BR0312801A - inibidores de azaindol cinase - Google Patents

inibidores de azaindol cinase

Info

Publication number
BR0312801A
BR0312801A BRPI0312801-6A BR0312801A BR0312801A BR 0312801 A BR0312801 A BR 0312801A BR 0312801 A BR0312801 A BR 0312801A BR 0312801 A BR0312801 A BR 0312801A
Authority
BR
Brazil
Prior art keywords
azaindol
formula
kinase inhibitors
compounds
useful
Prior art date
Application number
BRPI0312801-6A
Other languages
English (en)
Inventor
Rajeev Bhide
Rejean Ruel
Carl Thibeault
Alexandre L Heureux
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR0312801A publication Critical patent/BR0312801A/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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Abstract

"INIBIDORES DE AZAINDOL CINASE". A presente invenção refere-se a composto de fórmula (I), e seus sais farmaceuticamente aceitáveis. Os compostos de fórmula I inibem a atividade tirosina cinase de receptores de fator de crescimento como VEGFR-2 e FGFR-1, tornando-os úteis como agentes anticâncer. Os compostos de fórmula (I) também são úteis para o tratamento de outras doenças associadas com caminhos de transdução de sinal operando através de receptores de fator de crescimento.
BRPI0312801-6A 2002-07-19 2003-07-18 inibidores de azaindol cinase BR0312801A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39725602P 2002-07-19 2002-07-19
US44721303P 2003-02-13 2003-02-13
PCT/US2003/022554 WO2004009601A1 (en) 2002-07-19 2003-07-18 Azaindole kinase inhibitors

Publications (1)

Publication Number Publication Date
BR0312801A true BR0312801A (pt) 2007-06-26

Family

ID=30773005

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0312801-6A BR0312801A (pt) 2002-07-19 2003-07-18 inibidores de azaindol cinase
BRPI0312940-3A BRPI0312940B1 (pt) 2002-07-19 2003-07-18 Inibidores de quinases, composição e uso dos mesmos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0312940-3A BRPI0312940B1 (pt) 2002-07-19 2003-07-18 Inibidores de quinases, composição e uso dos mesmos.

Country Status (33)

Country Link
US (6) US6869952B2 (pt)
EP (3) EP1539763B1 (pt)
JP (2) JP4361485B2 (pt)
KR (1) KR100901939B1 (pt)
CN (3) CN101880283B (pt)
AR (1) AR040500A1 (pt)
AT (2) ATE505471T1 (pt)
AU (2) AU2003254088B2 (pt)
BR (2) BR0312801A (pt)
CA (2) CA2492665A1 (pt)
CO (1) CO5680407A2 (pt)
CY (1) CY1112628T1 (pt)
DE (1) DE60336732D1 (pt)
DK (1) DK1534290T3 (pt)
ES (1) ES2377963T3 (pt)
GE (2) GEP20074213B (pt)
HK (1) HK1072545A1 (pt)
HR (2) HRP20050058A2 (pt)
IL (3) IL166129A0 (pt)
IS (2) IS7646A (pt)
MX (2) MXPA05000715A (pt)
MY (1) MY134848A (pt)
NO (2) NO330132B1 (pt)
NZ (1) NZ537523A (pt)
PE (1) PE20040680A1 (pt)
PL (2) PL216663B1 (pt)
PT (1) PT1534290E (pt)
RS (2) RS52325B (pt)
RU (2) RU2331642C2 (pt)
SI (1) SI1534290T1 (pt)
TW (1) TWI329112B (pt)
UA (1) UA82846C2 (pt)
WO (2) WO2004009784A2 (pt)

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US6982265B1 (en) * 1999-05-21 2006-01-03 Bristol Myers Squibb Company Pyrrolotriazine inhibitors of kinases
US6670357B2 (en) * 2000-11-17 2003-12-30 Bristol-Myers Squibb Company Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
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TW200401638A (en) * 2002-06-20 2004-02-01 Bristol Myers Squibb Co Heterocyclic inhibitors of kinases
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KR101173510B1 (ko) * 2002-08-23 2012-08-21 슬로안-케테링인스티튜트퍼캔서리서치 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도
TW200420565A (en) 2002-12-13 2004-10-16 Bristol Myers Squibb Co C-6 modified indazolylpyrrolotriazines
JP2006516653A (ja) 2003-02-05 2006-07-06 ブリストル−マイヤーズ　スクイブ　カンパニー キナーゼ阻害剤ピロロトリアジンの製造方法
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