AR049276A1 - Compuestos carboxamidos opiodes y composiciones farmaceuticas que los contienen - Google Patents

Compuestos carboxamidos opiodes y composiciones farmaceuticas que los contienen

Info

Publication number
AR049276A1
AR049276A1 ARP050101970A ARP050101970A AR049276A1 AR 049276 A1 AR049276 A1 AR 049276A1 AR P050101970 A ARP050101970 A AR P050101970A AR P050101970 A ARP050101970 A AR P050101970A AR 049276 A1 AR049276 A1 AR 049276A1
Authority
AR
Argentina
Prior art keywords
group
lower alkyl
compounds
opiood
carboxamid
Prior art date
Application number
ARP050101970A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35064532&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR049276(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR049276A1 publication Critical patent/AR049276A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

La presente está dirigida a los compuestos carboxamidos opioides farmacéuticamente utiles como agentes para el tratamiento o la regulacion de un desorden en el sistema nervioso central. Reivindicacion 1: Una composicion que contiene un compuesto de la formula (1) donde: R1 y R2 se seleccionan independientemente del grupo que consta de H, alquilo inferior, y alquildiilo donde R1 y R2 se toman junto con los átomos a los cuales están ligados para formar un anillo monocíclico. R3 y R4; se seleccionan inependientemente el grupo que consta de H, alquilo inferior, y alquildiilo donde R3 y R4 se toman junto con los átomos a los cuales están ligados para formar un anillo monocíclico. Y es un sustituyente seleccionado del grupo que consta de alquilo inferior, alcoxi inferior, halogeno y trifluorometilo; y los enantiomeros, diasestereoisomeros, tautomeros, solvatos farmacéuticamente aceptables y sales de los mismos.
ARP050101970A 2004-05-14 2005-05-13 Compuestos carboxamidos opiodes y composiciones farmaceuticas que los contienen AR049276A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57129804P 2004-05-14 2004-05-14

Publications (1)

Publication Number Publication Date
AR049276A1 true AR049276A1 (es) 2006-07-12

Family

ID=35064532

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050101970A AR049276A1 (es) 2004-05-14 2005-05-13 Compuestos carboxamidos opiodes y composiciones farmaceuticas que los contienen

Country Status (22)

