UY32829A - Derivados de 3-heteroaril-metil-imidazo-[1,2-b]-pirididazin - 6 -ilo - Google Patents

Derivados de 3-heteroaril-metil-imidazo-[1,2-b]-pirididazin - 6 -ilo

Info

Publication number
UY32829A
UY32829A UY0001032829A UY32829A UY32829A UY 32829 A UY32829 A UY 32829A UY 0001032829 A UY0001032829 A UY 0001032829A UY 32829 A UY32829 A UY 32829A UY 32829 A UY32829 A UY 32829A
Authority
UY
Uruguay
Prior art keywords
formula
compound
pirididazin
heteroaril
metil
Prior art date
Application number
UY0001032829A
Other languages
English (en)
Inventor
Schoepfer Joseph
Mccarthy Clive
Furet Pascal
Stutz Stefan
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of UY32829A publication Critical patent/UY32829A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención se refiere a los compuestos de la fórmula (I), y a las sales de los mismos : en donde los sustituyentes son como se definen en la memoria descriptiva, a la aplicación de un compuesto de la fórmula (I) en un proceso para el tratamiento del cuerpo humano o animal, en particular con respecto a una enfermedad mediada por la cinasa de tirosina c-Met; al uso de un compuesto de la fórmula (1) para la elaboración de un medicamento para el tratamiento de estas enfermedades ; a composiciones farmacéuticas que comprenden un compuesto de la fórmula (I), opcionalmente en la presencia de un componente de combinación ; y a procesos para la preparación de un compuesto de la fórmula (I) .
UY0001032829A 2009-08-07 2010-08-05 Derivados de 3-heteroaril-metil-imidazo-[1,2-b]-pirididazin - 6 -ilo UY32829A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27375609P 2009-08-07 2009-08-07

Publications (1)

Publication Number Publication Date
UY32829A true UY32829A (es) 2011-03-31

Family

ID=42712662

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032829A UY32829A (es) 2009-08-07 2010-08-05 Derivados de 3-heteroaril-metil-imidazo-[1,2-b]-pirididazin - 6 -ilo

Country Status (15)

Country Link
US (1) US8389526B2 (es)
EP (1) EP2462143B1 (es)
JP (1) JP2013501037A (es)
KR (1) KR20120053030A (es)
CN (1) CN102482287B (es)
AR (1) AR077714A1 (es)
AU (1) AU2010280706A1 (es)
BR (1) BR112012002801A2 (es)
CA (1) CA2770248A1 (es)
ES (1) ES2426405T3 (es)
IN (1) IN2012DN00953A (es)
MX (1) MX2012001529A (es)
TW (1) TW201107332A (es)
UY (1) UY32829A (es)
WO (1) WO2011015652A1 (es)

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IN2012DN01453A (es) 2009-08-20 2015-06-05 Novartis Ag
CA2848809A1 (en) 2011-09-15 2013-03-21 Novartis Ag 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines as c-met tyrosine kinase
CN103958509B (zh) * 2011-09-15 2015-12-23 诺华股份有限公司 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物
BR112015010221B1 (pt) 2012-11-06 2022-09-13 Shanghai Fochon Pharmaceutical Co., Ltd. Inibidores de quinase alk, seus usos, composição farmacêutica, e método para fabricação de medicamento
JP2016510764A (ja) 2013-03-07 2016-04-11 カリフィア バイオ, インク.Califia Bio, Inc. 混合系キナーゼ阻害剤および治療法
CN109771642B (zh) 2017-11-13 2022-09-20 同济大学苏州研究院 c-MET激动型抗体及其用途
CN111226956B (zh) * 2019-11-26 2021-10-26 贵州医科大学 3,6-二取代咪唑[1,2-b]哒嗪类衍生物在制备抑制植物病原真菌杀菌剂中的应用

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EP2462143A1 (en) 2012-06-13
WO2011015652A1 (en) 2011-02-10
KR20120053030A (ko) 2012-05-24
CN102482287A (zh) 2012-05-30
ES2426405T3 (es) 2013-10-23
AR077714A1 (es) 2011-09-14
CN102482287B (zh) 2014-07-23
MX2012001529A (es) 2012-02-29
TW201107332A (en) 2011-03-01
AU2010280706A1 (en) 2012-02-09
JP2013501037A (ja) 2013-01-10
EP2462143B1 (en) 2013-05-29
BR112012002801A2 (pt) 2016-05-31
US8389526B2 (en) 2013-03-05

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