AU770377B2
(en)
*
|
1999-05-21 |
2004-02-19 |
Bristol-Myers Squibb Company |
Pyrrolotriazine inhibitors of kinases
|
JP4623483B2
(ja)
*
|
1999-08-23 |
2011-02-02 |
塩野義製薬株式会社 |
sPLA2阻害作用を有するピロロトリアジン誘導体
|
MXPA03000874A
(es)
*
|
2000-08-09 |
2003-06-06 |
Astrazeneca Ab |
Compuestos quimicos.
|
EP1313734B1
(en)
|
2000-09-01 |
2009-11-11 |
Novartis Vaccines and Diagnostics, Inc. |
Aza heterocyclic derivatives and their therapeutic use
|
AP1666A
(en)
|
2000-09-11 |
2006-09-29 |
Chiron Corp |
Quinolinone derivatives as tyrosine kinase inhibitors.
|
US20030028018A1
(en)
|
2000-09-11 |
2003-02-06 |
Chiron Coporation |
Quinolinone derivatives
|
KR100847605B1
(ko)
*
|
2000-11-17 |
2008-07-21 |
브리스톨-마이어스스퀴브컴파니 |
p38 키나제 관련 질병의 치료 방법 및 키나제 억제제로서유용한 피롤로트리아진 화합물
|
US6670357B2
(en)
*
|
2000-11-17 |
2003-12-30 |
Bristol-Myers Squibb Company |
Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
|
US6867300B2
(en)
|
2000-11-17 |
2005-03-15 |
Bristol-Myers Squibb Company |
Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
|
US6699890B2
(en)
|
2000-12-22 |
2004-03-02 |
Memory Pharmaceuticals Corp. |
Phosphodiesterase 4 inhibitors
|
US7153871B2
(en)
|
2001-01-22 |
2006-12-26 |
Memory Pharmaceuticals Corporation |
Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
|
CZ20031986A3
(cs)
*
|
2001-01-22 |
2003-12-17 |
Memory Pharmaceuticals Corporation |
N-substituované aniliny a difenylaminy inhibující PDE4 a farmaceutický prostředek, který je obsahuje
|
US7205320B2
(en)
|
2001-01-22 |
2007-04-17 |
Memory Pharmaceuticals Corp. |
Phosphodiesterase 4 inhibitors
|
TW200300350A
(en)
*
|
2001-11-14 |
2003-06-01 |
Bristol Myers Squibb Co |
C-5 modified indazolylpyrrolotriazines
|
US6900208B2
(en)
|
2002-03-28 |
2005-05-31 |
Bristol Myers Squibb Company |
Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
|
SE0200979D0
(sv)
|
2002-03-28 |
2002-03-28 |
Astrazeneca Ab |
New compounds
|
SE0302546D0
(sv)
|
2003-09-24 |
2003-09-24 |
Astrazeneca Ab |
New compounds
|
FR2838123B1
(fr)
*
|
2002-04-04 |
2005-06-10 |
Sanofi Synthelabo |
Nouveaux derives d'indolozine-1,2,3 substituee, inhibiteurs selectifs du b-fgf
|
US7388009B2
(en)
|
2002-04-23 |
2008-06-17 |
Bristol-Myers Squibb Company |
Heteroaryl-substituted pyrrolo-triazine compounds useful as kinase inhibitors
|
RU2375363C2
(ru)
|
2002-04-23 |
2009-12-10 |
Бристол-Маерс Сквибб Компани |
Пирролотриазиновые производные анилина, полезные в качестве ингибиторов киназы
|
EP1503996B1
(en)
*
|
2002-04-23 |
2008-12-24 |
Bristol-Myers Squibb Company |
Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
|
TW200400034A
(en)
|
2002-05-20 |
2004-01-01 |
Bristol Myers Squibb Co |
Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
|
CN1678734B
(zh)
*
|
2002-06-27 |
2012-12-12 |
韦尔瓦制药有限公司 |
分化调节试剂及其应用
|
AU2003256601B2
(en)
|
2002-07-19 |
2009-10-29 |
Memory Pharmaceuticals Corporation |
6-amino-1H-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors
|
JP2006504656A
(ja)
|
2002-07-19 |
2006-02-09 |
メモリー・ファーマシューティカルズ・コーポレイション |
