NI201000050A - Derivados de pirrolo [2, 3-d] pirimidina como inhibidores de proteínas quinasas b. - Google Patents

Derivados de pirrolo [2, 3-d] pirimidina como inhibidores de proteínas quinasas b.

Info

Publication number
NI201000050A
NI201000050A NI201000050A NI201000050A NI201000050A NI 201000050 A NI201000050 A NI 201000050A NI 201000050 A NI201000050 A NI 201000050A NI 201000050 A NI201000050 A NI 201000050A NI 201000050 A NI201000050 A NI 201000050A
Authority
NI
Nicaragua
Prior art keywords
compounds
pirrolo
pyrimidine
inhibitors
derivatives
Prior art date
Application number
NI201000050A
Other languages
English (en)
Inventor
David Johnson Paul
Leach Andrew
William Arthur Luke Richard
Stanley Matusiak Zbigniew
James Morris Jeffrey
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40251789&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NI201000050(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NI201000050A publication Critical patent/NI201000050A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se refiere a un grupo novedoso de compuestos de Fórmula (I) o sus sales: en la que Y, Z1, Z2, R1, R4, R5 y n son como se han descrito en la memoria descriptiva , que pueden ser útiles en el tratamiento o prevención de una enfermedad o afección médica mediada por la proteína quinasa B (PKB) tal como cáncer. La inveción también se refiere a composiciones farmacéuticas que comprenden dichos compuestos, procedimientos de tratamiento de enfermedades mediadas por PKB usando dichos compuestos y procedimientos para preparar los compuestos de Fórmula (I).
NI201000050A 2007-10-11 2010-04-09 Derivados de pirrolo [2, 3-d] pirimidina como inhibidores de proteínas quinasas b. NI201000050A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97919207P 2007-10-11 2007-10-11
US4786208P 2008-04-25 2008-04-25

Publications (1)

Publication Number Publication Date
NI201000050A true NI201000050A (es) 2011-12-22

Family

ID=40251789

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201000050A NI201000050A (es) 2007-10-11 2010-04-09 Derivados de pirrolo [2, 3-d] pirimidina como inhibidores de proteínas quinasas b.

Country Status (38)

Country Link
US (8) US8101623B2 (es)
EP (1) EP2201012B1 (es)
JP (2) JP4705695B2 (es)
KR (1) KR101494734B1 (es)
CN (1) CN101861321B (es)
AR (1) AR068846A1 (es)
AU (1) AU2008309383B2 (es)
BR (1) BRPI0818533B8 (es)
CA (1) CA2701057C (es)
CL (1) CL2008003023A1 (es)
CO (1) CO6270328A2 (es)
CR (1) CR11359A (es)
CU (1) CU23886B1 (es)
CY (1) CY1116929T1 (es)
DK (1) DK2201012T3 (es)
DO (1) DOP2010000103A (es)
EA (1) EA018512B1 (es)
ES (1) ES2522365T3 (es)
GT (1) GT201000082A (es)
HK (1) HK1143154A1 (es)
HN (1) HN2010000653A (es)
HR (1) HRP20140807T1 (es)
IL (1) IL204721A (es)
ME (1) ME01999B (es)
MX (1) MX2010003927A (es)
MY (1) MY150059A (es)
NI (1) NI201000050A (es)
NZ (1) NZ585261A (es)
PE (2) PE20130152A1 (es)
PL (1) PL2201012T3 (es)
PT (1) PT2201012E (es)
RS (1) RS53552B1 (es)
SA (1) SA08290625B1 (es)
SI (1) SI2201012T1 (es)
TW (1) TWI453021B (es)
UY (1) UY31384A1 (es)
WO (1) WO2009047563A1 (es)
ZA (1) ZA201002318B (es)

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Also Published As

Publication number Publication date
CN101861321A (zh) 2010-10-13
EA201000552A1 (ru) 2010-12-30
CU20100062A7 (es) 2011-10-05
US9492453B2 (en) 2016-11-15
US20180312516A1 (en) 2018-11-01
CU23886B1 (es) 2013-04-19
CN101861321B (zh) 2013-02-06
CA2701057A1 (en) 2009-04-16
ZA201002318B (en) 2012-09-26
PL2201012T3 (pl) 2014-11-28
US20240109902A1 (en) 2024-04-04
GT201000082A (es) 2015-03-10
AU2008309383A1 (en) 2009-04-16
KR101494734B1 (ko) 2015-02-26
CR11359A (es) 2010-07-15
BRPI0818533B8 (pt) 2021-05-25
JP2011500547A (ja) 2011-01-06
US20090163524A1 (en) 2009-06-25
MX2010003927A (es) 2010-04-30
US11236095B2 (en) 2022-02-01
US11760760B2 (en) 2023-09-19
CL2008003023A1 (es) 2009-11-27
US20200239483A1 (en) 2020-07-30
HRP20140807T1 (hr) 2014-11-21
HK1143154A1 (en) 2010-12-24
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