PT1791537E - Derivados de 3-ariltioindole-2-carboxamida e seus análogos como inibidores da cinase da caseína i - Google Patents
Derivados de 3-ariltioindole-2-carboxamida e seus análogos como inibidores da cinase da caseína i Download PDFInfo
- Publication number
- PT1791537E PT1791537E PT05785433T PT05785433T PT1791537E PT 1791537 E PT1791537 E PT 1791537E PT 05785433 T PT05785433 T PT 05785433T PT 05785433 T PT05785433 T PT 05785433T PT 1791537 E PT1791537 E PT 1791537E
- Authority
- PT
- Portugal
- Prior art keywords
- casein kinase
- arylthioindole
- analogs
- inhibitors
- carboxamide derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60334804P | 2004-08-19 | 2004-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1791537E true PT1791537E (pt) | 2010-01-19 |
Family
ID=35311784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT05785433T PT1791537E (pt) | 2004-08-19 | 2005-08-19 | Derivados de 3-ariltioindole-2-carboxamida e seus análogos como inibidores da cinase da caseína i |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8008340B2 (pt) |
| EP (1) | EP1791537B1 (pt) |
| JP (1) | JP4931814B2 (pt) |
| KR (1) | KR20070045264A (pt) |
| CN (1) | CN101039666A (pt) |
| AT (1) | ATE445396T1 (pt) |
| AU (1) | AU2005277460A1 (pt) |
| BR (1) | BRPI0514397A (pt) |
| CA (1) | CA2577511A1 (pt) |
| DE (1) | DE602005017162D1 (pt) |
| DK (1) | DK1791537T3 (pt) |
| ES (1) | ES2334927T3 (pt) |
| IL (1) | IL181155A0 (pt) |
| MX (1) | MX2007001077A (pt) |
| PL (1) | PL1791537T3 (pt) |
| PT (1) | PT1791537E (pt) |
| RU (1) | RU2391098C2 (pt) |
| SI (1) | SI1791537T1 (pt) |
| WO (1) | WO2006023590A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2716332A1 (en) * | 2008-02-22 | 2009-08-27 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
| EP2397481B1 (en) | 2009-02-12 | 2014-03-12 | Pharmadesign, Inc. | Inhibitor of casein kinase 1delta and casein kinase 1epsilon |
| DK2493876T3 (en) * | 2009-10-28 | 2014-03-10 | Pfizer | Imidazole derivatives AS casein kinase inhibitors |
| CN102917707A (zh) * | 2010-05-06 | 2013-02-06 | 默沙东公司 | 可用作faah调节剂的氮杂吲哚衍生物 |
| RU2562833C2 (ru) | 2010-08-09 | 2015-09-10 | НБ Хелс Лаборатори Ко. Лтд. | Ингибитор казеинкиназы 1 дельта и казеинкиназы 1 е |
| KR101350077B1 (ko) * | 2010-12-13 | 2014-01-14 | 한국화학연구원 | 신규한 3-인돌리논 유도체 및 이를 포함하는 조성물 |
| ES2650744T3 (es) * | 2010-12-14 | 2018-01-22 | Electrophoretics Limited | Inhibidores de la caseína quinasa 1 delta (CK1delta) |
| US9265772B2 (en) | 2012-05-11 | 2016-02-23 | Reset Therapeutics, Inc. | Carbazole-containing sulfonamides as cryptochrome modulators |
| TWI690521B (zh) | 2014-04-07 | 2020-04-11 | 美商同步製藥公司 | 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類 |
| WO2018133835A1 (en) * | 2017-01-20 | 2018-07-26 | National Institute Of Biological Sciences, Beijing | Nucleoside analogue regulating mammalian circadian rhythm |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3705934A1 (de) * | 1987-02-25 | 1988-09-08 | Nattermann A & Cie | Indolyl-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| CN1119856A (zh) * | 1993-02-24 | 1996-04-03 | 麦克公司 | Hiv逆转录酶抑制剂 |
