CY1116929T1 - Παραγωγα πυρρολο[2,3-d]πυριμιδινης ως αναστολεις πρωτεϊνικης κινασης β - Google Patents

Παραγωγα πυρρολο[2,3-d]πυριμιδινης ως αναστολεις πρωτεϊνικης κινασης β

Info

Publication number
CY1116929T1
CY1116929T1 CY20141100689T CY141100689T CY1116929T1 CY 1116929 T1 CY1116929 T1 CY 1116929T1 CY 20141100689 T CY20141100689 T CY 20141100689T CY 141100689 T CY141100689 T CY 141100689T CY 1116929 T1 CY1116929 T1 CY 1116929T1
Authority
CY
Cyprus
Prior art keywords
protein kinase
compounds
pyrrolo
kinase inhibitors
pyrimidine derivatives
Prior art date
Application number
CY20141100689T
Other languages
English (en)
Inventor
Paul David Johnson
Andrew Leach
Richard William Arthur Luke
Zbigniew Stanley Matusiak
Jeffrey James Morris
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40251789&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1116929(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CY1116929T1 publication Critical patent/CY1116929T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Abstract

Η εφεύρεση σχετίζεται με μία νέα ομάδα χημικών ενώσεων του Τύπου (Ι) ή άλατα αυτών: όπου τα Υ, Ζ1, Ζ2, R1, R4, R5 και το n είναι, όπως περιγράφεται στην παρούσα προδιαγραφή, κάτι το οποίο θα μπορούσε να είναι χρήσιμο στην θεραπευτική αντιμετώπιση ή την πρόληψη μίας ασθένειας ή μίας ιατρικής πάθησης η οποία διαμεσολαβείται μέσω της πρωτεϊνικής κινάσης Β (ΡΚΒ), όπως είναι ο καρκίνος. Η εφεύρεση σχετίζεται, επίσης, με φαρμακευτικές συνθέσεις οι οποίες περιλαμβάνουν τις εν λόγω χημικές ενώσεις, μεθόδους της θεραπευτικής αντιμετώπισης των ασθενειών οι οποίες διαμεσολαβούνται μέσω ΡΚΒ με την χρήση των εν λόγω χημικών ενώσεων και με μεθόδους για την παρασκευή των χημικών ενώσεων του Τύπου (Ι).
CY20141100689T 2007-10-11 2014-08-28 Παραγωγα πυρρολο[2,3-d]πυριμιδινης ως αναστολεις πρωτεϊνικης κινασης β CY1116929T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97919207P 2007-10-11 2007-10-11
US4786208P 2008-04-25 2008-04-25
EP08806741.8A EP2201012B1 (en) 2007-10-11 2008-10-09 Pyrrolo[2,3-d]pyrimidin derivatives as protein kinase b inhibitors

Publications (1)

Publication Number Publication Date
CY1116929T1 true CY1116929T1 (el) 2017-04-05

Family

ID=40251789

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100689T CY1116929T1 (el) 2007-10-11 2014-08-28 Παραγωγα πυρρολο[2,3-d]πυριμιδινης ως αναστολεις πρωτεϊνικης κινασης β

Country Status (38)

Country Link
US (8) US8101623B2 (el)
EP (1) EP2201012B1 (el)
JP (2) JP4705695B2 (el)
KR (1) KR101494734B1 (el)
CN (1) CN101861321B (el)
AR (1) AR068846A1 (el)
AU (1) AU2008309383B2 (el)
BR (1) BRPI0818533B8 (el)
CA (1) CA2701057C (el)
CL (1) CL2008003023A1 (el)
CO (1) CO6270328A2 (el)
CR (1) CR11359A (el)
CU (1) CU23886B1 (el)
CY (1) CY1116929T1 (el)
DK (1) DK2201012T3 (el)
DO (1) DOP2010000103A (el)
EA (1) EA018512B1 (el)
ES (1) ES2522365T3 (el)
GT (1) GT201000082A (el)
HK (1) HK1143154A1 (el)
HN (1) HN2010000653A (el)
HR (1) HRP20140807T1 (el)
IL (1) IL204721A (el)
ME (1) ME01999B (el)
MX (1) MX2010003927A (el)
MY (1) MY150059A (el)
NI (1) NI201000050A (el)
NZ (1) NZ585261A (el)
PE (2) PE20090964A1 (el)
PL (1) PL2201012T3 (el)
PT (1) PT2201012E (el)
RS (1) RS53552B1 (el)
SA (1) SA08290625B1 (el)
SI (1) SI2201012T1 (el)
TW (1) TWI453021B (el)
UY (1) UY31384A1 (el)
WO (1) WO2009047563A1 (el)
ZA (1) ZA201002318B (el)

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HN2010000653A (es) 2013-03-18
CU23886B1 (es) 2013-04-19
SI2201012T1 (sl) 2014-10-30
US20170057969A1 (en) 2017-03-02
CO6270328A2 (es) 2011-04-20
NI201000050A (es) 2011-12-22
DOP2010000103A (es) 2010-05-31
UY31384A1 (es) 2009-05-29
NZ585261A (en) 2011-10-28
US10059714B2 (en) 2018-08-28
PT2201012E (pt) 2014-09-04
TWI453021B (zh) 2014-09-21
CA2701057A1 (en) 2009-04-16
CL2008003023A1 (es) 2009-11-27
US20150182531A1 (en) 2015-07-02
BRPI0818533B1 (pt) 2020-12-01
KR101494734B1 (ko) 2015-02-26
US8101623B2 (en) 2012-01-24
AU2008309383B2 (en) 2012-04-19
HRP20140807T1 (hr) 2014-11-21
JP2011157364A (ja) 2011-08-18
US20090163524A1 (en) 2009-06-25
CN101861321B (zh) 2013-02-06
TW200927128A (en) 2009-07-01
PL2201012T3 (pl) 2014-11-28
IL204721A (en) 2013-10-31
PE20130152A1 (es) 2013-03-17
MY150059A (en) 2013-11-29
JP2011500547A (ja) 2011-01-06
IL204721A0 (en) 2010-11-30
AU2008309383A1 (en) 2009-04-16
US20200239483A1 (en) 2020-07-30
US20220220116A1 (en) 2022-07-14
CN101861321A (zh) 2010-10-13
CU20100062A7 (es) 2011-10-05
US9492453B2 (en) 2016-11-15
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BRPI0818533A2 (pt) 2017-06-06
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US10654855B2 (en) 2020-05-19
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US11760760B2 (en) 2023-09-19
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