CO6270328A2 - Derivados de pirrolo [2,3] pirimidina como inhibidores de proteinas quinasas b - Google Patents

Derivados de pirrolo [2,3] pirimidina como inhibidores de proteinas quinasas b

Info

Publication number
CO6270328A2
CO6270328A2 CO10054272A CO10054272A CO6270328A2 CO 6270328 A2 CO6270328 A2 CO 6270328A2 CO 10054272 A CO10054272 A CO 10054272A CO 10054272 A CO10054272 A CO 10054272A CO 6270328 A2 CO6270328 A2 CO 6270328A2
Authority
CO
Colombia
Prior art keywords
alkyl
bromo
fluoro
cyano
chloro
Prior art date
Application number
CO10054272A
Other languages
English (en)
Inventor
Paul D Johnson
Andrew Leach
Richard William Luke
Zbigniew Stanley Matusiak
Jeffrey Morris
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40251789&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6270328(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO6270328A2 publication Critical patent/CO6270328A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Abstract

1.- Un compuesto de Formula (I), o una sal farmacéuticamente aceptable del mismo:en la que: Y representa CH o N; Z1-Z2 representa un grupo seleccionado entre C(R6)CH, N=CH y C(R6)N; donde R6 representa hidrogeno, fluoro, cloro, bromo, ciano, metilo, etilo, difluorometilo, trifluorometilo o ciclopropilo; n es 0, 1 o 2; R1 representa alquilo C1-4, alquenilo C2-4, alquinilo C2-4, alcoxi C1-4, alcoxi C1-4 alquilo C1-4, fluoroalquilo C1-4, aminoalquilo C1-4, hidroxialquilo C1-4, ciano, cianoalquilo C1-4, cicloalquilo C3-5, -(CH2)pNHCOCH3, -(CH2)pNHSO2CH3, -(CH2)pNHCONH2, -(CH2)pNHCONR2R3, -(CH2)pNR2R3, -(CH2)pSO2NH2, -(CH2)pSO2NR2R3, -(CH2)pCONH2, -(CH2)pCONR2R3 o -(CH2)p-R7; donde p es 0, 1, 2 o 3; R2 representa hidrogeno o alquilo C1-3; R3 representa alquilo C1-3; y R7 representa fenilo; R7 representa un anillo heteroarilo monociclico de 5 o 6 miembros que comprende 1, 2 o 3 heteroatomos seleccionados de O, N o S; o R7 representa un anillo heterociclico de 4, 5 o 6 miembros monociclico que comprende 1, 2 o 3 heteroatomos seleccionados de O, N o S; en los que R7 esta opcionalmente sustituido con 1 o 2 sustituyentes seleccionados de alquilo C1-4, trifluorometilo, alcoxi C1-4, fluoro, cloro, bromo, y ciano; R4 representa hidrogeno, fluoro, cloro, bromo, ciano o trifluorometilo; y R5 representa hidrogeno, fluoro, cloro o bromo.
CO10054272A 2007-10-11 2010-05-06 Derivados de pirrolo [2,3] pirimidina como inhibidores de proteinas quinasas b CO6270328A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97919207P 2007-10-11 2007-10-11
US4786208P 2008-04-25 2008-04-25

Publications (1)

Publication Number Publication Date
CO6270328A2 true CO6270328A2 (es) 2011-04-20

Family

ID=40251789

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10054272A CO6270328A2 (es) 2007-10-11 2010-05-06 Derivados de pirrolo [2,3] pirimidina como inhibidores de proteinas quinasas b

Country Status (38)

Country Link
US (8) US8101623B2 (es)
EP (1) EP2201012B1 (es)
JP (2) JP4705695B2 (es)
KR (1) KR101494734B1 (es)
CN (1) CN101861321B (es)
AR (1) AR068846A1 (es)
AU (1) AU2008309383B2 (es)
BR (1) BRPI0818533B8 (es)
CA (1) CA2701057C (es)
CL (1) CL2008003023A1 (es)
CO (1) CO6270328A2 (es)
CR (1) CR11359A (es)
CU (1) CU23886B1 (es)
CY (1) CY1116929T1 (es)
DK (1) DK2201012T3 (es)
DO (1) DOP2010000103A (es)
EA (1) EA018512B1 (es)
ES (1) ES2522365T3 (es)
GT (1) GT201000082A (es)
HK (1) HK1143154A1 (es)
HN (1) HN2010000653A (es)
HR (1) HRP20140807T1 (es)
IL (1) IL204721A (es)
ME (1) ME01999B (es)
MX (1) MX2010003927A (es)
MY (1) MY150059A (es)
NI (1) NI201000050A (es)
NZ (1) NZ585261A (es)
PE (2) PE20090964A1 (es)
PL (1) PL2201012T3 (es)
PT (1) PT2201012E (es)
RS (1) RS53552B1 (es)
SA (1) SA08290625B1 (es)
SI (1) SI2201012T1 (es)
TW (1) TWI453021B (es)
UY (1) UY31384A1 (es)
WO (1) WO2009047563A1 (es)
ZA (1) ZA201002318B (es)

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CN101861321B (zh) 2007-10-11 2013-02-06 阿斯利康(瑞典)有限公司 作为蛋白激酶b抑制剂的吡咯并[2,3-d]嘧啶衍生物

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PE20090964A1 (es) 2009-08-15
DOP2010000103A (es) 2010-05-31
US20240109902A1 (en) 2024-04-04
KR20100101077A (ko) 2010-09-16
EA201000552A1 (ru) 2010-12-30
NZ585261A (en) 2011-10-28
HRP20140807T1 (hr) 2014-11-21
NI201000050A (es) 2011-12-22
BRPI0818533B8 (pt) 2021-05-25
US20150182531A1 (en) 2015-07-02
KR101494734B1 (ko) 2015-02-26
JP2011157364A (ja) 2011-08-18
GT201000082A (es) 2015-03-10
EP2201012A1 (en) 2010-06-30
US10654855B2 (en) 2020-05-19
CR11359A (es) 2010-07-15
CN101861321A (zh) 2010-10-13
BRPI0818533B1 (pt) 2020-12-01
US20220220116A1 (en) 2022-07-14
CA2701057A1 (en) 2009-04-16
PL2201012T3 (pl) 2014-11-28
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