N−置換されたアニリン及びジフェニルアミンアナログを含むホスホジエステラーゼ4インヒビター
|
KR100869417B1
(ko)
*
|
2002-07-19 |
2008-11-21 |
브리스톨-마이어스 스큅 컴퍼니 |
신규한 키나제 억제제
|
TWI329112B
(en)
|
2002-07-19 |
2010-08-21 |
Bristol Myers Squibb Co |
Novel inhibitors of kinases
|
US6933386B2
(en)
*
|
2002-07-19 |
2005-08-23 |
Bristol Myers Squibb Company |
Process for preparing certain pyrrolotriazine compounds
|
EP1388541A1
(en)
*
|
2002-08-09 |
2004-02-11 |
Centre National De La Recherche Scientifique (Cnrs) |
Pyrrolopyrazines as kinase inhibitors
|
WO2004018419A2
(en)
|
2002-08-23 |
2004-03-04 |
Chiron Corporation |
Benzimidazole quinolinones and uses thereof
|
BR0315705A
(pt)
|
2002-11-19 |
2005-09-06 |
Memory Pharm Corp |
Inibidores de fosfodiesterase-4
|
TW200420565A
(en)
*
|
2002-12-13 |
2004-10-16 |
Bristol Myers Squibb Co |
C-6 modified indazolylpyrrolotriazines
|
MXPA05008183A
(es)
*
|
2003-02-05 |
2005-10-05 |
Bristol Myers Squibb Co |
Proceso para preparar pirrolotriazina como inhibidores de cinasa.
|
US7102001B2
(en)
|
2003-12-12 |
2006-09-05 |
Bristol-Myers Squibb Company |
Process for preparing pyrrolotriazine
|
US7064203B2
(en)
*
|
2003-12-29 |
2006-06-20 |
Bristol Myers Squibb Company |
Di-substituted pyrrolotriazine compounds
|
MY145634A
(en)
*
|
2003-12-29 |
2012-03-15 |
Bristol Myers Squibb Co |
Pyrrolotriazine compounds as kinase inhibitors
|
EA012873B1
(ru)
|
2004-04-02 |
2009-12-30 |
Оси Фармасьютикалз, Инк. |
6,6-бициклические кольцевые замещенные гетеробициклические ингибиторы протеинкиназ
|
US7459562B2
(en)
|
2004-04-23 |
2008-12-02 |
Bristol-Myers Squibb Company |
Monocyclic heterocycles as kinase inhibitors
|
TW200538453A
(en)
|
2004-04-26 |
2005-12-01 |
Bristol Myers Squibb Co |
Bicyclic heterocycles as kinase inhibitors
|
UY28931A1
(es)
*
|
2004-06-03 |
2005-12-30 |
Bayer Pharmaceuticals Corp |
Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis
|
US7102002B2
(en)
*
|
2004-06-16 |
2006-09-05 |
Bristol-Myers Squibb Company |
Pyrrolotriazine kinase inhibitors
|
US7439246B2
(en)
|
2004-06-28 |
2008-10-21 |
Bristol-Myers Squibb Company |
Fused heterocyclic kinase inhibitors
|
US7432373B2
(en)
|
2004-06-28 |
2008-10-07 |
Bristol-Meyers Squibb Company |
Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
|
US20050288290A1
(en)
|
2004-06-28 |
2005-12-29 |
Borzilleri Robert M |
Fused heterocyclic kinase inhibitors
|
TW200600513A
(en)
|
2004-06-30 |
2006-01-01 |
Bristol Myers Squibb Co |
A method for preparing pyrrolotriazine compounds
|
US7102003B2
(en)
|
2004-07-01 |
2006-09-05 |
Bristol-Myers Squibb Company |
Pyrrolotriazine compounds
|
MY139689A
(en)
*
|
2004-07-20 |
2009-10-30 |
Osi Pharm Inc |
Imidazotriazines as protein kinase inhibitors
|
US7504521B2
(en)
|
2004-08-05 |
2009-03-17 |
Bristol-Myers Squibb Co. |
Methods for the preparation of pyrrolotriazine compounds
|
TW200618803A
(en)
|
2004-08-12 |
2006-06-16 |
Bristol Myers Squibb Co |
Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors
|
ATE479687T1
(de)
*
|
2004-10-15 |
2010-09-15 |
Takeda Pharmaceutical |