| BR0011437A (pt) * | 1999-06-08 | 2002-03-05 | Aventis Pharma Inc | Métodos de triagem para alterar proteìnas do ritmo circadiano |
| JP2005526090A (ja) * | 2002-03-13 | 2005-09-02 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 神経伝達物質調節因子としてのピラゾロ（１，５−ａ）ピリジン誘導体 |
| CA2493575A1 (en) * | 2002-08-09 | 2004-02-19 | Christopher J. Dinsmore | Tyrosine kinase inhibitors |
| RS50823B (sr) * | 2003-12-11 | 2010-08-31 | Aventis Pharmaceuticals Inc. | Supstituisani 1h-pirolo[3,2-b, 3,2-c, i 2,3-c]piridin-2-karboksamidi i srodni analozi kao inhibitori kazein kinaze i epsilon |
-
2005
- 2005-08-19 AU AU2005277460A patent/AU2005277460A1/en not_active Abandoned
- 2005-08-19 CA CA002577511A patent/CA2577511A1/en not_active Abandoned
- 2005-08-19 JP JP2007527987A patent/JP4931814B2/ja not_active Expired - Fee Related
- 2005-08-19 EP EP05785433A patent/EP1791537B1/en not_active Not-in-force
- 2005-08-19 DE DE602005017162T patent/DE602005017162D1/de active Active
- 2005-08-19 PT PT05785433T patent/PT1791537E/pt unknown
- 2005-08-19 DK DK05785433.3T patent/DK1791537T3/da active
- 2005-08-19 KR KR1020077003924A patent/KR20070045264A/ko not_active Application Discontinuation
- 2005-08-19 SI SI200530889T patent/SI1791537T1/sl unknown
- 2005-08-19 MX MX2007001077A patent/MX2007001077A/es not_active Application Discontinuation
- 2005-08-19 ES ES05785433T patent/ES2334927T3/es active Active
- 2005-08-19 CN CNA2005800346526A patent/CN101039666A/zh active Pending
- 2005-08-19 AT AT05785433T patent/ATE445396T1/de not_active IP Right Cessation
- 2005-08-19 RU RU2007109813/14A patent/RU2391098C2/ru not_active IP Right Cessation
- 2005-08-19 BR BRPI0514397-7A patent/BRPI0514397A/pt not_active IP Right Cessation
- 2005-08-19 WO PCT/US2005/029306 patent/WO2006023590A1/en active Application Filing
- 2005-08-19 PL PL05785433T patent/PL1791537T3/pl unknown
-
2007
- 2007-02-04 IL IL181155A patent/IL181155A0/en unknown
- 2007-02-15 US US11/675,230 patent/US8008340B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2577511A1 (en) | 2006-03-02 |
| ES2334927T3 (es) | 2010-03-17 |
| JP2008510704A (ja) | 2008-04-10 |
| DE602005017162D1 (de) | 2009-11-26 |
| US8008340B2 (en) | 2011-08-30 |
| KR20070045264A (ko) | 2007-05-02 |
| BRPI0514397A (pt) | 2008-06-10 |
| DK1791537T3 (da) | 2010-03-01 |
| PL1791537T3 (pl) | 2010-04-30 |
| MX2007001077A (es) | 2007-04-17 |
| CN101039666A (zh) | 2007-09-19 |
| SI1791537T1 (sl) | 2010-02-26 |
| WO2006023590A1 (en) | 2006-03-02 |
| JP4931814B2 (ja) | 2012-05-16 |
| RU2391098C2 (ru) | 2010-06-10 |
| EP1791537B1 (en) | 2009-10-14 |
| RU2007109813A (ru) | 2008-09-27 |
| ATE445396T1 (de) | 2009-10-15 |
| IL181155A0 (en) | 2007-07-04 |
| US20070142454A1 (en) | 2007-06-21 |
| AU2005277460A1 (en) | 2006-03-02 |
| EP1791537A1 (en) | 2007-06-06 |
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