DE60230683D1 - 3,6-disubstituierte azabicyclo-3.1.0 hexan-derivat - Google Patents

3,6-disubstituierte azabicyclo-3.1.0 hexan-derivat

Info

Publication number
DE60230683D1
DE60230683D1 DE60230683T DE60230683T DE60230683D1 DE 60230683 D1 DE60230683 D1 DE 60230683D1 DE 60230683 T DE60230683 T DE 60230683T DE 60230683 T DE60230683 T DE 60230683T DE 60230683 D1 DE60230683 D1 DE 60230683D1
Authority
DE
Germany
Prior art keywords
azabicyclo
hexan
derivative
relates
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60230683T
Other languages
English (en)
Inventor
Anita Mehta
Arundutt V Silamkoti
Jang Bahadur Gupta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ranbaxy Laboratories Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Application granted granted Critical
Publication of DE60230683D1 publication Critical patent/DE60230683D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
DE60230683T 2002-07-08 2002-07-08 3,6-disubstituierte azabicyclo-3.1.0 hexan-derivat Expired - Fee Related DE60230683D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2002/002663 WO2004004629A2 (en) 2002-07-08 2002-07-08 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists

Publications (1)

Publication Number Publication Date
DE60230683D1 true DE60230683D1 (de) 2009-02-12

Family

ID=30011691

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60230683T Expired - Fee Related DE60230683D1 (de) 2002-07-08 2002-07-08 3,6-disubstituierte azabicyclo-3.1.0 hexan-derivat
DE60309057T Expired - Fee Related DE60309057T2 (de) 2002-07-08 2003-04-11 Azabicycloderivate als antagonisten des muscarinischen rezeptors

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60309057T Expired - Fee Related DE60309057T2 (de) 2002-07-08 2003-04-11 Azabicycloderivate als antagonisten des muscarinischen rezeptors

Country Status (20)

