ATE300540T1 - Imidazopyridin-derivate - Google Patents

Imidazopyridin-derivate

Info

Publication number
ATE300540T1
ATE300540T1 AT01925980T AT01925980T ATE300540T1 AT E300540 T1 ATE300540 T1 AT E300540T1 AT 01925980 T AT01925980 T AT 01925980T AT 01925980 T AT01925980 T AT 01925980T AT E300540 T1 ATE300540 T1 AT E300540T1
Authority
AT
Austria
Prior art keywords
inhibiting activity
pi3k
medicaments
useful
imidazopyridine derivatives
Prior art date
Application number
AT01925980T
Other languages
English (en)
Inventor
Masahiko Hayakawa
Hiroyuki Kaizawa
Ken-Ichi Kawaguchi
Koyo Matsuda
Noriko Ishikawa
Tomonobu Koizumi
Mayumi Yamano
Minoru Okada
Mitsuaki Ohta
Original Assignee
Yamanouchi Pharma Co Ltd
Ludwig Inst Cancer Res
Imp Cancer Res Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd, Ludwig Inst Cancer Res, Imp Cancer Res Tech filed Critical Yamanouchi Pharma Co Ltd
Application granted granted Critical
Publication of ATE300540T1 publication Critical patent/ATE300540T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AT01925980T 2000-04-27 2001-04-26 Imidazopyridin-derivate ATE300540T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000128295 2000-04-27
PCT/JP2001/003649 WO2001083481A1 (fr) 2000-04-27 2001-04-26 Derives d'imidazopyridine

Publications (1)

Publication Number Publication Date
ATE300540T1 true ATE300540T1 (de) 2005-08-15

Family

ID=18637756

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01925980T ATE300540T1 (de) 2000-04-27 2001-04-26 Imidazopyridin-derivate

Country Status (11)

