncovirus induced cancer and methods of use thereof
|
JP2022533570A
(ja)
*
|
2019-05-13 |
2022-07-25 |
リレー セラピューティクス, インコーポレイテッド |
Fgfr阻害剤およびそれらの使用
|
CN110483523B
(zh)
*
|
2019-08-27 |
2022-11-22 |
药雅科技(上海)有限公司 |
一种吡唑并嘧啶衍生物表皮生长因子抑制剂及其制备方法与用途
|
KR20220066290A
(ko)
*
|
2019-08-29 |
2022-05-24 |
히버셀, 인크. |
Perk 억제 피롤로피리미딘 화합물
|
WO2021038540A1
(en)
|
2019-08-31 |
2021-03-04 |
Sun Pharma Advanced Research Company Limited |
Cycloalkylidene carboxylic acids and derivatives as btk inhibitors
|
WO2021184154A1
(en)
*
|
2020-03-16 |
2021-09-23 |
Flash Therapeutics, Llc |
Compounds for treating or inhibiting recurrence of acute myeloid leukemia
|
WO2022109001A1
(en)
|
2020-11-18 |
2022-05-27 |
Deciphera Pharmaceuticals, Llc |
Gcn2 and perk kinase inhibitors and methods of use thereof
|
TW202233625A
(zh)
*
|
2020-11-18 |
2022-09-01 |
美商傳達治療有限公司 |
Fgfr抑制劑及其製造及使用方法
|
CA3231948A1
(en)
*
|
2021-09-23 |
2023-03-30 |
Jingyu Hu |
Fgfr inhibitors and methods of use thereof
|
WO2023104035A1
(zh)
*
|
2021-12-06 |
2023-06-15 |
英矽智能科技(上海)有限公司 |
取代的单环或双环杂环化合物,其制法与医药上的用途
|
WO2023202625A1
(zh)
*
|
2022-04-20 |
2023-10-26 |
深圳福沃药业有限公司 |
Fgfr2抑制剂及使用方法
|