ATE342253T1 - Azabicycloderivate als antagonisten des muscarinischen rezeptors - Google Patents
Azabicycloderivate als antagonisten des muscarinischen rezeptorsInfo
- Publication number
- ATE342253T1 ATE342253T1 AT03762827T AT03762827T ATE342253T1 AT E342253 T1 ATE342253 T1 AT E342253T1 AT 03762827 T AT03762827 T AT 03762827T AT 03762827 T AT03762827 T AT 03762827T AT E342253 T1 ATE342253 T1 AT E342253T1
- Authority
- AT
- Austria
- Prior art keywords
- muscarinic receptor
- antagonists
- derivatives
- azabicyclo
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2002/002663 WO2004004629A2 (en) | 2002-07-08 | 2002-07-08 | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE342253T1 true ATE342253T1 (de) | 2006-11-15 |
Family
ID=30011691
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02743489T ATE419236T1 (de) | 2002-07-08 | 2002-07-08 | 3,6-disubstituierte azabicyclo-3.1.0 hexan- derivate als muscarinische rezeptorantagonisten |
AT03762827T ATE342253T1 (de) | 2002-07-08 | 2003-04-11 | Azabicycloderivate als antagonisten des muscarinischen rezeptors |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02743489T ATE419236T1 (de) | 2002-07-08 | 2002-07-08 | 3,6-disubstituierte azabicyclo-3.1.0 hexan- derivate als muscarinische rezeptorantagonisten |
Country Status (20)
Country | Link |
---|---|
US (2) | US7399779B2 (de) |
EP (2) | EP1546099B1 (de) |
JP (2) | JP2006502985A (de) |
CN (2) | CN1668585A (de) |
AT (2) | ATE419236T1 (de) |
AU (2) | AU2002345266B2 (de) |
BR (2) | BR0215801A (de) |
CA (2) | CA2492121A1 (de) |
CY (1) | CY1105879T1 (de) |
DE (2) | DE60230683D1 (de) |
DK (1) | DK1551803T3 (de) |
EA (3) | EA200500173A1 (de) |
ES (1) | ES2274275T3 (de) |
HK (2) | HK1079783A1 (de) |
MX (2) | MXPA05000434A (de) |
NZ (2) | NZ537584A (de) |
PT (1) | PT1551803E (de) |
SI (1) | SI1551803T1 (de) |
WO (2) | WO2004004629A2 (de) |
ZA (1) | ZA200500951B (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA200500173A1 (ru) | 2002-07-08 | 2005-08-25 | Рэнбакси Лабораториз Лимитед | Производные 3,6-дизамещенного азабицикло[3.1.0]гексана в качестве антагонистов мускариновых рецепторов |
EP1572648B1 (de) * | 2002-12-10 | 2008-07-09 | Ranbaxy Laboratories, Ltd. | 3,6-disubstituierte azabicyclo ¬3.1.0 -hexanderivative als antagonisten des muscarinrezeptors |
WO2004089898A1 (en) | 2003-04-09 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
US20070021487A1 (en) | 2003-04-11 | 2007-01-25 | Mohammad Salman | Azabicyclo derivatives as muscarinic receptor antagonists |
CN101838271A (zh) * | 2003-10-14 | 2010-09-22 | 辉瑞产品公司 | 作为甘氨酸转运蛋白抑制剂的二环[3.1.0]衍生物 |
EP1746998A1 (de) * | 2004-03-22 | 2007-01-31 | Ranbaxy Laboratories, Ltd. | Kombinationstherapie für symptome der unteren harnwege |
ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
WO2006003587A2 (en) * | 2004-07-01 | 2006-01-12 | Ranbaxy Laboratories Limited | Solid oral dosage forms of azabicyclo derivatives |
WO2006016245A1 (en) * | 2004-08-05 | 2006-02-16 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
US20080280883A1 (en) * | 2004-09-24 | 2008-11-13 | Mohammad Salman | Muscarinic Receptor Antagonists |
EP1796667A2 (de) * | 2004-09-27 | 2007-06-20 | Ranbaxy Laboratories Limited | Muscarinische rezeptor-antagonisten |
WO2006054162A1 (en) * | 2004-11-19 | 2006-05-26 | Ranbaxy Laboratories Limited | Azabicyclic muscarinic receptor antagonists |