Country Link
EP (1) EP1277754B8 (de)
JP (1) JP3729343B2 (de)
KR (1) KR100830859B1 (de)
CN (2) CN1173975C (de)
AT (1) ATE300540T1 (de)
AU (1) AU2001252609A1 (de)
CA (1) CA2407573C (de)
DE (1) DE60112272T2 (de)
DK (1) DK1277754T3 (de)
ES (1) ES2244613T3 (de)
WO (1) WO2001083481A1 (de)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0100567D0 (sv) * 2001-02-20 2001-02-20 Astrazeneca Ab Compounds
AU2002364889A1 (en) * 2001-09-24 2003-06-10 University Of Aarhus Methods for diagnosis and treatment of diseases associated with altered expression of nrf2
DE60215864T2 (de) * 2001-11-30 2007-05-31 Qlt Inc., Vancouver Behandlung von okularen neovaskularen erkrankungen
AU2003211424A1 (en) 2002-03-01 2003-09-16 Yamanouchi Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic compound
AU2003255845A1 (en) * 2002-08-22 2004-03-11 Piramed Limited Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents
EP1664037A1 (de) * 2003-09-04 2006-06-07 Warner-Lambert Company Llc Halogensubstituierte benzo [b] thiophene mit pi3k-hemmender wirkung als therapeutische mittel
EP1709019B1 (de) * 2004-01-12 2007-08-08 Applied Research Systems ARS Holding N.V. Thiazolderivate und deren verwendung
US20090209577A1 (en) * 2004-08-18 2009-08-20 Pfizer Inc. Novel Triazolopyridine Compounds
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
RU2007119637A (ru) * 2004-10-28 2008-12-10 Айрм Ллк (Bm) Соединения и композиции в качестве модуляторов hedgehog-пути
WO2006049339A1 (ja) 2004-11-08 2006-05-11 Banyu Pharmaceutical Co., Ltd. 新規縮環イミダゾール誘導体
US7723336B2 (en) 2005-09-22 2010-05-25 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途
AU2007297754B2 (en) * 2006-09-18 2012-05-17 Vertex Pharmaceuticals Incorporated Heterocyclic inhibitors of c-MET and uses thereof
RU2009120388A (ru) * 2006-10-30 2010-12-10 Новартис АГ (CH) Имидазопиридазины в качестве ингибиторов липидкиназы
EP1972631A1 (de) * 2007-03-23 2008-09-24 Novartis AG Imidazopyridazine als PI3K-Lipidkinaseinhibitoren
CA2670636A1 (en) 2006-11-27 2008-06-05 H. Lundbeck A/S Heteroaryl amide derivatives
AR064106A1 (es) * 2006-12-05 2009-03-11 Bayer Schering Pharma Ag Derivados de 2,3-dihidroimidazo [1,2-c] quinazolina sustituida utiles para el tratamiento de enfermedades y trastornos hiper-proliferativos asociados con la angiogenesis
CN101502484B (zh) * 2006-12-26 2011-04-20 济南康泉医药科技有限公司 同载糖皮质激素和化疗药物的抗癌缓释剂
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
PE20090188A1 (es) 2007-03-15 2009-03-20 Novartis Ag Compuestos heterociclicos como moduladores de la senda de hedgehog
EP2137184B1 (de) 2007-04-03 2013-05-08 Array Biopharma, Inc. Imidazo[1,2-a]pyridinverbindungen als rezeptortyrosinkinasehemmer
EA200970931A1 (ru) 2007-04-10 2010-04-30 Х. Лундбекк А/С Аналоги гетероариламидов
WO2008130951A1 (en) * 2007-04-17 2008-10-30 Bristol-Myers Squibb Company Fused heterocyclic 11-beta-hydroxysteroid dehydrogenase type i inhibitors
MX2009012066A (es) * 2007-05-09 2009-11-19 Novartis Ag Imidazopirinas sustituidas como inhibidoras de cinasa de lipido p13k.
CN101765596B (zh) * 2007-05-18 2015-04-29 拜耳知识产权有限责任公司 用于治疗过增生症状和与血管生成有关疾病的缺氧诱导因子(hif)抑制剂
EP2062893A1 (de) * 2007-10-18 2009-05-27 Bayer Schering Pharma AG Fusionierte Imidazole zur Behandlung von Krebs
JP5327652B2 (ja) * 2007-08-14 2013-10-30 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 癌処理のための融合されたイミダゾール
PT2200985E (pt) 2007-09-14 2011-07-21 Ortho Mcneil Janssen Pharm 4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas
UA100126C2 (en) 2007-09-14 2012-11-26 Аддекс Фарма С.А. 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1, 4'] bipyridinyl-2'-ones
EP2060565A1 (de) 2007-11-16 2009-05-20 4Sc Ag Neue bifunktionelle Verbindungen die Proteinkinasen und Histonedeacetylasen hemmen
CA2706578A1 (en) * 2007-11-27 2009-06-04 Cellzome Limited Amino triazoles as pi3k inhibitors
CN101981033B (zh) 2008-02-06 2015-02-04 百时美施贵宝公司 用作激酶抑制剂的取代的咪唑并哒嗪化合物
WO2009106577A1 (en) 2008-02-28 2009-09-03 Novartis Ag Imidazo [1,2-b] pyridazine derivatives for the treatment of c-met tyrosine kinase mediated disease
WO2009126861A2 (en) 2008-04-11 2009-10-15 Bristol-Myers Squibb Company Triazolopyridine compounds useful as dgat1 inhibitors
US8324241B2 (en) 2008-04-11 2012-12-04 Bristol-Myers Squibb Company Triazolo compounds useful as DGAT1 inhibitors
WO2010009139A2 (en) 2008-07-14 2010-01-21 Gilead Colorado, Inc. Imidazolyl pyrimidine inhibitor compounds
WO2010009166A1 (en) 2008-07-14 2010-01-21 Gilead Colorado, Inc. Oxindolyl inhibitor compounds
NZ602832A (en) 2008-07-14 2014-04-30 Gilead Sciences Inc Fused heterocyclic hdac inhibitor compounds
WO2010007099A1 (en) * 2008-07-15 2010-01-21 Cellzome Limited 2-aminoimidazo[1,2-b]pyridazine derivatives as pi3k inhibitors
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
AU2009276699A1 (en) 2008-07-28 2010-02-04 Gilead Sciences, Inc. Cycloalkylidene and heterocycloalkylidene histone deacetylase inhibitor compounds
US8895550B2 (en) 2008-08-19 2014-11-25 Array Biopharma Inc. Triazolopyridine compounds as PIM kinase inhibitors
US8557809B2 (en) 2008-08-19 2013-10-15 Array Biopharma Inc. Triazolopyridine compounds as PIM kinase inhibitors
US8987251B2 (en) 2008-08-19 2015-03-24 Array Biopharma Inc. Triazolopyridine compounds as PIM kinase inhibitors
TWI496779B (zh) 2008-08-19 2015-08-21 Array Biopharma Inc 作為pim激酶抑制劑之三唑吡啶化合物
AU2009289784B2 (en) 2008-09-02 2012-03-22 Addex Pharma S.A. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
TWI491610B (zh) 2008-10-09 2015-07-11 必治妥美雅史谷比公司 作為激酶抑制劑之咪唑并嗒腈
BRPI0921333A2 (pt) 2008-11-28 2015-12-29 Addex Pharmaceuticals Sa derivados de indol e benzoxazina como moduladores de receptores de glutamato metabotrópicos
WO2010074586A1 (en) * 2008-12-23 2010-07-01 Pathway Therapeutics Limited Pyrazolo[1,5-a]pyridine and imidazo[1,2-a]pyridine derivatives and their use in cancer therapy
EP2417135A1 (de) 2009-04-07 2012-02-15 Schering Corporation Substituierte triazolopyridine und analoga davon
BRPI1010831A2 (pt) 2009-05-12 2016-04-05 Addex Pharmaceuticals Sa derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
KR101753826B1 (ko) 2009-05-12 2017-07-04 얀센 파마슈티칼즈, 인코포레이티드 1,2,4―트리아졸로[4,3―a]피리딘 유도체 및 신경정신 질환의 치료 또는 예방을 위한 이들의 용도
JP2012529514A (ja) 2009-06-08 2012-11-22 ギリアード サイエンシーズ, インコーポレイテッド シクロアルキルカルバメートベンズアミドアニリンhdac阻害剤化合物
MX2011013165A (es) 2009-06-08 2012-01-30 Gilead Sciences Inc Compuestos inhibidores de hdac de alcanoilamino-benzamida-anilina.
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
MX2012001838A (es) 2009-08-12 2012-02-29 Novartis Ag Compuestos de hidrazona heterociclico y sus usos para tratar cancer e inflamacion.
IN2012DN01453A (de) 2009-08-20 2015-06-05 Novartis Ag
EP2496578A4 (de) 2009-11-05 2013-08-21 Univ Notre Dame Du Lac Imidazo[1,2-a]pyridin-verbindungen, ihre synthese und verfahren zu ihrer verwendung
JP2013510137A (ja) * 2009-11-06 2013-03-21 ピラマル・ライフ・サイエンシーズ・リミテッド イミダゾピリジン誘導体
JP5774602B2 (ja) * 2009-12-30 2015-09-09 アークル インコーポレイテッド 置換されたイミダゾピリジニル−アミノピリジン化合物
CN102971326A (zh) 2010-04-28 2013-03-13 百时美施贵宝公司 咪唑并哒嗪化合物及其在癌症中的用途
