EA200200562A1 - Антагонисты аденозиновых рецепторов и способы их получения и использования - Google Patents
Антагонисты аденозиновых рецепторов и способы их получения и использованияInfo
- Publication number
- EA200200562A1 EA200200562A1 EA200200562A EA200200562A EA200200562A1 EA 200200562 A1 EA200200562 A1 EA 200200562A1 EA 200200562 A EA200200562 A EA 200200562A EA 200200562 A EA200200562 A EA 200200562A EA 200200562 A1 EA200200562 A1 EA 200200562A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antagonists
- adenose
- receptors
- reception
- methods
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 5
- 201000010099 disease Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000009346 Adenosine receptors Human genes 0.000 abstract 1
- 108050000203 Adenosine receptors Proteins 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 238000011863 diuretic therapy Methods 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 239000000296 purinergic P1 receptor antagonist Substances 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Настоящее изобретение основано на неожиданном обнаружении того факта, что соединения формулы I являются сильнодействующими и селективными ингибиторами аденозинового рецептора A. Антагонисты аденозина Aмогут быть использованы для предупреждения и/или лечения многих заболеваний, включая нарушение работы сердца и кровообращения, дегенеративные расстройства центральной нервной системы, заболевания дыхательных путей и многие заболевания, для которых показано лечение диуретиками. В одном из своих вариантов настоящее изобретение относится к соединению формулы (I).Отчет о международном поиске был опубликован 2002.01.10.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16528399P | 1999-11-12 | 1999-11-12 | |
PCT/US2000/031100 WO2001034604A2 (en) | 1999-11-12 | 2000-11-13 | Adenosine receptor antagonists and methods of making and using the same |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200200562A1 true EA200200562A1 (ru) | 2002-10-31 |
EA010260B1 EA010260B1 (ru) | 2008-06-30 |
Family
ID=22598257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200200562A EA010260B1 (ru) | 1999-11-12 | 2000-11-13 | Антагонисты аденозиновых рецепторов и способы их получения и использования |
Country Status (33)
Country | Link |
---|---|
US (4) | US6605600B1 (ru) |
EP (2) | EP1230241B1 (ru) |
JP (1) | JP2003513976A (ru) |
KR (1) | KR100845488B1 (ru) |
CN (1) | CN1187354C (ru) |
AT (1) | ATE353328T1 (ru) |
AU (1) | AU784528B2 (ru) |
BG (1) | BG106693A (ru) |
BR (1) | BR0015540A (ru) |
CA (1) | CA2390590C (ru) |
CY (1) | CY1106560T1 (ru) |
CZ (1) | CZ20021615A3 (ru) |
DE (1) | DE60033310T2 (ru) |
DK (1) | DK1230241T3 (ru) |
EA (1) | EA010260B1 (ru) |
EE (1) | EE200200248A (ru) |
ES (1) | ES2281367T3 (ru) |
GE (1) | GEP20043267B (ru) |
HK (1) | HK1049153B (ru) |
HU (1) | HUP0203371A3 (ru) |
IL (1) | IL149486A0 (ru) |
IS (1) | IS6380A (ru) |
MX (1) | MXPA02004795A (ru) |
NO (1) | NO20022237L (ru) |
NZ (2) | NZ519427A (ru) |
PL (1) | PL198156B1 (ru) |
PT (1) | PT1230241E (ru) |
SK (1) | SK6622002A3 (ru) |
TR (1) | TR200301062T2 (ru) |
UA (1) | UA77937C2 (ru) |
WO (1) | WO2001034604A2 (ru) |
YU (1) | YU33702A (ru) |
ZA (1) | ZA200203702B (ru) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI229674B (en) | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
GEP20043267B (en) * | 1999-11-12 | 2004-06-25 | Biogen Inc Us | Adenosine Receptor Antagonists, Methods of Making and Using the Same |
PT1230243E (pt) * | 1999-11-12 | 2009-06-12 | Biogen Idec Inc | Policicloalquilpurinas como antagonistas dos receptores da adenosina |
BR0312137A (pt) * | 2002-06-12 | 2005-04-05 | Mcw Res Found Inc | Processo de tratamento de dano de reperfusão de isquemia usando antagonistas de receptor de adenosina |
WO2004009594A2 (en) * | 2002-07-19 | 2004-01-29 | Aryx Therapeutics | Xanthine derivatives having adenosine a1-receptor antagonist properties |
US20040229901A1 (en) * | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
WO2004089908A2 (en) * | 2003-04-14 | 2004-10-21 | Pfizer Products Inc. | 3-azabicyclo[3.2.1]octane derivatives |
WO2004096228A1 (en) * | 2003-04-25 | 2004-11-11 | Novacardia, Inc. | Method of improved diuresis in individuals with impaired renal function |
US7247639B2 (en) * | 2003-06-06 | 2007-07-24 | Endacea, Inc. | A1 adenosine receptor antagonists |
EP1989210A2 (en) * | 2006-03-02 | 2008-11-12 | Cv Therapeutics, Inc. | A2a adenosine receptor antagonists |
CA2648281A1 (en) * | 2006-04-06 | 2007-10-18 | Novacardia, Inc. | Co-administration of adenosine a1 receptor antagonists and anticonvulsants |
CN102516241B (zh) | 2006-05-19 | 2015-07-29 | 艾伯维巴哈马有限公司 | Cns活性的稠合的双环杂环取代的氮杂双环烷烃衍生物 |
JP2009540003A (ja) * | 2006-06-16 | 2009-11-19 | ノヴァカーディア,インク. | Aa1raの低頻度投与を含む腎機能の長期間にわたる改善 |
US20080242684A1 (en) * | 2007-03-29 | 2008-10-02 | Howard Dittrich | Methods of administration of adenosine a1 receptor antagonists |
WO2008121893A1 (en) * | 2007-03-29 | 2008-10-09 | Novacardia, Inc. | Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist |
US20090228097A1 (en) * | 2008-03-07 | 2009-09-10 | Abbott Cardiovascular Systems Inc. | A1 Adenosine Receptor Antagonist-Coated Implantable Medical Device |
CN114790164B (zh) | 2021-08-13 | 2022-12-27 | 苏州璞正医药有限公司 | 一种取代的异吲哚啉-1,3-二酮类pde4抑制剂及其药物用途 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3155664A (en) * | 1959-11-13 | 1964-11-03 | Endo Lab | Derivatives of theophylline |
DE8817122U1 (de) | 1988-12-22 | 1993-02-04 | Boehringer Ingelheim Kg, 55218 Ingelheim | Neue Xanthinderivate mit Adenosinantogenistischer Wirkung |
JPH06102662B2 (ja) * | 1989-09-01 | 1994-12-14 | 協和醗酵工業株式会社 | キサンチン誘導体 |
US5290782A (en) | 1989-09-01 | 1994-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
JP2988711B2 (ja) | 1989-10-20 | 1999-12-13 | 協和醗酵工業株式会社 | 縮合プリン誘導体 |
DE4019892A1 (de) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
CA2061544A1 (en) | 1991-02-25 | 1992-08-26 | Fumio Suzuki | Xanthine compounds |
DE69229257D1 (de) | 1991-11-08 | 1999-07-01 | Kyowa Hakko Kogyo Kk | Xanthinderivate zur Behandlung der Demenz |
US5336769A (en) | 1992-02-17 | 1994-08-09 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
US5342841A (en) | 1992-03-12 | 1994-08-30 | Kyowa Hakko Kogyo Co., Ltd. | Xanthine derivatives |
TW252044B (ru) | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
WO1994016702A1 (en) | 1993-01-26 | 1994-08-04 | Kyowa Hakko Kogyo Co., Ltd. | Remedy for irregular bowel movement |
US5395836A (en) | 1993-04-07 | 1995-03-07 | Kyowa Hakko Kogyo Co., Ltd. | 8-tricycloalkyl xanthine derivatives |
US5446046A (en) * | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
AU7675498A (en) | 1997-06-16 | 1999-01-04 | Kyowa Hakko Kogyo Co. Ltd. | Preventive and remedy for drug-induced nephropathy |
AU7675598A (en) | 1997-06-16 | 1999-01-04 | Kyowa Hakko Kogyo Co. Ltd. | Hepatic edema remedy |
DE19816857A1 (de) * | 1998-04-16 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
