BR0308391A - Derivados de pirazolo(1,5-a)piridina como moduladores neurotransmissores - Google Patents

Derivados de pirazolo(1,5-a)piridina como moduladores neurotransmissores

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Publication number
BR0308391A
BR0308391A BR0308391-8A BR0308391A BR0308391A BR 0308391 A BR0308391 A BR 0308391A BR 0308391 A BR0308391 A BR 0308391A BR 0308391 A BR0308391 A BR 0308391A
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Brazil
Prior art keywords
pyridine derivatives
pyrazolo
crf
neurotransmitter modulators
receptors
Prior art date
Application number
BR0308391-8A
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English (en)
Inventor
Jian-Min Fu
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of BR0308391A publication Critical patent/BR0308391A/pt

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    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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Abstract

"DERIVADOS DE PIRAZOLO(1,5-a)PIRIDINA COMO MODULADORES NEUROTRANSMISSORES". A presente invenção refere-se a novos derivados de pirazolo[1,5-a]piridina de fórmula geral (I) que se ligam com afinidade elevada aos receptores do CRF~ 1~, incluindo receptores do CRF~ 1~ humano. Esta invenção também refere-se aos métodos de uso dos compostos da invenção para tratar um distúrbio ou condição, cujo tratamento pode ser efetuado ou facilitado por antagonizar um receptor do CRF, tal como distúrbios ou doenças do CNS, particularmente distúrbios da ansiedade, e depressão e distúrbios relacionados ao estresse.
BR0308391-8A 2002-03-13 2003-03-11 Derivados de pirazolo(1,5-a)piridina como moduladores neurotransmissores BR0308391A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36376602P 2002-03-13 2002-03-13
US38057602P 2002-05-14 2002-05-14
US40354702P 2002-08-14 2002-08-14
PCT/US2003/007533 WO2003078435A1 (en) 2002-03-13 2003-03-11 Pyrazolo(1,5-a)pyridine derivatives as neurotransmitter modulators

Publications (1)

Publication Number Publication Date
BR0308391A true BR0308391A (pt) 2005-01-11

Family

ID=28046498

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308391-8A BR0308391A (pt) 2002-03-13 2003-03-11 Derivados de pirazolo(1,5-a)piridina como moduladores neurotransmissores

Country Status (8)

Country Link
US (1) US7151109B2 (pt)
EP (1) EP1485384A1 (pt)
JP (1) JP2005526090A (pt)
AU (1) AU2003220190A1 (pt)
BR (1) BR0308391A (pt)
CA (1) CA2478715A1 (pt)
MX (1) MXPA04008790A (pt)
WO (1) WO2003078435A1 (pt)

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RU2308457C2 (ru) 2001-04-27 2007-10-20 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Пиразоло [1, 5-а] пиридины и содержащие их лекарственные средства
US7176216B2 (en) 2002-10-22 2007-02-13 Eisai Co., Ltd. 7-phenylpyrazolopyridine compounds
NZ538860A (en) * 2002-10-22 2006-07-28 Eisai Co Ltd 7-Phenyl pyrazolopyridine compounds
SI1747220T1 (sl) * 2003-12-11 2009-08-31 Aventis Pharma Inc Substituirani 1H-pirolo(3,2-b, 3,2-c in 2,3-c)piridin-2-karboksamidi in sorodni analogi kot inhibitorji kazein kinaze I epsilon
CN1942468B (zh) 2004-04-12 2011-06-22 卫材R&D管理有限公司 吡唑缩合环衍生物的制造方法
MX2007001077A (es) * 2004-08-19 2007-04-17 Aventis Pharma Inc Derivados de 3-ariltioindol-2-carboxamida y analogos de los mismos como inhibidores de caseina quinasa ie.
US20100056791A1 (en) * 2006-09-01 2010-03-04 Yasushi Kohno Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same
EA201300152A1 (ru) 2006-11-27 2013-07-30 Х. Лундбекк А/С Гетероариламидные производные
JP2010523668A (ja) 2007-04-10 2010-07-15 ハー・ルンドベック・アクチエゼルスカベット Ｐ２ｘ７拮抗薬としてのヘテロアリールアミド類似体
EP2090576A1 (en) * 2008-02-01 2009-08-19 Merz Pharma GmbH & Co.KGaA 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators
US8431603B2 (en) 2008-04-15 2013-04-30 Eisai R&D Management Co., Ltd. 3-phenylpyrazolo[5,1-b]thiazole compounds
EP2320737B1 (en) * 2008-08-05 2013-07-17 Merck Sharp & Dohme Corp. Pyrazolo-[1,5-a]-pyridines as mark inhibitors
FR2950344B1 (fr) 2009-09-18 2011-11-25 Sanofi Aventis Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique.
AR078521A1 (es) 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
EP2523552B1 (en) 2010-01-14 2015-05-13 Merck Sharp & Dohme Corp. Pyrazolo[1,5-a]pyrimidines as mark inhibitors
PE20130395A1 (es) 2010-06-24 2013-04-10 Gilead Sciences Inc Pirazolo[1,5-a]pirimidinas para tratamiento antiviral
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
ES2647486T3 (es) 2011-12-22 2017-12-21 Gilead Sciences, Inc. Pirazolo[1,5-a]pirimidinas como agentes antivirales
AU2013249280B2 (en) 2012-04-17 2017-10-12 Gilead Sciences, Inc. Compounds and methods for antiviral treatment
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives

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DE3942355A1 (de) * 1989-12-21 1991-06-27 Boehringer Mannheim Gmbh N- und o-substituierte aminophenolderivate, zwischenprodukte zu deren herstellung, deren verwendung als hydrolasesubstrate, ein entsprechendes bestimmungsverfahren und hierfuer geeignetes diagnostisches mittel
AU746706B2 (en) 1997-07-03 2002-05-02 Du Pont Pharmaceuticals Company Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
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FR2822690B1 (fr) * 2001-03-27 2003-05-09 Oreal Composition pour la teinture d'oxydation contenant au moins une base d'oxydation 3-amino pyrazolo[1,5-a]- pyridine et au moins un coupleur pyrazolotriazole particulier
FR2822692B1 (fr) * 2001-03-27 2005-01-28 Oreal Composition pour la teinture d'oxydation contenant au moins une base d'oxydation 3-amino pyrazolo-[1,5-a]-pyridine et au moins un coupleur aminophenol particulier
FR2822689B1 (fr) * 2001-03-27 2005-01-28 Oreal Composition pour la teinture d'oxydation contenant au moins une base d'oxydation 3-amino pyrazolo-[1,5-a] pyridine et au moins un coupleur du type 2-amino 3-hydroxy pyridine
FR2822691B1 (fr) * 2001-03-27 2005-02-25 Oreal Composition pour la teinture d'oxydation contenant au moins une base d'oxydation 3-amino pyrazolo-[1,5-a]-pyridine et au moins un coupleur pyridinique particulier
RU2308457C2 (ru) * 2001-04-27 2007-10-20 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Пиразоло [1, 5-а] пиридины и содержащие их лекарственные средства

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WO2003078435A1 (en) 2003-09-25
EP1485384A1 (en) 2004-12-15
AU2003220190A1 (en) 2003-09-29
CA2478715A1 (en) 2003-09-25
US7151109B2 (en) 2006-12-19
US20040002511A1 (en) 2004-01-01
JP2005526090A (ja) 2005-09-02
MXPA04008790A (es) 2004-11-26

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