Kinaseinhibitoren
|
US7151176B2
(en)
*
|
2004-10-21 |
2006-12-19 |
Bristol-Myers Squibb Company |
Pyrrolotriazine compounds
|
US7759337B2
(en)
|
2005-03-03 |
2010-07-20 |
Amgen Inc. |
Phthalazine compounds and methods of use
|
US7534882B2
(en)
|
2005-04-06 |
2009-05-19 |
Bristol-Myers Squibb Company |
Method for preparing pyrrolotriazine compounds via in situ amination of pyrroles
|
MY145694A
(en)
|
2005-04-11 |
2012-03-30 |
Xenon Pharmaceuticals Inc |
Spiroheterocyclic compounds and their uses as therapeutic agents
|
MY158766A
(en)
|
2005-04-11 |
2016-11-15 |
Xenon Pharmaceuticals Inc |
Spiro-oxindole compounds and their uses as therapeutic agents
|
KR100695700B1
(ko)
*
|
2005-04-20 |
2007-03-15 |
김세중 |
조립식 경량벽체 패널과 그 조립구조
|
KR100672087B1
(ko)
*
|
2005-04-25 |
2007-01-19 |
재단법인 포항산업과학연구원 |
폐단형 스터드부재 및 이를 이용한 단열 벽체 시스템
|
JP5545925B2
(ja)
|
2005-05-17 |
2014-07-09 |
ノバルティス アーゲー |
ヘテロ環化合物の合成方法
|
US7576082B2
(en)
|
2005-06-24 |
2009-08-18 |
Hoffman-La Roche Inc. |
Oxindole derivatives
|
US7405213B2
(en)
*
|
2005-07-01 |
2008-07-29 |
Bristol-Myers Squibb Company |
Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
|
US7402582B2
(en)
|
2005-07-01 |
2008-07-22 |
Bristol-Myers Squibb Company |
Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
|
CA2621303A1
(en)
|
2005-09-01 |
2007-03-08 |
Bristol-Myers Squibb Company |
Biomarkers and methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators
|
US7880004B2
(en)
|
2005-09-15 |
2011-02-01 |
Bristol-Myers Squibb Company |
Met kinase inhibitors
|
US8062838B2
(en)
|
2005-09-20 |
2011-11-22 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
US7547782B2
(en)
|
2005-09-30 |
2009-06-16 |
Bristol-Myers Squibb Company |
Met kinase inhibitors
|
US8431695B2
(en)
|
2005-11-02 |
2013-04-30 |
Bayer Intellectual Property Gmbh |
Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases
|
US7514435B2
(en)
*
|
2005-11-18 |
2009-04-07 |
Bristol-Myers Squibb Company |
Pyrrolotriazine kinase inhibitors
|
US7348325B2
(en)
|
2005-11-30 |
2008-03-25 |
Bristol-Myers Squibb Company |
Pyrrolotriazine kinase inhibitors
|
AR057960A1
(es)
|
2005-12-02 |
2007-12-26 |
Osi Pharm Inc |
Inhibidores de proteina quinasa biciclicos
|
AU2006320440B2
(en)
*
|
2005-12-02 |
2012-04-05 |
Bayer Healthcare Llc |
Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
|
PE20070855A1
(es)
|
2005-12-02 |
2007-10-14 |
Bayer Pharmaceuticals Corp |
Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
|
US8063208B2
(en)
|
2006-02-16 |
2011-11-22 |
Bristol-Myers Squibb Company |
Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
|
EP2032989B2
(en)
|
2006-06-30 |
2015-10-28 |
Merck Sharp & Dohme Corp. |
Igfbp2 biomarker
|
PL2041138T3
(pl)
|
2006-07-07 |
2014-11-28 |
Bristol Myers Squibb Co |
Pirolotriazyny jako inhibitory kinazy
|
US7605160B2
(en)
|
2006-08-09 |
2009-10-20 |
Bristol-Myers Squibb Company |
Pyrrolotriazine kinase inhibitors
|
US7531539B2
(en)
|
2006-08-09 |
2009-05-12 |
Bristol-Myers Squibb Company |
Pyrrolotriazine kinase inhibitors
