BR0011437A - Métodos de triagem para alterar proteìnas do ritmo circadiano - Google Patents

Métodos de triagem para alterar proteìnas do ritmo circadiano

Info

Publication number
BR0011437A
BR0011437A BR0011437-5A BR0011437A BR0011437A BR 0011437 A BR0011437 A BR 0011437A BR 0011437 A BR0011437 A BR 0011437A BR 0011437 A BR0011437 A BR 0011437A
Authority
BR
Brazil
Prior art keywords
alter
ability
directed
screening methods
phosphorylation
Prior art date
Application number
BR0011437-5A
Other languages
English (en)
Inventor
George Keesler
Cesare Mondadori
Zhengbin Yao
Fernando Camacho
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of BR0011437A publication Critical patent/BR0011437A/pt

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrophonic Musical Instruments (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Patente de Invenção: "MéTODOS DE TRIAGEM PARA ALTERAR PROTEìNAS DO RITMO CIRCADIANO". A presente invenção é orientada para métodos para identificar compostos de teste que alterem os ritmos circadianos dos mamíferos, e mais especificamente, é orientada para métodos para determinar a capacidade de um composto de teste para alterar a fosforilação hCKI <sym> e <sym> de uma proteína Período humana. A presente invenção é orientada também para um método para determinar a capacidade de um composto de teste para seletivamente alterar fosforilação, interação com, ou alternativamente degradação, de uma ou mais proteínas Período humanas relativas a sua capacidade para alterar fosforilação, interação com, ou alternativamente degradação, de uma proteína Período humana diferente.
BR0011437-5A 1999-06-08 2000-06-07 Métodos de triagem para alterar proteìnas do ritmo circadiano BR0011437A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32774599A 1999-06-08 1999-06-08
PCT/US2000/015633 WO2000075669A1 (en) 1999-06-08 2000-06-07 Screening methods for altering circadian rhythm proteins

Publications (1)

Publication Number Publication Date
BR0011437A true BR0011437A (pt) 2002-03-05

Family

ID=23277866

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011437-5A BR0011437A (pt) 1999-06-08 2000-06-07 Métodos de triagem para alterar proteìnas do ritmo circadiano

Country Status (15)

Country Link
US (1) US6555328B1 (pt)
EP (1) EP1183541B1 (pt)
JP (1) JP4583682B2 (pt)
KR (1) KR100722176B1 (pt)
AT (1) ATE322016T1 (pt)
AU (1) AU767800B2 (pt)
BR (1) BR0011437A (pt)
CA (1) CA2375450C (pt)
DE (1) DE60026998T2 (pt)
IL (2) IL146729A0 (pt)
MX (1) MXPA01011417A (pt)
NO (3) NO330241B1 (pt)
NZ (1) NZ514603A (pt)
WO (1) WO2000075669A1 (pt)
ZA (1) ZA200108962B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436628B1 (en) 1998-06-19 2002-08-20 The Rockefeller University Methods of identifying an agent which modulates period and doubletime protein interaction
US6476188B1 (en) 1998-06-19 2002-11-05 The Rockefeller University Clock gene and methods of use thereof
CA2375450C (en) * 1999-06-08 2009-04-28 Aventis Pharmaceuticals Inc. Screening methods for altering circadian rhythm proteins
WO2001036618A2 (en) * 1999-11-18 2001-05-25 Mitsubishi Pharma Corporation Transgenic mammals into which a period 1 promoter that confers rhythmical expression has been introduced
GB0103110D0 (en) * 2000-08-25 2001-03-28 Aventis Pharma Inc A membrane penetrating peptide encoded by a nuclear localization sequence from human period 1
EP1358315A4 (en) * 2001-01-11 2005-11-16 Univ Utah Res Found IDENTIFYING AN ADVANCED SLEEP PHASE SYNDROME GENE IN PEOPLE
AU2003278333A1 (en) * 2002-10-25 2004-05-13 University Of Surrey Polymorphism in the per3 gene as a indicator in the diagnosis and treatment of circadian rhythm sleep disorders
EP1576133A2 (en) * 2002-11-27 2005-09-21 University of Utah Research Foundation Casein kinase i epsilon and casein kinase i delta and sleep in humans
JO2629B1 (en) * 2004-08-19 2012-06-24 افينتيس فارما سوتيكالز انك Branched carboxylic acid amides containing thienobirol, carboxylic acid amides containing pyrolithiazole, and the like as kinase inhibitors casein epsilon
JO2724B1 (en) * 2004-08-19 2013-09-15 افينتس فارماسوتيكالز انك 3-Alternative-5 -6-Amino Alkyl Indole-2-Carboxyl Acid Amide and Related Isotopes as Casein Kinase Inhibitors
DK1791537T3 (da) * 2004-08-19 2010-03-01 Aventis Pharma Inc 3-arylthioindol-2-carboxamidderivater og analoger deraf som inhibitorer af casein-kinase
US20100028871A1 (en) * 2006-05-31 2010-02-04 National Institute Of Radiological Sciences Light-inducible and rhythmically expressed genes and method for screening substances that affect an internal clock system
ES2425179T3 (es) * 2006-10-25 2013-10-11 The Rockefeller University Métodos para el tratamiento de trastornos relacionados con beta-amiloide y composiciones para los mismos
FR2918986B1 (fr) 2007-07-19 2009-09-04 Sanofi Aventis Sa Derives de 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]- pyridazine, leur preparation et leur application en therapeutique
CN105744948B (zh) * 2013-10-14 2020-03-24 南京大学 进食节律提前综合征的识别方法及其应用
KR101600144B1 (ko) * 2013-12-20 2016-03-04 서울대학교산학협력단 일주기 리듬 수면장애 및 시차 부적응에 대한 예방 또는 치료제 스크리닝 방법
CA2935985A1 (en) 2014-01-09 2015-07-16 Intra-Cellular Therapies, Inc. Organic compounds
WO2017083835A1 (en) * 2015-11-13 2017-05-18 The Trustees Of Columbia University In The City Of New York Inhibition of tor complex 2 increases immunity against bacterial infection
WO2023129377A1 (en) * 2022-01-03 2023-07-06 The Johns Hopkins University Methods and materials for treating heart attack

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1157137A (ja) * 1997-08-28 1999-03-02 Sanyo Bussan Kk 遊技機用特別図柄表示装置
KR100246893B1 (ko) * 1997-12-29 2000-05-01 윤종용 전자렌지용 도어
WO1999057137A1 (en) * 1998-05-07 1999-11-11 The President & Fellows Of Harvard College Compositions and methods involving regulation of mammalian circadian rhythms
CA2375450C (en) * 1999-06-08 2009-04-28 Aventis Pharmaceuticals Inc. Screening methods for altering circadian rhythm proteins

Also Published As

Publication number Publication date
NO20100431L (no) 2002-02-05
MXPA01011417A (es) 2002-06-04
IL146729A0 (en) 2002-07-25
JP4583682B2 (ja) 2010-11-17
NO330241B1 (no) 2011-03-14
IL146729A (en) 2007-06-17
DE60026998D1 (de) 2006-05-18
EP1183541A1 (en) 2002-03-06
US6555328B1 (en) 2003-04-29
ATE322016T1 (de) 2006-04-15
CA2375450C (en) 2009-04-28
CA2375450A1 (en) 2000-12-14
AU767800B2 (en) 2003-11-27
NZ514603A (en) 2003-10-31
NO20100430L (no) 2002-02-05
NO20015972D0 (no) 2001-12-06
KR100722176B1 (ko) 2007-05-29
AU5468900A (en) 2000-12-28
KR20020033101A (ko) 2002-05-04
EP1183541B1 (en) 2006-03-29
WO2000075669A1 (en) 2000-12-14
JP2003501074A (ja) 2003-01-14
DE60026998T2 (de) 2007-04-05
ZA200108962B (en) 2003-01-30
NO20015972L (no) 2002-02-05