TWI541243B (zh) 2010-09-10 2016-07-11 拜耳知識產權公司 經取代咪唑并嗒
AU2011328203B2 (en) 2010-11-08 2015-03-19 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
ES2536433T3 (es) 2010-11-08 2015-05-25 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
EP2649069B1 (de) 2010-11-08 2015-08-26 Janssen Pharmaceuticals, Inc. 1,2,4-triazol[4,3-a]pyridinderivate und ihre verwendung als positive allosterische mglur2-rezeptormodulatoren
WO2012068204A1 (en) * 2010-11-18 2012-05-24 Janssen Pharmaceutica Nv Fused heteroaryl inhibitors of pro-matrix metalloproteinase activation
WO2012087833A1 (en) 2010-12-22 2012-06-28 Abbott Laboratories Hepatitis c inhibitors and uses thereof
CN102030752A (zh) * 2011-01-06 2011-04-27 贵阳中医学院 一种制备化合物2-(咪唑并[1,2-a]吡啶-3-基)乙腈的方法
US9000186B2 (en) 2011-02-01 2015-04-07 Kyowa Hakko Kirin Co., Ltd. Ring-fused heterocyclic derivative
EP2678329B1 (de) 2011-02-25 2015-11-18 Array Biopharma Inc. Triazolopyridin verbindungen als pim kinase hemmer
ME02316B (me) 2011-04-07 2016-06-20 Bayer Ip Gmbh Imidazopiridazini kao inhibitori akt kinaze
WO2012156379A1 (en) * 2011-05-13 2012-11-22 Universität Zürich PIK3/P110α INHIBITORS FOR PREVENTION OF RESTENOSIS BY APPLICATION AS AN IMPLANT COATING
KR101274986B1 (ko) * 2011-07-27 2013-06-17 한국과학기술원 이미다조피리딘 유도체, 이를 포함하는 PI3K 및/또는 mTOR 저해제용 약학 조성물 및 PI3K 및/또는 mTOR과 연관된 질환 치료용 약학 조성물
TW201410677A (zh) 2012-07-31 2014-03-16 Kyowa Hakko Kirin Co Ltd 縮環雜環化合物
US8796305B2 (en) 2012-11-05 2014-08-05 Bayer Pharma Aktiengesellschaft Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use
US9624214B2 (en) 2012-11-05 2017-04-18 Bayer Pharma Aktiengesellschaft Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
US8778964B2 (en) 2012-11-05 2014-07-15 Bayer Pharma Aktiengesellschaft Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use
US9126998B2 (en) 2012-11-05 2015-09-08 Bayer Pharma AG Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
JP6056872B2 (ja) * 2012-11-30 2017-01-11 アステラス製薬株式会社 イミダゾピリジン化合物
MX2015010714A (es) 2013-02-19 2016-06-14 Pfizer Compuestos de azabencimidazol.
CN105339368B (zh) 2013-06-04 2017-08-15 拜耳制药股份公司 3‑芳基‑取代的咪唑并[1,2‑a]吡啶及其用途
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
HUE045610T2 (hu) 2014-01-21 2020-01-28 Janssen Pharmaceutica Nv 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait vagy ortosztérikus agonistáit tartalmazó kombinációk és alkalmazásuk
MX2016009471A (es) 2014-01-21 2016-10-13 Janssen Pharmaceutica Nv Combinaciones que comprenden agonistas ortostericos o moduladores alostericos positivos del receptor glutamatergico metabotropico de subtipo 2 y su uso.
US9493442B2 (en) 2014-02-13 2016-11-15 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
CR20200199A (es) 2014-02-13 2020-06-19 Incyte Corp CICLOPROPILAMINA COMO INHIBIDOR DE LA LSD1 (Divisional 2016-0396)
EP3105226B1 (de) 2014-02-13 2019-09-04 Incyte Corporation Cyclopropylamine als lsd1-hemmer
JP2017507140A (ja) 2014-02-19 2017-03-16 バイエル・ファルマ・アクティエンゲゼルシャフト 3−(ピリミジン−2−イル)イミダゾ[1,2−a]ピリジン
JP2017508810A (ja) 2014-03-21 2017-03-30 バイエル・ファルマ・アクティエンゲゼルシャフト シアノ置換イミダゾ[1,2−a]ピリジンカルボキサミドおよびその使用
JP6578298B2 (ja) * 2014-03-24 2019-09-18 アークル インコーポレイテッド 3−(3−(4−(1−アミノシクロブチル)フェニル)−5−フェニル−3h−イミダゾ[4,5−b]ピリジン−2−イル)ピリジン−2−アミンを調製する方法
HUE046150T2 (hu) * 2014-04-22 2020-02-28 Arqule Inc Helyettesített imidazopiridinil-amino-piridin vegyületek sói és polimorf formái
JP2017514898A (ja) 2014-05-02 2017-06-08 バイエル・ファルマ・アクティエンゲゼルシャフト 心血管疾患の治療のためのn−(2−アミノ−5−フルオロ−2−メチルペンチル)−8−[(2,6−ジフルオロベンジル)オキシ]−2−メチルイミダゾ[1,2−a]ピリジン−3−カルボキサミドの、並びにジ−及びトリフルオロ誘導体のエナンチオマー
