PE20091468A1 - DERIVADOS DE 3-METIL-IMIDAZO-[1,2-b]-PIRIDAZINA - Google Patents

DERIVADOS DE 3-METIL-IMIDAZO-[1,2-b]-PIRIDAZINA

Info

Publication number
PE20091468A1
PE20091468A1 PE2009000287A PE2009000287A PE20091468A1 PE 20091468 A1 PE20091468 A1 PE 20091468A1 PE 2009000287 A PE2009000287 A PE 2009000287A PE 2009000287 A PE2009000287 A PE 2009000287A PE 20091468 A1 PE20091468 A1 PE 20091468A1
Authority
PE
Peru
Prior art keywords
methyl
pyridazin
imidazo
imidazine
pyridazine
Prior art date
Application number
PE2009000287A
Other languages
English (en)
Inventor
Pascal Furet
Clive Mccarthy
Joseph Schoepfer
Carsten Spanka
Melanie Stang
Frederic Stauffer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39672115&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091468(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20091468A1 publication Critical patent/PE20091468A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 3-METIL-IMIDAZO-[1,2-b]-PIRIDAZINA DE FORMULA (I) DONDE R1 ES HETEROCICLILO, CICLOALQUILO, ALCOXILO, ENTRE OTROS; R2 ES HETEROCICLILO O ARILO OPCIONALMENTE SUSTITUIDOS; R3 ES H, ALQUILO INFERIOR, HALOGENO, ENTRE OTROS; R3' ES H, HALOGENO, OH, ENTRE OTROS; A1 ES UN ENLACE, -SO2-, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (RAC)-[6-(1-METIL-1H-PIRAZOL-4-IL)-IMIDAZO-[1,2-b]-PIRIDAZIN-3-IL]-QUINOLIN-6-IL-METANOL, 6-[6-(1-METIL-1H-PIRAZOL-4-IL)-IMIDAZO-[1,2-b]-PIRIDAZIN-3-IL-METIL]-QUINOLINA, (RAC)-(4-METOXI-FENIL)-[6-(1-METIL-1H-PIRAZOL-4-IL)-IMIDAZO-[1,2-b]-PIRIDAZIN-3-IL]-METANOL, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA CINASA DE TIROSINA c-MET SIENDO UTILES PARA EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS TALES COMO CANCER DE PULMON, CANCER DE MAMA, MELANOMA, SARCOMA
PE2009000287A 2008-02-28 2009-02-26 DERIVADOS DE 3-METIL-IMIDAZO-[1,2-b]-PIRIDAZINA PE20091468A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08152068 2008-02-28

Publications (1)

Publication Number Publication Date
PE20091468A1 true PE20091468A1 (es) 2009-10-22

Family

ID=39672115

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000287A PE20091468A1 (es) 2008-02-28 2009-02-26 DERIVADOS DE 3-METIL-IMIDAZO-[1,2-b]-PIRIDAZINA

Country Status (25)

Country Link
US (1) US8822468B2 (es)
EP (1) EP2265614A1 (es)
JP (1) JP5576802B2 (es)
KR (1) KR20100128305A (es)
CN (1) CN102015716B (es)
AR (1) AR070487A1 (es)
AU (1) AU2009218459A1 (es)
BR (1) BRPI0908504A2 (es)
CA (1) CA2717034A1 (es)
CL (1) CL2009000443A1 (es)
CO (1) CO6300957A2 (es)
CR (1) CR11620A (es)
DO (1) DOP2010000263A (es)
EA (1) EA201001365A1 (es)
EC (1) ECSP10010427A (es)
IL (1) IL207434A0 (es)
MA (1) MA32167B1 (es)
MX (1) MX2010009414A (es)
NI (1) NI201000145A (es)
PE (1) PE20091468A1 (es)
SM (1) SMAP201000112A (es)
TW (1) TW200940545A (es)
UY (1) UY31676A1 (es)
WO (1) WO2009106577A1 (es)
ZA (1) ZA201005602B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY32049A (es) * 2008-08-14 2010-03-26 Takeda Pharmaceutical Inhibidores de cmet
US20110053968A1 (en) 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
US8389526B2 (en) * 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
AU2010283806A1 (en) 2009-08-12 2012-03-01 Novartis Ag Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
MX2012002179A (es) 2009-08-20 2012-03-16 Novartis Ag Compuestos heterociclicos de oxima.
CN102906092B (zh) 2009-12-31 2016-08-03 和记黄埔医药（上海）有限公司 某些三唑并吡啶化合物和三唑并吡嗪化合物、其组合物和其使用方法
US20110195066A1 (en) * 2010-02-05 2011-08-11 Auspex Pharmaceuticals, Inc. Quinoline inhibitors of tyrosine kinase
EP2588107A1 (en) * 2010-07-01 2013-05-08 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
AR085183A1 (es) 2010-07-30 2013-09-18 Lilly Co Eli Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer
US8637516B2 (en) * 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
WO2012175591A1 (en) * 2011-06-22 2012-12-27 Bayer Intellectual Property Gmbh Heterocyclyl aminoimidazopyridazines
CN103958509B (zh) * 2011-09-15 2015-12-23 诺华股份有限公司 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物
UY34329A (es) 2011-09-15 2013-04-30 Novartis Ag Compuestos de triazolopiridina
CN103122000B (zh) * 2012-09-03 2013-12-25 中美冠科生物技术（太仓）有限公司 用作抗肿瘤药物的高选择性的c-Met激酶抑制剂
CN105164124B (zh) 2012-11-19 2017-03-15 诺华股份有限公司 用于治疗寄生虫疾病的化合物和组合物
EP2964230A4 (en) 2013-03-07 2016-10-26 Califia Bio Inc KINASEHEMMER WITH MIXED ABSTRACT AND TREATMENT PROCESS THEREWITH
AR097543A1 (es) * 2013-09-06 2016-03-23 Lexicon Pharmaceuticals Inc COMPUESTOS BASADOS EN IMIDAZO[1,2-b]PIRIDAZINA, COMPOSICIONES QUE LOS COMPRENDEN Y SUS MÉTODOS DE USO
CN105326793A (zh) * 2014-08-06 2016-02-17 中美冠科生物技术（太仓）有限公司 一种包含c-Met激酶抑制剂的固体分散体及其制备方法和用途
WO2016097359A1 (en) * 2014-12-19 2016-06-23 Janssen Pharmaceutica Nv Heterocyclyl linked imidazopyridazine derivatives as pi3kbeta inhibitors
US10087187B2 (en) * 2014-12-19 2018-10-02 Janssen Pharmaceutica Nv Imidazopyridazine derivatives as PI3KB inhibitors
JP7117293B2 (ja) * 2016-09-16 2022-08-12 ヘルムホルツ ツェントゥルム ミュンヘン ドイチェス フォルシュングスツェントゥルム フューア ゲズントハイト ウント ウムヴェルト （ゲーエムベーハー） Ｔｒａｆ６阻害剤
WO2018138050A1 (de) 2017-01-26 2018-08-02 Bayer Aktiengesellschaft Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel
WO2018237349A1 (en) * 2017-06-23 2018-12-27 University Of Washington TYPE 1 METHIONYL-ARNT SYNTHASEASE INHIBITORS AND METHODS OF USE
US20230059009A1 (en) * 2019-12-18 2023-02-23 The Regents Of The University Of California Inhibitors of lin28 and methods of use thereof

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3489755A (en) 1966-08-03 1970-01-13 Pfizer & Co C Imidazo (1,2-b) pyridazines
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds
FR2619818B1 (fr) * 1987-09-01 1990-01-12 Sanofi Sa Imidazo (1,2-b) pyridazines, procede pour leur preparation et compositions pharmaceutiques les contenant
CA2057089A1 (en) 1990-12-07 1992-06-08 Eric E. Allen Substituted pyrazolopyrimidines and imidazopyridazines as angiotensin ii antagonists
DE60112272T2 (de) 2000-04-27 2006-05-24 Astellas Pharma Inc. Imidazopyridin-derivate
TWI312347B (en) 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
ATE425160T1 (de) 2002-12-18 2009-03-15 Vertex Pharma Benzisoxazolderivate, die sich als inhibitoren von proteinkinasen eigen
CN1816528A (zh) 2003-06-30 2006-08-09 麦克公司 作为雄激素受体调节剂的17－乙酰氨基－4－氮杂甾类衍生物
US7037909B2 (en) 2003-07-02 2006-05-02 Sugen, Inc. Tetracyclic compounds as c-Met inhibitors
US7122548B2 (en) 2003-07-02 2006-10-17 Sugen, Inc. Triazolotriazine compounds and uses thereof
EP1677799A4 (en) 2003-10-21 2008-09-10 Merck & Co Inc TRIAZOLO-PYRIDAZINE COMPOUNDS AND DERIVATIVES THEREOF FOR THE TREATMENT OF NEUROPATHIC PAIN
US7576072B2 (en) 2003-11-19 2009-08-18 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
EP1711495A2 (en) 2004-01-23 2006-10-18 Amgen Inc. Quinoline, quinazoline, pyridine and pyrimidine counds and their use in the treatment of inflammation, angiogenesis and cancer
US20090023737A1 (en) 2004-02-12 2009-01-22 Neurogen Corporation Imidazo-Pyridazines, Triazolo-Pyridazines and Related Benzodiazepine Receptor Ligands
US7456289B2 (en) 2004-12-31 2008-11-25 National Health Research Institutes Anti-tumor compounds
CA2602444C (en) 2005-03-23 2013-03-19 F.Hoffmann-La Roche Ag Acetylenyl-pyrazolo-pyrimidine derivatives as mglur2 antagonists
US20090156617A1 (en) 2005-05-12 2009-06-18 Northrup Alan B Tyrosine kinase inhibitors
EP1910369A1 (en) * 2005-07-29 2008-04-16 Astellas Pharma Inc. Fused heterocycles as lck inhibitors
US20070078136A1 (en) 2005-09-22 2007-04-05 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
US7348325B2 (en) 2005-11-30 2008-03-25 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
CA2630884A1 (en) 2005-11-30 2007-06-07 Vertex Pharmaceuticals Incorporated Inhibitors of c-met and uses thereof
NZ568807A (en) 2005-12-21 2011-05-27 Janssen Pharmaceutica Nv Triazolopyridazines as tyrosine kinase modulators
NL2000613C2 (nl) 2006-05-11 2007-11-20 Pfizer Prod Inc Triazoolpyrazinederivaten.
EP2032578A2 (en) 2006-05-30 2009-03-11 Pfizer Products Incorporated Triazolopyridazine derivatives
PE20121506A1 (es) * 2006-07-14 2012-11-26 Amgen Inc Compuestos triazolopiridinas como inhibidores de c-met
US8198448B2 (en) * 2006-07-14 2012-06-12 Amgen Inc. Fused heterocyclic derivatives and methods of use
US8217177B2 (en) * 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
TW200817409A (en) 2006-08-04 2008-04-16 Takeda Pharmaceutical Fused heterocyclic derivative and use thereof
EP2057164A1 (en) 2006-08-07 2009-05-13 Incyte Corporation Triazolotriazines as kinase inhibitors
US20100144738A1 (en) 2006-09-05 2010-06-10 William Bornmann Inhibitors of c-met and uses thereof
WO2008030579A2 (en) 2006-09-07 2008-03-13 Biogen Idec Ma Inc. Irak modulators for treating an inflammatory condition, cell proliferative disorder, immune disorder
PT2081937E (pt) 2006-10-23 2012-10-15 Sgx Pharmaceuticals Inc Moduladores de proteína-cinase de triazolo-piridazina
KR101588583B1 (ko) 2006-11-22 2016-01-28 인사이트 코포레이션 키나제 억제제로서의 이미다조트리아진 및 이미다조피리미딘
AR064420A1 (es) 2006-12-21 2009-04-01 Alcon Mfg Ltd Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop).
US8125627B2 (en) 2007-04-27 2012-02-28 Alakai Defense Systems, Inc. Laser spectroscopy system
JP5548123B2 (ja) 2007-06-21 2014-07-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ６−｛ジフルオロ［６−（１−メチル−１Ｈ−ピラゾル−４−イル）［１，２，４］トリアゾロ［４，３−ｂ］ピリダジン−３−イル］メチル｝キノリンの多形および水和物の形態、塩、ならびに製造方法
US20110046127A1 (en) * 2007-11-08 2011-02-24 Paolo Pevarello Imidazopyridazines for Use as Protein Kinase Inhibitors
US20110097189A1 (en) 2007-12-31 2011-04-28 Aaron Sandoval Boundary layer effect turbine
JP2009227599A (ja) 2008-03-21 2009-10-08 Daiichi Sankyo Co Ltd イミダゾピリダジン誘導体

