PE20091468A1 - DERIVADOS DE 3-METIL-IMIDAZO-[1,2-b]-PIRIDAZINA - Google Patents

DERIVADOS DE 3-METIL-IMIDAZO-[1,2-b]-PIRIDAZINA

Info

Publication number
PE20091468A1
PE20091468A1 PE2009000287A PE2009000287A PE20091468A1 PE 20091468 A1 PE20091468 A1 PE 20091468A1 PE 2009000287 A PE2009000287 A PE 2009000287A PE 2009000287 A PE2009000287 A PE 2009000287A PE 20091468 A1 PE20091468 A1 PE 20091468A1
Authority
PE
Peru
Prior art keywords
methyl
pyridazin
imidazo
imidazine
pyridazine
Prior art date
Application number
PE2009000287A
Other languages
English (en)
Inventor
Pascal Furet
Clive Mccarthy
Joseph Schoepfer
Carsten Spanka
Melanie Stang
Frederic Stauffer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39672115&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091468(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20091468A1 publication Critical patent/PE20091468A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 3-METIL-IMIDAZO-[1,2-b]-PIRIDAZINA DE FORMULA (I) DONDE R1 ES HETEROCICLILO, CICLOALQUILO, ALCOXILO, ENTRE OTROS; R2 ES HETEROCICLILO O ARILO OPCIONALMENTE SUSTITUIDOS; R3 ES H, ALQUILO INFERIOR, HALOGENO, ENTRE OTROS; R3' ES H, HALOGENO, OH, ENTRE OTROS; A1 ES UN ENLACE, -SO2-, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (RAC)-[6-(1-METIL-1H-PIRAZOL-4-IL)-IMIDAZO-[1,2-b]-PIRIDAZIN-3-IL]-QUINOLIN-6-IL-METANOL, 6-[6-(1-METIL-1H-PIRAZOL-4-IL)-IMIDAZO-[1,2-b]-PIRIDAZIN-3-IL-METIL]-QUINOLINA, (RAC)-(4-METOXI-FENIL)-[6-(1-METIL-1H-PIRAZOL-4-IL)-IMIDAZO-[1,2-b]-PIRIDAZIN-3-IL]-METANOL, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA CINASA DE TIROSINA c-MET SIENDO UTILES PARA EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS TALES COMO CANCER DE PULMON, CANCER DE MAMA, MELANOMA, SARCOMA
PE2009000287A 2008-02-28 2009-02-26 DERIVADOS DE 3-METIL-IMIDAZO-[1,2-b]-PIRIDAZINA PE20091468A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08152068 2008-02-28

Publications (1)

Publication Number Publication Date
PE20091468A1 true PE20091468A1 (es) 2009-10-22

Family

ID=39672115

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000287A PE20091468A1 (es) 2008-02-28 2009-02-26 DERIVADOS DE 3-METIL-IMIDAZO-[1,2-b]-PIRIDAZINA

Country Status (25)

Country Link
US (1) US8822468B2 (es)
EP (1) EP2265614A1 (es)
JP (1) JP5576802B2 (es)
KR (1) KR20100128305A (es)
CN (1) CN102015716B (es)
AR (1) AR070487A1 (es)
AU (1) AU2009218459A1 (es)
BR (1) BRPI0908504A2 (es)
CA (1) CA2717034A1 (es)
CL (1) CL2009000443A1 (es)
CO (1) CO6300957A2 (es)
CR (1) CR11620A (es)
DO (1) DOP2010000263A (es)
EA (1) EA201001365A1 (es)
EC (1) ECSP10010427A (es)
IL (1) IL207434A0 (es)
MA (1) MA32167B1 (es)
MX (1) MX2010009414A (es)
NI (1) NI201000145A (es)
PE (1) PE20091468A1 (es)
SM (1) SMAP201000112A (es)
TW (1) TW200940545A (es)
UY (1) UY31676A1 (es)
WO (1) WO2009106577A1 (es)
ZA (1) ZA201005602B (es)

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RU2770404C2 (ru) * 2016-09-16 2022-04-15 Гельмгольц Центрум Мюнхен - Дойчес Форшунгсцентрум Фюр Гезундхайт Унд Умвельт (Гмбх) Ингибиторы traf 6
WO2018138050A1 (de) 2017-01-26 2018-08-02 Bayer Aktiengesellschaft Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel
US11584744B2 (en) * 2017-06-23 2023-02-21 University Of Washington Inhibitors of type 1 methionyl-tRNA synthetase and methods of using them
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Also Published As

Publication number Publication date
EP2265614A1 (en) 2010-12-29
US8822468B2 (en) 2014-09-02
MA32167B1 (fr) 2011-03-01
ZA201005602B (en) 2011-04-28
MX2010009414A (es) 2010-09-24
JP5576802B2 (ja) 2014-08-20
NI201000145A (es) 2011-03-02
DOP2010000263A (es) 2010-09-30
IL207434A0 (en) 2010-12-30
US20090264406A1 (en) 2009-10-22
CO6300957A2 (es) 2011-07-21
ECSP10010427A (es) 2010-09-30
SMAP201000112A (it) 2010-11-12
CN102015716A (zh) 2011-04-13
BRPI0908504A2 (pt) 2015-08-11
EA201001365A1 (ru) 2011-04-29
JP2011513279A (ja) 2011-04-28
WO2009106577A1 (en) 2009-09-03
CN102015716B (zh) 2014-09-17
CL2009000443A1 (es) 2010-09-10
TW200940545A (en) 2009-10-01
AU2009218459A1 (en) 2009-09-03
UY31676A1 (es) 2009-09-30
CR11620A (es) 2010-10-08
CA2717034A1 (en) 2009-09-03
AR070487A1 (es) 2010-04-07
KR20100128305A (ko) 2010-12-07

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