|
BRPI0719210A2
(pt)
|
2006-10-12 |
2015-05-05 |
Xenon Pharmaceuticals Inc |
Uso de compostos espiro-oxindol como agentes terapêuticos
|
US8268998B2
(en)
|
2006-11-03 |
2012-09-18 |
Bristol-Myers Squibb Company |
Pyrrolotriazine kinase inhibitors
|
JP5180967B2
(ja)
*
|
2006-11-03 |
2013-04-10 |
ブリストル−マイヤーズ スクイブ カンパニー |
ピロロトリアジンキナーゼ阻害剤
|
EP2111402B1
(en)
*
|
2007-01-05 |
2012-03-07 |
Bristol-Myers Squibb Company |
Aminopyrazole kinase inhibitors
|
US20100234381A1
(en)
|
2007-04-13 |
2010-09-16 |
Bristol-Myers Squibb Company |
Biomarkers and methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators
|
US8198438B2
(en)
|
2007-04-18 |
2012-06-12 |
Bristol-Myers Squibb Company |
Pyrrolotriazine kinase inhibitors
|
EP2203060A4
(en)
|
2007-09-25 |
2010-12-22 |
Bayer Healthcare Llc |
PYRROLOTRIAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER BY INHIBITING AURORA KINASE
|
AU2008308691B2
(en)
|
2007-10-01 |
2013-11-07 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of fibroblast growth factor receptor 4 expression
|
WO2009055343A2
(en)
|
2007-10-22 |
2009-04-30 |
Schering Corporation |
Fully human anti-vegf antibodies and methods of using
|
EA201070841A1
(ru)
|
2008-01-11 |
2011-02-28 |
Натко Фарма Лимитед |
НОВЫЕ ПИРАЗОЛО[3,4-d]ПИРИМИДИНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ПРОТИВОРАКОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВ
|
US8404694B2
(en)
|
2008-03-20 |
2013-03-26 |
Amgen Inc. |
Aurora kinase modulators and method of use
|
WO2010019473A1
(en)
|
2008-08-14 |
2010-02-18 |
Amgen Inc. |
Aurora kinase modulators and methods of use
|
EP2344504B1
(en)
*
|
2008-10-08 |
2014-06-04 |
Bristol-Myers Squibb Company |
Pyrrolotriazine kinase inhibitors
|
US8497269B2
(en)
|
2008-10-10 |
2013-07-30 |
Amgen Inc. |
Phthalazine compounds as p38 map kinase modulators and methods of use thereof
|
WO2010042646A1
(en)
|
2008-10-10 |
2010-04-15 |
Amgen Inc. |
Aza- and diaza-phthalazine compounds as p38 map kinase modulators and methods of use thereof
|
CA2741024A1
(en)
|
2008-10-17 |
2010-04-22 |
Xenon Pharmaceuticals Inc. |
Spiro-oxindole compounds and their use as therapeutic agents
|
CN102256983B
(zh)
|
2008-10-17 |
2017-04-05 |
泽农医药公司 |
螺羟吲哚化合物及其作为治疗剂的用途
|
EP2349235A1
(en)
|
2008-11-07 |
2011-08-03 |
Triact Therapeutics, Inc. |
Use of catecholic butane derivatives in cancer therapy
|
AR074830A1
(es)
|
2008-12-19 |
2011-02-16 |
Cephalon Inc |
Pirrolotriazinas como inhibidores de alk y jak2
|
US8273754B2
(en)
|
2008-12-30 |
2012-09-25 |
Arqule, Inc. |
Substituted 1H-pyrazolo[3,4-D]pyrimidine-6-amine compounds
|
US20120189641A1
(en)
|
2009-02-25 |
2012-07-26 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
WO2010099137A2
(en)
|
2009-02-26 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
In situ methods for monitoring the emt status of tumor cells in vivo
|
WO2010099138A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
EP2401613A2
(en)
|
2009-02-27 |
2012-01-04 |
OSI Pharmaceuticals, LLC |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
