ES2485867T3 - Compuestos opioides de carboxamido - Google Patents
Compuestos opioides de carboxamido Download PDFInfo
- Publication number
- ES2485867T3 ES2485867T3 ES05757373.5T ES05757373T ES2485867T3 ES 2485867 T3 ES2485867 T3 ES 2485867T3 ES 05757373 T ES05757373 T ES 05757373T ES 2485867 T3 ES2485867 T3 ES 2485867T3
- Authority
- ES
- Spain
- Prior art keywords
- opioid
- alkyl
- hydrogen
- carboxamide compounds
- alkyldiyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
Un compuesto de la Fórmula (I)**Fórmula** donde: R1 y R2 se seleccionan independientemente del grupo consistente en hidrógeno, C1-4 alquilo y alquildiil donde R1 y R2 se toman junto con los átomos a los que están unidos para formar un anillo monocíclico; R3 y R4 se seleccionan independientemente del grupo consistente en hidrógeno, C1-4 alquilo, C3-7 cicloalquilo y alquildiil donde R3 y R4 se toman junto con los átomos a los que están unidos para formar un anillo monocíclico; Y es hidrógeno, C1-4 alquilo, C1-4 alcoxi, halógeno o trifluorometilo; y enantiómeros, diastereómeros, tautómeros, solvatos y sales de los mismos farmacéuticamente aceptables.
Description
Claims (1)
-
imagen1 imagen2
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57129804P | 2004-05-14 | 2004-05-14 | |
US571298P | 2004-05-14 | ||
PCT/US2005/016581 WO2005113486A1 (en) | 2004-05-14 | 2005-05-11 | Carboxamido opioid compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2485867T3 true ES2485867T3 (es) | 2014-08-14 |
Family
ID=35064532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES05757373.5T Active ES2485867T3 (es) | 2004-05-14 | 2005-05-11 | Compuestos opioides de carboxamido |
Country Status (22)
Country | Link |
---|---|
US (2) | US7244866B2 (es) |
EP (1) | EP1748978B1 (es) |
JP (1) | JP5420170B2 (es) |
KR (1) | KR101204751B1 (es) |
CN (1) | CN1984879B (es) |
AR (1) | AR049276A1 (es) |
AU (1) | AU2005245403B2 (es) |
BR (1) | BRPI0511137A (es) |
CA (1) | CA2566601C (es) |
CR (1) | CR8811A (es) |
EA (1) | EA013261B1 (es) |
EC (1) | ECSP067008A (es) |
ES (1) | ES2485867T3 (es) |
HK (1) | HK1101246A1 (es) |
IL (1) | IL179196A (es) |
MX (1) | MXPA06013270A (es) |
NO (1) | NO20065768L (es) |
NZ (1) | NZ551288A (es) |
TW (1) | TWI418345B (es) |
UA (1) | UA90432C2 (es) |
WO (1) | WO2005113486A1 (es) |
ZA (1) | ZA200610446B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0511137A (pt) * | 2004-05-14 | 2007-11-27 | Janssen Pharmaceutica Nv | compostos opióides de carboxamido |
US20060254029A1 (en) * | 2005-05-11 | 2006-11-16 | Conrad Swenson | Pocket loss prevention device |
KR101581289B1 (ko) * | 2007-05-31 | 2015-12-31 | 세프라코 아이엔시. | 모노아민 재흡수 억제제로서 페닐 치환된 시클로알킬아민 |
CA2754984C (en) * | 2009-03-19 | 2018-06-26 | Alkermes, Inc. | Morphinan derivatives with high oral bioavailability |
HUE043963T2 (hu) * | 2009-12-04 | 2019-09-30 | Alkermes Pharma Ireland Ltd | Morfinán származékok gyógyszer-túladagolás kezelésére |
SI3446565T1 (sl) | 2010-08-23 | 2024-03-29 | Alkermes Pharma Ireland Limited | Metode zdravljenja povečanja teže, povzročene z antipsihotiki |
US9029543B2 (en) | 2011-04-05 | 2015-05-12 | Alkermes, Inc. | Process for the synthesis of quaternary amine compounds |
BR112014012409B8 (pt) | 2011-12-15 | 2022-09-13 | Alkermes Pharma Ireland Ltd | Composições de buprenorfina e antagonistas do receptor mu-opioide |
US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
WO2014190271A2 (en) | 2013-05-24 | 2014-11-27 | Alkermes Pharma Ireland Limted | Methods for treating depressive symptoms |
JP2016519161A (ja) | 2013-05-24 | 2016-06-30 | アルカームス ファーマ アイルランド リミテッド | モルファン及びモルフィナン類似物及び使用の方法 |
CN104940709A (zh) * | 2015-07-22 | 2015-09-30 | 张秋英 | 一种镇痛麻醉喷雾剂 |
CN105055756A (zh) * | 2015-09-18 | 2015-11-18 | 张秋英 | 一种阴部挫伤用镇痛气雾剂 |
EP3570838A4 (en) | 2017-01-17 | 2021-01-27 | Mebias Discovery, Inc. | SUBSTITUTED 3-DIALKYLAMINOMETHYL-PIPERIDINE-4-YL-BENZAMIDE AND METHOD FOR MANUFACTURING AND USING THEREOF |
EP4243768A1 (en) | 2020-11-12 | 2023-09-20 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0507863A4 (en) * | 1989-12-28 | 1993-07-07 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
