ATE205490T1 - Substituierte heteroaromatische derivate - Google Patents

Substituierte heteroaromatische derivate

Info

Publication number
ATE205490T1
ATE205490T1 AT96932827T AT96932827T ATE205490T1 AT E205490 T1 ATE205490 T1 AT E205490T1 AT 96932827 T AT96932827 T AT 96932827T AT 96932827 T AT96932827 T AT 96932827T AT E205490 T1 ATE205490 T1 AT E205490T1
Authority
AT
Austria
Prior art keywords
heteroaromatic ring
signifies
diseases
gastrointestinal
halogen
Prior art date
Application number
AT96932827T
Other languages
English (en)
Inventor
Toshiaki Banyu Mase
Morihiro Banyu Mitsuya
Kensuke Banyu Kobayashi
Kazuhito Banyu Noguchi
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Application granted granted Critical
Publication of ATE205490T1 publication Critical patent/ATE205490T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT96932827T 1995-10-13 1996-10-07 Substituierte heteroaromatische derivate ATE205490T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP29171695 1995-10-13
JP35134295 1995-12-26
PCT/JP1996/002904 WO1997013766A1 (en) 1995-10-13 1996-10-07 Substituted heteroaromatic derivatives

Publications (1)

Publication Number Publication Date
ATE205490T1 true ATE205490T1 (de) 2001-09-15

Family

ID=26558669

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96932827T ATE205490T1 (de) 1995-10-13 1996-10-07 Substituierte heteroaromatische derivate

Country Status (7)

Country Link
US (1) US6130232A (de)
EP (1) EP0863141B1 (de)
AT (1) ATE205490T1 (de)
AU (1) AU7145996A (de)
CA (1) CA2234619A1 (de)
DE (1) DE69615214T2 (de)
WO (1) WO1997013766A1 (de)

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US6319920B1 (en) * 1998-02-27 2001-11-20 Syntex (U.S.A.) Llc 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives
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US6693202B1 (en) 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
WO2000066579A1 (en) * 1999-04-28 2000-11-09 Banyu Pharmaceutical Co., Ltd. Processes for the preparation of piperidylmethylpyridine derivatives
AU6686700A (en) * 1999-08-23 2001-03-19 H. Lundbeck A/S Treatment of urinary incontinence
GB9923077D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
ATE299494T1 (de) 1999-12-07 2005-07-15 Theravance Inc Carbamat-derivate als muscarin-rezeptor antonisten
UA73543C2 (uk) * 1999-12-07 2005-08-15 Тераванс, Інк. Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
IL150650A0 (en) 2000-01-20 2003-02-12 Eisai Co Ltd Piperidine derivatives and pharmaceutical compositions containing the same
FR2816940A1 (fr) * 2000-11-23 2002-05-24 Lipha Derives de 4-(biphenylcarbonylamino)-piperidine, compositions les contenant et leur utilisation
EP1345937B1 (de) 2000-12-22 2005-09-28 Almirall Prodesfarma AG Chinuclidincarbamat derivate und deren verwendung als m3 antagonisten
SI1353919T1 (sl) * 2000-12-28 2006-12-31 Almirall Prodesfarma Ag Novi derivati kinuklidina in medicinske zmesi, kijih vsebujejo.
GB0107822D0 (en) * 2001-03-28 2001-05-23 Phytopharm Plc Sapogenin derivatives their synthesis and use methods based upon their use
US20050130948A1 (en) * 2002-03-27 2005-06-16 Daryl Rees Therapeutic methods and uses of sapogenins and their derivatives
KR101130212B1 (ko) * 2002-03-27 2012-04-13 파이토팜 피엘씨 사포게닌 및 그 유도체의 치료 방법 및 사용법
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ES2203327B1 (es) 2002-06-21 2005-06-16 Almirall Prodesfarma, S.A. Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
ES2204295B1 (es) 2002-07-02 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de quinuclidina-amida.
EA200500173A1 (ru) 2002-07-08 2005-08-25 Рэнбакси Лабораториз Лимитед Производные 3,6-дизамещенного азабицикло[3.1.0]гексана в качестве антагонистов мускариновых рецепторов
EP1546098B1 (de) * 2002-07-31 2008-05-28 Ranbaxy Laboratories Limited 3,6-disubstituierte azabicyclo [3.1.0]hexanderivate, die sich als muscarinrezeptorantagonisten eignen
HK1079708A1 (zh) * 2002-08-09 2006-04-13 Ranbaxy Laboratories, Ltd. 可用作毒蕈碱性受体拮抗剂的3，6-二取代氮杂二环[3．1．10]己烷衍生物
EP1534675B1 (de) * 2002-08-23 2009-02-25 Ranbaxy Laboratories, Ltd. Fluor- und sulfonylaminohaltige, 3,6-disubstituierte azabicyclo¬3.1.0 hexanderivate als muscarinrezeptorantagonisten
AU2003267802A1 (en) * 2002-10-29 2004-05-25 Pharmacia & Upjohn Company Llc Quaternary ammonium compounds as muscarinic receptor antagonists
TW200800953A (en) 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
AU2002353286A1 (en) * 2002-12-10 2004-06-30 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
WO2004056767A1 (en) * 2002-12-23 2004-07-08 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
AU2002347553A1 (en) * 2002-12-23 2004-07-14 Ranbaxy Laboratories Limited Flavaxate derivatives as muscarinic receptor antagonists
US7488748B2 (en) * 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
PE20040950A1 (es) 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
EP1618091A1 (de) 2003-04-09 2006-01-25 Ranbaxy Laboratories, Ltd. Substituierte azabicyclohexanderivate als antagonisten von muscarinrezeptoren
WO2004089899A1 (en) 2003-04-10 2004-10-21 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EP1615634B1 (de) * 2003-04-10 2007-05-16 Ranbaxy Laboratories, Ltd. Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten
WO2004089900A1 (en) * 2003-04-11 2004-10-21 Ranbaxy Laboratories Limited Azabicyclo derivatives as muscarinic receptor antagonists
TW200510298A (en) * 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
JP2007524641A (ja) 2003-07-11 2007-08-30 セラヴァンス， インコーポレーテッド 置換４−アミノ−１−ベンジルピペリジン化合物
KR100500760B1 (ko) * 2003-07-22 2005-07-14 동방에프티엘 주식회사 염산 프로피베린의 제조방법
ES2329586T3 (es) 2003-11-21 2009-11-27 Theravance, Inc. Compuestos que tienen actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarino.
EP1725525A1 (de) * 2004-03-11 2006-11-29 Theravance, Inc. Als muscarinrezeptorantagonisten geeignete diphenylmethylverbindungen
EP1723142A1 (de) * 2004-03-11 2006-11-22 Theravance, Inc. Als antagonisten des muskarinrezeptors geeignete diphenylmethylverbindungen
DE602004018844D1 (de) * 2004-06-16 2009-02-12 Ranbaxy Lab Ltd Als antagonisten des muscarinrezeptors geeignete xanthinderivate
EP1781607A2 (de) * 2004-08-19 2007-05-09 Ranbaxy Laboratories Limited Pyrrolidinderivate als antagonisten des muscarinrezeptors
US20080280883A1 (en) * 2004-09-24 2008-11-13 Mohammad Salman Muscarinic Receptor Antagonists
WO2006035303A1 (en) * 2004-09-29 2006-04-06 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
WO2006054162A1 (en) * 2004-11-19 2006-05-26 Ranbaxy Laboratories Limited Azabicyclic muscarinic receptor antagonists
EP1828126A1 (de) * 2004-12-15 2007-09-05 Ranbaxy Laboratories Limited Säureadditionssalze von antagonisten des muskarinrezeptors
US20080319043A1 (en) * 2005-05-03 2008-12-25 Mohammad Salman 3,6-Disubstituted Azabicyclo (3.1.0) Hexane Derivatives as Muscarinic Receptor Antagonists
WO2007045979A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
GB0602778D0 (en) 2006-02-10 2006-03-22 Glaxo Group Ltd Novel compound
US20090010923A1 (en) * 2007-04-24 2009-01-08 University Of Maryland, Baltimore Treatment of cancer with anti-muscarinic receptor agents

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JPS6018661B2 (ja) * 1976-01-01 1985-05-11 太田製薬株式会社 １−（１，３−ジオキソラン−４−イルメチル）ピペリジノ−ル誘導体
JPS5679688A (en) * 1979-12-04 1981-06-30 Ota Seiyaku Kk 4-acyloxy-1- 1,3-dioxoran-2-ylmethyl piperidine derivative and its production
IT1231238B (it) * 1987-09-21 1991-11-26 Angeli Inst Spa Derivati ammidinici
GB8825505D0 (en) * 1988-11-01 1988-12-07 Pfizer Ltd Therapeutic agents
JP3294961B2 (ja) * 1993-12-10 2002-06-24 杏林製薬株式会社 新規イミダゾール誘導体及びその製造法
JP2717928B2 (ja) * 1994-01-31 1998-02-25 東洋電機製造株式会社 給水装置
JPH07258250A (ja) * 1994-03-25 1995-10-09 Yamanouchi Pharmaceut Co Ltd エステル誘導体
KR19990008109A (ko) * 1995-04-28 1999-01-25 나가사까 겐지로 1,4-이치환 피페리딘 유도체
CA2179574A1 (en) * 1995-06-26 1996-12-27 Tomomi Okada Substituted piperidine derivative and medicine comprising the same

Also Published As

Publication number Publication date
EP0863141A4 (de) 1999-01-27
DE69615214T2 (de) 2002-06-27
WO1997013766A1 (en) 1997-04-17
AU7145996A (en) 1997-04-30
EP0863141B1 (de) 2001-09-12
DE69615214D1 (de) 2001-10-18
CA2234619A1 (en) 1997-04-17
US6130232A (en) 2000-10-10
EP0863141A1 (de) 1998-09-09

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