JP2012519281A
(ja)
|
2009-02-27 |
2012-08-23 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
|
JP5656976B2
(ja)
|
2009-04-29 |
2015-01-21 |
ローカス ファーマシューティカルズ インコーポレイテッド |
ピロロトリアジン化合物
|
AR077252A1
(es)
|
2009-06-29 |
2011-08-10 |
Xenon Pharmaceuticals Inc |
Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
|
CN105037355B
(zh)
|
2009-08-10 |
2017-06-06 |
萨穆梅德有限公司 |
Wnt信号传导途径的吲唑抑制剂及其治疗用途
|
AU2010306768B2
(en)
|
2009-10-14 |
2016-08-04 |
Xenon Pharmaceuticals Inc. |
Synthetic methods for spiro-oxindole compounds
|
US8088815B2
(en)
|
2009-12-02 |
2012-01-03 |
Hoffman-La Roche Inc. |
Spiroindolinone pyrrolidines
|
JP5822844B2
(ja)
|
2009-12-21 |
2015-11-24 |
サミュメッド リミテッド ライアビリティ カンパニー |
1H−ピラゾロ[3,4−b]ピリジンおよびその治療的使用
|
US8288431B2
(en)
|
2010-02-17 |
2012-10-16 |
Hoffmann-La Roche Inc. |
Substituted spiroindolinones
|
EP2538919B1
(en)
|
2010-02-26 |
2017-07-12 |
Xenon Pharmaceuticals Inc. |
Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
|
CA2783665A1
(en)
|
2010-03-03 |
2011-09-09 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
EP2519826A2
(en)
|
2010-03-03 |
2012-11-07 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
US20130005733A1
(en)
|
2010-03-09 |
2013-01-03 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
US8217044B2
(en)
|
2010-04-28 |
2012-07-10 |
Hoffmann-La Roche Inc. |
Spiroindolinone pyrrolidines
|
EP2576561A1
(en)
*
|
2010-05-28 |
2013-04-10 |
Biocryst Pharmaceuticals, Inc. |
Heterocyclic compounds as janus kinase inhibitors
|
US20120214830A1
(en)
|
2011-02-22 |
2012-08-23 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
|
AU2012232670A1
(en)
|
2011-03-23 |
2013-09-12 |
Ariel-University Research And Development Company Ltd. |
Treatment of proliferative disorders with a chemiluminescent agent
|
US9896730B2
(en)
|
2011-04-25 |
2018-02-20 |
OSI Pharmaceuticals, LLC |
Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
|
CA2839437A1
(en)
|
2011-06-16 |
2012-12-20 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of fibroblast growth factor receptor 4 expression
|
AP3529A
(en)
*
|
2011-07-01 |
2016-01-11 |
Bayer Ip Gmbh |
Hydroxymethylaryl-substituted pyrrolotriazines as alk1 inhibitors
|
SG10201914121YA
(en)
|
2011-09-14 |
2020-03-30 |
Samumed Llc |
Indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors
|
JP6047582B2
(ja)
|
2011-12-15 |
2016-12-21 |
バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH |
置換ベンゾチエニル−ピロロトリアジンおよび癌の処置におけるその使用
|
UY34484A
(es)
*
|
2011-12-15 |
2013-07-31 |
Bayer Ip Gmbh |
Benzotienilo-pirrolotriazinas disustituidas y sus usos
|
CA2865021C
(en)
|
2012-02-23 |
2020-06-30 |
Bayer Intellectual Property Gmbh |
Substituted benzothienyl-pyrrolotriazines and uses thereof
|
PH12017500997A1
(en)
|
2012-04-04 |
2018-02-19 |
Samumed Llc |
Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
CN102675323B
(zh)
*
|
2012-06-01 |
2014-04-09 |
南京药石药物研发有限公司 |
吡咯并[2,1-f][1,2,4]三嗪衍生物及其抗肿瘤用途
|
WO2014082230A1
(zh)
*
|
2012-11-28 |
2014-06-05 |
上海希迈医药科技有限公司 |