WO2016007736A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyrazines as lsd1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
WO2016007727A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
WO2016007731A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyridines and imidazopyrazines as lsd1 inhibitors
JP6713982B2 (ja) 2014-07-24 2020-06-24 ファイザー・インク ピラゾロピリミジン化合物
MX2017001565A (es) 2014-08-06 2017-04-27 Pfizer Compuestos de imidazopiridazina.
JP2017536396A (ja) 2014-12-02 2017-12-07 バイエル・ファルマ・アクティエンゲゼルシャフト ヘテロアリール置換イミダゾ[1,2−a]ピリジンおよびその使用
AU2016243939B2 (en) 2015-04-03 2020-09-03 Incyte Holdings Corporation Heterocyclic compounds as LSD1 inhibitors
TWI765860B (zh) 2015-08-12 2022-06-01 美商英塞特公司 Lsd1抑制劑之鹽
WO2017049321A1 (en) 2015-09-17 2017-03-23 Miller Marvin J Benzyl amine-containing heterocyclic compounds and compositions useful against mycobacterial infection
GB201602527D0 (en) * 2016-02-12 2016-03-30 Glaxosmithkline Ip Dev Ltd Chemical compounds
WO2017181973A1 (zh) * 2016-04-20 2017-10-26 苏州苏领生物医药有限公司 五元杂环类化合物及其制备方法、药物组合物和用途
CN107304202A (zh) * 2016-04-20 2017-10-31 苏州苏领生物医药有限公司 五元杂环类化合物及其制备方法、药物组合物和用途
JP6999574B2 (ja) 2016-04-22 2022-01-18 インサイト・コーポレイション Lsd1阻害剤の製剤
WO2017197151A1 (en) 2016-05-11 2017-11-16 Emory University Phosphotidylinositol 3-kinase inhibitors
WO2018013430A2 (en) 2016-07-12 2018-01-18 Arisan Therapeutics Inc. Heterocyclic compounds for the treatment of arenavirus infection
WO2018184976A1 (de) 2017-04-05 2018-10-11 Bayer Pharma Aktiengesellschaft Substituierte imidazo[1,2-a]pyridincarboxamide und ihre verwendung
MA50440A (fr) 2017-10-24 2020-09-02 Bayer Ag Imidazopyridinamides substituées et leur utilisation
US10968200B2 (en) 2018-08-31 2021-04-06 Incyte Corporation Salts of an LSD1 inhibitor and processes for preparing the same
SG11202109786UA (en) 2019-03-19 2021-10-28 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic aza-benzothiophene and aza-benzofuran compounds
WO2020216669A1 (de) 2019-04-23 2020-10-29 Bayer Aktiengesellschaft Phenylsubstituierte imidazopyridinamide und ihre verwendung
KR20220161420A (ko) * 2020-04-27 2022-12-06 주식회사 오토텍바이오 Ubr 박스 도메인 리간드로의 화합물
WO2021242581A1 (en) 2020-05-29 2021-12-02 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic heterocyclic compounds
CN113135913B (zh) * 2021-04-28 2022-05-24 沈阳药科大学 3-取代基-6-吡啶类取代基-六元并五元杂环类衍生物及其制法与用途
CA3236894A1 (en) 2021-11-01 2023-05-04 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic pyrrolopyridazine compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735956A (en) * 1985-09-13 1988-04-05 Merck & Co., Inc. Certain 1,4-dihydro-2,6-di-lower hydrocarbyl-4-heterocyclic-3,5-pyridine dicarboxylates which are useful as calcium channel blockers
JP2782823B2 (ja) * 1989-08-21 1998-08-06 吉富製薬株式会社 ニコチン酸アミド化合物
IL96432A0 (en) * 1989-11-30 1991-08-16 Schering Ag Pesticidal compositions containing pyridine derivatives and novel pyridine derivatives
AU5348396A (en) * 1995-05-01 1996-11-21 Fujisawa Pharmaceutical Co., Ltd. Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivati ves and their use as bone resorption inhibitors
GB9927687D0 (en) * 1999-11-23 2000-01-19 Merck Sharp & Dohme Therapeutic agents
ES2317889T3 (es) * 2000-03-01 2009-05-01 Janssen Pharmaceutica Nv Derivados de tiazolilo 2,4-disustituido.
DE10038019A1 (de) * 2000-08-04 2002-02-14 Bayer Ag Substituierte Triazolopyrid(az)ine
WO2002034748A1 (en) * 2000-10-24 2002-05-02 Sankyo Company, Limited Imidazopyridine derivatives

Also Published As

Publication number Publication date
CN1308327C (zh) 2007-04-04
EP1277754B1 (de) 2005-07-27
WO2001083481A1 (fr) 2001-11-08
JP3729343B2 (ja) 2005-12-21
KR100830859B1 (ko) 2008-05-21
AU2001252609A1 (en) 2001-11-12
CN1600783A (zh) 2005-03-30
CA2407573A1 (en) 2001-11-08
DK1277754T3 (da) 2005-11-14
CN1173975C (zh) 2004-11-03
CN1426413A (zh) 2003-06-25
EP1277754A1 (de) 2003-01-22
CA2407573C (en) 2011-09-13
EP1277754A4 (de) 2003-06-04
DE60112272T2 (de) 2006-05-24
ES2244613T3 (es) 2005-12-16
KR20030014206A (ko) 2003-02-15
EP1277754B8 (de) 2005-09-28
DE60112272D1 (de) 2005-09-01

Similar Documents

Publication Publication Date Title
ATE300540T1 (de) Imidazopyridin-derivate
DE60144322D1 (de) Kondensierte heteroarylderivate
NL300927I1 (nl) tivozanib of een zout of hydraat ervan, in het bijzonder het hydrochloride-monohydraat
TR200201505T2 (tr) Terapötik maddeler olarak pirazolopirimidinler
GB9801690D0 (en) Therapeutic agents
MXPA03011039A (es) Nuevos compuestos heterociclicos, su preparacion y uso como medicamentos, particularmente como agentes anti-bacterianos.
SE0202463D0 (sv) Novel compounds
BG106585A (en) Kinase inhibitors as therapeutic agents
ATE296826T1 (de) Pyrazolo(1,5)pyridinderivate
TR200200579T2 (tr) Amino-tirazolpiridin türevleri.
IL156873A0 (en) Pharmaceutically active piperidine derivatives
AU2002246728A1 (en) Carboline derivatives
HK1155146A1 (zh) 作為藥物活性劑的茚衍生物
ATE346067T1 (de) Carbolinderivate
NO20052866L (no) Imidazokinolinderivater som adenosin A3 reseptorligander
ATE300541T1 (de) Pyrazolopyridinderivate
TR200403436T2 (tr) Kristalin 1-metilkarbapenem türevleri.
DE60117847D1 (de) Farnesyltransferase hemmende, in der 4-stellung substituierte chinolin- und chinazolinderivate
DK1313740T3 (da) Prodrugs af imidazopyridinderivater
TR200001452T2 (tr) Bifenilamidin türevleri.
ATE480527T1 (de) Thiadiazolinderivate zur krebsbehandlung
CA2412596A1 (en) Cyclic gmp-specific phosphodiesterase inhibitors
TR200402546T4 (tr) Taksan türevleri hazırlamak için işlem.
ATE330958T1 (de) Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate
DE60105618D1 (de) Dihydroporphyrinderivate und ihre verwendung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties