AR033379A1 - Compuestos de difenilurea, procedimiento para su preparacion y composiciones farmaceuticas que los contienen - Google Patents
Compuestos de difenilurea, procedimiento para su preparacion y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR033379A1 AR033379A1 ARP010103052A ARP010103052A AR033379A1 AR 033379 A1 AR033379 A1 AR 033379A1 AR P010103052 A ARP010103052 A AR P010103052A AR P010103052 A ARP010103052 A AR P010103052A AR 033379 A1 AR033379 A1 AR 033379A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- group
- alkyl
- ring
- attached
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Compuestos de difenilurea de formula (1) en la cual R1, R2, R3 y R4 representan independientemente un átomo de hidrogeno, un átomo de halogeno o un grupo alquilo, alcoxi, hidroxi, alquiltio, mercapto, ciano, amino (opcionalmente substituido por uno o dos grupos alquilo), nitro, carboxi, alcoxicarbonilo, aminocarbonilo (opcionalmente substituido por uno o dos grupos alquilo) o carbamoilo, o en pares, forman conjuntamente con los átomos de carbono a los cuales están unidos, un anillo fenilo o un heterociclo aromático que tiene entre 5 y 7 miembros de anillo y que contiene entre 1 y 3 heteroátomos seleccionados entre nitrogeno, oxígeno y azufre, L1 y L2 cada uno representa un átomo de hidrogeno o conjuntamente forman un grupo -CH2-CH2-, X1 adosado en la posicion 2 o 3 del anillo aromático, representa un enlace, y en ese caso X2 representa un átomo de hidrogeno, un átomo de halogeno, un grupo alquilo, alcoxi, hidroxi, nitro o ciano, o un grupo amino (opcionalmente substituido por uno o dos grupos alquilo), o, X1 y X2, conjuntamente con dos átomos de carbono adyacentes a los cuales están unidos en la posicion 2, 3 o 4 del anillo aromático, forman un grupo cicloalquilo (C4-7), en el cual uno o dos grupos -CH2- del anillo cicloalquilo están opcionalmente reemplazados por un átomo de oxígeno o un grupo NH (opcionalmente substituido por un grupo alquilo), y en el cual un átomo de carbono del anillo cicloalquilo está substituido por el grupo G, X3 representa un átomo de hidrogeno, un átomo de halogeno, un grupo alquilo, alcoxi, hidroxi, nitro o ciano, o un grupo amino (opcionalmente substituido por uno o dos grupos alquilo), G representa un grupo seleccionado entre las formulas G1, G2, G3 y G4 en las cuales: las líneas entrecortadas indican la presencia opcional de un enlace doble, Alk representa un grupo alquileno (C1-6) lineal o ramificado en el cual, cuando G1 o G2 contiene un grupo imidazolina, el grupo Alk- está adosado en la posicion 2 del anillo, n es 0 o 1, T3 representa un grupo alquilo, arilo opcionalmente substituido, arilalquilo opcionalmente substituido, heteroarilo opcionalmente substituido o heteroarilalquilo opcionalmente substituido, T4 representa un grupo alquilo, arilo opcionalmente substituido, arilalquilo opcionalmente substituido, heteroarilo opcionalmente substituido o heteroarilalquilo opcionalmente substituido, enantiomeros y diastereoisomeros de los mismos, y también las sales de adicion de los mismos con un ácido o una base farmacéuticamente aceptable. Procedimiento para su preparacion y composiciones farmacéuticas que los contienen. Los compuestos son utiles como ligandos a2/5-HT2c mixtos y en consecuencia, son utiles en el tratamiento de la depresion, ansiedad, esquizofrenia, enfermedad de Parkinson, alteraciones cognitivas, alteraciones de la libido y disfuncion sexual, alteraciones del sueno, abuso de drogas, y alteraciones de comportamiento impulsivo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0008378A FR2810979B1 (fr) | 2000-06-29 | 2000-06-29 | Nouveaux derives de diphenyluree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
Publication Number | Publication Date |
---|---|
AR033379A1 true AR033379A1 (es) | 2003-12-17 |
Family