吡咯并三嗪类衍生物、其制备方法及其在医药上的应用
|
US9908867B2
(en)
|
2013-01-08 |
2018-03-06 |
Samumed, Llc |
3-(benzoimidazol-2-yl)-indazole inhibitors of the Wnt signaling pathway and therapeutic uses thereof
|
US9447105B2
(en)
|
2013-01-24 |
2016-09-20 |
Council Of Scientific & Industrial Research |
Triazine compounds and a process for preparation thereof
|
AU2014223548A1
(en)
|
2013-02-26 |
2015-10-15 |
Triact Therapeutics, Inc. |
Cancer therapy
|
US9050345B2
(en)
*
|
2013-03-11 |
2015-06-09 |
Bristol-Myers Squibb Company |
Pyrrolotriazines as potassium ion channel inhibitors
|
CN105008366B
(zh)
*
|
2013-03-11 |
2017-11-14 |
百时美施贵宝公司 |
作为钾离子通道抑制剂的吡咯并哒嗪类化合物
|
CN105026399B
(zh)
*
|
2013-03-11 |
2017-06-23 |
百时美施贵宝公司 |
作为钾离子通道抑制剂的吡咯并三嗪类化合物
|
WO2014160521A1
(en)
|
2013-03-15 |
2014-10-02 |
Blueprint Medicines Corporation |
Piperazine derivatives and their use as kit modulators
|
EP3044593A4
(en)
|
2013-09-09 |
2017-05-17 |
Triact Therapeutics, Inc. |
Cancer therapy
|
US9334263B2
(en)
|
2013-10-17 |
2016-05-10 |
Blueprint Medicines Corporation |
Compositions useful for treating disorders related to kit
|
PL3057969T3
(pl)
*
|
2013-10-17 |
2018-11-30 |
Blueprint Medicines Corporation |
Kompozycje użyteczne do leczenia zaburzeń związanych z KIT
|
WO2015081783A1
(zh)
*
|
2013-12-06 |
2015-06-11 |
江苏奥赛康药业股份有限公司 |
吡咯并[2,1-f][1,2,4]三嗪类衍生物及其制备方法和用途
|
CN104725381B
(zh)
*
|
2013-12-19 |
2018-04-10 |
南京圣和药业股份有限公司 |
生长因子受体抑制剂及其应用
|
US9388239B2
(en)
|
2014-05-01 |
2016-07-12 |
Consejo Nacional De Investigation Cientifica |
Anti-human VEGF antibodies with unusually strong binding affinity to human VEGF-A and cross reactivity to human VEGF-B
|
WO2016022569A1
(en)
|
2014-08-04 |
2016-02-11 |
Blueprint Medicines Corporation |
Compositions useful for treating disorders related to kit
|
WO2016040181A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
WO2016040182A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
|
WO2016040190A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
|
WO2016040180A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
WO2016040185A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
|
WO2016040184A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
WO2016040193A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
|
WO2016040188A1
(en)
|
2014-09-08 |
2016-03-17 |
Samumed, Llc |
3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
|
WO2016127068A1
(en)
|
2015-02-05 |
2016-08-11 |
Teva Pharmaceuticals International Gmbh |
Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound
|
CN104876935B
(zh)
*
|
2015-05-18 |
2017-04-19 |
南方医科大学 |
2‑氨基吡咯并[1,2‑f][1,2,4]三嗪类化合物、合成方法及应用
|
KR20180048635A
(ko)
*
|
2015-07-24 |
2018-05-10 |
블루프린트 메디신즈 코포레이션 |
Kit 및 pdgfr에 관련된 장애를 치료하는데 유용한 조성물
|
US10166218B2
(en)
|
2015-08-03 |
2019-01-01 |
Samumed, Llc |
3-(1H-indol-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
|
WO2017024015A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
WO2017023987A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
|
