NO20092372L - Substituerte acetofenoner anvendelige som PDE4-inhibitorer - Google Patents

Substituerte acetofenoner anvendelige som PDE4-inhibitorer

Info

Publication number
NO20092372L
NO20092372L NO20092372A NO20092372A NO20092372L NO 20092372 L NO20092372 L NO 20092372L NO 20092372 A NO20092372 A NO 20092372A NO 20092372 A NO20092372 A NO 20092372A NO 20092372 L NO20092372 L NO 20092372L
Authority
NO
Norway
Prior art keywords
represent
independently
pde4 inhibitors
haloalkyl
hydroxyalkyl
Prior art date
Application number
NO20092372A
Other languages
English (en)
Inventor
Jakob Felding
Simon Feldbaek Nielsen
Original Assignee
Leo Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharma As filed Critical Leo Pharma As
Publication of NO20092372L publication Critical patent/NO20092372L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Den foreliggende oppfinnelsen relaterer seg til en forbindelse ifølge formel I I hvori X1, X2, X3, X4 og X5 uavhengig av hverandre representerer -CH- eller N; eller X3, X4 og X5 uavhengig av hverandre representerer -CH- eller N, og X1 og X2 uavhengig av hverandre representerer C eller N og danner del av en ytterligere 6-leddet aromatisk ring; R1 representerer hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, hydroksyalkyl, eller alkylkarbonyl, hvor alle eventuelt er substituert; R2 og R3 representerer uavhengig hydrogen,-CH2-C(O)NR-R', alkyl, cykloalkyl, alkenyl, cykloalkenyl, alkynyl, haloalkyl, hydroksyalkyl, heterocykloalkenyl, alkylaryl, alkylalkoksykarbonyl, alkylkarbonyloksy, eller alkoksyalkyl, hvor alle eventuelt er substituert; R11 representerer hydrogen, halogen, cyano, amino, alkoksy eller alkylamino, X1-X5 representerer -CH- eller N, inkludert N-oksider, enantiomerer og diastereomerer; og farmasøytisk akseptable salter, hydrater, eller solvater derav. Oppfinnelsen relaterer seg ytterligere til en prosess for fremstillingen av nevnte forbindelser, til nevnte forbindelser for anvendelse i terapi, til farmasøytiske sammensetninger omfattende nevnte forbindelser, til fremgangsmåter for å behandle sykdommer, f.eks. dermale sykdommer, med nevnte forbindelser, og for anvendelsen av nevnte forbindelser i fremstillingen av medikamenter.
NO20092372A 2006-12-22 2009-06-22 Substituerte acetofenoner anvendelige som PDE4-inhibitorer NO20092372L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87168906P 2006-12-22 2006-12-22
US94547007P 2007-06-21 2007-06-21
PCT/DK2007/000564 WO2008077404A1 (en) 2006-12-22 2007-12-21 Substituted acetophenones useful as pde4 inhibitors

Publications (1)

Publication Number Publication Date
NO20092372L true NO20092372L (no) 2009-07-14

Family

ID=39156588

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092372A NO20092372L (no) 2006-12-22 2009-06-22 Substituerte acetofenoner anvendelige som PDE4-inhibitorer

Country Status (24)