Country Link
US (2) US7399779B2 (de)
EP (2) EP1546099B1 (de)
JP (2) JP2006502985A (de)
CN (2) CN1668585A (de)
AT (2) ATE419236T1 (de)
AU (2) AU2002345266B2 (de)
BR (2) BR0215801A (de)
CA (2) CA2492121A1 (de)
CY (1) CY1105879T1 (de)
DE (2) DE60230683D1 (de)
DK (1) DK1551803T3 (de)
EA (3) EA200500173A1 (de)
ES (1) ES2274275T3 (de)
HK (2) HK1079783A1 (de)
MX (2) MXPA05000434A (de)
NZ (2) NZ537584A (de)
PT (1) PT1551803E (de)
SI (1) SI1551803T1 (de)
WO (2) WO2004004629A2 (de)
ZA (1) ZA200500951B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ537584A (en) 2002-07-08 2006-07-28 Ranbaxy Lab Ltd 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
ATE400553T1 (de) 2002-12-10 2008-07-15 Ranbaxy Lab Ltd 3,6-disubstituierte azabicyclo 3.1.0 - hexanderivative als antagonisten des muscarinrezeptors
EP1618091A1 (de) 2003-04-09 2006-01-25 Ranbaxy Laboratories, Ltd. Substituierte azabicyclohexanderivate als antagonisten von muscarinrezeptoren
EA009387B1 (ru) * 2003-04-11 2007-12-28 Рэнбакси Лабораториз Лимитед Азабициклические производные в качестве антагонистов мускаринового рецептора
KR20060095865A (ko) * 2003-10-14 2006-09-04 화이자 프로덕츠 인크. 글리신 수송 억제제로서의 비시클릭 [3.1.0] 유도체
WO2005092341A1 (en) * 2004-03-22 2005-10-06 Ranbaxy Laboratories Limited Combination therapy for lower urinary tract symptoms
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
WO2006003587A2 (en) * 2004-07-01 2006-01-12 Ranbaxy Laboratories Limited Solid oral dosage forms of azabicyclo derivatives
WO2006016245A1 (en) * 2004-08-05 2006-02-16 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
US20080280883A1 (en) * 2004-09-24 2008-11-13 Mohammad Salman Muscarinic Receptor Antagonists
EP1796667A2 (de) * 2004-09-27 2007-06-20 Ranbaxy Laboratories Limited Muscarinische rezeptor-antagonisten
US20100016400A1 (en) * 2004-11-19 2010-01-21 Naresh Kumar Azabicyclic muscarinic receptor antagonists
EP1828126A1 (de) * 2004-12-15 2007-09-05 Ranbaxy Laboratories Limited Säureadditionssalze von antagonisten des muskarinrezeptors
EP1888525A1 (de) * 2005-05-03 2008-02-20 Ranbaxy Laboratories Limited 3,6-disubstituierte azabicyclo[3.1.0]hexanderivate als antagonisten des muskarinrezeptors
US20090131410A1 (en) 2005-10-05 2009-05-21 Naresh Kumar 3-azabicyclooctane derivatives as muscarinic receptor antagonists
JP2009512676A (ja) * 2005-10-19 2009-03-26 ランバクシー ラボラトリーズ リミテッド ムスカリン性受容体アンタゴニストの医薬組成物
BRPI0620844A2 (pt) 2005-12-30 2011-11-29 Ranbaxy Lab Ltd compostos antagonistas dos receptores muscarìnicos, seus métodos de preparação, composições farmacêuticas compreendendo os mesmos, usos dos referidos compostos na preparação de medicamentos
EP1968980A1 (de) 2005-12-30 2008-09-17 Ranbaxy Laboratories, Ltd. Muscarin-rezeptor-antagonisten
US20100152269A1 (en) * 2006-12-21 2010-06-17 Ranbaxy Laboratories Limited Modified-release formulations of azabicyclo derivatives
US20090326004A1 (en) 2008-06-03 2009-12-31 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
EP2621902B1 (de) 2010-09-28 2017-04-12 Panacea Biotec Ltd 3-azabicyclo[3.1.0]hexanverbindungen zur behandlung von zns-erkrankungen
EP3570832A4 (de) * 2017-01-17 2020-06-10 Board Of Regents, The University Of Texas System Verbindungen als inhibitoren der indolamin-2,3-dioxygenase und/oder tryptophan-dioxygenase
WO2020018670A1 (en) 2018-07-17 2020-01-23 Board Of Regents, The University Of Texas System Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
CN111317754B (zh) * 2018-12-13 2022-02-18 泰州医药城国科化物生物医药科技有限公司 一种北豆根总碱的制备方法及应用