WO2006064304A1 (en) * | 2004-12-15 | 2006-06-22 | Ranbaxy Laboratories Limited | Acid addition salts of muscarinic receptor antagonists |
EP1888525A1 (de) * | 2005-05-03 | 2008-02-20 | Ranbaxy Laboratories Limited | 3,6-disubstituierte azabicyclo[3.1.0]hexanderivate als antagonisten des muskarinrezeptors |
WO2007039884A1 (en) | 2005-10-05 | 2007-04-12 | Ranbaxy Laboratories Limited | 3 -azabicyclooctane derivatives as muscarinic receptor antagonists |
CA2626612A1 (en) * | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of muscarinic receptor antagonists |
US20090137623A1 (en) | 2005-12-30 | 2009-05-28 | Naresh Kumar | Muscarinic receptor antagonists |
KR20080089461A (ko) | 2005-12-30 | 2008-10-06 | 랜박시 래보러터리스 리미티드 | 무스카린 수용체 길항제 |
EP2120886A2 (de) * | 2006-12-21 | 2009-11-25 | Ranbaxy Laboratories Limited | Formulierungen von azabicyclo-derivaten mit modifizierter freisetzung |
US20090326004A1 (en) | 2008-06-03 | 2009-12-31 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
WO2012042539A2 (en) | 2010-09-28 | 2012-04-05 | Panacea Biotec Ltd | Novel bicyclic compounds |
CN110191709A (zh) * | 2017-01-17 | 2019-08-30 | 德州大学系统董事会 | 可用作吲哚胺2,3-双加氧酶和/或色氨酸双加氧酶抑制剂的化合物 |
WO2020018670A1 (en) | 2018-07-17 | 2020-01-23 | Board Of Regents, The University Of Texas System | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
CN111317754B (zh) * | 2018-12-13 | 2022-02-18 | 泰州医药城国科化物生物医药科技有限公司 | 一种北豆根总碱的制备方法及应用 |
Family Cites Families (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2490714A (en) | 1947-05-13 | 1949-12-06 | Du Pont | Preparation of diazoacetic esters |
NL124473C (de) | 1960-07-26 | |||
SE8800207D0 (sv) | 1988-01-22 | 1988-01-22 | Kabivitrum Ab | Nya aminer, deras anvendning och framstellning |
US5001160A (en) | 1988-04-28 | 1991-03-19 | Marion Laboratories, Inc. | 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders |
GB8906166D0 (en) | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
HU219403B (hu) | 1989-08-16 | 2001-04-28 | Pfizer Inc. | Azabiciklo-csoporttal helyettesített kinolon- és naftiridon-karbonsavak és eljárás ezek előállítására |
US5164402A (en) | 1989-08-16 | 1992-11-17 | Pfizer Inc | Azabicyclo quinolone and naphthyridinone carboxylic acids |
GB8928042D0 (en) | 1989-12-12 | 1990-02-14 | Pfizer Ltd | Muscarinic receptor antagonists |
US5281601A (en) | 1989-12-12 | 1994-01-25 | Pfizer Inc. | Muscarinic receptor antagonists |
FR2659323B1 (fr) | 1990-03-07 | 1992-06-12 | Synthelabo | Derives de 4-(aminomethyl) piperidine, leur preparation et leur application en therapeutique. |
JPH0492921A (ja) | 1990-08-03 | 1992-03-25 | Fujitsu Ltd | 指数関数演算器 |
GB9020051D0 (en) | 1990-09-13 | 1990-10-24 | Pfizer Ltd | Muscarinic receptor antagonists |
GB9202443D0 (en) | 1992-02-05 | 1992-03-18 | Fujisawa Pharmaceutical Co | A novel substituted-acetamide compound and a process for the preparation thereof |
FI100051B (fi) | 1992-02-18 | 1997-09-15 | Favorit Oy | Kompostori |
JPH0635958A (ja) | 1992-07-14 | 1994-02-10 | Hitachi Ltd | 語句検索方法 |
JP3429338B2 (ja) | 1992-07-27 | 2003-07-22 | 杏林製薬株式会社 | 新規なアリールグリシンアミド誘導体及びその製造法 |
JPH06135958A (ja) | 1992-10-28 | 1994-05-17 | Tanabe Seiyaku Co Ltd | ベンゾシクロヘプテン誘導体及びその製法 |
SE9203318D0 (sv) | 1992-11-06 | 1992-11-06 | Kabi Pharmacia Ab | Novel 3,3-diphenylpropylamines, their use and preparation |
DE59306269D1 (de) | 1993-02-24 | 1997-05-28 | Siemens Ag | Sperrwandler-Schaltnetzteil mit einem Halbleiterschaltelement geringer Spannungsfestigkeit |