WO2017023980A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
|
WO2017024003A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc |
3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
WO2017023972A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
US10226453B2
(en)
|
2015-08-03 |
2019-03-12 |
Samumed, Llc |
3-(1H-indol-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
|
WO2017023984A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
|
WO2017023996A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
|
WO2017023975A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
|
US10392383B2
(en)
|
2015-08-03 |
2019-08-27 |
Samumed, Llc |
3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
WO2017023988A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc. |
3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
|
WO2017024021A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc |
3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof
|
US10519169B2
(en)
|
2015-08-03 |
2019-12-31 |
Samumed, Llc |
3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
|
WO2017023986A1
(en)
|
2015-08-03 |
2017-02-09 |
Samumed, Llc |
3-(1h-indol-2-yl)-1h-indazoles and therapeutic uses thereof
|
US10206909B2
(en)
|
2015-08-03 |
2019-02-19 |
Samumed, Llc |
3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
|
US10463651B2
(en)
|
2015-08-03 |
2019-11-05 |
Samumed, Llc |
3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-indazoles and therapeutic uses thereof
|
CN108472290A
(zh)
|
2015-11-06 |
2018-08-31 |
萨穆梅德有限公司 |
治疗骨关节炎
|
HRP20221277T1
(hr)
*
|
2016-04-28 |
2022-12-23 |
Takeda Pharmaceutical Company Limited |
Kondenzirani heterociklični spoj
|
PT3464285T
(pt)
|
2016-06-01 |
2022-12-20 |
Biosplice Therapeutics Inc |
Processo para preparar n-(5-(3-(7-(3-fluorofenil)-3himidazo[4,5-c]piridin-2-il)-1h-indazol-5-il)piridin-3-il)-3-metilbutanamida
|
AU2017345699A1
(en)
|
2016-10-21 |
2019-05-16 |
Samumed, Llc |
Methods of using indazole-3-carboxamides and their use as Wnt/B-catenin signaling pathway inhibitors
|
WO2018085865A1
(en)
|
2016-11-07 |
2018-05-11 |
Samumed, Llc |
Single-dose, ready-to-use injectable formulations
|
KR102398659B1
(ko)
|
2017-03-17 |
2022-05-16 |
주식회사 대웅제약 |
카이네이즈 저해제로서의 피롤로트리아진 유도체
|
US11040979B2
(en)
|
2017-03-31 |
2021-06-22 |
Blueprint Medicines Corporation |
Substituted pyrrolo[1,2-b]pyridazines for treating disorders related to KIT and PDGFR
|
EP3782998B1
(en)
|
2018-04-16 |
2023-05-10 |
Shenzhen TargetRx, Inc. |
Substituted pyrrolotriazine compound, pharmaceutical composition thereof and use thereof
|
TW202104231A
(zh)
|
2019-04-12 |
2021-02-01 |
美商藍印藥品公司 |
用於治療kit 及pdgfra 介導之疾病的組合物及方法
|
WO2020210669A1
(en)
|
2019-04-12 |
2020-10-15 |
Blueprint Medicines Corporation |
Crystalline forms of (s)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amine and methods of making
|
WO2021094209A1
(en)
|
2019-11-12 |
2021-05-20 |
Bayer Aktiengesellschaft |
Substituted pyrrolo triazine carboxamide derivatives as prostaglandin ep3 receptor antagonists
|