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2490714A (en) 1947-05-13 1949-12-06 Du Pont Preparation of diazoacetic esters
NL267508A (de) 1960-07-26
SE8800207D0 (sv) 1988-01-22 1988-01-22 Kabivitrum Ab Nya aminer, deras anvendning och framstellning
US5001160A (en) 1988-04-28 1991-03-19 Marion Laboratories, Inc. 1-aryl-1-hydroxy-1-substituted-3-(4-substituted-1-piperazinyl)-2-propanones and their use in treatment of neurogenic bladder disorders
GB8906166D0 (en) 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
PL166381B1 (pl) 1989-08-16 1995-05-31 Pfizer Sposób wytwarzania nowych podstawionych kwasów 7-azabicyklochinolonokarboksylowych PL PL PL PL
US5164402A (en) 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
GB8928042D0 (en) 1989-12-12 1990-02-14 Pfizer Ltd Muscarinic receptor antagonists
US5281601A (en) 1989-12-12 1994-01-25 Pfizer Inc. Muscarinic receptor antagonists
FR2659323B1 (fr) 1990-03-07 1992-06-12 Synthelabo Derives de 4-(aminomethyl) piperidine, leur preparation et leur application en therapeutique.
JPH0492921A (ja) 1990-08-03 1992-03-25 Fujitsu Ltd 指数関数演算器
GB9020051D0 (en) 1990-09-13 1990-10-24 Pfizer Ltd Muscarinic receptor antagonists
GB9202443D0 (en) 1992-02-05 1992-03-18 Fujisawa Pharmaceutical Co A novel substituted-acetamide compound and a process for the preparation thereof
FI100051B (fi) 1992-02-18 1997-09-15 Favorit Oy Kompostori
JPH0635958A (ja) 1992-07-14 1994-02-10 Hitachi Ltd 語句検索方法
JP3429338B2 (ja) 1992-07-27 2003-07-22 杏林製薬株式会社 新規なアリールグリシンアミド誘導体及びその製造法
JPH06135958A (ja) 1992-10-28 1994-05-17 Tanabe Seiyaku Co Ltd ベンゾシクロヘプテン誘導体及びその製法
SE9203318D0 (sv) 1992-11-06 1992-11-06 Kabi Pharmacia Ab Novel 3,3-diphenylpropylamines, their use and preparation
DE59306269D1 (de) 1993-02-24 1997-05-28 Siemens Ag Sperrwandler-Schaltnetzteil mit einem Halbleiterschaltelement geringer Spannungsfestigkeit
NO2005012I1 (no) 1994-12-28 2005-06-06 Debio Rech Pharma Sa Triptorelin og farmasoytisk akseptable salter derav
EP0823423B1 (de) 1995-04-28 2004-06-16 Banyu Pharmaceutical Co., Ltd. 1,4-disubstituierte piperidinderivate
CA2179574A1 (en) 1995-06-26 1996-12-27 Tomomi Okada Substituted piperidine derivative and medicine comprising the same
AU7145996A (en) 1995-10-13 1997-04-30 Banyu Pharmaceutical Co., Ltd. Substituted heteroaromatic derivatives
AU2793197A (en) 1996-05-31 1998-01-05 Banyu Pharmaceutical Co., Ltd. 1,4-disubstituted piperidine derivatives
EP0932401A1 (de) 1996-07-01 1999-08-04 Sepracor, Inc. Methoden und zusammensetzungen zur behandlung von harninkontiniez mittels enantiomerishc angereichertem (r,r)-glycopyrrolat
US6063808A (en) 1996-07-01 2000-05-16 Sepracor Inc. Methods and compositions for treating urinary incontinence using enantiomerically enriched (S,S)-glycopyrrolate
EP0909172A4 (de) 1996-07-01 1999-06-09 Sepracor Inc Verfahren und zusammensetzungen zur behandlung von harninkontinenz unter verwendung von enantiomer-angereichertem (r,s)-glycopyrrolat
WO1998000109A1 (en) 1996-07-01 1998-01-08 Sepracor, Inc. Methods and compositions for treating urinary incontinence using enantiomerically enriched (s,r)-glycopyrrolate
PE92198A1 (es) 1996-08-01 1999-01-09 Banyu Pharma Co Ltd Derivados de 1,4-piperidina disustituida que contienen fluor
KR20000057548A (ko) 1996-12-13 2000-09-25 알프레드 엘. 미첼슨 광학적 전송물질 및 결합재
CA2291778A1 (en) * 1997-05-29 1998-12-03 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
US6319920B1 (en) 1998-02-27 2001-11-20 Syntex (U.S.A.) Llc 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives
TWI244481B (en) 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
UA73543C2 (uk) 1999-12-07 2005-08-15 Тераванс, Інк. Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором
US7238709B2 (en) 1999-12-07 2007-07-03 Theravance, Inc. Therapeutic carbamates
SE9904765D0 (sv) 1999-12-23 1999-12-23 Astra Ab Pharmaceutically-useful compounds
PL361361A1 (en) 2000-05-25 2004-10-04 F.Hoffmann-La Roche Ag Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists
MXPA02011418A (es) 2000-05-25 2003-04-25 Hoffmann La Roche 1-aminoalquil-lactamas sustituidas y su uso como antagonistas del receptor muscarinico.
EP1294697A1 (de) 2000-06-14 2003-03-26 Muscagen Limited 1,2,3,5-tetrahydrobenzo[c]azepin-4-on derivate mit muskarinantagonistischer wirkung
AU6610001A (en) 2000-06-27 2002-01-08 S A L V A T Lab Sa Carbamates derived from arylalkylamines
AU2001271027B2 (en) 2000-07-11 2005-07-07 Msd K.K. Ester derivatives
ATE305468T1 (de) 2000-12-22 2005-10-15 Almirall Prodesfarma Ag Chinuclidincarbamat derivate und deren verwendung als m3 antagonisten
CN1250545C (zh) 2000-12-28 2006-04-12 阿尔米雷尔普罗迪斯制药有限公司 新的奎宁环衍生物类及含有这类衍生物的药物组合物
WO2002083863A2 (en) 2001-04-17 2002-10-24 Sepracor, Inc. Thiazole and other heterocyclic ligands and use thereof
PL370087A1 (en) 2001-10-17 2005-05-16 Ucb, S.A. Quinuclidine derivatives, processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors
AU2002352124A1 (en) 2001-12-03 2003-06-17 F. Hoffmann-La Roche Ag Aminotetralin derivatives as muscarinic receptor antagonists
CN100352806C (zh) 2001-12-03 2007-12-05 弗·哈夫曼-拉罗切有限公司 作为毒蕈碱受体拮抗剂的4－哌啶基烷基胺衍生物
NZ537584A (en) 2002-07-08 2006-07-28 Ranbaxy Lab Ltd 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
DE60226906D1 (de) 2002-07-31 2008-07-10 Ranbaxy Lab Ltd 3,6-disubstituierte azabicyclo ä3.1.0ühexanderivate, die sich als muscarinrezeptorantagonisten eignen
EP1545508A4 (de) 2002-08-09 2009-11-25 Ranbaxy Lab Ltd 3,6-disubstituierte azabicyclo ¬3.1.0 hexan-derivate als muscarinische rezeptor-antagonisten
JP2006501236A (ja) 2002-08-23 2006-01-12 ランバクシー ラボラトリーズ リミテッド ムスカリン性レセプター拮抗薬としてのフルオロおよびスルホニルアミノ含有３，６−二置換アザビシクロ（３．１．０）ヘキサン誘導体
ATE400553T1 (de) 2002-12-10 2008-07-15 Ranbaxy Lab Ltd 3,6-disubstituierte azabicyclo 3.1.0 - hexanderivative als antagonisten des muscarinrezeptors
US7465751B2 (en) 2002-12-23 2008-12-16 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
WO2004056810A1 (en) 2002-12-23 2004-07-08 Ranbaxy Laboratories Limited Xanthine derivatives as muscarinic receptor antagonists
AU2002347553A1 (en) 2002-12-23 2004-07-14 Ranbaxy Laboratories Limited Flavaxate derivatives as muscarinic receptor antagonists
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
WO2004069835A1 (en) 2003-02-07 2004-08-19 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EP1618091A1 (de) 2003-04-09 2006-01-25 Ranbaxy Laboratories, Ltd. Substituierte azabicyclohexanderivate als antagonisten von muscarinrezeptoren
EA009059B1 (ru) 2003-04-10 2007-10-26 Рэнбакси Лабораториз Лимитед Замещенные производные азабициклогексана в качестве антагонистов мускаринового рецептора
EP1615887A1 (de) 2003-04-10 2006-01-18 Ranbaxy Laboratories, Ltd. 3, 6-disubstitutierte azabicyclohexanderivate als muscarinrezeptorantagonisten
EA009387B1 (ru) 2003-04-11 2007-12-28 Рэнбакси Лабораториз Лимитед Азабициклические производные в качестве антагонистов мускаринового рецептора
FR2855805B1 (fr) 2003-06-06 2005-08-05 Vallourec Vitry Element de structure pour vehicule, capable d'un meilleur comportement aux chocs
WO2005092341A1 (en) 2004-03-22 2005-10-06 Ranbaxy Laboratories Limited Combination therapy for lower urinary tract symptoms
EP1796667A2 (de) 2004-09-27 2007-06-20 Ranbaxy Laboratories Limited Muscarinische rezeptor-antagonisten
EP1828126A1 (de) 2004-12-15 2007-09-05 Ranbaxy Laboratories Limited Säureadditionssalze von antagonisten des muskarinrezeptors