NO2005012I1 (no) | 1994-12-28 | 2005-06-06 | Debio Rech Pharma Sa | Triptorelin og farmasoytisk akseptable salter derav |
ATE269305T1 (de) * | 1995-04-28 | 2004-07-15 | Banyu Pharma Co Ltd | 1,4-disubstituierte piperidinderivate |
CA2179574A1 (en) | 1995-06-26 | 1996-12-27 | Tomomi Okada | Substituted piperidine derivative and medicine comprising the same |
ATE205490T1 (de) | 1995-10-13 | 2001-09-15 | Banyu Pharma Co Ltd | Substituierte heteroaromatische derivate |
AU2793197A (en) | 1996-05-31 | 1998-01-05 | Banyu Pharmaceutical Co., Ltd. | 1,4-disubstituted piperidine derivatives |
EP0909163A4 (de) | 1996-07-01 | 1999-06-09 | Sepracor Inc | Verfahren und mittel zur behandlung der harninkontinenz unter hauptsaechlicher verwendung des (s,r)-glycopyrrolat enantiomers |
US6063808A (en) | 1996-07-01 | 2000-05-16 | Sepracor Inc. | Methods and compositions for treating urinary incontinence using enantiomerically enriched (S,S)-glycopyrrolate |
WO1998000132A1 (en) | 1996-07-01 | 1998-01-08 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using enantiomerically enriched (r,s)-glycopyrrolate |
WO1998000016A1 (en) | 1996-07-01 | 1998-01-08 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using enantiomerically enriched (r,r)-glycopyrrolate |
PE92198A1 (es) * | 1996-08-01 | 1999-01-09 | Banyu Pharma Co Ltd | Derivados de 1,4-piperidina disustituida que contienen fluor |
KR20000057548A (ko) | 1996-12-13 | 2000-09-25 | 알프레드 엘. 미첼슨 | 광학적 전송물질 및 결합재 |
EP1001764A4 (de) | 1997-05-29 | 2005-08-24 | Merck & Co Inc | Heterozyklische amide als zelladhäsionshemmern |
US6319920B1 (en) | 1998-02-27 | 2001-11-20 | Syntex (U.S.A.) Llc | 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives |
TWI244481B (en) | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
UA73543C2 (uk) | 1999-12-07 | 2005-08-15 | Тераванс, Інк. | Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором |
CA2392028C (en) | 1999-12-07 | 2009-08-18 | Theravance, Inc. | Carbamate derivatives having muscarinic receptor antagonist activity |
SE9904765D0 (sv) | 1999-12-23 | 1999-12-23 | Astra Ab | Pharmaceutically-useful compounds |
DE60106607T2 (de) | 2000-05-25 | 2006-02-09 | F. Hoffmann-La Roche Ag | Substituierte 1-aminoalkyl-lactame und ihre verwendung als muscarinrezeptor antagonisten |
WO2001090081A1 (en) | 2000-05-25 | 2001-11-29 | F. Hoffmann-La Roche Ag | Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists |
EP1294697A1 (de) | 2000-06-14 | 2003-03-26 | Muscagen Limited | 1,2,3,5-tetrahydrobenzo[c]azepin-4-on derivate mit muskarinantagonistischer wirkung |
SI1300407T2 (sl) | 2000-06-27 | 2011-09-30 | S A L V A T Lab Sa | Karbamati, izvedeni iz arilalkilaminov |
EP1302458A4 (de) | 2000-07-11 | 2005-10-19 | Banyu Pharma Co Ltd | Esterderivate |
RU2296762C2 (ru) | 2000-12-22 | 2007-04-10 | Альмиралль Продесфарма Аг | Карбаматы хинуклидина, способы их получения и фармацевтическая композиция на их основе |
BR0116624A (pt) | 2000-12-28 | 2003-12-23 | Almirall Prodesfarma Ag | Composto, processo para produzir o mesmo, composição farmacêutica, uso do composto ou da composição farmacêutica, e, produto de combinação |
AU2002314744A1 (en) | 2001-04-17 | 2002-10-28 | Sepracor, Inc. | Thiazole and other heterocyclic ligands and use thereof |
RU2004110717A (ru) | 2001-10-17 | 2005-10-20 | Юсиби, С.А. (Be) | Производные хинуклидина, способы их получения и их применение в качестве и нгибиторов м2- и/или м3- мускариновых рецепторов |
JP4322675B2 (ja) | 2001-12-03 | 2009-09-02 | エフ.ホフマン−ラ ロシュ アーゲー | ムスカリン受容体アンタゴニストとしてのアミノテトラリン誘導体 |
EP1453805B1 (de) | 2001-12-03 | 2010-12-22 | F. Hoffmann-La Roche AG | 4-piperidinylalkylamin-derivate, antagonisten von muscarinrezeptoren |
EA200500173A1 (ru) | 2002-07-08 | 2005-08-25 | Рэнбакси Лабораториз Лимитед | Производные 3,6-дизамещенного азабицикло[3.1.0]гексана в качестве антагонистов мускариновых рецепторов |
EP1546098B1 (de) | 2002-07-31 | 2008-05-28 | Ranbaxy Laboratories Limited | 3,6-disubstituierte azabicyclo [3.1.0]hexanderivate, die sich als muscarinrezeptorantagonisten eignen |
WO2004014363A1 (en) | 2002-08-09 | 2004-02-19 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonist |
WO2004018422A1 (en) | 2002-08-23 | 2004-03-04 | Ranbaxy Laboratories Limited | Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists |
EP1572648B1 (de) | 2002-12-10 | 2008-07-09 | Ranbaxy Laboratories, Ltd. | 3,6-disubstituierte azabicyclo ¬3.1.0 -hexanderivative als antagonisten des muscarinrezeptors |
AU2002347552A1 (en) | 2002-12-23 | 2004-07-14 | Ranbaxy Laboratories Limited | 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists |
WO2004056810A1 (en) | 2002-12-23 | 2004-07-08 | Ranbaxy Laboratories Limited | Xanthine derivatives as muscarinic receptor antagonists |
ATE386738T1 (de) | 2002-12-23 | 2008-03-15 | Ranbaxy Lab Ltd | Flavaxat-derivate als muscarin-rezeptor antagonisten |
US7488748B2 (en) | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
EP1594871A1 (de) | 2003-02-07 | 2005-11-16 | Ranbaxy Laboratories Limited | Substituierte azabicyclohexan-derivate als muscarinische rezeptor-antagonisten |
WO2004089898A1 (en) | 2003-04-09 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
AU2003223010A1 (en) | 2003-04-10 | 2004-11-01 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
CN100406009C (zh) | 2003-04-10 | 2008-07-30 | 兰贝克赛实验室有限公司 | 作为毒蕈碱受体拮抗剂的取代的氮杂双环己烷衍生物 |
US20070021487A1 (en) | 2003-04-11 | 2007-01-25 | Mohammad Salman | Azabicyclo derivatives as muscarinic receptor antagonists |
FR2855805B1 (fr) | 2003-06-06 | 2005-08-05 | Vallourec Vitry | Element de structure pour vehicule, capable d'un meilleur comportement aux chocs |
EP1746998A1 (de) | 2004-03-22 | 2007-01-31 | Ranbaxy Laboratories, Ltd. | Kombinationstherapie für symptome der unteren harnwege |
EP1796667A2 (de) | 2004-09-27 | 2007-06-20 | Ranbaxy Laboratories Limited | Muscarinische rezeptor-antagonisten |
WO2006064304A1 (en) | 2004-12-15 | 2006-06-22 | Ranbaxy Laboratories Limited | Acid addition salts of muscarinic receptor antagonists |
-
2002
- 2002-07-08 EA EA200500173A patent/EA200500173A1/ru unknown
- 2002-07-08 WO PCT/IB2002/002663 patent/WO2004004629A2/en active Application Filing
- 2002-07-08 EP EP02743489A patent/EP1546099B1/de not_active Expired - Lifetime
- 2002-07-08 NZ NZ537584A patent/NZ537584A/en unknown
- 2002-07-08 DE DE60230683T patent/DE60230683D1/de not_active Expired - Fee Related
- 2002-07-08 MX MXPA05000434A patent/MXPA05000434A/es unknown
- 2002-07-08 US US10/520,573 patent/US7399779B2/en not_active Expired - Fee Related
- 2002-07-08 CN CNA028295528A patent/CN1668585A/zh active Pending
- 2002-07-08 AU AU2002345266A patent/AU2002345266B2/en not_active Expired - Fee Related
- 2002-07-08 AT AT02743489T patent/ATE419236T1/de not_active IP Right Cessation
- 2002-07-08 CA CA002492121A patent/CA2492121A1/en not_active Abandoned
