BR9913887A - Composto, e, métodos de inibir a atividade de proteìna quinase, de tratar um paciente que tenha uma condição que seja mediada pela atividade da proteìna quinase e de diminuir a fertilidade em um paciente - Google Patents

Composto, e, métodos de inibir a atividade de proteìna quinase, de tratar um paciente que tenha uma condição que seja mediada pela atividade da proteìna quinase e de diminuir a fertilidade em um paciente

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Publication number
BR9913887A
BR9913887A BR9913887-5A BR9913887A BR9913887A BR 9913887 A BR9913887 A BR 9913887A BR 9913887 A BR9913887 A BR 9913887A BR 9913887 A BR9913887 A BR 9913887A
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Brazil
Prior art keywords
kinase activity
patient
protein kinase
treating
compound
Prior art date
Application number
BR9913887-5A
Other languages
English (en)
Inventor
Gavin C Hirst
David Calderwood
Rainer Munschauer
Lee D Arnold
David N Johnston
Paul Rafferty
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of BR9913887A publication Critical patent/BR9913887A/pt

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)

Abstract

"COMPOSTO, E, MéTODOS DE INIBIR A ATIVIDADE DE PROTEìNA QUINASE, DE TRATAR UM PACIENTE QUE TENHA UMA CONDIçãO QUE SEJA MEDIADA PELA ATIVIDADE DA PROTEìNA QUINASE E DE DIMINUIR A FERTILIDADE EM UM PACIENTE". Compostos químicos que tenham a fórmula estrutural (I) e seus sais e metabólitos fisiologicamente aceitáveis, são inibidores da atividade de serina/treonina e tirosina quinases. Diversas das quinases, cujas atividades são inibidas por estes compostos químicos, estão envolvidas em processos imunológicos, hiperproliferativos ou angiogênicos. Assim, estes compostos químicos podem melhorar estados de doença onde a angiogênese ou hiperproliferação celular endotelial é um fator. Estes compostos podem ser usados para tratar câncer e distúrbios hiperproliferativos, artrite reumatóide, distúrbios do sistema imune, rejeições a transplante e distúrbios inflamatórios.
BR9913887-5A 1998-09-18 1999-09-17 Composto, e, métodos de inibir a atividade de proteìna quinase, de tratar um paciente que tenha uma condição que seja mediada pela atividade da proteìna quinase e de diminuir a fertilidade em um paciente BR9913887A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10083498P 1998-09-18 1998-09-18
US10083298P 1998-09-18 1998-09-18
US10094698P 1998-09-18 1998-09-18
US10083398P 1998-09-18 1998-09-18
PCT/US1999/021560 WO2000017203A1 (en) 1998-09-18 1999-09-17 Pyrrolopyrimidines as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
BR9913887A true BR9913887A (pt) 2001-10-23

Family

ID=27493158

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9913887-5A BR9913887A (pt) 1998-09-18 1999-09-17 Composto, e, métodos de inibir a atividade de proteìna quinase, de tratar um paciente que tenha uma condição que seja mediada pela atividade da proteìna quinase e de diminuir a fertilidade em um paciente

Country Status (19)

Country Link
EP (1) EP1114053A1 (pt)
JP (1) JP2002526500A (pt)
KR (1) KR20010085824A (pt)
CN (1) CN1335849A (pt)
AU (1) AU753555C (pt)
BG (1) BG105346A (pt)
BR (1) BR9913887A (pt)
CA (1) CA2344249A1 (pt)
CZ (1) CZ2001960A3 (pt)
HK (1) HK1039326A1 (pt)
HU (1) HUP0200403A3 (pt)
ID (1) ID29028A (pt)
IL (1) IL141866A0 (pt)
NO (1) NO20011356L (pt)
NZ (1) NZ510588A (pt)
PL (1) PL346700A1 (pt)
SK (1) SK3842001A3 (pt)
TR (1) TR200101186T2 (pt)
WO (1) WO2000017203A1 (pt)

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