UY31812A - Derivados de cinolina como inhibidores de csf-1 - Google Patents

Derivados de cinolina como inhibidores de csf-1

Info

Publication number
UY31812A
UY31812A UY0001031812A UY31812A UY31812A UY 31812 A UY31812 A UY 31812A UY 0001031812 A UY0001031812 A UY 0001031812A UY 31812 A UY31812 A UY 31812A UY 31812 A UY31812 A UY 31812A
Authority
UY
Uruguay
Prior art keywords
csf
inhibitors
manufacture
chemical compounds
relates
Prior art date
Application number
UY0001031812A
Other languages
English (en)
Inventor
Kevin Daly
Scott David
Ye Qing
David Del Valle
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY31812A publication Critical patent/UY31812A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/28—Cinnolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a compuestos químicos de la fórmula (I): o sus sales farmacéuticamente aceptables, que poseen una actividad inhibitoria de la quinasa CSF-1R y por consiguiente son útiles por su actividad anti cancerígena y por lo tanto en métodos de tratamiento del cuerpo humano o animal. La invención se refiere también a procedimientos para la fabricación de dichos compuestos químicos, a las composiciones farmacéuticas que los contienen y a su uso en la fabricación de medicamentos utilizados en la producción de un efecto anti cancerígeno en un animal de sangre caliente como el hombre.
UY0001031812A 2008-05-07 2009-05-06 Derivados de cinolina como inhibidores de csf-1 UY31812A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5118808P 2008-05-07 2008-05-07
US8289108P 2008-07-23 2008-07-23

Publications (1)

Publication Number Publication Date
UY31812A true UY31812A (es) 2010-01-05

Family

ID=40894839

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001031812A UY31812A (es) 2008-05-07 2009-05-06 Derivados de cinolina como inhibidores de csf-1

Country Status (10)

Country Link
US (1) US20110190272A1 (es)
EP (1) EP2310375A1 (es)
JP (1) JP2011520804A (es)
CN (1) CN102089286A (es)
AR (1) AR071753A1 (es)
CL (1) CL2009001112A1 (es)
PE (1) PE20091848A1 (es)
TW (1) TW200948803A (es)
UY (1) UY31812A (es)
WO (1) WO2009136191A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011003191A (es) * 2008-10-14 2011-04-27 Actelion Pharmaceuticals Ltd Derivados de fenetilamida y sus analogos heterociclicos.
CN104370825B (zh) * 2014-09-29 2017-04-19 人福医药集团股份公司 作为激酶抑制剂的取代杂环化合物及其制备方法和用途
WO2016115013A1 (en) * 2015-01-12 2016-07-21 Janssen Pharmaceutica Nv Cinnoline derivatives useful as cb-1 receptor inverse agonists
WO2021144360A1 (en) * 2020-01-17 2021-07-22 F. Hoffmann-La Roche Ag Small molecule csf-1r inhibitors in therapeutic and cosmetic uses

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
DK273689A (da) * 1988-06-06 1989-12-07 Sanofi Sa 4-amino-3-carboxyquinoliner og -naphthyridiner, fremgangsmaade til deres fremstilling og anvendelse deraf i laegemidler
JPH04211661A (ja) * 1990-03-28 1992-08-03 Otsuka Pharmaceut Co Ltd キノリン誘導体及び該誘導体を含有する抗潰瘍剤
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
SE0101675D0 (sv) * 2001-05-11 2001-05-11 Astrazeneca Ab Novel composition
GB0322726D0 (en) * 2003-09-27 2003-10-29 Glaxo Group Ltd Compounds
WO2006124996A2 (en) * 2005-05-17 2006-11-23 Supergen, Inc. Inhibitors of polo-like kinase-1
PT2010496E (pt) * 2006-04-14 2010-10-13 Astrazeneca Ab 4-anilinoquinolina-3-carboxamidas como inibidores de csf-1r cinase
TW200829555A (en) * 2006-11-10 2008-07-16 Astrazeneca Ab Chemical compounds
CL2008000191A1 (es) * 2007-01-25 2008-08-22 Astrazeneca Ab Compuestos derivados de 4-amino-cinnotina-3-carboxamida; inhibidores de csf-1r quinasa; su proceso de preparacion; y su uso para tratar el cancer.
CA2712000A1 (en) * 2008-01-28 2009-08-06 Medimmune Limited Stabilized angiopoietin-2 antibodies and uses thereof

Also Published As

Publication number Publication date
TW200948803A (en) 2009-12-01
WO2009136191A1 (en) 2009-11-12
US20110190272A1 (en) 2011-08-04
AR071753A1 (es) 2010-07-14
JP2011520804A (ja) 2011-07-21
PE20091848A1 (es) 2010-01-08
CN102089286A (zh) 2011-06-08
CL2009001112A1 (es) 2010-03-05
EP2310375A1 (en) 2011-04-20

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Effective date: 20130123