EP0955301A3 (en) * | 1998-04-27 | 2001-04-18 | Pfizer Products Inc. | 7-aza-bicyclo[2.2.1]-heptane derivatives, their preparation and use according to their affinity for neuronal nicotinic acetylcholine receptors |
WO2000001388A1 (fr) | 1998-07-02 | 2000-01-13 | Kyowa Hakko Kogyo Co., Ltd. | Medicaments antidiabetiques |
GEP20043267B (en) * | 1999-11-12 | 2004-06-25 | Biogen Inc Us | Adenosine Receptor Antagonists, Methods of Making and Using the Same |
PT1230243E (pt) * | 1999-11-12 | 2009-06-12 | Biogen Idec Inc | Policicloalquilpurinas como antagonistas dos receptores da adenosina |
-
2000
- 2000-11-13 GE GEAP20006495A patent/GEP20043267B/en unknown
- 2000-11-13 CZ CZ20021615A patent/CZ20021615A3/cs unknown
- 2000-11-13 WO PCT/US2000/031100 patent/WO2001034604A2/en active IP Right Grant
- 2000-11-13 AU AU20421/01A patent/AU784528B2/en not_active Ceased
- 2000-11-13 TR TR2003/01062T patent/TR200301062T2/xx unknown
- 2000-11-13 HU HU0203371A patent/HUP0203371A3/hu unknown
- 2000-11-13 ES ES00983698T patent/ES2281367T3/es not_active Expired - Lifetime
- 2000-11-13 NZ NZ519427A patent/NZ519427A/en not_active IP Right Cessation
- 2000-11-13 SK SK662-2002A patent/SK6622002A3/sk unknown
- 2000-11-13 KR KR1020027006022A patent/KR100845488B1/ko not_active IP Right Cessation
- 2000-11-13 AT AT00983698T patent/ATE353328T1/de active
- 2000-11-13 PT PT00983698T patent/PT1230241E/pt unknown
- 2000-11-13 BR BR0015540-3A patent/BR0015540A/pt not_active Application Discontinuation
- 2000-11-13 EP EP00983698A patent/EP1230241B1/en not_active Expired - Lifetime
- 2000-11-13 EP EP06026675A patent/EP1775297A3/en not_active Withdrawn
- 2000-11-13 UA UA2002064854A patent/UA77937C2/uk unknown
- 2000-11-13 DE DE60033310T patent/DE60033310T2/de not_active Expired - Lifetime
- 2000-11-13 IL IL14948600A patent/IL149486A0/xx unknown
- 2000-11-13 YU YU33702A patent/YU33702A/sh unknown
- 2000-11-13 CA CA2390590A patent/CA2390590C/en not_active Expired - Fee Related
- 2000-11-13 EE EEP200200248A patent/EE200200248A/xx unknown
- 2000-11-13 EA EA200200562A patent/EA010260B1/ru not_active IP Right Cessation
- 2000-11-13 MX MXPA02004795A patent/MXPA02004795A/es active IP Right Grant
- 2000-11-13 JP JP2001536551A patent/JP2003513976A/ja active Pending
- 2000-11-13 PL PL356044A patent/PL198156B1/pl not_active IP Right Cessation
- 2000-11-13 US US09/711,554 patent/US6605600B1/en not_active Expired - Fee Related
- 2000-11-13 CN CNB008161984A patent/CN1187354C/zh not_active Expired - Fee Related
- 2000-11-13 DK DK00983698T patent/DK1230241T3/da active
-
2002
- 2002-05-09 ZA ZA200203702A patent/ZA200203702B/xx unknown
- 2002-05-10 IS IS6380A patent/IS6380A/is unknown
- 2002-05-10 NO NO20022237A patent/NO20022237L/no not_active Application Discontinuation
- 2002-05-13 BG BG106693A patent/BG106693A/bg unknown
- 2002-12-23 HK HK02109300.4A patent/HK1049153B/zh not_active IP Right Cessation
-
2003
- 2003-06-12 US US10/461,534 patent/US20030225038A1/en not_active Abandoned
- 2003-09-01 NZ NZ527918A patent/NZ527918A/en not_active IP Right Cessation
-
2005
- 2005-05-13 US US11/128,550 patent/US20050222179A1/en not_active Abandoned
-
2007
- 2007-05-04 CY CY20071100590T patent/CY1106560T1/el unknown
- 2007-07-27 US US11/829,269 patent/US20080004293A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
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HC1A | Change in name of an applicant in a eurasian application | ||
FA9A | Withdrawal of a eurasian application | ||
NF9A | Restoration of lapsed right to a eurasian application |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |