BR0315845A - Compostos de pirazina como moduladores de crf - Google Patents

Compostos de pirazina como moduladores de crf

Info

Publication number
BR0315845A
BR0315845A BR0315845-4A BR0315845A BR0315845A BR 0315845 A BR0315845 A BR 0315845A BR 0315845 A BR0315845 A BR 0315845A BR 0315845 A BR0315845 A BR 0315845A
Authority
BR
Brazil
Prior art keywords
crf
pyrazine compounds
modulators
disorder
crf modulators
Prior art date
Application number
BR0315845-4A
Other languages
English (en)
Inventor
John Warren Mickelson
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of BR0315845A publication Critical patent/BR0315845A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Pulmonology (AREA)
  • Hematology (AREA)
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Abstract

"COMPOSTOS DE PIRAZINA COMO MODULADORES DO CRF". São revelados derivados de pirazina, composições farmacêuticas contendo-os e métodos para a sua utilização para tratar um distúrbio ou patologia em que o tratamento pode ser efetuado ou facilitado pela antagonização de um receptor do CRF, tal como um distúrbio relacionado com a ansiedade ou distúrbio afetivo.
BR0315845-4A 2002-11-21 2003-11-11 Compostos de pirazina como moduladores de crf BR0315845A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42814602P 2002-11-21 2002-11-21
PCT/IB2003/005183 WO2004046136A1 (en) 2002-11-21 2003-11-11 Pyrazine compounds as crf modulators

Publications (1)

Publication Number Publication Date
BR0315845A true BR0315845A (pt) 2005-09-27

Family

ID=32326631

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0315845-4A BR0315845A (pt) 2002-11-21 2003-11-11 Compostos de pirazina como moduladores de crf

Country Status (10)

Country Link
US (1) US20040157860A1 (pt)
EP (1) EP1565454A1 (pt)
JP (1) JP2006514628A (pt)
AR (1) AR042085A1 (pt)
AU (1) AU2003278542A1 (pt)
BR (1) BR0315845A (pt)
CA (1) CA2499133A1 (pt)
MX (1) MXPA05005408A (pt)
TW (1) TW200424195A (pt)
WO (1) WO2004046136A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7932256B2 (en) 2008-07-31 2011-04-26 Bristol-Myers Squibb Company (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-(6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile: a pyrazinone modulator of corticotropin-releasing factor receptor activity
WO2010014687A1 (en) * 2008-07-31 2010-02-04 Bristol-Myers Squibb Company Substituted carbamate derivatives as modulators of corticotropin-releasing factor receptor activity
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
CN112142716B (zh) * 2020-10-29 2021-08-31 山东新时代药业有限公司 一种5元杂芳基取代的吡嗪衍生物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4081542A (en) * 1975-04-21 1978-03-28 Merck & Co., Inc. Piperazinylpyrazines
US5883105A (en) * 1996-04-03 1999-03-16 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5872136A (en) * 1996-04-03 1999-02-16 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
US5880140A (en) * 1996-04-03 1999-03-09 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
PA8467401A1 (es) * 1998-02-17 2000-09-29 Pfizer Prod Inc Procedimiento para tratar la insuficiencia cardiaca
CO5271670A1 (es) * 1999-10-29 2003-04-30 Pfizer Prod Inc Antagonistas del factor de liberacion de corticitropina y composiciones relacionadas
US6995161B2 (en) * 2000-02-16 2006-02-07 Neurogen Corporation Substituted arylpyrazines
CA2450262A1 (en) * 2001-06-12 2002-12-19 Neurogen Corporation 2,5-diarylpyrazines, 2,5-diarylpyridines and 2,5-diarylpyrimidines as crf1 receptor modulators
CA2480497A1 (en) * 2002-04-26 2003-11-06 Pharmacia & Upjohn Company Substituted pyrazine derivatives

Also Published As

Publication number Publication date
EP1565454A1 (en) 2005-08-24
US20040157860A1 (en) 2004-08-12
AU2003278542A1 (en) 2004-06-15
JP2006514628A (ja) 2006-05-11
WO2004046136A1 (en) 2004-06-03
TW200424195A (en) 2004-11-16
CA2499133A1 (en) 2004-06-03
MXPA05005408A (es) 2005-08-03
WO2004046136A9 (en) 2005-05-26
AR042085A1 (es) 2005-06-08

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