ATE425160T1 - Benzisoxazolderivate, die sich als inhibitoren von proteinkinasen eigen - Google Patents
Benzisoxazolderivate, die sich als inhibitoren von proteinkinasen eigenInfo
- Publication number
- ATE425160T1 ATE425160T1 AT03814019T AT03814019T ATE425160T1 AT E425160 T1 ATE425160 T1 AT E425160T1 AT 03814019 T AT03814019 T AT 03814019T AT 03814019 T AT03814019 T AT 03814019T AT E425160 T1 ATE425160 T1 AT E425160T1
- Authority
- AT
- Austria
- Prior art keywords
- protein kinase
- kinase inhibitors
- compounds
- benzisoxazole derivatives
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43488002P | 2002-12-18 | 2002-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE425160T1 true ATE425160T1 (de) | 2009-03-15 |
Family
ID=32682120
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03814019T ATE425160T1 (de) | 2002-12-18 | 2003-12-17 | Benzisoxazolderivate, die sich als inhibitoren von proteinkinasen eigen |
Country Status (6)
Country | Link |
---|---|
US (1) | US7226919B2 (de) |
EP (1) | EP1581526B1 (de) |
AT (1) | ATE425160T1 (de) |
AU (1) | AU2003297160A1 (de) |
DE (1) | DE60326646D1 (de) |
WO (1) | WO2004058749A1 (de) |
Families Citing this family (62)
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TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
CN1678321A (zh) | 2002-07-29 | 2005-10-05 | 里格尔药品股份有限公司 | 用2,4-嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法 |
US7122542B2 (en) | 2003-07-30 | 2006-10-17 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
EP1778224B1 (de) * | 2004-07-19 | 2014-03-26 | The Johns-Hopkins University | Flt3-inhibitoren zur immunsuppression |
DE102005018389A1 (de) | 2005-04-20 | 2006-10-26 | Sanofi-Aventis Deutschland Gmbh | Azolderivate als Inhibitoren von Lipasen und Phospholipasen |
CN101228161B (zh) * | 2005-05-20 | 2012-10-10 | 沃泰克斯药物股份有限公司 | 适用作蛋白激酶抑制剂的吡咯并吡啶类 |
SG162726A1 (en) | 2005-05-27 | 2010-07-29 | San Raffaele Centro Fond | Gene vector comprising mi-rna |
GB0510922D0 (en) * | 2005-05-27 | 2005-07-06 | Fond Ct San Rafaelle Del Monte | Hsi |
NZ563454A (en) | 2005-06-08 | 2011-03-31 | Rigel Pharmaceuticals Inc | 2,4-diaminopyrimidine derivatives for inhibition of the JAK pathway |
US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
US8071768B2 (en) | 2005-06-10 | 2011-12-06 | Janssen Pharmaceutica, N.V. | Alkylquinoline and alkylquinazoline kinase modulators |
US7825244B2 (en) | 2005-06-10 | 2010-11-02 | Janssen Pharmaceutica Nv | Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis |
US20060281788A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
WO2007016674A2 (en) * | 2005-08-02 | 2007-02-08 | Lexicon Genetics Incorporated | 2-aminoaryl pyridines as protein kinases inhibitors |
CA2626623C (en) | 2005-10-18 | 2016-08-30 | Janssen Pharmaceutica N.V. | Method of inhibiting flt3 kinase |
US8962643B2 (en) | 2006-02-24 | 2015-02-24 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
EP2016070B1 (de) | 2006-04-20 | 2016-01-13 | Janssen Pharmaceutica N.V. | Inhibitoren von c-fms-kinase |
US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
KR101367645B1 (ko) | 2006-04-20 | 2014-02-27 | 얀센 파마슈티카 엔.브이. | C-fms 키나제의 저해제로서의 복소환식 화합물 |
EP2089369B1 (de) | 2006-10-19 | 2011-02-02 | Rigel Pharmaceuticals, Inc. | 2,4-pyridimediamon-derivate als hemmer von jak-kinasen zur behandlung von autoimmunerkrankungen |
WO2008082840A1 (en) * | 2006-12-29 | 2008-07-10 | Abbott Laboratories | Pim kinase inhibitors as cancer chemotherapeutics |
JO3240B1 (ar) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
NZ586662A (en) * | 2007-12-19 | 2012-08-31 | Vertex Pharma | PYRAZOLO[1,5-a]PYRIMIDINES USEFUL AS JANUS KINASE 2 INHIBITORS |
SI2265607T1 (sl) | 2008-02-15 | 2017-06-30 | Rigel Pharmaceuticals, Inc. | Spojine pirimidin-2-amina in njihova uporaba kot inhibitorji JAK kinaz |
JP5576802B2 (ja) | 2008-02-28 | 2014-08-20 | ノバルティス アーゲー | C−Metチロシンキナーゼ介在疾患の治療用のイミダゾ[1,2−b]ピリダジン誘導体 |
ES2546502T3 (es) | 2008-04-16 | 2015-09-24 | Portola Pharmaceuticals, Inc. | 2,6-Diamino-pirimidin-5-il-carboxamidas como inhibidores de syk o JAK quinasas |
US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
AU2009238590A1 (en) | 2008-04-22 | 2009-10-29 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
US8895550B2 (en) | 2008-08-19 | 2014-11-25 | Array Biopharma Inc. | Triazolopyridine compounds as PIM kinase inhibitors |
TWI496779B (zh) | 2008-08-19 | 2015-08-21 | Array Biopharma Inc | 作為pim激酶抑制劑之三唑吡啶化合物 |
US8557809B2 (en) | 2008-08-19 | 2013-10-15 | Array Biopharma Inc. | Triazolopyridine compounds as PIM kinase inhibitors |
US8987251B2 (en) | 2008-08-19 | 2015-03-24 | Array Biopharma Inc. | Triazolopyridine compounds as PIM kinase inhibitors |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
WO2011083124A1 (en) | 2010-01-05 | 2011-07-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Flt3 receptor antagonists for the treatment or the prevention of pain disorders |
CA2786800C (en) | 2010-01-12 | 2018-02-27 | Ab Science | Thiazole and oxazole kinase inhibitors |
EP2975027A1 (de) | 2010-11-01 | 2016-01-20 | Portola Pharmaceuticals, Inc. | Nicotinamide als jak-kinasemodulatoren |
EP2662078A1 (de) * | 2010-11-10 | 2013-11-13 | National Jewish Health | Verfahren zur Behandlung von allergischen Zuständen |
ES2563152T3 (es) | 2011-02-25 | 2016-03-11 | Array Biopharma Inc. | Compuestos de triazolopiridina como inhibidores de quinasa PIM |
EP2688890B1 (de) | 2011-03-22 | 2017-08-30 | Advinus Therapeutics Limited | Substituierte kondensierte tricyclische verbindungen, zusammensetzungen und medizinische anwendungen davon |
MX363696B (es) | 2011-04-21 | 2019-03-28 | Origenis Gmbh | Pirazolo[4,3-d]pirimidinas utiles como inhibidores de cinasas. |
MX363551B (es) | 2011-11-23 | 2019-03-27 | Portola Pharmaceuticals Inc Star | Compuestos derivados de pirazina como inhibidores de cinasa. |
US9096579B2 (en) | 2012-04-20 | 2015-08-04 | Boehringer Ingelheim International Gmbh | Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments |
RS61664B1 (sr) | 2012-04-24 | 2021-04-29 | Vertex Pharma | Inhibitori dna-pk |
EP2882757B1 (de) | 2012-08-07 | 2016-10-05 | Janssen Pharmaceutica, N.V. | Verfahren zur herstellung heterocyclischer esterderivate |
JOP20180012A1 (ar) | 2012-08-07 | 2019-01-30 | Janssen Pharmaceutica Nv | عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد |
JP6407504B2 (ja) | 2012-09-21 | 2018-10-17 | アログ・ファーマシューティカルズ・インコーポレイテッドArog Pharmaceuticals,Inc. | 恒常的に活性であるリン酸化型flt3キナーゼの阻害方法 |
WO2014045305A1 (en) | 2012-09-21 | 2014-03-27 | Advinus Therapeutics Limited | Substituted fused tricyclic compounds, compositions and medicinal applications thereof |
EP2903970A4 (de) | 2012-10-08 | 2016-11-30 | Portola Pharm Inc | Substituierte pyrimidinylkinasehemmer |