Similar Documents

Publication Publication Date Title
NO20100431L (no) Fremgangsmate for a endre degradering av det humane klokkeproteinet hPeriode1 (hPER1)
CY1108655T1 (el) ΘΕΙΟΖΟΛΙΔΙΝ-4-ΟΝΕΣ ΓΙΑ ΤΗΝ ΑΝΑΣΤΟΛΗ ΠΡΩΤΕΪΝΩΝ hYAK3
ATE279181T1 (de) Verwendung von 5ht-6 antagonisten zur behandlung adhd
EA199900758A1 (ru) Малые молекулы, полезные при лечении воспалительных заболеваний
EA200100589A1 (ru) Азабициклоалканы как модуляторы ccr5
EA200001244A1 (ru) Комбинационная терапия для лечения биполярных расстройств
EA199700280A1 (ru) Ингибиторы протеинкиназы с
CY1105836T1 (el) 12, 13-τροποποιημενα παραγωγα εποθιλονης
ID26328A (id) Penghambat raf kinase menggunakan urea heterosiklik tersubstitusi aril dan heteroaril
ATE394658T1 (de) Spurendetektion von analyten mit hilfe artifizieller olfaktometrie
ATE414149T1 (de) Survivin, ein protein das zelluläre apoptosis hemmt, und dessen modulation
EA200400241A1 (ru) Направленные к мишени мультимерные контрастные вещества, основанные на пептидах
EA200100780A1 (ru) Антагонисты tweak и рецептора tweak и их использование для лечения иммунологических заболеваний
ATE269303T1 (de) Arylpiperazinyl-cyclohexyl indolderivate zur behandlung von depressionen
EA200000349A1 (ru) Способ лечения оппозиционного расстройства
DE60032795D1 (de) Nordihydroguaiaretinsäurederivate zur behandlung von tumoren
DE69739026D1 (de) Nitril-Hydratase, ihre Derivate und Verfahren zur Herstellung von Verbindungen
EA200100012A1 (ru) Мостиковые инденопирролокарбазолы
DE69903410T2 (de) Entkarbonisierung von gasen unter verwendung von zeolithischen adsorptionsmitteln
CY1105380T1 (el) Προτιμωμενα τμηματα της νευρικης νηματικης πρωτεϊνης και μεθοδοι χρησης αυτων
DE69621799D1 (de) Verwendung von gabapentin und seine derivate in der behandlung von manie und bipolare störungen
DK0948604T3 (da) Screeningsmetoder for forbindelser som binder til PYK2-polypeptidet
EA199800867A1 (ru) Соединения тетрагидробетакарболина
DE69606837D1 (de) Gerät zur Überprüfung der Bestimmungen von klinischen Analysen
EA200500603A1 (ru) ПРОИЗВОДНЫЕ [6,7-ДИГИДРО-5H-ИМИДАЗО[1,2-α]ИМИДАЗОЛ-3-СУЛЬФОНИЛАМИНО]ПРОПИОНАМИДА

Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: AVENTIS PHARMACEUTICALS, INC. (US)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020070165509/RJ DE 23/11/2007.

B25A Requested transfer of rights approved

Owner name: HMR PHARMA, INC. (US)

Free format text: TRANSFERIDO DE: AVENTIS PHARMACEUTICALS, INC.

B25A Requested transfer of rights approved

Owner name: AVENTIS HOLDINGS INC. (US)

Free format text: TRANSFERIDO DE: HMR PHARMA, INC.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: AVENTISUB II INC. (US)

Free format text: TRANSFERIDO DE: AVENTIS HOLDINGS INC.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O ART. 24, ART. 8O COMBINADO COM ART. 13 E ART. 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.