Also Published As

Publication number Publication date
JP2006502985A (ja) 2006-01-26
CN1681784A (zh) 2005-10-12
AU2002345266A1 (en) 2004-01-23
EA007932B1 (ru) 2007-02-27
ES2274275T3 (es) 2007-05-16
EA200500173A1 (ru) 2005-08-25
EA200501595A1 (ru) 2006-06-30
US20060111425A1 (en) 2006-05-25
US20070004791A1 (en) 2007-01-04
HK1079783A1 (en) 2006-04-13
PT1551803E (pt) 2007-01-31
US7399779B2 (en) 2008-07-15
EP1551803B1 (de) 2006-10-11
AU2002345266B2 (en) 2009-07-02
EA009942B1 (ru) 2008-04-28
BR0312572A (pt) 2005-05-10
CN100519526C (zh) 2009-07-29
DE60309057T2 (de) 2007-04-12
MXPA05000434A (es) 2005-04-19
AU2003226579A1 (en) 2004-01-23
EP1551803A1 (de) 2005-07-13
EP1546099B1 (de) 2008-12-31
CA2491998A1 (en) 2004-01-15
ATE342253T1 (de) 2006-11-15
DE60309057D1 (de) 2006-11-23
CN1668585A (zh) 2005-09-14
AU2003226579B2 (en) 2009-01-22
US7544708B2 (en) 2009-06-09
NZ537584A (en) 2006-07-28
WO2004004629A2 (en) 2004-01-15
EP1546099A4 (de) 2006-08-02
ATE419236T1 (de) 2009-01-15
CA2492121A1 (en) 2004-01-15
WO2004004629A3 (en) 2004-05-21
MXPA05000435A (es) 2005-04-19
EP1546099A2 (de) 2005-06-29
WO2004005252A1 (en) 2004-01-15
EP1551803B8 (de) 2006-12-13
HK1082728A1 (en) 2006-06-16
ZA200500951B (en) 2006-07-26
SI1551803T1 (sl) 2007-02-28
CY1105879T1 (el) 2011-02-02
JP2005535655A (ja) 2005-11-24
DK1551803T3 (da) 2007-02-19
BR0215801A (pt) 2005-05-10
EA200500172A1 (ru) 2005-08-25
NZ537585A (en) 2006-07-28

Similar Documents

Publication Publication Date Title
ZA200500951B (en) Azabicyclo derivatives as muscarinic receptor antagonists
DE60231341D1 (de) Fluor- und sulfonylaminohaltige, 3,6-disubstituierptorantagonisten
MX2009012579A (es) Antagonistas piridil piperidina del receptor de orexina.
HK1085724A1 (en) 3,6-disubstituted azabicyclo 3.1.0-hexane derivatives as muscarinic receptor antagonists
HK1079787A1 (zh) 用作毒蕈碱受體拮抗劑的3，6-二取代的氮雜雙環[3．1．0]己烷衍生物
MY161834A (en) Substituted diazepan compounds as orexin receptor antagonists
WO2005013894A3 (en) Benzodiazepine cgrp receptor antagonists
WO2004091514A3 (en) Cgrp receptor antagonists
WO2006035282A3 (en) Muscarinic receptor antagonists
EA200501593A1 (ru) Азабициклические производные в качестве антагонистов мускаринового рецептора
WO2004067510A8 (en) 3,6-disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
WO2006018708A3 (en) Pyrrolidine derivatives as muscarinic receptor antagonists
DE60225195D1 (de) Flavaxat-derivate als muscarin-rezeptor antagonisten
ATE429421T1 (de) Arylindenopyridin- und arylindenopyrimidinverbindungen und ihre verwendung als adenosin-a2a-rezeptor antagonisten
DE60313898D1 (de) Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten
WO2006032994A3 (en) Muscarinic receptor antagonists
WO2007007281A3 (en) Muscarinic receptor antagonists
DE602004018844D1 (de) Als antagonisten des muscarinrezeptors geeignete xanthinderivate

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: RANBAXY LABORATORIES, LTD., GURGAON, IN

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee