EA200500172A1 - Азабициклопроизводные в качестве антагонистов мускариновых рецепторов - Google Patents

Азабициклопроизводные в качестве антагонистов мускариновых рецепторов

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Publication number
EA200500172A1
EA200500172A1 EA200500172A EA200500172A EA200500172A1 EA 200500172 A1 EA200500172 A1 EA 200500172A1 EA 200500172 A EA200500172 A EA 200500172A EA 200500172 A EA200500172 A EA 200500172A EA 200500172 A1 EA200500172 A1 EA 200500172A1
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Prior art keywords
relates
derivatives
antagonists
compounds
present
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EA200500172A
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English (en)
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EA007932B1 (ru
Inventor
Мохаммад Салман
Анита Мехта
Пакала Кумара Савитру Сарма
Шанкар Джейрам Шетти
Санкаранарейянан Дхармараджан
Нареш Кумар
Арундутт Висванатан Силамкоти
Анита Чагх
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Рэнбакси Лабораториз Лимитед
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Publication of EA200500172A1 publication Critical patent/EA200500172A1/ru
Publication of EA007932B1 publication Critical patent/EA007932B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Настоящее изобретение относится к антагонистам мускариновых рецепторов, которые полезны, между прочим, при лечении различных расстройств респираторной, мочевой и желудочно-кишечной систем, опосредованных мускариновыми рецепторами. В частности, изобретение относится к производным азабициклосоединений, включая, например, 6-замещенные азабицикло[3.1.0]гексаны и 2,4,6-тризамещенные производные. Изобретение также относится к фармацевтическим композициям, содержащим соединения настоящего изобретения, и способам лечения заболеваний, опосредованных мускариновыми рецепторами.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500172A 2002-07-08 2003-04-11 Азабициклопроизводные в качестве антагонистов мускариновых рецепторов EA007932B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IB2002/002663 WO2004004629A2 (en) 2002-07-08 2002-07-08 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
PCT/IB2003/001367 WO2004005252A1 (en) 2002-07-08 2003-04-11 Azabicyclo derivatives as muscarinic receptor antagonists

Publications (2)

Publication Number Publication Date
EA200500172A1 true EA200500172A1 (ru) 2005-08-25
EA007932B1 EA007932B1 (ru) 2007-02-27

Family

ID=30011691

Family Applications (3)

Application Number Title Priority Date Filing Date
EA200500173A EA200500173A1 (ru) 2002-07-08 2002-07-08 Производные 3,6-дизамещенного азабицикло[3.1.0]гексана в качестве антагонистов мускариновых рецепторов
EA200500172A EA007932B1 (ru) 2002-07-08 2003-04-11 Азабициклопроизводные в качестве антагонистов мускариновых рецепторов
EA200501595A EA009942B1 (ru) 2002-07-08 2004-01-07 Азабициклические производные в качестве антагонистов мускаринового рецептора

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200500173A EA200500173A1 (ru) 2002-07-08 2002-07-08 Производные 3,6-дизамещенного азабицикло[3.1.0]гексана в качестве антагонистов мускариновых рецепторов

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200501595A EA009942B1 (ru) 2002-07-08 2004-01-07 Азабициклические производные в качестве антагонистов мускаринового рецептора

Country Status (20)

Country Link
US (2) US7399779B2 (ru)
EP (2) EP1546099B1 (ru)
JP (2) JP2006502985A (ru)
CN (2) CN1668585A (ru)
AT (2) ATE419236T1 (ru)
AU (2) AU2002345266B2 (ru)
BR (2) BR0215801A (ru)
CA (2) CA2492121A1 (ru)
CY (1) CY1105879T1 (ru)
DE (2) DE60230683D1 (ru)
DK (1) DK1551803T3 (ru)
EA (3) EA200500173A1 (ru)
ES (1) ES2274275T3 (ru)
HK (2) HK1079783A1 (ru)
MX (2) MXPA05000434A (ru)
NZ (2) NZ537584A (ru)
PT (1) PT1551803E (ru)
SI (1) SI1551803T1 (ru)
WO (2) WO2004004629A2 (ru)
ZA (1) ZA200500951B (ru)

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AU2002345266A1 (en) 2004-01-23
EA007932B1 (ru) 2007-02-27
ES2274275T3 (es) 2007-05-16
EA200500173A1 (ru) 2005-08-25
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US20060111425A1 (en) 2006-05-25
US20070004791A1 (en) 2007-01-04
HK1079783A1 (en) 2006-04-13
PT1551803E (pt) 2007-01-31
US7399779B2 (en) 2008-07-15
EP1551803B1 (en) 2006-10-11
AU2002345266B2 (en) 2009-07-02
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BR0312572A (pt) 2005-05-10
CN100519526C (zh) 2009-07-29
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ATE342253T1 (de) 2006-11-15
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CN1668585A (zh) 2005-09-14
AU2003226579B2 (en) 2009-01-22
US7544708B2 (en) 2009-06-09
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ATE419236T1 (de) 2009-01-15
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