DK1791537T3 - 3-arylthioindol-2-carboxamidderivater og analoger deraf som inhibitorer af casein-kinase - Google Patents
3-arylthioindol-2-carboxamidderivater og analoger deraf som inhibitorer af casein-kinaseInfo
- Publication number
- DK1791537T3 DK1791537T3 DK05785433.3T DK05785433T DK1791537T3 DK 1791537 T3 DK1791537 T3 DK 1791537T3 DK 05785433 T DK05785433 T DK 05785433T DK 1791537 T3 DK1791537 T3 DK 1791537T3
- Authority
- DK
- Denmark
- Prior art keywords
- casein kinase
- arylthioindole
- analogues
- inhibitors
- carboxamide derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60334804P | 2004-08-19 | 2004-08-19 | |
| PCT/US2005/029306 WO2006023590A1 (en) | 2004-08-19 | 2005-08-19 | 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE Iϵ |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1791537T3 true DK1791537T3 (da) | 2010-03-01 |
Family
ID=35311784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05785433.3T DK1791537T3 (da) | 2004-08-19 | 2005-08-19 | 3-arylthioindol-2-carboxamidderivater og analoger deraf som inhibitorer af casein-kinase |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8008340B2 (da) |
| EP (1) | EP1791537B1 (da) |
| JP (1) | JP4931814B2 (da) |
| KR (1) | KR20070045264A (da) |
| CN (1) | CN101039666A (da) |
| AT (1) | ATE445396T1 (da) |
| AU (1) | AU2005277460A1 (da) |
| BR (1) | BRPI0514397A (da) |
| CA (1) | CA2577511A1 (da) |
| DE (1) | DE602005017162D1 (da) |
| DK (1) | DK1791537T3 (da) |
| ES (1) | ES2334927T3 (da) |
| IL (1) | IL181155A0 (da) |
| MX (1) | MX2007001077A (da) |
| PL (1) | PL1791537T3 (da) |
| PT (1) | PT1791537E (da) |
| RU (1) | RU2391098C2 (da) |
| SI (1) | SI1791537T1 (da) |
| WO (1) | WO2006023590A1 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201001330A1 (ru) * | 2008-02-22 | 2011-04-29 | Айрм Ллк | Соединения и композиции в качестве модуляторов активности gpr119 |
| US9018238B2 (en) | 2009-02-12 | 2015-04-28 | Pharmadesign, Inc. | Inhibitor of casein kinase 1δ and casein kinase 1ε |
| ES2460065T3 (es) * | 2009-10-28 | 2014-05-13 | Pfizer Inc. | Derivados de imidazol como inhibidores de la caseína quinasa |
| US20130059850A1 (en) * | 2010-05-06 | 2013-03-07 | Merck Sharp & Dohme Corp. | Aza-indole derivatives useful as modulators of faah |
| US8710231B2 (en) * | 2010-08-09 | 2014-04-29 | Pharmadesign, Inc. | Inhibitor of casein kinase 1delta and casein kinase 1E |
| KR101350077B1 (ko) * | 2010-12-13 | 2014-01-14 | 한국화학연구원 | 신규한 3-인돌리논 유도체 및 이를 포함하는 조성물 |
| DK2835131T3 (da) * | 2010-12-14 | 2017-12-04 | Electrophoretics Ltd | Inhibitorer af kaseinkinase 1 delta (CK1delta) |
| MX361457B (es) | 2012-05-11 | 2018-12-06 | Reset Therapeutics Inc | Sulfonamidas que contienen carbazol como moduladoras de criptocromo. |
| TWI690521B (zh) | 2014-04-07 | 2020-04-11 | 美商同步製藥公司 | 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類 |
| WO2018133835A1 (en) * | 2017-01-20 | 2018-07-26 | National Institute Of Biological Sciences, Beijing | Nucleoside analogue regulating mammalian circadian rhythm |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3705934A1 (de) * | 1987-02-25 | 1988-09-08 | Nattermann A & Cie | Indolyl-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| AU6254294A (en) * | 1993-02-24 | 1994-09-14 | Merck & Co., Inc. | Inhibitors of hiv reverse transcriptase |
| CA2375450C (en) * | 1999-06-08 | 2009-04-28 | Aventis Pharmaceuticals Inc. | Screening methods for altering circadian rhythm proteins |
| BR0308391A (pt) * | 2002-03-13 | 2005-01-11 | Pharmacia & Upjohn Co Llc | Derivados de pirazolo(1,5-a)piridina como moduladores neurotransmissores |
| WO2004014300A2 (en) * | 2002-08-09 | 2004-02-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| WO2005061498A1 (en) * | 2003-12-11 | 2005-07-07 | Aventis Pharmaceuticals Inc. | Substituted 1h-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase i epsilon |
-
2005
- 2005-08-19 DK DK05785433.3T patent/DK1791537T3/da active
- 2005-08-19 KR KR1020077003924A patent/KR20070045264A/ko not_active Application Discontinuation
- 2005-08-19 ES ES05785433T patent/ES2334927T3/es active Active
- 2005-08-19 BR BRPI0514397-7A patent/BRPI0514397A/pt not_active IP Right Cessation
- 2005-08-19 EP EP05785433A patent/EP1791537B1/en not_active Not-in-force
- 2005-08-19 MX MX2007001077A patent/MX2007001077A/es not_active Application Discontinuation
- 2005-08-19 CA CA002577511A patent/CA2577511A1/en not_active Abandoned
- 2005-08-19 CN CNA2005800346526A patent/CN101039666A/zh active Pending
- 2005-08-19 WO PCT/US2005/029306 patent/WO2006023590A1/en active Application Filing
- 2005-08-19 AU AU2005277460A patent/AU2005277460A1/en not_active Abandoned
- 2005-08-19 SI SI200530889T patent/SI1791537T1/sl unknown
- 2005-08-19 JP JP2007527987A patent/JP4931814B2/ja not_active Expired - Fee Related
- 2005-08-19 DE DE602005017162T patent/DE602005017162D1/de active Active
- 2005-08-19 PL PL05785433T patent/PL1791537T3/pl unknown
- 2005-08-19 PT PT05785433T patent/PT1791537E/pt unknown
- 2005-08-19 AT AT05785433T patent/ATE445396T1/de not_active IP Right Cessation
- 2005-08-19 RU RU2007109813/14A patent/RU2391098C2/ru not_active IP Right Cessation
-
2007
- 2007-02-04 IL IL181155A patent/IL181155A0/en unknown
- 2007-02-15 US US11/675,230 patent/US8008340B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE445396T1 (de) | 2009-10-15 |
| US8008340B2 (en) | 2011-08-30 |
| DE602005017162D1 (de) | 2009-11-26 |
| AU2005277460A1 (en) | 2006-03-02 |
| WO2006023590A1 (en) | 2006-03-02 |
| IL181155A0 (en) | 2007-07-04 |
| RU2391098C2 (ru) | 2010-06-10 |
| BRPI0514397A (pt) | 2008-06-10 |
| EP1791537A1 (en) | 2007-06-06 |
| ES2334927T3 (es) | 2010-03-17 |
| PL1791537T3 (pl) | 2010-04-30 |
| JP4931814B2 (ja) | 2012-05-16 |
| KR20070045264A (ko) | 2007-05-02 |
| SI1791537T1 (sl) | 2010-02-26 |
| CN101039666A (zh) | 2007-09-19 |
| RU2007109813A (ru) | 2008-09-27 |
| US20070142454A1 (en) | 2007-06-21 |
| MX2007001077A (es) | 2007-04-17 |
| JP2008510704A (ja) | 2008-04-10 |
| EP1791537B1 (en) | 2009-10-14 |
| PT1791537E (pt) | 2010-01-19 |
| CA2577511A1 (en) | 2006-03-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1791537T3 (da) | 3-arylthioindol-2-carboxamidderivater og analoger deraf som inhibitorer af casein-kinase | |
| WO2005110410A3 (en) | Kinase inhibitors as therapeutic agents | |
| TN2010000019A1 (en) | Solid preparation comprising alogliptin and metformin hydrochloride | |
| WO2005075425A3 (en) | Substituted bisarylurea derivatives as kinase inhibitors | |
| NO20080865L (no) | Spirokromanonderivater som acetyl-koenzym-A-karboksylase(ACC)inhibitorer | |
| CO6361856A2 (es) | Compuestos de pirazolopirimidina inhibidores de jak y metodos | |
| UA97348C2 (en) | HETEROCYCLIC NF-kB INHIBITORS | |
| EA201000805A1 (ru) | Бис-(сульфониламино)производные в терапии 066 | |
| MX2007004248A (es) | Derivados heterociclicos de bisarilurea sustituidos como inhibidores de cinasa. | |
| EA201070167A1 (ru) | Замещенные производные индазола, активные как ингибиторы киназы | |
| EA201101672A1 (ru) | Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина | |
| SE0400284D0 (sv) | Novel compounds | |
| EA200501849A1 (ru) | Производные пиразолохиназолина: способ получения и применение в качестве ингибиторов киназ | |
| TW200637810A (en) | Substituted N-aminomethylenesulfonamides, their preparation and use as medicaments | |
| NO20091889L (no) | Inhibitorer av spiroketon acetyl-CoA karboksylase | |
| EA201001013A1 (ru) | Бис(сульфониламино)производные для применения в терапии | |
| DK1753723T3 (da) | Substituerede quinolinderivater som mitotiske kinesininhibitorer | |
| EA200970585A1 (ru) | Бензамидные производные как агонисты ер-рецепторов | |
| NO20065719L (no) | I det vesentlige rene 2-{[2-(2-metylamino-pyrimidin-4-yl)-1H-indol-5-karbonyl]-amlno}-3-(fenylpyridin-2-yl-amino)-propionsyre som en IkB kinaseinhibitor. | |
| NO20091590L (no) | Heterocykliske amidforbindelser anvendbare som kinaseinhibitorer | |
| MX346186B (es) | Inhibidores de proteina cinasas. | |
| HK1133012A1 (en) | Pyrimidinones as casein kinase ii (ck2) modulators | |
| NO20083708L (no) | 4-Fenyl-tiazol-5-karboksylsyre og 4-fenyl-tiazol-5-karboksylmider som PLK1-inhibitorer | |
| EA200970041A1 (ru) | Ингибиторы акт (протеинкиназы в) | |
| MX2022003504A (es) | Inhibidor de irak y metodo de preparacion para el mismo y uso del mismo. |