DK1747220T3 - Substituerede 1H-pyrrolo[3,2-B, 3,2-C og 2,3-C]pyridin-2-carboxamider og relaterede analoger som inhibitorer af casein kinase I epsilon - Google Patents

Substituerede 1H-pyrrolo[3,2-B, 3,2-C og 2,3-C]pyridin-2-carboxamider og relaterede analoger som inhibitorer af casein kinase I epsilon

Info

Publication number
DK1747220T3
DK1747220T3 DK04812567T DK04812567T DK1747220T3 DK 1747220 T3 DK1747220 T3 DK 1747220T3 DK 04812567 T DK04812567 T DK 04812567T DK 04812567 T DK04812567 T DK 04812567T DK 1747220 T3 DK1747220 T3 DK 1747220T3
Authority
DK
Denmark
Prior art keywords
inhibitors
compounds
casein kinase
carboxamides
pyrrolo
Prior art date
Application number
DK04812567T
Other languages
Danish (da)
English (en)
Inventor
William A Metz
Frank Halley
Gilles Dutruc-Rosset
Yong Mi Choi-Sledeski
Gregory B Poli
David M Fink
Gilles Doerflinger
Bao-Guo Huang
Ann Marie Gelormini
Juan A Gamboa
Andrew Giovanni
Joachim E Roehr
Joseph T Tsay
Fernando Camacho
William J Hurst
Stephen W Harnish
Yulin Chiang
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of DK1747220T3 publication Critical patent/DK1747220T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK04812567T 2003-12-11 2004-12-01 Substituerede 1H-pyrrolo[3,2-B, 3,2-C og 2,3-C]pyridin-2-carboxamider og relaterede analoger som inhibitorer af casein kinase I epsilon DK1747220T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52876403P 2003-12-11 2003-12-11
PCT/US2004/040080 WO2005061498A1 (en) 2003-12-11 2004-12-01 Substituted 1h-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase i epsilon

Publications (1)

Publication Number Publication Date
DK1747220T3 true DK1747220T3 (da) 2009-08-10

Family

ID=34710096

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04812567T DK1747220T3 (da) 2003-12-11 2004-12-01 Substituerede 1H-pyrrolo[3,2-B, 3,2-C og 2,3-C]pyridin-2-carboxamider og relaterede analoger som inhibitorer af casein kinase I epsilon

Country Status (21)