ID=8851854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010103052A AR033379A1 (es) | 2000-06-29 | 2001-06-27 | Compuestos de difenilurea, procedimiento para su preparacion y composiciones farmaceuticas que los contienen |
Country Status (24)
Country | Link |
---|---|
US (2) | US6784183B2 (es) |
EP (1) | EP1170288B9 (es) |
JP (1) | JP3933889B2 (es) |
KR (1) | KR100485018B1 (es) |
CN (1) | CN1241916C (es) |
AR (1) | AR033379A1 (es) |
AT (1) | ATE273283T1 (es) |
AU (1) | AU780022B2 (es) |
BR (1) | BR0102607A (es) |
CA (1) | CA2352405C (es) |
DE (1) | DE60104776T2 (es) |
DK (1) | DK1170288T3 (es) |
EA (1) | EA005128B1 (es) |
ES (1) | ES2227088T3 (es) |
FR (1) | FR2810979B1 (es) |
HK (1) | HK1042698B (es) |
HU (1) | HUP0102723A3 (es) |
NO (1) | NO320310B1 (es) |
NZ (1) | NZ512658A (es) |
PL (1) | PL348392A1 (es) |
PT (1) | PT1170288E (es) |
SI (1) | SI1170288T1 (es) |
TR (1) | TR200402069T4 (es) |
ZA (1) | ZA200105394B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10139416A1 (de) * | 2001-08-17 | 2003-03-06 | Aventis Pharma Gmbh | Aminoalkyl substituierte aromatische Bicyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
TW200306783A (en) * | 2002-04-29 | 2003-12-01 | Fmc Corp | Pesticidal heterocycles |
US20060229335A1 (en) * | 2002-12-24 | 2006-10-12 | Bradley Teegarden | Diarylamine and arylheteroarylamine pyrazole derivatives as modulators of 5ht2a |
EP1610753A4 (en) * | 2003-02-20 | 2007-07-04 | Encysive Pharmaceuticals Inc | UROTENSIN-II RECEPTOR ANTAGONISTS OF PHENYLENEDIAMINE AND ANTAGONISTS OF CCR-9 |
EP1558582B1 (en) * | 2003-07-22 | 2005-12-21 | Arena Pharmaceuticals, Inc. | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto |
FR2859723B1 (fr) * | 2003-09-16 | 2005-10-21 | Servier Lab | Nouveaux derives de benzoindoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
ATE521589T1 (de) | 2003-09-25 | 2011-09-15 | Dompe Spa | Amidine und derivate davon und pharmazeutische zusammensetzungen, die diese enthalten |
ATE548353T1 (de) * | 2004-03-23 | 2012-03-15 | Arena Pharm Inc | Verfahren zur herstellung von substituierte n- aryl-n'-ä3-(1h-pyrazol-5-yl)phenylü-harnstoffe and intermediate davon. |
SA05260357B1 (ar) * | 2004-11-19 | 2008-09-08 | ارينا فارماسيتو تيكالز ، أنك | مشتقات 3_فينيل_بيرازول كمعدلات لمستقبل سيروتينين 5_ht2a مفيدة في علاج الاضطرابات المتعلقه به |
WO2006060762A2 (en) * | 2004-12-03 | 2006-06-08 | Arena Pharmaceuticals, Inc. | Pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
ES2465469T3 (es) | 2005-01-14 | 2014-06-05 | Gilead Connecticut, Inc. | Diaril ureas 1,3-sustituidas como moduladores de la actividad quinasa |
US20080200530A1 (en) * | 2005-01-19 | 2008-08-21 | Unett David J | Diaryl and Arylheteroaryl Urea Derivatives as Modulators of 5-Ht2a Serotonin Receptor Useful for the Prophylaxis or Treatment of Progressive Multifocal Leukoencephalopathy |
WO2007024294A2 (en) | 2005-05-03 | 2007-03-01 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
WO2007136689A2 (en) | 2006-05-18 | 2007-11-29 | Arena Pharmaceuticals, Inc. | Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-ht2a serotonin receptor |
CA2646076C (en) | 2006-05-18 | 2015-06-30 | Arena Pharmaceuticals, Inc. | Ethers, secondary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
EP2018371B1 (en) | 2006-05-18 | 2015-03-04 | Arena Pharmaceuticals, Inc. | Primary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
CN100390150C (zh) * | 2006-06-05 | 2008-05-28 | 吴汝林 | 盐酸咪唑苯脲的制备方法 |
TWI415845B (zh) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與5-ht2a血清素受體相關聯病症之作為5-ht2a血清素受體之調節劑的吡唑衍生物 |
MX2009008777A (es) | 2007-02-13 | 2009-08-25 | Schering Corp | Derivados y analogos de cromano como agonistas de los receptores alfa2c adrenergicos funcionalmente selectivos. |
EP2398776A1 (en) | 2007-02-13 | 2011-12-28 | Schering Corporation | Functionally selective alpha2c adrenoreceptor agonists |
