ATE445396T1 - 3-arylthioindol-2-carbonsäureamidderivate und ihre analoge als hemmer von caseinkinase i - Google Patents
3-arylthioindol-2-carbonsäureamidderivate und ihre analoge als hemmer von caseinkinase iInfo
- Publication number
- ATE445396T1 ATE445396T1 AT05785433T AT05785433T ATE445396T1 AT E445396 T1 ATE445396 T1 AT E445396T1 AT 05785433 T AT05785433 T AT 05785433T AT 05785433 T AT05785433 T AT 05785433T AT E445396 T1 ATE445396 T1 AT E445396T1
- Authority
- AT
- Austria
- Prior art keywords
- caseinkinase
- arylthioindole
- analogues
- inhibitors
- acid amide
- Prior art date
Links
- 102000008122 Casein Kinase I Human genes 0.000 title 1
- 108010049812 Casein Kinase I Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000005403 Casein Kinases Human genes 0.000 abstract 1
- 108010031425 Casein Kinases Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60334804P | 2004-08-19 | 2004-08-19 | |
| PCT/US2005/029306 WO2006023590A1 (en) | 2004-08-19 | 2005-08-19 | 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE Iϵ |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE445396T1 true ATE445396T1 (de) | 2009-10-15 |
Family
ID=35311784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05785433T ATE445396T1 (de) | 2004-08-19 | 2005-08-19 | 3-arylthioindol-2-carbonsäureamidderivate und ihre analoge als hemmer von caseinkinase i |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8008340B2 (de) |
| EP (1) | EP1791537B1 (de) |
| JP (1) | JP4931814B2 (de) |
| KR (1) | KR20070045264A (de) |
| CN (1) | CN101039666A (de) |
| AT (1) | ATE445396T1 (de) |
| AU (1) | AU2005277460A1 (de) |
| BR (1) | BRPI0514397A (de) |
| CA (1) | CA2577511A1 (de) |
| DE (1) | DE602005017162D1 (de) |
| DK (1) | DK1791537T3 (de) |
| ES (1) | ES2334927T3 (de) |
| IL (1) | IL181155A0 (de) |
| MX (1) | MX2007001077A (de) |
| PL (1) | PL1791537T3 (de) |
| PT (1) | PT1791537E (de) |
| RU (1) | RU2391098C2 (de) |
| SI (1) | SI1791537T1 (de) |
| WO (1) | WO2006023590A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110172244A1 (en) * | 2008-02-22 | 2011-07-14 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
| JP4748823B2 (ja) * | 2009-02-12 | 2011-08-17 | 株式会社ファルマデザイン | カゼインキナーゼ１δ及びカゼインキナーゼ１ε阻害剤 |
| JP5784620B2 (ja) * | 2009-10-28 | 2015-09-24 | ファイザー・インク | カゼインキナーゼ阻害剤としてのイミダゾール誘導体 |
| BR112012028055A2 (pt) * | 2010-05-06 | 2019-09-24 | Merck Sharp & Dohme | composto, uso do mesmo, composição farmacêutica, e, métodos de tratar uma doença mediada |
| AU2011290238B8 (en) * | 2010-08-09 | 2015-09-03 | Nb Health Laboratory Co. Ltd. | Inhibitor of casein kinase 1delta and casein kinase 1E |
| KR101350077B1 (ko) * | 2010-12-13 | 2014-01-14 | 한국화학연구원 | 신규한 3-인돌리논 유도체 및 이를 포함하는 조성물 |
| JP5937102B2 (ja) * | 2010-12-14 | 2016-06-22 | エレクトロフォレティクス リミテッド | カゼインキナーゼ１デルタ（ｃｋ１デルタ）阻害剤 |
| NZ728724A (en) * | 2012-05-11 | 2018-03-23 | Reset Therapeutics Inc | Carbazole-containing sulfonamides as cryptochrome modulators |
| TWI690521B (zh) | 2014-04-07 | 2020-04-11 | 美商同步製藥公司 | 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類 |
| WO2018133835A1 (en) * | 2017-01-20 | 2018-07-26 | National Institute Of Biological Sciences, Beijing | Nucleoside analogue regulating mammalian circadian rhythm |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3705934A1 (de) * | 1987-02-25 | 1988-09-08 | Nattermann A & Cie | Indolyl-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| EP0686148A4 (de) * | 1993-02-24 | 1996-02-07 | Merck & Co Inc | Inhibitoren der hiv inversen transcriptase |
| US5807693A (en) * | 1994-11-23 | 1998-09-15 | Icos Corporation | Calcineurin inhibitory compounds and anchoring protein |
| AU767800B2 (en) * | 1999-06-08 | 2003-11-27 | Aventisub Ii Inc. | Screening methods for altering circadian rhythm proteins |
| JP2005526090A (ja) * | 2002-03-13 | 2005-09-02 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 神経伝達物質調節因子としてのピラゾロ（１，５−ａ）ピリジン誘導体 |
| WO2004005501A1 (en) * | 2002-07-08 | 2004-01-15 | Bayer Healthcare Ag | Regulation of human casein kinase i epsilon |
| WO2004014300A2 (en) * | 2002-08-09 | 2004-02-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| JP4691506B2 (ja) * | 2003-12-11 | 2011-06-01 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | カゼインキナーゼＩεの阻害剤としての置換１Ｈ−ピロロ［３，２−ｂ，３，２−ｃ，及び２，３−ｃ］ピリジン−２−カルボキシアミド及び関連類似物 |
-
2005
- 2005-08-19 ES ES05785433T patent/ES2334927T3/es not_active Expired - Lifetime
- 2005-08-19 KR KR1020077003924A patent/KR20070045264A/ko not_active Withdrawn
- 2005-08-19 MX MX2007001077A patent/MX2007001077A/es not_active Application Discontinuation
- 2005-08-19 AU AU2005277460A patent/AU2005277460A1/en not_active Abandoned
- 2005-08-19 JP JP2007527987A patent/JP4931814B2/ja not_active Expired - Fee Related
- 2005-08-19 RU RU2007109813/14A patent/RU2391098C2/ru not_active IP Right Cessation
- 2005-08-19 PT PT05785433T patent/PT1791537E/pt unknown
- 2005-08-19 AT AT05785433T patent/ATE445396T1/de not_active IP Right Cessation
- 2005-08-19 CN CNA2005800346526A patent/CN101039666A/zh active Pending
- 2005-08-19 EP EP05785433A patent/EP1791537B1/de not_active Expired - Lifetime
- 2005-08-19 DK DK05785433.3T patent/DK1791537T3/da active
- 2005-08-19 SI SI200530889T patent/SI1791537T1/sl unknown
- 2005-08-19 WO PCT/US2005/029306 patent/WO2006023590A1/en not_active Ceased
- 2005-08-19 BR BRPI0514397-7A patent/BRPI0514397A/pt not_active IP Right Cessation
- 2005-08-19 CA CA002577511A patent/CA2577511A1/en not_active Abandoned
- 2005-08-19 PL PL05785433T patent/PL1791537T3/pl unknown
- 2005-08-19 DE DE602005017162T patent/DE602005017162D1/de not_active Expired - Lifetime
-
2007
- 2007-02-04 IL IL181155A patent/IL181155A0/en unknown
- 2007-02-15 US US11/675,230 patent/US8008340B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2334927T3 (es) | 2010-03-17 |
| WO2006023590A1 (en) | 2006-03-02 |
| BRPI0514397A (pt) | 2008-06-10 |
| AU2005277460A1 (en) | 2006-03-02 |
| PT1791537E (pt) | 2010-01-19 |
| JP2008510704A (ja) | 2008-04-10 |
| KR20070045264A (ko) | 2007-05-02 |
| DE602005017162D1 (de) | 2009-11-26 |
| US8008340B2 (en) | 2011-08-30 |
| IL181155A0 (en) | 2007-07-04 |
| PL1791537T3 (pl) | 2010-04-30 |
| EP1791537A1 (de) | 2007-06-06 |
| SI1791537T1 (sl) | 2010-02-26 |
| RU2391098C2 (ru) | 2010-06-10 |
| JP4931814B2 (ja) | 2012-05-16 |
| US20070142454A1 (en) | 2007-06-21 |
| MX2007001077A (es) | 2007-04-17 |
| DK1791537T3 (da) | 2010-03-01 |
| RU2007109813A (ru) | 2008-09-27 |
| CN101039666A (zh) | 2007-09-19 |
| CA2577511A1 (en) | 2006-03-02 |
| EP1791537B1 (de) | 2009-10-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201101672A1 (ru) | Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина | |
| EA200900152A1 (ru) | Ингибиторы пирролотриазинкиназы | |
| WO2007056517A3 (en) | Pharmaceutical salts and polymorphs of n- (5-chl0r0-2-pyridinyl) -2- [ [4- [ (dimethylamino) iminomethyl] benzoyl] amino] -5-meth oxy-benzamide, a factor xa inhibitor | |
| IL181155A0 (en) | 3-arylthioindole-2-carboxamide derivatives and analogs thereof as inhibitors of casein kinase i?á | |
| EA201070167A1 (ru) | Замещенные производные индазола, активные как ингибиторы киназы | |
| EA201101671A1 (ru) | Замещенные производные аминопропионовой кислоты в качестве ингибиторов неприлизина | |
| TNSN06411A1 (en) | Pyrimidine urea derivatives as kinase inhibitors | |
| EA200970611A1 (ru) | Замещенные пиразолохиназолиновые производные, способ их получения и их применение в качестве ингибиторов киназы | |
| IL198979A (en) | Enzyme inhibitors diacylglycerol o-acetyltransferase type 1 | |
| NZ593295A (en) | Preparation method of dihydroindene amide compounds, their pharmaceutical compositions containing compounds thereof and use as protein kinase inhibitor | |
| NO20091590L (no) | Heterocykliske amidforbindelser anvendbare som kinaseinhibitorer | |
| DK1539700T3 (da) | 8-hydroxyquinolin-derivater | |
| ATE307810T1 (de) | Imidazol-2-carbonsäureamid derivate als raf- kinase-inhibitoren | |
| WO2004001059A3 (en) | Heterocyclic inhibitors of kinases | |
| AU2009258496A8 (en) | Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity | |
| TW200728307A (en) | Novel spirochromanone derivatives | |
| MY144232A (en) | 5-substituted-2-phenylamino benzamides as mek inhibitors | |
| SE0400284D0 (sv) | Novel compounds | |
| WO2006007378A3 (en) | Pyrrolotriazine kinase inhibitors | |
| MX2009011059A (es) | Aminopirimidinas utiles como inhibidores de cinasas. | |
| ATE404536T1 (de) | Substituierte chinolinderivate als inhibitoren von mitotischem kinesin | |
| MX2007004248A (es) | Derivados heterociclicos de bisarilurea sustituidos como inhibidores de cinasa. | |
| UA97348C2 (en) | HETEROCYCLIC NF-kB INHIBITORS | |
| EA200901474A1 (ru) | Соли [4-(6-фтор-7-метиламино-2,4-диоксо-1,4-дигидро-2н-хиназолин-3-ил)фенил]-5-хлортиофен-2-илсульфонилмочевины в различных кристаллических формах и фармацевтические композиции на их основе | |
| ATE373636T1 (de) | Amidderivate als inhibitoren der enzymatischen aktivität von renin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1791537 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |