BR0316755A - Indazolilpirrolotriazinas modificadas por c-6 - Google Patents

Indazolilpirrolotriazinas modificadas por c-6

Info

Publication number
BR0316755A
BR0316755A BR0316755-0A BR0316755A BR0316755A BR 0316755 A BR0316755 A BR 0316755A BR 0316755 A BR0316755 A BR 0316755A BR 0316755 A BR0316755 A BR 0316755A
Authority
BR
Brazil
Prior art keywords
compounds
formula
useful
growth factor
modified
Prior art date
Application number
BR0316755-0A
Other languages
English (en)
Inventor
Gregory D Vite
Ashvinikumar V Gavai
Brian E Fink
Harold Mastalerz
John F Kadow
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR0316755A publication Critical patent/BR0316755A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

"INDAZOLILPIRROLOTRIAZINAS MODIFICADAS POR C-6". A presente invenção refere-se a compostos de fórmula I e sais farmaceuticamente aceitáveis destes. Os compostos de fórmula I inibem a atividade de tirosina cinase de receptores de fator de crescimento tais como HER1, HER2 e HER4, desse modo tornando-os úteis como agentes antiproliferativos. Os compostos de fórmula I são também úteis para o tratamento de outras doenças associadas com trilhas de transdução de sinal operando através de receptores de fator de crescimento.
BR0316755-0A 2002-12-13 2003-12-12 Indazolilpirrolotriazinas modificadas por c-6 BR0316755A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43319002P 2002-12-13 2002-12-13
PCT/US2003/039542 WO2004054514A2 (en) 2002-12-13 2003-12-12 C-6 modified indazolylpyrrolotriazines

Publications (1)

Publication Number Publication Date
BR0316755A true BR0316755A (pt) 2005-10-25

Family

ID=32595133

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0316755-0A BR0316755A (pt) 2002-12-13 2003-12-12 Indazolilpirrolotriazinas modificadas por c-6

Country Status (27)

Country Link
US (2) US6916815B2 (pt)
EP (1) EP1569937B1 (pt)
JP (1) JP4511367B2 (pt)
KR (1) KR101073801B1 (pt)
CN (2) CN1726216A (pt)
AR (1) AR042450A1 (pt)
AT (1) ATE534648T1 (pt)
AU (1) AU2003300877B2 (pt)
BR (1) BR0316755A (pt)
CA (1) CA2509650C (pt)
CO (1) CO5570660A2 (pt)
DK (1) DK1569937T3 (pt)
ES (1) ES2374393T3 (pt)
HR (1) HRP20050535A2 (pt)
IS (1) IS7890A (pt)
MX (1) MXPA05006164A (pt)
NO (1) NO20052733L (pt)
NZ (1) NZ540338A (pt)
PE (1) PE20040805A1 (pt)
PL (1) PL377517A1 (pt)
PT (1) PT1569937E (pt)
RS (1) RS20050441A (pt)
RU (1) RU2356903C2 (pt)
TW (1) TW200420565A (pt)
UA (1) UA80591C2 (pt)
WO (1) WO2004054514A2 (pt)
ZA (1) ZA200504507B (pt)

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US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
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US7402582B2 (en) * 2005-07-01 2008-07-22 Bristol-Myers Squibb Company Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
WO2007035428A1 (en) 2005-09-15 2007-03-29 Bristol-Myers Squibb Company Met kinase inhibitors
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
US7514435B2 (en) * 2005-11-18 2009-04-07 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7348325B2 (en) 2005-11-30 2008-03-25 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US8063208B2 (en) 2006-02-16 2011-11-22 Bristol-Myers Squibb Company Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
CN101395158A (zh) 2006-03-07 2009-03-25 百时美施贵宝公司 可作为激酶抑制剂的吡咯并三嗪苯胺前体药物化合物
AU2007310777A1 (en) 2006-10-26 2008-05-02 Novo Nordisk A/S IL-21 variants
WO2008074863A1 (en) * 2006-12-21 2008-06-26 Novo Nordisk A/S Interleukin-21 variants with altered binding to the il-21 receptor
US20090083483A1 (en) * 2007-09-24 2009-03-26 International Business Machines Corporation Power Conservation In A RAID Array
US8166326B2 (en) * 2007-11-08 2012-04-24 International Business Machines Corporation Managing power consumption in a computer
US20090132842A1 (en) * 2007-11-15 2009-05-21 International Business Machines Corporation Managing Computer Power Consumption In A Computer Equipment Rack
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Also Published As

Publication number Publication date
CN101723948A (zh) 2010-06-09
JP4511367B2 (ja) 2010-07-28
TW200420565A (en) 2004-10-16
PE20040805A1 (es) 2004-11-20
CA2509650C (en) 2007-10-30
EP1569937A4 (en) 2007-08-08
AU2003300877A1 (en) 2004-07-09
US6916815B2 (en) 2005-07-12
CA2509650A1 (en) 2004-07-01
JP2006509826A (ja) 2006-03-23
AU2003300877B2 (en) 2010-02-18
NZ540338A (en) 2008-05-30
IS7890A (is) 2005-06-10
KR20050084242A (ko) 2005-08-26
EP1569937B1 (en) 2011-11-23
ZA200504507B (en) 2006-08-30
EP1569937A2 (en) 2005-09-07
RU2005120650A (ru) 2006-01-20
UA80591C2 (en) 2007-10-10
US20040142931A1 (en) 2004-07-22
US7148220B2 (en) 2006-12-12
PL377517A1 (pl) 2006-02-06
NO20052733D0 (no) 2005-06-07
DK1569937T3 (da) 2012-01-02
ES2374393T3 (es) 2012-02-16
RS20050441A (en) 2007-04-10
CO5570660A2 (es) 2005-10-31
CN1726216A (zh) 2006-01-25
MXPA05006164A (es) 2005-08-26
NO20052733L (no) 2005-07-07
AR042450A1 (es) 2005-06-22
WO2004054514A3 (en) 2004-10-07
ATE534648T1 (de) 2011-12-15
WO2004054514A2 (en) 2004-07-01
KR101073801B1 (ko) 2011-10-13
PT1569937E (pt) 2012-01-04
US20050222153A1 (en) 2005-10-06
RU2356903C2 (ru) 2009-05-27
HRP20050535A2 (en) 2005-12-31

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014.