UY31676A1 - "derivados de 3-metil-imidiazo-[1,2-b]-piridazina" - Google Patents
"derivados de 3-metil-imidiazo-[1,2-b]-piridazina"Info
- Publication number
- UY31676A1 UY31676A1 UY031676A UY31676A UY31676A1 UY 31676 A1 UY31676 A1 UY 31676A1 UY 031676 A UY031676 A UY 031676A UY 31676 A UY31676 A UY 31676A UY 31676 A1 UY31676 A1 UY 31676A1
- Authority
- UY
- Uruguay
- Prior art keywords
- compound
- imidiazo
- piridazina
- derivatives
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Compuestos de la fórmula (I) y sales de los mismos: en donde los sustituyentes son como se definen en la memoria descriptiva; aplicación de dicho compuesto en un proceso para el tratamiento del cuerpo humano o animal, en particular con respecto una enfermedad mediada por la cinasa de tirosina c-Met; uso de dicho compuesto para la fabricación de un medicamento para tratamiento de dichas enfermedades; composiciones farmacéuticas comprendiendo dicho compuesto , opcionalmente en la presencia de un componente de combinación; procesos para la preparación de un compuesto de la fórmula (I).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08152068 | 2008-02-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY31676A1 true UY31676A1 (es) | 2009-09-30 |
Family
ID=39672115
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY031676A UY31676A1 (es) | 2008-02-28 | 2009-02-26 | "derivados de 3-metil-imidiazo-[1,2-b]-piridazina" |
Country Status (25)
Country | Link |
---|---|
US (1) | US8822468B2 (es) |
EP (1) | EP2265614A1 (es) |
JP (1) | JP5576802B2 (es) |
KR (1) | KR20100128305A (es) |
CN (1) | CN102015716B (es) |
AR (1) | AR070487A1 (es) |
AU (1) | AU2009218459A1 (es) |
BR (1) | BRPI0908504A2 (es) |
CA (1) | CA2717034A1 (es) |
CL (1) | CL2009000443A1 (es) |
CO (1) | CO6300957A2 (es) |
CR (1) | CR11620A (es) |
DO (1) | DOP2010000263A (es) |
EA (1) | EA201001365A1 (es) |
EC (1) | ECSP10010427A (es) |
IL (1) | IL207434A0 (es) |
MA (1) | MA32167B1 (es) |
MX (1) | MX2010009414A (es) |
NI (1) | NI201000145A (es) |
PE (1) | PE20091468A1 (es) |
SM (1) | SMAP201000112A (es) |
TW (1) | TW200940545A (es) |
UY (1) | UY31676A1 (es) |
WO (1) | WO2009106577A1 (es) |
ZA (1) | ZA201005602B (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY32049A (es) | 2008-08-14 | 2010-03-26 | Takeda Pharmaceutical | Inhibidores de cmet |
US20110053968A1 (en) * | 2009-06-09 | 2011-03-03 | Auspex Pharmaceuticals, Inc. | Aminopyrimidine inhibitors of tyrosine kinase |
US8389526B2 (en) * | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
BR112012003262A8 (pt) | 2009-08-12 | 2016-05-17 | Novartis Ag | compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação |
CA2771432A1 (en) | 2009-08-20 | 2011-02-24 | Novartis Ag | Heterocyclic oxime compounds |
AU2010338712B2 (en) * | 2009-12-31 | 2015-04-02 | Hutchison Medipharma Limited | Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor |
US20110195066A1 (en) * | 2010-02-05 | 2011-08-11 | Auspex Pharmaceuticals, Inc. | Quinoline inhibitors of tyrosine kinase |
US20130315895A1 (en) * | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
AR085183A1 (es) | 2010-07-30 | 2013-09-18 | Lilly Co Eli | Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer |
UY33597A (es) | 2010-09-09 | 2012-04-30 | Irm Llc | Compuestos y composiciones como inhibidores de la trk |
JP5944497B2 (ja) * | 2011-06-22 | 2016-07-05 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | ヘテロシクリルアミノイミダゾピリダジン |
MX339302B (es) | 2011-09-15 | 2016-05-19 | Novartis Ag | 3-(quinolin-6-il-tio)-[1,2,4]-triazolo-[4,3-a]-piridinas 6-sustituidas como cinasas de tirosina. |
CN103958509B (zh) * | 2011-09-15 | 2015-12-23 | 诺华股份有限公司 | 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物 |
CN103122000B (zh) * | 2012-09-03 | 2013-12-25 | 中美冠科生物技术(太仓)有限公司 | 用作抗肿瘤药物的高选择性的c-Met激酶抑制剂 |
TWI600654B (zh) | 2012-11-19 | 2017-10-01 | 艾姆公司 | 用於治療寄生蟲疾病之化合物及組合物 |
CA2901427A1 (en) | 2013-03-07 | 2014-09-12 | Califia Bio, Inc. | Mixed lineage kinase inhibitors and method of treatments |
AR097543A1 (es) * | 2013-09-06 | 2016-03-23 | Lexicon Pharmaceuticals Inc | COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO |
CN105326793A (zh) * | 2014-08-06 | 2016-02-17 | 中美冠科生物技术(太仓)有限公司 | 一种包含c-Met激酶抑制剂的固体分散体及其制备方法和用途 |
CN107108634B (zh) * | 2014-12-19 | 2020-09-15 | 詹森药业有限公司 | 作为PI3Kβ抑制剂的咪唑并哒嗪衍生物 |
JP6586463B2 (ja) * | 2014-12-19 | 2019-10-02 | ヤンセン ファーマシューティカ エヌ.ベー. | PI3Kβ阻害剤としての複素環連結イミダゾピリダジン誘導体 |
US10669278B2 (en) | 2016-09-16 | 2020-06-02 | Helmholtz Zentrum Muenchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) | TRAF 6 inhibitors |
WO2018138050A1 (de) | 2017-01-26 | 2018-08-02 | Bayer Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
US11584744B2 (en) * | 2017-06-23 | 2023-02-21 | University Of Washington | Inhibitors of type 1 methionyl-tRNA synthetase and methods of using them |
US20230059009A1 (en) * | 2019-12-18 | 2023-02-23 | The Regents Of The University Of California | Inhibitors of lin28 and methods of use thereof |
Family Cites Families (39)
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US3489755A (en) * | 1966-08-03 | 1970-01-13 | Pfizer & Co C | Imidazo (1,2-b) pyridazines |
GB8719368D0 (en) * | 1987-08-15 | 1987-09-23 | Wellcome Found | Heterocyclic compounds |
FR2619818B1 (fr) * | 1987-09-01 | 1990-01-12 | Sanofi Sa | Imidazo (1,2-b) pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant |
CA2057089A1 (en) | 1990-12-07 | 1992-06-08 | Eric E. Allen | Substituted pyrazolopyrimidines and imidazopyridazines as angiotensin ii antagonists |
AU2001252609A1 (en) | 2000-04-27 | 2001-11-12 | Imperial Cancer Research Technology Ltd. | Imidazopyridine derivatives |
TWI312347B (en) * | 2001-02-08 | 2009-07-21 | Eisai R&D Man Co Ltd | Bicyclic nitrogen-containing condensed ring compounds |
DE60326646D1 (de) | 2002-12-18 | 2009-04-23 | Vertex Pharma | Benzisoxazolderivate, die sich als inhibitoren von proteinkinasen eigen |
CA2530048A1 (en) | 2003-06-30 | 2005-01-20 | Merck & Co., Inc. | 17-acetamido-4-azasteroid derivatives as androgen receptor modulators |
US7037909B2 (en) | 2003-07-02 | 2006-05-02 | Sugen, Inc. | Tetracyclic compounds as c-Met inhibitors |
US7122548B2 (en) | 2003-07-02 | 2006-10-17 | Sugen, Inc. | Triazolotriazine compounds and uses thereof |