Country Link
US (2) US7402672B2 (sr)
EP (1) EP1747220B1 (sr)
JP (1) JP4691506B2 (sr)
KR (1) KR20060113754A (sr)
CN (1) CN100439367C (sr)
AT (1) ATE428711T1 (sr)
AU (1) AU2004303826A1 (sr)
BR (1) BRPI0417520A (sr)
CA (1) CA2549183A1 (sr)
DE (1) DE602004020685D1 (sr)
DK (1) DK1747220T3 (sr)
ES (1) ES2324871T3 (sr)
HK (1) HK1098742A1 (sr)
HR (1) HRP20090380T1 (sr)
IL (1) IL175875A0 (sr)
PL (1) PL1747220T3 (sr)
PT (1) PT1747220E (sr)
RS (1) RS50823B (sr)
SI (1) SI1747220T1 (sr)
TW (1) TW200530234A (sr)
WO (1) WO2005061498A1 (sr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2629B1 (en) * 2004-08-19 2012-06-24 افينتيس فارما سوتيكالز انك Branched carboxylic acid amides containing thienobirol, carboxylic acid amides containing pyrolithiazole, and the like as kinase inhibitors casein epsilon
SI1791537T1 (sl) * 2004-08-19 2010-02-26 Aventis Pharma Inc 3-ariltioindol-2-karboksamidni derivati in njihovi analogi kot inhibitorji kazein-kinaze I
JO2724B1 (en) 2004-08-19 2013-09-15 افينتس فارماسوتيكالز انك 3-Alternative-5 -6-Amino Alkyl Indole-2-Carboxyl Acid Amide and Related Isotopes as Casein Kinase Inhibitors
CN101305010A (zh) * 2005-09-01 2008-11-12 阿雷生物药品公司 Raf抑制剂化合物及其用法
WO2007048065A2 (en) * 2005-10-21 2007-04-26 Exelixis, Inc. Pyrimidinones as casein kinase ii (ck2) modulators
FR2918061B1 (fr) 2007-06-28 2010-10-22 Sanofi Aventis Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
FR2918986B1 (fr) 2007-07-19 2009-09-04 Sanofi Aventis Sa Derives de 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]- pyridazine, leur preparation et leur application en therapeutique
FR2939134A1 (fr) 2008-12-01 2010-06-04 Sanofi Aventis Derives de 6-cycloamino-3-(1h-pyrrolo°2,3-b!pyridin-4-yl) imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique
FR2940285A1 (fr) 2008-12-19 2010-06-25 Sanofi Aventis Derives de 6-cycloamino-2-thienyl-3-(pyridin-4-yl)imidazo °1,2-b!-pyridazine et 6-cycloamino-2-furanyl-3- (pyridin-4-yl)imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique
FR2940284B1 (fr) 2008-12-19 2011-02-18 Sanofi Aventis Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique
FR2945289A1 (fr) 2009-05-11 2010-11-12 Sanofi Aventis Derives de 2-cycloamino-5-(pyridin-4-yl)imidazo°2,1-b! °1,3,4!thiadiazole, leur preparation et leur application en therapeutique
SI2493876T1 (sl) * 2009-10-28 2014-04-30 Pfizer Inc. Derivati imidazola kot inhibitorji kazein-kinaze
FR2960876B1 (fr) 2010-06-03 2012-07-27 Sanofi Aventis Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
WO2014111871A1 (en) 2013-01-17 2014-07-24 Aurigene Discovery Technologies Limited 4,5-dihydroisoxazole derivatives as nampt inhibitors
WO2014182033A1 (en) * 2013-05-08 2014-11-13 Yuhan Corporation Process for the preparation of pyrrolo[2,3-c]pyridine derivatives or pharmaceutically acceptable salts thereof
KR101657599B1 (ko) * 2013-05-20 2016-09-19 주식회사유한양행 피롤로[2,3-c]피리딘 유도체 또는 이의 약학적으로 허용가능한 염의 제조방법
UY35834A (es) * 2013-11-14 2015-05-29 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Piperazinas de pirazolo sustituido como inhibidores de caseína quinasa 1 delta y epsilon
CN104945313A (zh) * 2015-06-19 2015-09-30 洪帅金 一种2-甲基-3-溴吡啶的制备方法
CN104974082A (zh) * 2015-07-26 2015-10-14 陈吉美 一种2-甲基-4-溴吡啶的制备方法
CN105198802A (zh) * 2015-11-03 2015-12-30 江苏梦得电镀化学品有限公司 一种2-甲基-3-溴吡啶的制备方法
US10973820B2 (en) 2017-12-13 2021-04-13 Facio Intellectual Property B.V. Compounds for treatment of diseases related to DUX4 expression
TW202112368A (zh) 2019-06-13 2021-04-01 荷蘭商法西歐知識產權股份有限公司 用於治療有關dux4表現之疾病的抑制劑組合

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675332A (en) * 1984-12-10 1987-06-23 Warner-Lambert Company Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
US5527819A (en) 1991-09-06 1996-06-18 Merck & Co., Inc. Inhibitors of HIV reverse transcriptase
WO1994019321A1 (en) * 1993-02-24 1994-09-01 Merck & Co., Inc. Inhibitors of hiv reverse transcriptase
EP0763035A4 (en) 1994-06-09 1997-10-01 Smithkline Beecham Corp ENDOTHELIN RECEPTOR ANTAGONISTS
US5977134A (en) 1996-12-05 1999-11-02 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US6432989B1 (en) * 1999-08-27 2002-08-13 Pfizer Inc Use of CRF antagonists to treat circadian rhythm disorders
GEP20063814B (en) 2001-10-02 2006-05-10 Upjohn Co Azabicyclic-Substituted Fused-Heteroaryl Compounds for Treatment of DiseaseAzabicyclic-Substituted Fused-Heteroaryl Compounds for Treatment of Disease
AU2003220190A1 (en) 2002-03-13 2003-09-29 Pharmacia & Upjohn Company Llc Pyrazolo(1,5-a)pyridine derivatives as neurotransmitter modulators
AU2003226724A1 (en) * 2002-03-27 2003-10-08 Glaxo Group Limited Quinoline and aza-indole derivatives and their use as 5-ht6 ligands