Also Published As

Publication number Publication date
KR20100128305A (ko) 2010-12-07
CN102015716A (zh) 2011-04-13
UY31676A1 (es) 2009-09-30
MA32167B1 (fr) 2011-03-01
CA2717034A1 (en) 2009-09-03
TW200940545A (en) 2009-10-01
NI201000145A (es) 2011-03-02
JP5576802B2 (ja) 2014-08-20
BRPI0908504A2 (pt) 2015-08-11
AR070487A1 (es) 2010-04-07
EA201001365A1 (ru) 2011-04-29
SMAP201000112A (it) 2010-11-12
AU2009218459A1 (en) 2009-09-03
IL207434A0 (en) 2010-12-30
JP2011513279A (ja) 2011-04-28
ZA201005602B (en) 2011-04-28
ECSP10010427A (es) 2010-09-30
MX2010009414A (es) 2010-09-24
CL2009000443A1 (es) 2010-09-10
US20090264406A1 (en) 2009-10-22
DOP2010000263A (es) 2010-09-30
CN102015716B (zh) 2014-09-17
EP2265614A1 (en) 2010-12-29
CO6300957A2 (es) 2011-07-21
CR11620A (es) 2010-10-08
US8822468B2 (en) 2014-09-02
WO2009106577A1 (en) 2009-09-03

Similar Documents

Publication Publication Date Title
PE20091468A1 (es) DERIVADOS DE 3-METIL-IMIDAZO-[1,2-b]-PIRIDAZINA
JP6318156B2 (ja) キナーゼをモジュレートするための化合物および方法、ならびにその指標
PE20070752A1 (es) Triazolopiridazinas como moduladores de quinasa
EA202090659A1 (ru) СОСТАВЫ, СОДЕРЖАЩИЕ 6-(2-ГИДРОКСИ-2-МЕТИЛПРОПОКСИ)-4-(6-(6-((6-МЕТОКСИПИРИДИН-3-ИЛ)МЕТИЛ)-3,6-ДИАЗАБИЦИКЛО[3.1.1]ГЕПТАН-3-ИЛ)ПИРИДИН-3-ИЛ)ПИРАЗОЛО[1,5-a]ПИРИДИН-3-КАРБОНИТРИЛ
PE20090506A1 (es) DERIVADOS DE IMIDAZO-[1,2-b]-PIRIDAZIN COMO INHIBIDORES DE ALK5 Y/O ALK4
PE20080893A1 (es) Triazoles biciclicos como moduladores de la proteina cinasa
AU2016314898B2 (en) 2,4-bis(nitrogen-containing group)-substituted pyrimidine compound, preparation method and use thereof
PE20090596A1 (es) Imidazoles biciclicos fusionados
PE20130457A1 (es) INHIBIDORES DE mTOR CINASA PARA INDICADORES DE ONCOLOGIA Y ENFERMEDADES ASOCIADAS CON LA TRAYECTORIA mTOR/PI3K/AKT
EA201792394A3 (ru) Производные 2-(2,4,5-замещенного анилино)пиримидина в качестве модуляторов egfr, полезных для лечения рака
PE20091485A1 (es) DERIVADOS DE PIRROLO-[2,3-d]-PIRIMIDINA COMO INHIBIDORES DE CINASAS
PE20110572A1 (es) DERIVADOS DE IMIDAZO[1,2-a]PIRIDINA COMO INHIBIDORES DE MET
PE20091833A1 (es) Derivados heterociclicos espiro biciclicos o heterociclicos biciclicos, puenteados, de pirazolo [1,5-a]pirimidinas como inhibidores de quinasas raf y metodos para su preparacion
NZ626394A (en) Substituted annulated pyrimidines and triazines, and use thereof
NZ712378A (en) Synthetic methods for spiro-oxindole compounds
EA201001236A1 (ru) Производные пиридо[4,3-d]пиримидинона в качестве ингибиторов киназ
PE20090493A1 (es) DERIVADOS DE LA 6-CICLOAMINO-3-(PIRIDAZIN-4-IL)IMIDAZO[1,2-b]-PIRIDAZINA, SU PREPARACION Y SU APLICACION EN TERAPEUTICA
NZ605889A (en) Fused heterocyclic compounds as phosphodiesterases (pdes) inhibitors
PE20110545A1 (es) Compuestos de triazolopiridina como inhibidores de jak
NZ591449A (en) Picolinamide derivatives as kinase inhibitors
PE20091211A1 (es) Derivados de pirazolopirimidina como moduladores de pde9a
PE20090714A1 (es) Imidazopiridazinas y pirrolo-pirimidinas sustituidas como inhibidores de cinasa de lipido
MX347040B (es) Inhibidores de tirosina-cinasas.
PE20091849A1 (es) Compuestos y composiciones como inhibidores de cinasa
PE20121438A1 (es) Derivados de imidazopiridina o imidazopirimidina como inhibidores de fosfodiesterasa 10a

Legal Events

Date Code Title Description
FD Application declared void or lapsed