JP2007509150A (ja) | 2003-10-21 | 2007-04-12 | メルク エンド カムパニー インコーポレーテッド | 神経障害性疼痛の治療において有用なトリアゾロ−ピリダジン化合物および、この誘導体 |
US7598383B2 (en) | 2003-11-19 | 2009-10-06 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
WO2005073224A2 (en) | 2004-01-23 | 2005-08-11 | Amgen Inc | Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer |
WO2005080355A1 (en) | 2004-02-12 | 2005-09-01 | Neurogen Corporation | Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands |
US7456289B2 (en) * | 2004-12-31 | 2008-11-25 | National Health Research Institutes | Anti-tumor compounds |
ATE460417T1 (de) * | 2005-03-23 | 2010-03-15 | Hoffmann La Roche | Acetylenylpyrazolopyrimidinderivate als mglur2- antagonsten |
US20090156617A1 (en) | 2005-05-12 | 2009-06-18 | Northrup Alan B | Tyrosine kinase inhibitors |
WO2007013673A1 (en) * | 2005-07-29 | 2007-02-01 | Astellas Pharma Inc. | Fused heterocycles as lck inhibitors |
US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
JP5144532B2 (ja) | 2005-11-30 | 2013-02-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | c−Met阻害剤及び用法 |
US7348325B2 (en) * | 2005-11-30 | 2008-03-25 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
DK1966214T3 (en) | 2005-12-21 | 2017-02-13 | Janssen Pharmaceutica Nv | TRIAZOLPYRIDAZINES AS TYROSINKINASA MODULATORS |
NL2000613C2 (nl) * | 2006-05-11 | 2007-11-20 | Pfizer Prod Inc | Triazoolpyrazinederivaten. |
JP2009538899A (ja) | 2006-05-30 | 2009-11-12 | ファイザー・プロダクツ・インク | トリアゾロピリダジン誘導体 |
US8217177B2 (en) * | 2006-07-14 | 2012-07-10 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
US8198448B2 (en) * | 2006-07-14 | 2012-06-12 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
PE20080403A1 (es) * | 2006-07-14 | 2008-04-25 | Amgen Inc | Derivados heterociclicos fusionados y metodos de uso |
AR062207A1 (es) | 2006-08-04 | 2008-10-22 | Takeda Pharmaceutical | Derivados de imidazopiridazina inhibidores de quinasas utiles para prevenir y/o tratar el cancer. |
TW200817410A (en) * | 2006-08-07 | 2008-04-16 | Incyte Corp | Triazolotriazines as kinase inhibitors |
US20100144738A1 (en) | 2006-09-05 | 2010-06-10 | William Bornmann | Inhibitors of c-met and uses thereof |
CA2663091A1 (en) | 2006-09-07 | 2008-03-13 | Biogen Idec Ma Inc. | Modulators of interleukin-1 receptor-associated kinase |
BRPI0717317A2 (pt) | 2006-10-23 | 2013-10-22 | Sgx Pharmaceuticals Inc | Modularoes da proteína cinase triazalopiridazina |
JP5572388B2 (ja) | 2006-11-22 | 2014-08-13 | インサイト・コーポレイション | キナーゼ阻害剤としてのイミダゾトリアジンおよびイミダゾピリミジン |
AR064420A1 (es) * | 2006-12-21 | 2009-04-01 | Alcon Mfg Ltd | Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop). |
WO2009011954A2 (en) | 2007-04-27 | 2009-01-22 | Alaka'i Consulting & Engineering, Inc. | Laser spectroscopy system |
EP2170894A1 (en) | 2007-06-21 | 2010-04-07 | Janssen Pharmaceutica N.V. | Polymorphic and hydrate forms, salts and process for preparing 6-{difluoro[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline |
EP2217601A1 (en) * | 2007-11-08 | 2010-08-18 | Centro Nacional de Investigaciones Oncológicas (CNIO) | Imidazopyridazines for use as protein kinase inhibitors |
