DE60327375D1 - Arylindenopyridin- und arylindenopyrimidinverbindungen und ihre verwendung als adenosin-a2a-rezeptor antagonisten - Google Patents
Arylindenopyridin- und arylindenopyrimidinverbindungen und ihre verwendung als adenosin-a2a-rezeptor antagonistenInfo
- Publication number
- DE60327375D1 DE60327375D1 DE60327375T DE60327375T DE60327375D1 DE 60327375 D1 DE60327375 D1 DE 60327375D1 DE 60327375 T DE60327375 T DE 60327375T DE 60327375 T DE60327375 T DE 60327375T DE 60327375 D1 DE60327375 D1 DE 60327375D1
- Authority
- DE
- Germany
- Prior art keywords
- adenosine
- compounds
- arylindenopyridine
- arylindenopyrimidine
- receptor antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2003/031471 WO2005042500A1 (en) | 2003-10-03 | 2003-10-03 | Arylindenopyridines and arylindenopyridines and their use as adenosine a2a receptor antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60327375D1 true DE60327375D1 (de) | 2009-06-04 |
Family
ID=34548801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60327375T Expired - Lifetime DE60327375D1 (de) | 2003-10-03 | 2003-10-03 | Arylindenopyridin- und arylindenopyrimidinverbindungen und ihre verwendung als adenosin-a2a-rezeptor antagonisten |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1673354B1 (de) |
| JP (1) | JP4725963B2 (de) |
| CN (1) | CN1878761A (de) |
| AT (1) | ATE429421T1 (de) |
| AU (1) | AU2003275430A1 (de) |
| BR (1) | BR0318521A (de) |
| CA (1) | CA2540686A1 (de) |
| CY (1) | CY1109808T1 (de) |
| DE (1) | DE60327375D1 (de) |
| DK (1) | DK1673354T3 (de) |
| EA (1) | EA200600688A1 (de) |
| EC (1) | ECSP066474A (de) |
| ES (1) | ES2326075T3 (de) |
| HK (1) | HK1091200A1 (de) |
| HR (1) | HRP20060127A2 (de) |
| IL (1) | IL174678A0 (de) |
| IS (1) | IS8377A (de) |
| NO (1) | NO20061981L (de) |
| PT (1) | PT1673354E (de) |
| RS (1) | RS20060237A (de) |
| SI (1) | SI1673354T1 (de) |
| WO (1) | WO2005042500A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
| EA015344B1 (ru) | 2006-07-11 | 2011-06-30 | Янссен Фармацевтика, Н.В. | Бензофуро- и бензотиенопиримидиновые модуляторы гистаминового рецептора н |
| US8735411B2 (en) | 2006-10-02 | 2014-05-27 | Abbvie Inc. | Macrocyclic benzofused pyrimidine derivatives |
| US7985745B2 (en) | 2006-10-02 | 2011-07-26 | Abbott Laboratories | Method for pain treatment |
| US7960400B2 (en) | 2007-08-27 | 2011-06-14 | Duquesne University Of The Holy Ghost | Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof |
| CN101835759A (zh) | 2007-10-24 | 2010-09-15 | 詹森药业有限公司 | 芳基茚并嘧啶及其作为腺苷A2a受体拮抗剂的用途 |
| PA8801401A1 (es) * | 2007-10-25 | 2009-05-15 | Janssen Pharmaceutica Nv | Arilindenopirimidinas y su uso como adenosina a2a |
| US20100093763A1 (en) * | 2008-10-13 | 2010-04-15 | Barbay J Kent | PHENYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINES AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS |
| US20110105541A1 (en) * | 2009-10-29 | 2011-05-05 | Jackson Paul F | ALKYL SUBSTITUTED ARYLINDENOPYRIMIDINES AND THEIR USE AS HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONISTS |
| US20110105492A1 (en) * | 2009-10-29 | 2011-05-05 | Jackson Paul F | ARYL SUBSTITUTED ARYLINDENOPYRIMIDINES AND THEIR USE AS HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONISTS |
| US20110105494A1 (en) * | 2009-10-29 | 2011-05-05 | Jackson Paul F | Heteroaryl substituted arylindenopyrimidines and their use as highly selective adenosine a2a receptor antagonists |
| US20110105493A1 (en) * | 2009-10-29 | 2011-05-05 | Jackson Paul F | HETEROCYCLYL SUBSTITUTED ARYLINDENOPYRIMIDINES AND THEIR USE AS HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONISTS |
| US20110105540A1 (en) * | 2009-10-29 | 2011-05-05 | Jackson Paul F | 2-AMINO-9-[4-(4-METHOXY-PHENOXY)-PIPERIDIN-1-YL]-4-PHENYL-INDENO[1,2-D]PYRIMIDIN-5-ONE AND ITS USE AS A HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONIST |
| EP3245186A1 (de) | 2015-01-16 | 2017-11-22 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Verfahren zur herstellung von phenolen aus biomasse |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993008167A1 (en) * | 1991-10-24 | 1993-04-29 | Nippon Soda Co., Ltd. | Novel heterocyclic derivative and agrohorticultural bactericide containing same |
| CA2168739A1 (en) * | 1993-09-15 | 1995-03-23 | William Barnaby Davey | Fused tricyclic heteroaromatic derivatives |
| JP2001139556A (ja) * | 1999-03-18 | 2001-05-22 | Nippon Soda Co Ltd | インデノピリジンおよびインデノピリミジン化合物並びにその製造法 |
| BR0108611A (pt) * | 2000-02-25 | 2003-05-06 | Hoffmann La Roche | Moduladores de receptor de adenosina |
| EP1385843A1 (de) * | 2001-04-18 | 2004-02-04 | Ortho-Mcneil Pharmaceutical, Inc. | Arylindenopyridine mit pde-inhibierender wirkung |
| US6958328B2 (en) * | 2001-04-18 | 2005-10-25 | Ortho-Mcneil Pharmaceutical, Inc | Arylindenopyridines and related therapeutic and prophylactic methods |
-
2003
- 2003-10-03 BR BRPI0318521-4A patent/BR0318521A/pt not_active IP Right Cessation
- 2003-10-03 EP EP03759708A patent/EP1673354B1/de not_active Expired - Lifetime
- 2003-10-03 RS YUP-2006/0237A patent/RS20060237A/sr unknown
- 2003-10-03 SI SI200331625T patent/SI1673354T1/sl unknown
- 2003-10-03 EA EA200600688A patent/EA200600688A1/ru unknown
- 2003-10-03 WO PCT/US2003/031471 patent/WO2005042500A1/en active Application Filing
- 2003-10-03 DK DK03759708T patent/DK1673354T3/da active
- 2003-10-03 JP JP2005510193A patent/JP4725963B2/ja not_active Expired - Fee Related
- 2003-10-03 CN CNA2003801107612A patent/CN1878761A/zh active Pending
- 2003-10-03 AU AU2003275430A patent/AU2003275430A1/en not_active Abandoned
- 2003-10-03 DE DE60327375T patent/DE60327375D1/de not_active Expired - Lifetime
- 2003-10-03 AT AT03759708T patent/ATE429421T1/de active
- 2003-10-03 PT PT03759708T patent/PT1673354E/pt unknown
- 2003-10-03 CA CA002540686A patent/CA2540686A1/en not_active Abandoned
- 2003-10-03 ES ES03759708T patent/ES2326075T3/es not_active Expired - Lifetime
-
2006
- 2006-03-27 IS IS8377A patent/IS8377A/is unknown
- 2006-03-30 HR HR20060127A patent/HRP20060127A2/xx not_active Application Discontinuation
- 2006-03-30 IL IL174678A patent/IL174678A0/en unknown
- 2006-04-03 EC EC2006006474A patent/ECSP066474A/es unknown
- 2006-05-03 NO NO20061981A patent/NO20061981L/no not_active Application Discontinuation
- 2006-10-25 HK HK06111781.4A patent/HK1091200A1/xx not_active IP Right Cessation
-
2009
- 2009-07-14 CY CY20091100752T patent/CY1109808T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20061981L (no) | 2006-07-03 |
| JP4725963B2 (ja) | 2011-07-13 |
| RS20060237A (en) | 2008-11-28 |
| DK1673354T3 (da) | 2009-07-27 |
| SI1673354T1 (sl) | 2009-10-31 |
| ATE429421T1 (de) | 2009-05-15 |
| ES2326075T3 (es) | 2009-09-30 |
| EP1673354A1 (de) | 2006-06-28 |
| CN1878761A (zh) | 2006-12-13 |
| EP1673354B1 (de) | 2009-04-22 |
| PT1673354E (pt) | 2009-07-14 |
| CA2540686A1 (en) | 2005-05-12 |
| IL174678A0 (en) | 2006-08-20 |
| ECSP066474A (es) | 2006-10-10 |
| HRP20060127A2 (en) | 2006-07-31 |
| IS8377A (is) | 2006-03-27 |
| WO2005042500A1 (en) | 2005-05-12 |
| JP2007521243A (ja) | 2007-08-02 |
| EA200600688A1 (ru) | 2006-10-27 |
| AU2003275430A1 (en) | 2005-05-19 |
| BR0318521A (pt) | 2006-09-12 |
| CY1109808T1 (el) | 2014-09-10 |
| HK1091200A1 (en) | 2007-01-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC., RA, US |
|
| 8364 | No opposition during term of opposition |