EA200600688A1 - Арилинденпиридины и арилинденпиримидины и их применение в качестве антагонистов аденозинового рецептора а2а - Google Patents

Арилинденпиридины и арилинденпиримидины и их применение в качестве антагонистов аденозинового рецептора а2а

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Publication number
EA200600688A1
EA200600688A1 EA200600688A EA200600688A EA200600688A1 EA 200600688 A1 EA200600688 A1 EA 200600688A1 EA 200600688 A EA200600688 A EA 200600688A EA 200600688 A EA200600688 A EA 200600688A EA 200600688 A1 EA200600688 A1 EA 200600688A1
Authority
EA
Eurasian Patent Office
Prior art keywords
arylindenpyrimidines
arylindenpyridines
antagonists
application
adenosine receptor
Prior art date
Application number
EA200600688A
Other languages
English (en)
Inventor
Джеффри Р. Хайнтцельман
Джеймс Л. Баллингтон
Кеннет С. Руперт
Original Assignee
Орто-Макнейл Фармасьютикал, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Орто-Макнейл Фармасьютикал, Инк. filed Critical Орто-Макнейл Фармасьютикал, Инк.
Publication of EA200600688A1 publication Critical patent/EA200600688A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Данное изобретение предлагает новые арилиденпиридины и арилиденпиримидины формулы (I) и (II), в которых R, R, R, Rи Х определены в описании, и фармацевтические композиции, содержащие вышеупомянутые вещества, подходящие для лечения расстройств, ослабляемых при антагонистическом воздействии на аденозиновые А2а рецепторы. Данное изобретение предлагает терапевтические и профилактические способы с использованием настоящих соединений и фармацевтических композиций.
EA200600688A 2003-10-03 2003-10-03 Арилинденпиридины и арилинденпиримидины и их применение в качестве антагонистов аденозинового рецептора а2а EA200600688A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2003/031471 WO2005042500A1 (en) 2003-10-03 2003-10-03 Arylindenopyridines and arylindenopyridines and their use as adenosine a2a receptor antagonist

Publications (1)

Publication Number Publication Date
EA200600688A1 true EA200600688A1 (ru) 2006-10-27

Family

ID=34548801

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600688A EA200600688A1 (ru) 2003-10-03 2003-10-03 Арилинденпиридины и арилинденпиримидины и их применение в качестве антагонистов аденозинового рецептора а2а

Country Status (22)

Country Link
EP (1) EP1673354B1 (ru)
JP (1) JP4725963B2 (ru)
CN (1) CN1878761A (ru)
AT (1) ATE429421T1 (ru)
AU (1) AU2003275430A1 (ru)
BR (1) BR0318521A (ru)
CA (1) CA2540686A1 (ru)
CY (1) CY1109808T1 (ru)
DE (1) DE60327375D1 (ru)
DK (1) DK1673354T3 (ru)
EA (1) EA200600688A1 (ru)
EC (1) ECSP066474A (ru)
ES (1) ES2326075T3 (ru)
HK (1) HK1091200A1 (ru)
HR (1) HRP20060127A2 (ru)
IL (1) IL174678A0 (ru)
IS (1) IS8377A (ru)
NO (1) NO20061981L (ru)
PT (1) PT1673354E (ru)
RS (1) RS20060237A (ru)
SI (1) SI1673354T1 (ru)
WO (1) WO2005042500A1 (ru)

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ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
EA015344B1 (ru) 2006-07-11 2011-06-30 Янссен Фармацевтика, Н.В. Бензофуро- и бензотиенопиримидиновые модуляторы гистаминового рецептора н
US8735411B2 (en) 2006-10-02 2014-05-27 Abbvie Inc. Macrocyclic benzofused pyrimidine derivatives
US7985745B2 (en) 2006-10-02 2011-07-26 Abbott Laboratories Method for pain treatment
US7960400B2 (en) 2007-08-27 2011-06-14 Duquesne University Of The Holy Ghost Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof
CN101835759A (zh) 2007-10-24 2010-09-15 詹森药业有限公司 芳基茚并嘧啶及其作为腺苷A2a受体拮抗剂的用途
PA8801401A1 (es) * 2007-10-25 2009-05-15 Janssen Pharmaceutica Nv Arilindenopirimidinas y su uso como adenosina a2a
US20100093763A1 (en) * 2008-10-13 2010-04-15 Barbay J Kent PHENYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINES AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
US20110105541A1 (en) * 2009-10-29 2011-05-05 Jackson Paul F ALKYL SUBSTITUTED ARYLINDENOPYRIMIDINES AND THEIR USE AS HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONISTS
US20110105492A1 (en) * 2009-10-29 2011-05-05 Jackson Paul F ARYL SUBSTITUTED ARYLINDENOPYRIMIDINES AND THEIR USE AS HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONISTS
US20110105494A1 (en) * 2009-10-29 2011-05-05 Jackson Paul F Heteroaryl substituted arylindenopyrimidines and their use as highly selective adenosine a2a receptor antagonists
US20110105493A1 (en) * 2009-10-29 2011-05-05 Jackson Paul F HETEROCYCLYL SUBSTITUTED ARYLINDENOPYRIMIDINES AND THEIR USE AS HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONISTS
US20110105540A1 (en) * 2009-10-29 2011-05-05 Jackson Paul F 2-AMINO-9-[4-(4-METHOXY-PHENOXY)-PIPERIDIN-1-YL]-4-PHENYL-INDENO[1,2-D]PYRIMIDIN-5-ONE AND ITS USE AS A HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONIST
EP3245186A1 (en) 2015-01-16 2017-11-22 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Method to prepare phenolics from biomass

Family Cites Families (6)

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WO1993008167A1 (en) * 1991-10-24 1993-04-29 Nippon Soda Co., Ltd. Novel heterocyclic derivative and agrohorticultural bactericide containing same
CA2168739A1 (en) * 1993-09-15 1995-03-23 William Barnaby Davey Fused tricyclic heteroaromatic derivatives
JP2001139556A (ja) * 1999-03-18 2001-05-22 Nippon Soda Co Ltd インデノピリジンおよびインデノピリミジン化合物並びにその製造法
BR0108611A (pt) * 2000-02-25 2003-05-06 Hoffmann La Roche Moduladores de receptor de adenosina
EP1385843A1 (en) * 2001-04-18 2004-02-04 Ortho-Mcneil Pharmaceutical, Inc. Arylindenopyridines with pde inhibiting activity
US6958328B2 (en) * 2001-04-18 2005-10-25 Ortho-Mcneil Pharmaceutical, Inc Arylindenopyridines and related therapeutic and prophylactic methods

Also Published As

Publication number Publication date
NO20061981L (no) 2006-07-03
JP4725963B2 (ja) 2011-07-13
RS20060237A (en) 2008-11-28
DK1673354T3 (da) 2009-07-27
SI1673354T1 (sl) 2009-10-31
ATE429421T1 (de) 2009-05-15
ES2326075T3 (es) 2009-09-30
EP1673354A1 (en) 2006-06-28
CN1878761A (zh) 2006-12-13
EP1673354B1 (en) 2009-04-22
PT1673354E (pt) 2009-07-14
CA2540686A1 (en) 2005-05-12
IL174678A0 (en) 2006-08-20
DE60327375D1 (de) 2009-06-04
ECSP066474A (es) 2006-10-10
HRP20060127A2 (en) 2006-07-31
IS8377A (is) 2006-03-27
WO2005042500A1 (en) 2005-05-12
JP2007521243A (ja) 2007-08-02
AU2003275430A1 (en) 2005-05-19
BR0318521A (pt) 2006-09-12
CY1109808T1 (el) 2014-09-10
HK1091200A1 (en) 2007-01-12

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