US20110097189A1 (en) | 2007-12-31 | 2011-04-28 | Aaron Sandoval | Boundary layer effect turbine |
JP2009227599A (ja) | 2008-03-21 | 2009-10-08 | Daiichi Sankyo Co Ltd | イミダゾピリダジン誘導体 |
-
2009
- 2009-02-26 JP JP2010548110A patent/JP5576802B2/ja not_active Expired - Fee Related
- 2009-02-26 PE PE2009000287A patent/PE20091468A1/es not_active Application Discontinuation
- 2009-02-26 MX MX2010009414A patent/MX2010009414A/es not_active Application Discontinuation
- 2009-02-26 CN CN200980114928.XA patent/CN102015716B/zh not_active Expired - Fee Related
- 2009-02-26 WO PCT/EP2009/052302 patent/WO2009106577A1/en active Application Filing
- 2009-02-26 EP EP09714429A patent/EP2265614A1/en not_active Withdrawn
- 2009-02-26 CA CA2717034A patent/CA2717034A1/en not_active Abandoned
- 2009-02-26 AR ARP090100659A patent/AR070487A1/es unknown
- 2009-02-26 KR KR1020107021426A patent/KR20100128305A/ko not_active Application Discontinuation
- 2009-02-26 EA EA201001365A patent/EA201001365A1/ru unknown
- 2009-02-26 UY UY031676A patent/UY31676A1/es not_active Application Discontinuation
- 2009-02-26 AU AU2009218459A patent/AU2009218459A1/en not_active Abandoned
- 2009-02-26 BR BRPI0908504-1A patent/BRPI0908504A2/pt not_active IP Right Cessation
- 2009-02-27 CL CL2009000443A patent/CL2009000443A1/es unknown
- 2009-02-27 TW TW098106564A patent/TW200940545A/zh unknown
- 2009-03-02 US US12/396,137 patent/US8822468B2/en not_active Expired - Fee Related
-
2010
- 2010-08-05 IL IL207434A patent/IL207434A0/en unknown
- 2010-08-05 ZA ZA2010/05602A patent/ZA201005602B/en unknown
- 2010-08-06 CR CR11620A patent/CR11620A/es not_active Application Discontinuation
- 2010-08-27 NI NI201000145A patent/NI201000145A/es unknown
- 2010-08-27 CO CO10106017A patent/CO6300957A2/es not_active Application Discontinuation
- 2010-08-27 DO DO2010000263A patent/DOP2010000263A/es unknown
- 2010-08-27 EC EC2010010427A patent/ECSP10010427A/es unknown
- 2010-09-24 MA MA33198A patent/MA32167B1/fr unknown
- 2010-09-28 SM SM201000112T patent/SMAP201000112A/it unknown
Also Published As
Publication number | Publication date |
---|---|
CO6300957A2 (es) | 2011-07-21 |
KR20100128305A (ko) | 2010-12-07 |
US20090264406A1 (en) | 2009-10-22 |
PE20091468A1 (es) | 2009-10-22 |
CR11620A (es) | 2010-10-08 |
CN102015716A (zh) | 2011-04-13 |
EP2265614A1 (en) | 2010-12-29 |
CA2717034A1 (en) | 2009-09-03 |
CL2009000443A1 (es) | 2010-09-10 |
MX2010009414A (es) | 2010-09-24 |
ECSP10010427A (es) | 2010-09-30 |
JP2011513279A (ja) | 2011-04-28 |
DOP2010000263A (es) | 2010-09-30 |
AU2009218459A1 (en) | 2009-09-03 |
US8822468B2 (en) | 2014-09-02 |
NI201000145A (es) | 2011-03-02 |
WO2009106577A1 (en) | 2009-09-03 |
SMAP201000112A (it) | 2010-11-12 |
MA32167B1 (fr) | 2011-03-01 |
IL207434A0 (en) | 2010-12-30 |
ZA201005602B (en) | 2011-04-28 |
AR070487A1 (es) | 2010-04-07 |
BRPI0908504A2 (pt) | 2015-08-11 |
JP5576802B2 (ja) | 2014-08-20 |
EA201001365A1 (ru) | 2011-04-29 |
TW200940545A (en) | 2009-10-01 |
CN102015716B (zh) | 2014-09-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20180831 |