ATE536353T1 - 2-(4-amino-1,2,5-oxadiazol-4-yl)-imidazol- verbindungen als protein kinase inhibitoren - Google Patents

2-(4-amino-1,2,5-oxadiazol-4-yl)-imidazol- verbindungen als protein kinase inhibitoren

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Publication number
ATE536353T1
ATE536353T1 AT04781796T AT04781796T ATE536353T1 AT E536353 T1 ATE536353 T1 AT E536353T1 AT 04781796 T AT04781796 T AT 04781796T AT 04781796 T AT04781796 T AT 04781796T AT E536353 T1 ATE536353 T1 AT E536353T1
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AT
Austria
Prior art keywords
oxadiazole
amino
protein kinase
kinase inhibitors
imidazole compounds
Prior art date
Application number
AT04781796T
Other languages
English (en)
Inventor
Jon Come
Jeremy Green
Craig Marhefka
Scott Harbeson
Ly Pham
Original Assignee
Vertex Pharma
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Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE536353T1 publication Critical patent/ATE536353T1/de

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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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AT04781796T 2003-08-20 2004-08-20 2-(4-amino-1,2,5-oxadiazol-4-yl)-imidazol- verbindungen als protein kinase inhibitoren ATE536353T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49661703P 2003-08-20 2003-08-20
PCT/US2004/027182 WO2005019190A2 (en) 2003-08-20 2004-08-20 (4 -amino -1,2, 5-oxadiazol-4-yl) -hetξroaromatic compounds useful as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
ATE536353T1 true ATE536353T1 (de) 2011-12-15

Family

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AT04781796T ATE536353T1 (de) 2003-08-20 2004-08-20 2-(4-amino-1,2,5-oxadiazol-4-yl)-imidazol- verbindungen als protein kinase inhibitoren

Country Status (7)

Country Link
US (1) US7157476B2 (de)
EP (1) EP1660467B1 (de)
JP (1) JP2007512230A (de)
AT (1) ATE536353T1 (de)
AU (1) AU2004267094A1 (de)
CA (1) CA2536253A1 (de)
WO (1) WO2005019190A2 (de)

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KR20040084896A (ko) 2002-02-06 2004-10-06 버텍스 파마슈티칼스 인코포레이티드 Ｇｓｋ-3의 억제제로서 유용한 헤테로아릴 화합물
JP2006514684A (ja) 2002-10-30 2006-05-11 バーテックス　ファーマシューティカルズ　インコーポレイテッド Ｒｏｃｋおよび他のプロテインキナーゼとして有用な組成物

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US7157476B2 (en) 2007-01-02
JP2007512230A (ja) 2007-05-17
AU2004267094A1 (en) 2005-03-03
EP1660467A2 (de) 2006-05-31
EP1660467B1 (de) 2011-12-07

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