Country Link
US (2) US7244866B2 (es)
EP (1) EP1748978B1 (es)
JP (1) JP5420170B2 (es)
KR (1) KR101204751B1 (es)
CN (1) CN1984879B (es)
AR (1) AR049276A1 (es)
AU (1) AU2005245403B2 (es)
BR (1) BRPI0511137A (es)
CA (1) CA2566601C (es)
CR (1) CR8811A (es)
EA (1) EA013261B1 (es)
EC (1) ECSP067008A (es)
ES (1) ES2485867T3 (es)
HK (1) HK1101246A1 (es)
IL (1) IL179196A (es)
MX (1) MXPA06013270A (es)
NO (1) NO20065768L (es)
NZ (1) NZ551288A (es)
TW (1) TWI418345B (es)
UA (1) UA90432C2 (es)
WO (1) WO2005113486A1 (es)
ZA (1) ZA200610446B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA013261B1 (ru) * 2004-05-14 2010-04-30 Янссен Фармацевтика, Н.В. Опиоидные соединения, замещенные карбоксамидогруппой
US20060254029A1 (en) * 2005-05-11 2006-11-16 Conrad Swenson Pocket loss prevention device
CN103936605B (zh) * 2007-05-31 2017-09-01 赛诺维信制药公司 苯基取代的环烷胺作为一元胺再摄取抑制剂
EP3170395A1 (en) * 2009-03-19 2017-05-24 Alkermes Pharma Ireland Limited Morphinan derivatives with high oral bioavailability
US9119848B2 (en) * 2009-12-04 2015-09-01 Alkermes Pharma Ireland Limited Morphinan derivatives for the treatment of drug overdose
SI3446565T1 (sl) 2010-08-23 2024-03-29 Alkermes Pharma Ireland Limited Metode zdravljenja povečanja teže, povzročene z antipsihotiki
US9029543B2 (en) 2011-04-05 2015-05-12 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
LT3153171T (lt) 2011-12-15 2018-12-10 Alkermes Pharma Ireland Limited Samidorfanas (alks 33) derinyje su buprenorfinu, skirtas depresinių sutrikimų gydymui
WO2014190271A2 (en) 2013-05-24 2014-11-27 Alkermes Pharma Ireland Limted Methods for treating depressive symptoms
CA2911231C (en) 2013-05-24 2021-12-07 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
CN104940709A (zh) * 2015-07-22 2015-09-30 张秋英 一种镇痛麻醉喷雾剂
CN105055756A (zh) * 2015-09-18 2015-11-18 张秋英 一种阴部挫伤用镇痛气雾剂
CA3050515A1 (en) 2017-01-17 2018-07-26 Mebias Discovery, Inc. Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same
EP4243768A1 (en) 2020-11-12 2023-09-20 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0507863A4 (en) * 1989-12-28 1993-07-07 Virginia Commonwealth University Sigma receptor ligands and the use thereof
US6071970A (en) * 1993-02-08 2000-06-06 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
DE4426245A1 (de) * 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
ES2304477T3 (es) * 2000-10-31 2008-10-16 Rensselaer Polytechnic Institute Procedimiento de preparacion de compuestos con afinidad a receptores opioides.
DE10059413A1 (de) * 2000-11-30 2002-06-20 Gruenenthal Gmbh Verwendung von substituierten 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz
DE10146275A1 (de) * 2001-09-18 2003-04-24 Gruenenthal Gmbh Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz
WO2003048113A1 (en) 2001-11-30 2003-06-12 Sepracor Inc. Tramadol analogs and uses thereof
DE10213051B4 (de) 2002-03-23 2013-03-07 Grünenthal GmbH Substituierte 4-Aminocyclohexanole
AU2003275855B2 (en) * 2002-10-25 2009-04-23 Paladin Labs (Barbados) Inc. Sustained-release tramadol formulations with 24-hour efficacy
SI1725537T1 (sl) 2004-03-15 2011-11-30 Janssen Pharmaceutica Nv Nove spojine kot modulatorji opioidnih receptorjev
EA013261B1 (ru) * 2004-05-14 2010-04-30 Янссен Фармацевтика, Н.В. Опиоидные соединения, замещенные карбоксамидогруппой

Also Published As

Publication number Publication date
CN1984879B (zh) 2011-07-27
ECSP067008A (es) 2006-12-29
IL179196A0 (en) 2007-03-08
US20080280990A1 (en) 2008-11-13
EA013261B1 (ru) 2010-04-30
US7244866B2 (en) 2007-07-17
UA90432C2 (uk) 2010-04-26
NZ551288A (en) 2010-10-29
CA2566601A1 (en) 2005-12-01
ZA200610446B (en) 2008-07-30
AU2005245403A1 (en) 2005-12-01
TWI418345B (zh) 2013-12-11
BRPI0511137A (pt) 2007-11-27
WO2005113486A1 (en) 2005-12-01
CR8811A (es) 2009-01-14
US7745492B2 (en) 2010-06-29
AU2005245403B2 (en) 2012-04-19
CN1984879A (zh) 2007-06-20
EA200602115A1 (ru) 2007-04-27
KR101204751B1 (ko) 2012-11-27
TW200605871A (en) 2006-02-16
CA2566601C (en) 2013-04-09
NO20065768L (no) 2007-02-07
JP5420170B2 (ja) 2014-02-19
IL179196A (en) 2012-10-31
HK1101246A1 (en) 2007-10-12
JP2007537278A (ja) 2007-12-20
KR20070015613A (ko) 2007-02-05
EP1748978A1 (en) 2007-02-07
EP1748978B1 (en) 2014-06-04
US20050256203A1 (en) 2005-11-17
MXPA06013270A (es) 2007-04-23
ES2485867T3 (es) 2014-08-14

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