Also Published As

Publication number Publication date
US7402672B2 (en) 2008-07-22
EP1747220B1 (en) 2009-04-15
ES2324871T3 (es) 2009-08-18
JP2007513950A (ja) 2007-05-31
PT1747220E (pt) 2009-07-08
PL1747220T3 (pl) 2009-09-30
WO2005061498A1 (en) 2005-07-07
DE602004020685D1 (de) 2009-05-28
CN1906194A (zh) 2007-01-31
HK1098742A1 (en) 2007-07-27
HRP20090380T1 (hr) 2009-08-31
US20080200496A1 (en) 2008-08-21
KR20060113754A (ko) 2006-11-02
RS50823B (sr) 2010-08-31
TW200530234A (en) 2005-09-16
BRPI0417520A (pt) 2007-03-06
US20050131012A1 (en) 2005-06-16
JP4691506B2 (ja) 2011-06-01
CN100439367C (zh) 2008-12-03
AU2004303826A1 (en) 2005-07-07
CA2549183A1 (en) 2005-07-07
IL175875A0 (en) 2006-10-05
ATE428711T1 (de) 2009-05-15
EP1747220A1 (en) 2007-01-31
SI1747220T1 (sl) 2009-08-31
US7626027B2 (en) 2009-12-01

Similar Documents

Publication Publication Date Title
HK1098742A1 (en) Substituted 1h-pyrrolo [3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase i epsilon
ATE390421T1 (de) Aminoheterocyclen als vr-1 antagonisten zur behandlung von schmerzen
DE602004007239D1 (de) 4-AMINOTHIENOÄ2,3-dÜ PYRIMIDIN -6-CARBONITRIL-DERIVATIVE ZUR VERWENDUNG ALS PDE7 INHIBITOREN
IL187438A0 (en) Pyrrolopyridine derivatives and pharmaceutical compositions containing the same
CY1109558T1 (el) Παραγωγα βενζο[d]αζεπινης για την θεραπεια νευρολογικων διαταραχων
ATE371656T1 (de) Heteroaryl-pyrimidinderivate als jak-inhibitoren
EA200600811A1 (ru) НОВЫЕ ПРОИЗВОДНЫЕ ТЕТРАГИДРОСПИРО {ПИПЕРИДИН-2,7'-ПИРРОЛО [3,2-b]ПИРИДИНА} И НОВЫЕ ПРОИЗВОДНЫЕ ИНДОЛА, ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ РАССТРОЙСТВ, СВЯЗАННЫХ С 5-HT-РЕЦЕПТОРОМ
NO20072795L (no) Pyrazol [1,5-a]pyrimidiner som er nyttige som inhibitorer av proteinkinaser
EA200300248A1 (ru) Бициклопиразолы, активные в качестве ингибиторов киназы, способ их получения и включающие их фармацевтические композиции
DE60314603D1 (de) Zusammensetzungen brauchbar als protein-kinase- inhibitoren
UY27755A1 (es) Nuevas composiciones farmacéuticas basadas en anticolinérgicos e inhibidores.
ATE466580T1 (de) Azolylaminoazine als proteinkinasehemmer
ATE468336T1 (de) Azolylaminoazine als proteinkinasehemmer
HK1096673A1 (en) Compositions useful as inhibitors of protein kinases
RS20050041A (en) Azaindole kinase inhibitors
ATE450530T1 (de) Zusammensetzungen zur verwendung als protein- kinase-inhibitoren
BG108207A (en) Cyclopropylindole derivatives as selective serotonin reuptake inhibitors
IS8175A (is) Píperasín afleiður og aðferðir við notkun þeirra
NO20052272L (no) CCR1-antagonister for behandling av blant annet demylinerene inflamasjonssykdom
GB0112348D0 (en) Compounds
PT828728E (pt) Di-hidrobenzofuranos de fenilo
JO2629B1 (en) Branched carboxylic acid amides containing thienobirol, carboxylic acid amides containing pyrolithiazole, and the like as kinase inhibitors casein epsilon
ATE367380T1 (de) Zur behandlung von zns-erkrankungen geeignete piperazinylchinolinderivate
TW200621711A (en) 3-substituted-5- and 6-aminoalkyl indole-2-carboxylic acid amides and related analogs as inhibitors of casein kinase I ε
NO20081818L (no) Arylsulfonylkromaner som 5-HT6-inhibitorer - indolylmaleimidderivater som protein kinaseinhibitorer