US9567327B2 (en) | 2007-08-15 | 2017-02-14 | Arena Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
US9034911B2 (en) | 2008-10-28 | 2015-05-19 | Arena Pharmaceuticals, Inc. | Composition of a 5-HT2A serotonin receptor modulator useful for the treatment of disorders related thereto |
WO2010062321A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto |
WO2011075596A1 (en) | 2009-12-18 | 2011-06-23 | Arena Pharmaceuticals, Inc. | Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
EA031470B1 (ru) * | 2013-03-15 | 2019-01-31 | Бристол-Майерс Сквибб Компани | Ингибиторы ido |
KR20180022792A (ko) | 2015-06-12 | 2018-03-06 | 엑소반트 사이언시즈 게엠베하 | 렘 수면 행동 장애의 예방 및 치료에 유용한 디아릴 및 아릴헤테로아릴 우레아 유도체 |
CN108472285A (zh) | 2015-07-15 | 2018-08-31 | 阿速万科学有限责任公司 | 用于预防和治疗与神经退行性疾病相关联的幻觉的二芳基和芳基杂芳基脲衍生物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1981000543A1 (en) * | 1979-08-23 | 1981-03-05 | Caterpillar Tractor Co | Track assembly anti-torsion chains and method |
GB9313913D0 (en) * | 1993-07-06 | 1993-08-18 | Smithkline Beecham Plc | Novel compounds |
WO1995006044A1 (en) * | 1993-08-20 | 1995-03-02 | Smithkline Beecham Plc | Amide and urea derivatives as 5ht1d receptor antagonists |
GB9420999D0 (en) * | 1994-10-18 | 1994-12-07 | Smithkline Beecham Plc | Novel compounds |
JP2001508767A (ja) * | 1996-12-02 | 2001-07-03 | 藤沢薬品工業株式会社 | 5―ht拮抗作用を有するインドール―ウレア誘導体 |
EP0975614A1 (en) * | 1997-04-18 | 2000-02-02 | Smithkline Beecham Plc | A bicyclic aryl or a bicyclic heterocyclic ring containing compounds having a combined 5ht1a, 5ht1b and 5ht1d receptor antagonistic activity |
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2000
- 2000-06-29 FR FR0008378A patent/FR2810979B1/fr not_active Expired - Fee Related
-
2001
- 2001-06-27 AR ARP010103052A patent/AR033379A1/es active IP Right Grant
- 2001-06-27 KR KR10-2001-0036983A patent/KR100485018B1/ko not_active IP Right Cessation
- 2001-06-28 EA EA200100600A patent/EA005128B1/ru not_active IP Right Cessation
- 2001-06-28 JP JP2001195947A patent/JP3933889B2/ja not_active Expired - Fee Related
- 2001-06-28 NZ NZ512658A patent/NZ512658A/xx unknown
- 2001-06-28 NO NO20013254A patent/NO320310B1/no not_active IP Right Cessation
- 2001-06-29 PT PT01401712T patent/PT1170288E/pt unknown
- 2001-06-29 AU AU54144/01A patent/AU780022B2/en not_active Ceased
- 2001-06-29 PL PL01348392A patent/PL348392A1/xx not_active Application Discontinuation
- 2001-06-29 BR BR0102607-0A patent/BR0102607A/pt not_active Application Discontinuation
- 2001-06-29 EP EP01401712A patent/EP1170288B9/fr not_active Expired - Lifetime
- 2001-06-29 CA CA002352405A patent/CA2352405C/fr not_active Expired - Fee Related
- 2001-06-29 AT AT01401712T patent/ATE273283T1/de not_active IP Right Cessation
- 2001-06-29 HU HU0102723A patent/HUP0102723A3/hu unknown
- 2001-06-29 DK DK01401712T patent/DK1170288T3/da active
- 2001-06-29 TR TR2004/02069T patent/TR200402069T4/xx unknown
- 2001-06-29 US US09/896,278 patent/US6784183B2/en not_active Expired - Fee Related
- 2001-06-29 SI SI200130180T patent/SI1170288T1/ unknown
- 2001-06-29 DE DE60104776T patent/DE60104776T2/de not_active Expired - Lifetime
- 2001-06-29 CN CNB011232757A patent/CN1241916C/zh not_active Expired - Fee Related
- 2001-06-29 ES ES01401712T patent/ES2227088T3/es not_active Expired - Lifetime
- 2001-06-29 ZA ZA200105394A patent/ZA200105394B/xx unknown
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2002
- 2002-05-31 HK HK02104086.5A patent/HK1042698B/zh not_active IP Right Cessation
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2004
- 2004-06-07 US US10/862,546 patent/US7026357B2/en not_active Expired - Fee Related
Also Published As
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Publication | Publication Date | Title |
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