WO2014060112A1 (en) | 2012-10-19 | 2014-04-24 | Origenis Gmbh | Pyrazolo[4,3-d]pyrimidines as kinase inhibitors |
BR112015016282A2 (pt) | 2013-01-07 | 2017-07-11 | Arog Pharmaceuticals Inc | crenolanibe para tratamento de distúrbios proliferativos de flt3 mutado |
RS58374B1 (sr) | 2013-03-12 | 2019-03-29 | Vertex Pharma | Inhibitori dnk-pk |
EP3057953B1 (de) | 2013-10-17 | 2018-08-15 | Vertex Pharmaceuticals Incorporated | Co-kristalle von (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)chinolin-4-carboxamid und deuterierten derivaten davon als dna-pk-hemmer |
US10463658B2 (en) | 2013-10-25 | 2019-11-05 | Videra Pharmaceuticals, Llc | Method of inhibiting FLT3 kinase |
US10065937B2 (en) | 2014-07-31 | 2018-09-04 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | FLT3 receptor antagonists |
EP3254698A1 (de) | 2016-06-08 | 2017-12-13 | Universite De Montpellier | Flt3-rezeptor-inhibitoren bei niedriger dosierung zur behandlung von neuropathischem schmerz |
US11352328B2 (en) | 2016-07-12 | 2022-06-07 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus |
TW201815418A (zh) | 2016-09-27 | 2018-05-01 | Vertex Pharma | 使用dna破壞劑及dna-pk抑制劑之組合治療癌症的方法 |
CA3024012A1 (en) | 2016-11-02 | 2018-05-11 | Arog Pharmaceuticals, Inc. | Crenolanib for treating flt3 mutated proliferative disorders associated mutations |
KR20200013683A (ko) | 2017-05-17 | 2020-02-07 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 오피오이드에 의한 통증 치료 개선용 flt3 저해제 |
WO2019057649A1 (en) | 2017-09-19 | 2019-03-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA |
US11713310B2 (en) | 2020-07-20 | 2023-08-01 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
US11969420B2 (en) | 2020-10-30 | 2024-04-30 | Arog Pharmaceuticals, Inc. | Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
GB9914258D0 (en) | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
WO2001000207A1 (en) | 1999-06-30 | 2001-01-04 | Merck & Co., Inc. | Src kinase inhibitor compounds |
EP1194152A4 (de) | 1999-06-30 | 2002-11-06 | Merck & Co Inc | Verbindungen zur SRC Kinase-Hemmung |
EP1218369B1 (de) | 1999-08-13 | 2008-07-23 | Vertex Pharmaceuticals Incorporated | INHIBITOREN DER c-JUN N-TERMINALEN KINASE (JNK) UND ANDERE PROTEIN-KINASEN |
GB9924862D0 (en) | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
NZ521068A (en) * | 2000-03-29 | 2005-04-29 | Cyclacel Ltd | 2-substituted 4-heteroaryl-pyrimidines and their use in the treatment of proliferative disorders |
JP4541695B2 (ja) * | 2001-06-15 | 2010-09-08 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼインヒビターとしての5−(2−アミノピリミジン−4−イル)ベンズイソキサゾール |
-
2003
- 2003-12-17 DE DE60326646T patent/DE60326646D1/de not_active Expired - Lifetime
- 2003-12-17 US US10/738,965 patent/US7226919B2/en not_active Expired - Fee Related
- 2003-12-17 AU AU2003297160A patent/AU2003297160A1/en not_active Abandoned
- 2003-12-17 WO PCT/US2003/039989 patent/WO2004058749A1/en not_active Application Discontinuation
- 2003-12-17 AT AT03814019T patent/ATE425160T1/de not_active IP Right Cessation
- 2003-12-17 EP EP03814019A patent/EP1581526B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2004058749A1 (en) | 2004-07-15 |
EP1581526B1 (de) | 2009-03-11 |
US7226919B2 (en) | 2007-06-05 |
AU2003297160A1 (en) | 2004-07-22 |
DE60326646D1 (de) | 2009-04-23 |
EP1581526A1 (de) | 2005-10-05 |
US20040186115A1 (en) | 2004-09-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |