RS50823B - Supstituisani 1h-pirolo[3,2-b, 3,2-c, i 2,3-c]piridin-2-karboksamidi i srodni analozi kao inhibitori kazein kinaze i epsilon - Google Patents

Supstituisani 1h-pirolo[3,2-b, 3,2-c, i 2,3-c]piridin-2-karboksamidi i srodni analozi kao inhibitori kazein kinaze i epsilon

Info

Publication number
RS50823B
RS50823B RSP-2009/0302A RSP20090302A RS50823B RS 50823 B RS50823 B RS 50823B RS P20090302 A RSP20090302 A RS P20090302A RS 50823 B RS50823 B RS 50823B
Authority
RS
Serbia
Prior art keywords
alkyl
group
acyl
ring
heterocycle
Prior art date
Application number
RSP-2009/0302A
Other languages
English (en)
Inventor
William A. Metz
Frank Halley
Gilles Dutruc-Rosset
Yong Mi Choi-Sledeski
Gregory B. Poli
David M. Fink
Gilles Doerflinger
Bao-Guo Huang
Ann Marie Gelormini
Juan A. Gamboa
Andrew Giovanni
Joseph T. Tsay
Fernando Camacho
Joachim E. Roehr
William J. Hurst
Yulin Chiang
Stephen W. Harnish
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of RS50823B publication Critical patent/RS50823B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
RSP-2009/0302A 2003-12-11 2004-12-01 Supstituisani 1h-pirolo[3,2-b, 3,2-c, i 2,3-c]piridin-2-karboksamidi i srodni analozi kao inhibitori kazein kinaze i epsilon RS50823B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52876403P 2003-12-11 2003-12-11
PCT/US2004/040080 WO2005061498A1 (en) 2003-12-11 2004-12-01 Substituted 1h-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase i epsilon

Publications (1)

Publication Number Publication Date
RS50823B true RS50823B (sr) 2010-08-31

Family

ID=34710096

Family Applications (1)

Application Number Title Priority Date Filing Date
RSP-2009/0302A RS50823B (sr) 2003-12-11 2004-12-01 Supstituisani 1h-pirolo[3,2-b, 3,2-c, i 2,3-c]piridin-2-karboksamidi i srodni analozi kao inhibitori kazein kinaze i epsilon

Country Status (21)

Country Link
US (2) US7402672B2 (sr)
EP (1) EP1747220B1 (sr)
JP (1) JP4691506B2 (sr)
KR (1) KR20060113754A (sr)
CN (1) CN100439367C (sr)
AT (1) ATE428711T1 (sr)
AU (1) AU2004303826A1 (sr)
BR (1) BRPI0417520A (sr)
CA (1) CA2549183A1 (sr)
DE (1) DE602004020685D1 (sr)
DK (1) DK1747220T3 (sr)
ES (1) ES2324871T3 (sr)
HK (1) HK1098742A1 (sr)
HR (1) HRP20090380T1 (sr)
IL (1) IL175875A0 (sr)
PL (1) PL1747220T3 (sr)
PT (1) PT1747220E (sr)
RS (1) RS50823B (sr)
SI (1) SI1747220T1 (sr)
TW (1) TW200530234A (sr)
WO (1) WO2005061498A1 (sr)

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JO2724B1 (en) 2004-08-19 2013-09-15 افينتس فارماسوتيكالز انك 3-Alternative-5 -6-Amino Alkyl Indole-2-Carboxyl Acid Amide and Related Isotopes as Casein Kinase Inhibitors
DK1791537T3 (da) * 2004-08-19 2010-03-01 Aventis Pharma Inc 3-arylthioindol-2-carboxamidderivater og analoger deraf som inhibitorer af casein-kinase
JO2629B1 (en) 2004-08-19 2012-06-24 افينتيس فارما سوتيكالز انك Branched carboxylic acid amides containing thienobirol, carboxylic acid amides containing pyrolithiazole, and the like as kinase inhibitors casein epsilon
CA2620864A1 (en) * 2005-09-01 2007-03-08 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof
US8372851B2 (en) * 2005-10-21 2013-02-12 Exelixis, Inc. Pyrazolo pyrimidines as casein kinase II (CK2) modulators
FR2918061B1 (fr) * 2007-06-28 2010-10-22 Sanofi Aventis Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
FR2918986B1 (fr) * 2007-07-19 2009-09-04 Sanofi Aventis Sa Derives de 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]- pyridazine, leur preparation et leur application en therapeutique
FR2939134A1 (fr) 2008-12-01 2010-06-04 Sanofi Aventis Derives de 6-cycloamino-3-(1h-pyrrolo°2,3-b!pyridin-4-yl) imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique
FR2940284B1 (fr) 2008-12-19 2011-02-18 Sanofi Aventis Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique
FR2940285A1 (fr) 2008-12-19 2010-06-25 Sanofi Aventis Derives de 6-cycloamino-2-thienyl-3-(pyridin-4-yl)imidazo °1,2-b!-pyridazine et 6-cycloamino-2-furanyl-3- (pyridin-4-yl)imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique
FR2945289A1 (fr) 2009-05-11 2010-11-12 Sanofi Aventis Derives de 2-cycloamino-5-(pyridin-4-yl)imidazo°2,1-b! °1,3,4!thiadiazole, leur preparation et leur application en therapeutique
ES2460065T3 (es) * 2009-10-28 2014-05-13 Pfizer Inc. Derivados de imidazol como inhibidores de la caseína quinasa
FR2960876B1 (fr) 2010-06-03 2012-07-27 Sanofi Aventis Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
WO2014111871A1 (en) 2013-01-17 2014-07-24 Aurigene Discovery Technologies Limited 4,5-dihydroisoxazole derivatives as nampt inhibitors
KR101657597B1 (ko) * 2013-05-08 2016-09-19 주식회사유한양행 피롤로[2,3-c]피리딘 유도체 또는 이의 약학적으로 허용가능한 염의 제조방법
WO2014189238A1 (en) * 2013-05-20 2014-11-27 Yuhan Corporation Process for the preparation of pyrrolo[2,3-c]pyridine derivatives or pharmaceutically acceptable salts thereof
TW201605859A (zh) * 2013-11-14 2016-02-16 必治妥美雅史谷比公司 作為酪蛋白激酶１δ／ε抑制劑之新穎經取代之吡唑并－哌
CN104945313A (zh) * 2015-06-19 2015-09-30 洪帅金 一种2-甲基-3-溴吡啶的制备方法
CN104974082A (zh) * 2015-07-26 2015-10-14 陈吉美 一种2-甲基-4-溴吡啶的制备方法
CN105198802A (zh) * 2015-11-03 2015-12-30 江苏梦得电镀化学品有限公司 一种2-甲基-3-溴吡啶的制备方法
US10973820B2 (en) 2017-12-13 2021-04-13 Facio Intellectual Property B.V. Compounds for treatment of diseases related to DUX4 expression
TW202112368A (zh) 2019-06-13 2021-04-01 荷蘭商法西歐知識產權股份有限公司 用於治療有關dux4表現之疾病的抑制劑組合

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US4675332A (en) * 1984-12-10 1987-06-23 Warner-Lambert Company Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
US5527819A (en) 1991-09-06 1996-06-18 Merck & Co., Inc. Inhibitors of HIV reverse transcriptase
AU6254294A (en) 1993-02-24 1994-09-14 Merck & Co., Inc. Inhibitors of hiv reverse transcriptase
JPH10510510A (ja) 1994-06-09 1998-10-13 スミスクライン・ビーチャム・コーポレイション エンドセリン受容体拮抗物質
US5977134A (en) 1996-12-05 1999-11-02 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6432989B1 (en) * 1999-08-27 2002-08-13 Pfizer Inc Use of CRF antagonists to treat circadian rhythm disorders
ES2383001T3 (es) 2001-10-02 2012-06-15 Pharmacia & Upjohn Company Llc Compuestos de heteroarilo condensado sustituidos con azabicíclico para el tratamiento de enfermedades
BR0308391A (pt) * 2002-03-13 2005-01-11 Pharmacia & Upjohn Co Llc Derivados de pirazolo(1,5-a)piridina como moduladores neurotransmissores
WO2003080608A2 (en) * 2002-03-27 2003-10-02 Glaxo Group Limited Quinoline and aza-indole derivatives and their use as 5-ht6 ligands

Also Published As

Publication number Publication date
US20080200496A1 (en) 2008-08-21
KR20060113754A (ko) 2006-11-02
ES2324871T3 (es) 2009-08-18
SI1747220T1 (sl) 2009-08-31
AU2004303826A1 (en) 2005-07-07
ATE428711T1 (de) 2009-05-15
DK1747220T3 (da) 2009-08-10
CA2549183A1 (en) 2005-07-07
JP4691506B2 (ja) 2011-06-01
US7626027B2 (en) 2009-12-01
US20050131012A1 (en) 2005-06-16
WO2005061498A1 (en) 2005-07-07
HRP20090380T1 (hr) 2009-08-31
TW200530234A (en) 2005-09-16
CN100439367C (zh) 2008-12-03
DE602004020685D1 (de) 2009-05-28
HK1098742A1 (en) 2007-07-27
EP1747220A1 (en) 2007-01-31
PL1747220T3 (pl) 2009-09-30
EP1747220B1 (en) 2009-04-15
CN1906194A (zh) 2007-01-31
JP2007513950A (ja) 2007-05-31
US7402672B2 (en) 2008-07-22
PT1747220E (pt) 2009-07-08
BRPI0417520A (pt) 2007-03-06
IL175875A0 (en) 2006-10-05

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