- 2002-07-08 JP JP2004519029A patent/JP2006502985A/ja active Pending
- 2002-07-08 BR BR0215801-9A patent/BR0215801A/pt not_active IP Right Cessation
-
2003
- 2003-04-11 CA CA002491998A patent/CA2491998A1/en not_active Abandoned
- 2003-04-11 AU AU2003226579A patent/AU2003226579B2/en not_active Ceased
- 2003-04-11 EP EP03762827A patent/EP1551803B8/de not_active Expired - Lifetime
- 2003-04-11 MX MXPA05000435A patent/MXPA05000435A/es active IP Right Grant
- 2003-04-11 DE DE60309057T patent/DE60309057T2/de not_active Expired - Fee Related
- 2003-04-11 BR BR0312572-6A patent/BR0312572A/pt not_active IP Right Cessation
- 2003-04-11 PT PT03762827T patent/PT1551803E/pt unknown
- 2003-04-11 NZ NZ537585A patent/NZ537585A/en unknown
- 2003-04-11 WO PCT/IB2003/001367 patent/WO2004005252A1/en active IP Right Grant
- 2003-04-11 CN CNB038211300A patent/CN100519526C/zh not_active Expired - Fee Related
- 2003-04-11 US US10/520,572 patent/US7544708B2/en not_active Expired - Fee Related
- 2003-04-11 ES ES03762827T patent/ES2274275T3/es not_active Expired - Lifetime
- 2003-04-11 JP JP2004519035A patent/JP2005535655A/ja active Pending
- 2003-04-11 AT AT03762827T patent/ATE342253T1/de not_active IP Right Cessation
- 2003-04-11 DK DK03762827T patent/DK1551803T3/da active
- 2003-04-11 SI SI200330515T patent/SI1551803T1/sl unknown
- 2003-04-11 EA EA200500172A patent/EA007932B1/ru not_active IP Right Cessation
-
2004
- 2004-01-07 EA EA200501595A patent/EA009942B1/ru not_active IP Right Cessation
-
2005
- 2005-02-02 ZA ZA200500951A patent/ZA200500951B/xx unknown
- 2005-12-28 HK HK05112034.8A patent/HK1079783A1/xx not_active IP Right Cessation
-
2006
- 2006-01-13 HK HK06100635A patent/HK1082728A1/xx not_active IP Right Cessation
- 2006-12-21 CY CY20061101846T patent/CY1105879T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1082728A1 (en) | Azabicyclo derivatives as muscarinic receptor antagonists | |
DE60231341D1 (de) | Fluor- und sulfonylaminohaltige, 3,6-disubstituierptorantagonisten | |
TW200505903A (en) | CGRP receptor antagonists | |
WO2005013894A3 (en) | Benzodiazepine cgrp receptor antagonists | |
EP1615914A4 (de) | Cgrp-rezeptorantagonisten | |
IL182317A0 (en) | Cgrp receptor antagonists | |
EP1804919A4 (de) | Cgrp-rezeptorantagonisten | |
HK1079787A1 (zh) | 用作毒蕈碱受體拮抗劑的3,6-二取代的氮雜雙環[3.1.0]己烷衍生物 | |
WO2005000807A3 (en) | Benzodiazepine cgrp receptor antagonists | |
WO2006041830A3 (en) | Cgrp receptor antagonists | |
EP1802372A4 (de) | Cgrp-rezeptorantagonisten | |
WO2006035282A3 (en) | Muscarinic receptor antagonists | |
ATE400553T1 (de) | 3,6-disubstituierte azabicyclo 3.1.0 - hexanderivative als antagonisten des muscarinrezeptors | |
EA200501593A1 (ru) | Азабициклические производные в качестве антагонистов мускаринового рецептора | |
WO2006018708A3 (en) | Pyrrolidine derivatives as muscarinic receptor antagonists | |
DE60225195D1 (de) | Flavaxat-derivate als muscarin-rezeptor antagonisten | |
WO2004067510A8 (en) | 3,6-disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists | |
DE60313898D1 (de) | Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten | |
WO2006032994A3 (en) | Muscarinic receptor antagonists | |
WO2007007281A3 (en) | Muscarinic receptor antagonists | |
DE602004018844D1 (de) | Als antagonisten des muscarinrezeptors geeignete xanthinderivate |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1551803 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |