DE602005017162D1 - 3-arylthioindol-2-carbonsäureamidderivate und ihre analoge als hemmer von caseinkinase i - Google Patents

3-arylthioindol-2-carbonsäureamidderivate und ihre analoge als hemmer von caseinkinase i

Info

Publication number
DE602005017162D1
DE602005017162D1 DE602005017162T DE602005017162T DE602005017162D1 DE 602005017162 D1 DE602005017162 D1 DE 602005017162D1 DE 602005017162 T DE602005017162 T DE 602005017162T DE 602005017162 T DE602005017162 T DE 602005017162T DE 602005017162 D1 DE602005017162 D1 DE 602005017162D1
Authority
DE
Germany
Prior art keywords
arylthioindole
analogues
inhibitors
carboxylic acid
acid amide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005017162T
Other languages
English (en)
Inventor
William Arthur Metz Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Publication of DE602005017162D1 publication Critical patent/DE602005017162D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DE602005017162T 2004-08-19 2005-08-19 3-arylthioindol-2-carbonsäureamidderivate und ihre analoge als hemmer von caseinkinase i Active DE602005017162D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60334804P 2004-08-19 2004-08-19
PCT/US2005/029306 WO2006023590A1 (en) 2004-08-19 2005-08-19 3-ARYLTHIOINDOLE-2-CARBOXAMIDE DERIVATIVES AND ANALOGS THEREOF AS INHIBITORS OF CASEIN KINASE Iϵ

Publications (1)

Publication Number Publication Date
DE602005017162D1 true DE602005017162D1 (de) 2009-11-26

Family

ID=35311784

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005017162T Active DE602005017162D1 (de) 2004-08-19 2005-08-19 3-arylthioindol-2-carbonsäureamidderivate und ihre analoge als hemmer von caseinkinase i

Country Status (19)

Country Link
US (1) US8008340B2 (de)
EP (1) EP1791537B1 (de)
JP (1) JP4931814B2 (de)
KR (1) KR20070045264A (de)
CN (1) CN101039666A (de)
AT (1) ATE445396T1 (de)
AU (1) AU2005277460A1 (de)
BR (1) BRPI0514397A (de)
CA (1) CA2577511A1 (de)
DE (1) DE602005017162D1 (de)
DK (1) DK1791537T3 (de)
ES (1) ES2334927T3 (de)
IL (1) IL181155A0 (de)
MX (1) MX2007001077A (de)
PL (1) PL1791537T3 (de)
PT (1) PT1791537E (de)
RU (1) RU2391098C2 (de)
SI (1) SI1791537T1 (de)
WO (1) WO2006023590A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201001330A1 (ru) * 2008-02-22 2011-04-29 Айрм Ллк Соединения и композиции в качестве модуляторов активности gpr119
US9018238B2 (en) 2009-02-12 2015-04-28 Pharmadesign, Inc. Inhibitor of casein kinase 1δ and casein kinase 1ε
EP2493876B1 (de) * 2009-10-28 2014-02-12 Pfizer Inc Imidazolderivate als casein-kinasehemmer
AU2011248175A1 (en) * 2010-05-06 2012-10-25 Merck Sharp & Dohme Corp. Aza-Indole derivatives useful as modulators of FAAH
JP5181156B2 (ja) 2010-08-09 2013-04-10 株式会社ファルマデザイン カゼインキナーゼ１δ及びカゼインキナーゼ１ε阻害剤
KR101350077B1 (ko) * 2010-12-13 2014-01-14 한국화학연구원 신규한 3-인돌리논 유도체 및 이를 포함하는 조성물
DK2835131T3 (en) * 2010-12-14 2017-12-04 Electrophoretics Ltd Casein kinase 1 delta inhibitors (CK1 delta)
CA2873214C (en) 2012-05-11 2021-02-16 Reset Therapeutics, Inc. Carbazole-containing sulfonamides as cryptochrome modulators
TWI690521B (zh) 2014-04-07 2020-04-11 美商同步製藥公司 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類
WO2018133835A1 (en) * 2017-01-20 2018-07-26 National Institute Of Biological Sciences, Beijing Nucleoside analogue regulating mammalian circadian rhythm

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3705934A1 (de) * 1987-02-25 1988-09-08 Nattermann A & Cie Indolyl-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
PL175788B1 (pl) * 1993-02-24 1999-02-26 Merck & Co Inc Amidowe pochodne indolu i zawierające je kompozycje farmaceutyczne
WO2000075669A1 (en) * 1999-06-08 2000-12-14 Aventis Pharmaceuticals Inc. Screening methods for altering circadian rhythm proteins
CA2478715A1 (en) * 2002-03-13 2003-09-25 Pharmacia & Upjohn Company Novel pyrazolo [1,5-a]pyridine derivatives and their use as neurotransmitter modulators
JP4335136B2 (ja) * 2002-08-09 2009-09-30 メルク エンド カムパニー インコーポレーテッド チロシンキナーゼ阻害薬
CN100439367C (zh) * 2003-12-11 2008-12-03 安万特药物公司 作为酪蛋白激酶Iε抑制剂的取代的1H-吡咯并[3,2-b、3,2-c和2,3-c]吡啶-2-甲酰胺以及相关类似物

Also Published As

Publication number Publication date
AU2005277460A1 (en) 2006-03-02
ES2334927T3 (es) 2010-03-17
US20070142454A1 (en) 2007-06-21
CN101039666A (zh) 2007-09-19
EP1791537A1 (de) 2007-06-06
CA2577511A1 (en) 2006-03-02
MX2007001077A (es) 2007-04-17
JP2008510704A (ja) 2008-04-10
BRPI0514397A (pt) 2008-06-10
IL181155A0 (en) 2007-07-04
RU2391098C2 (ru) 2010-06-10
PL1791537T3 (pl) 2010-04-30
RU2007109813A (ru) 2008-09-27
SI1791537T1 (sl) 2010-02-26
ATE445396T1 (de) 2009-10-15
JP4931814B2 (ja) 2012-05-16
EP1791537B1 (de) 2009-10-14
PT1791537E (pt) 2010-01-19
DK1791537T3 (da) 2010-03-01
US8008340B2 (en) 2011-08-30
KR20070045264A (ko) 2007-05-02
WO2006023590A1 (en) 2006-03-02

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