US6071970A (en) * | 1993-02-08 | 2000-06-06 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
CA2426942C (en) * | 2000-10-31 | 2014-06-03 | Mark P. Wentland | 8-carboxamido-2,6-methano-3-benzazocines |
DE10059413A1 (de) * | 2000-11-30 | 2002-06-20 | Gruenenthal Gmbh | Verwendung von substituierten 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz |
DE10146275A1 (de) * | 2001-09-18 | 2003-04-24 | Gruenenthal Gmbh | Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz |
US6780891B2 (en) * | 2001-11-30 | 2004-08-24 | Sepracor Inc. | Tramadol analogs and uses thereof |
DE10213051B4 (de) | 2002-03-23 | 2013-03-07 | Grünenthal GmbH | Substituierte 4-Aminocyclohexanole |
UA84277C2 (ru) * | 2002-10-25 | 2008-10-10 | Лабофарм Инк. | Композиция трамадола с пролонгированным высвобождением с 24-часовым действием |
SI1725537T1 (sl) | 2004-03-15 | 2011-11-30 | Janssen Pharmaceutica Nv | Nove spojine kot modulatorji opioidnih receptorjev |
BRPI0511137A (pt) * | 2004-05-14 | 2007-11-27 | Janssen Pharmaceutica Nv | compostos opióides de carboxamido |
-
2005
- 2005-05-11 BR BRPI0511137-4A patent/BRPI0511137A/pt not_active IP Right Cessation
- 2005-05-11 CA CA2566601A patent/CA2566601C/en not_active Expired - Fee Related
- 2005-05-11 JP JP2007513340A patent/JP5420170B2/ja not_active Expired - Fee Related
- 2005-05-11 NZ NZ551288A patent/NZ551288A/en not_active IP Right Cessation
- 2005-05-11 EP EP05757373.5A patent/EP1748978B1/en active Active
- 2005-05-11 MX MXPA06013270A patent/MXPA06013270A/es active IP Right Grant
- 2005-05-11 ES ES05757373.5T patent/ES2485867T3/es active Active
- 2005-05-11 AU AU2005245403A patent/AU2005245403B2/en not_active Ceased
- 2005-05-11 EA EA200602115A patent/EA013261B1/ru not_active IP Right Cessation
- 2005-05-11 WO PCT/US2005/016581 patent/WO2005113486A1/en active Application Filing
- 2005-05-11 US US11/126,771 patent/US7244866B2/en active Active
- 2005-05-11 KR KR1020067026102A patent/KR101204751B1/ko active IP Right Grant
- 2005-05-11 CN CN2005800237355A patent/CN1984879B/zh not_active Expired - Fee Related
- 2005-05-13 TW TW094115467A patent/TWI418345B/zh not_active IP Right Cessation
- 2005-05-13 AR ARP050101970A patent/AR049276A1/es not_active Application Discontinuation
- 2005-11-05 UA UAA200612496A patent/UA90432C2/uk unknown
-
2006
- 2006-11-12 IL IL179196A patent/IL179196A/en not_active IP Right Cessation
- 2006-11-15 EC EC2006007008A patent/ECSP067008A/es unknown
- 2006-12-13 ZA ZA200610446A patent/ZA200610446B/en unknown
- 2006-12-13 CR CR8811A patent/CR8811A/es not_active Application Discontinuation
- 2006-12-14 NO NO20065768A patent/NO20065768L/no not_active Application Discontinuation
-
2007
- 2007-08-02 HK HK07108442.0A patent/HK1101246A1/xx not_active IP Right Cessation
-
2008
- 2008-07-30 US US12/182,462 patent/US7745492B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2005245403B2 (en) | 2012-04-19 |
ECSP067008A (es) | 2006-12-29 |
NZ551288A (en) | 2010-10-29 |
KR101204751B1 (ko) | 2012-11-27 |
MXPA06013270A (es) | 2007-04-23 |
IL179196A (en) | 2012-10-31 |
EP1748978A1 (en) | 2007-02-07 |
NO20065768L (no) | 2007-02-07 |
AU2005245403A1 (en) | 2005-12-01 |
BRPI0511137A (pt) | 2007-11-27 |
IL179196A0 (en) | 2007-03-08 |
EA013261B1 (ru) | 2010-04-30 |
UA90432C2 (uk) | 2010-04-26 |
JP2007537278A (ja) | 2007-12-20 |
US20050256203A1 (en) | 2005-11-17 |
US20080280990A1 (en) | 2008-11-13 |
US7745492B2 (en) | 2010-06-29 |
JP5420170B2 (ja) | 2014-02-19 |
US7244866B2 (en) | 2007-07-17 |
TW200605871A (en) | 2006-02-16 |
CN1984879B (zh) | 2011-07-27 |
EA200602115A1 (ru) | 2007-04-27 |
CN1984879A (zh) | 2007-06-20 |
TWI418345B (zh) | 2013-12-11 |
EP1748978B1 (en) | 2014-06-04 |
ZA200610446B (en) | 2008-07-30 |
CA2566601C (en) | 2013-04-09 |
AR049276A1 (es) | 2006-07-12 |
CR8811A (es) | 2009-01-14 |
CA2566601A1 (en) | 2005-12-01 |
HK1101246A1 (en) | 2007-10-12 |
WO2005113486A1 (en) | 2005-12-01 |
KR20070015613A (ko) | 2007-02-05 |
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