Country Link
US (3) US8148537B2 (no)
EP (1) EP2125736B1 (no)
JP (1) JP5342451B2 (no)
KR (1) KR101507717B1 (no)
AT (1) ATE503742T1 (no)
AU (1) AU2007336538B2 (no)
BR (1) BRPI0721113A2 (no)
CA (1) CA2673370C (no)
CR (1) CR10877A (no)
CY (1) CY1111596T1 (no)
DE (1) DE602007013617D1 (no)
DK (1) DK2125736T3 (no)
GT (1) GT200900172A (no)
HK (1) HK1135392A1 (no)
HR (1) HRP20110464T1 (no)
IL (1) IL199383A (no)
MX (1) MX2009006593A (no)
MY (1) MY146022A (no)
NO (1) NO20092372L (no)
NZ (1) NZ577863A (no)
PL (1) PL2125736T3 (no)
PT (1) PT2125736E (no)
RU (1) RU2493149C2 (no)
WO (1) WO2008077404A1 (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2452872T3 (es) 2009-12-22 2014-04-03 Leo Pharma A/S Composición farmacéutica que comprende una mezcla solvente y un derivado o análogo de vitamina D
CN102781425B (zh) 2009-12-22 2014-08-13 利奥制药有限公司 含有维生素d类似物以及溶剂和表面活性剂混合物的皮肤用组合物
WO2011076208A2 (en) 2009-12-22 2011-06-30 Leo Pharma A/S Calcipotriol monohydrate nanocrystals
CN102775345A (zh) * 2011-05-13 2012-11-14 上海特化医药科技有限公司 制备罗氟司特的方法及中间体
WO2014083099A1 (en) * 2012-11-30 2014-06-05 Leo Pharma A/S A method of inhibiting the expression of il-22 in activated t-cells
WO2014096018A1 (en) * 2012-12-19 2014-06-26 Leo Pharma A/S Methods for the preparation of substituted acetophenones
CN114621139A (zh) 2013-10-22 2022-06-14 奇斯药制品公司 用于制备pde4抑制剂的方法
RU2697251C2 (ru) 2014-06-23 2019-08-13 Лео Фарма А/С Способы получения 1, 3-бензодиоксольных гетероциклических соединений
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
PL3390407T3 (pl) 2015-12-18 2024-01-29 UNION therapeutics A/S Sposoby otrzymywania heterocyklicznych związków 1,3-benzodioksolu
KR101702648B1 (ko) * 2016-05-10 2017-02-03 주식회사 엑티브온 피부 외용제용 보존제, 이를 포함하는 화장료 조성물 및 약학 조성물
AU2018286964B2 (en) 2017-06-20 2022-04-14 UNION therapeutics A/S Methods for the preparation of 1,3-benzodioxole heterocyclic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW263495B (no) * 1992-12-23 1995-11-21 Celltech Ltd
GB9401460D0 (en) * 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
DK0771794T3 (da) * 1995-05-19 2006-09-11 Kyowa Hakko Kogyo Kk Oxygenholdige heterocykliske forbindelser
US6514996B2 (en) * 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
EP0943613A4 (en) 1996-11-19 2002-07-10 Kyowa Hakko Kogyo Kk HETEROCYCLIC COMPOUNDS CONTAINING OXYGEN
CN1761466A (zh) * 2003-03-17 2006-04-19 协和发酵工业株式会社 慢性皮肤疾病的治疗及/或预防剂
WO2006040645A1 (en) * 2004-10-11 2006-04-20 Ranbaxy Laboratories Limited N-(3,5-dichloropyridin-4-yl)-2,4,5-alkoxy and 2,3,4-alkoxy benzamide derivatives as pde-iv (phophodiesterase type-iv) inhibitors for the treatment of inflammatory diseases such as asthma
AU2006257863A1 (en) * 2005-06-10 2006-12-21 F. Hoffmann-La Roche Ag Trisubstituted amines as phosphodiesterase 4 inhibitors

Also Published As

Publication number Publication date
CY1111596T1 (el) 2015-10-07
ATE503742T1 (de) 2011-04-15
EP2125736B1 (en) 2011-03-30
AU2007336538A1 (en) 2008-07-03
MX2009006593A (es) 2009-07-02
US8148537B2 (en) 2012-04-03
GT200900172A (es) 2011-10-05
DE602007013617D1 (de) 2011-05-12
PT2125736E (pt) 2011-07-01
AU2007336538B2 (en) 2012-04-05
EP2125736A1 (en) 2009-12-02
PL2125736T3 (pl) 2011-09-30
US8497380B2 (en) 2013-07-30
WO2008077404A1 (en) 2008-07-03
IL199383A (en) 2015-02-26
CA2673370A1 (en) 2008-07-03
CA2673370C (en) 2015-11-17
CR10877A (es) 2009-07-10
BRPI0721113A2 (pt) 2014-10-07
HK1135392A1 (en) 2010-06-04
US8324394B2 (en) 2012-12-04
RU2009128191A (ru) 2011-01-27
US20130012716A1 (en) 2013-01-10
MY146022A (en) 2012-06-15
JP5342451B2 (ja) 2013-11-13
JP2010513334A (ja) 2010-04-30
HRP20110464T1 (hr) 2011-07-31
US20100035908A1 (en) 2010-02-11
US20120165539A1 (en) 2012-06-28
KR20090098990A (ko) 2009-09-18
DK2125736T3 (da) 2011-07-11
RU2493149C2 (ru) 2013-09-20
NZ577863A (en) 2012-04-27
KR101507717B1 (ko) 2015-04-08

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