IN2012DN00953A - - Google Patents

Info

Publication number
IN2012DN00953A
IN2012DN00953A IN953DEN2012A IN2012DN00953A IN 2012DN00953 A IN2012DN00953 A IN 2012DN00953A IN 953DEN2012 A IN953DEN2012 A IN 953DEN2012A IN 2012DN00953 A IN2012DN00953 A IN 2012DN00953A
Authority
IN
India
Prior art keywords
formula
compound
treatment
medicament
substituents
Prior art date
Application number
Inventor
Pascal Furet
Clive Mccarthy
Joseph Schoepfer
Stefan Stutz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IN2012DN00953A publication Critical patent/IN2012DN00953A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to compounds of formula (I) and salts thereof, wherein the substituents are as defined in the specification, the application of a compound of formula (I) in a process for the treatment of the human or animal body, in particular with regard to C-Met tyrosine kinase mediated disease; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharamaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner; processes for the preparation of a compound of formula (I).
IN953DEN2012 2009-08-07 2010-08-06 IN2012DN00953A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27375609P 2009-08-07 2009-08-07
PCT/EP2010/061485 WO2011015652A1 (en) 2009-08-07 2010-08-06 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives as c-met tyrosine kinase modulators

Publications (1)

Publication Number Publication Date
IN2012DN00953A true IN2012DN00953A (en) 2015-04-10

Family

ID=42712662

Family Applications (1)

Application Number Title Priority Date Filing Date
IN953DEN2012 IN2012DN00953A (en) 2009-08-07 2010-08-06

Country Status (15)

Country Link
US (1) US8389526B2 (en)
EP (1) EP2462143B1 (en)
JP (1) JP2013501037A (en)
KR (1) KR20120053030A (en)
CN (1) CN102482287B (en)
AR (1) AR077714A1 (en)
AU (1) AU2010280706A1 (en)
BR (1) BR112012002801A2 (en)
CA (1) CA2770248A1 (en)
ES (1) ES2426405T3 (en)
IN (1) IN2012DN00953A (en)
MX (1) MX2012001529A (en)
TW (1) TW201107332A (en)
UY (1) UY32829A (en)
WO (1) WO2011015652A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5781510B2 (en) 2009-08-12 2015-09-24 ノバルティス アーゲー Heterocyclic hydrazone compounds and their use for the treatment of cancer and inflammation
WO2011020861A1 (en) 2009-08-20 2011-02-24 Novartis Ag Heterocyclic oxime compounds
CN103958509B (en) * 2011-09-15 2015-12-23 诺华股份有限公司 As 3-(quinoline-6-base sulfo-)-[1,2,4] triazolo [4,3-A] pyridine compounds that the 6-of tyrosine kinase inhibitor replaces
JP5957526B2 (en) 2011-09-15 2016-07-27 ノバルティス アーゲー 6-Substituted 3- (quinolin-6-ylthio)-[1,2,4] triazolo [4,3-A] pyrazine as tyrosine kinase
KR102156398B1 (en) 2012-11-06 2020-09-15 상하이 포천 파마슈티컬 씨오 엘티디 Alk kinase inhibitors
WO2014138692A1 (en) 2013-03-07 2014-09-12 Califia Bio, Inc. Mixed lineage kinase inhibitors and method of treatments
CN109771642B (en) * 2017-11-13 2022-09-20 同济大学苏州研究院 c-MET agonistic antibodies and uses thereof
CN111226956B (en) * 2019-11-26 2021-10-26 贵州医科大学 Application of 3, 6-disubstituted imidazo [1,2-b ] pyridazine derivative in preparation of bactericide for inhibiting plant pathogenic fungi

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