ATE464303T1 - Als inhibitoren von rock und anderen proteinkinasen geeignete zusammensetzungen - Google Patents
Als inhibitoren von rock und anderen proteinkinasen geeignete zusammensetzungenInfo
- Publication number
- ATE464303T1 ATE464303T1 AT05744555T AT05744555T ATE464303T1 AT E464303 T1 ATE464303 T1 AT E464303T1 AT 05744555 T AT05744555 T AT 05744555T AT 05744555 T AT05744555 T AT 05744555T AT E464303 T1 ATE464303 T1 AT E464303T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- protein kinases
- rock
- compositions suitable
- compositions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 102000001253 Protein Kinase Human genes 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108060006633 protein kinase Proteins 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Gynecology & Obstetrics (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56587904P | 2004-04-28 | 2004-04-28 | |
PCT/US2005/014558 WO2005105780A2 (en) | 2004-04-28 | 2005-04-27 | Compositions useful as inhibitors of rock and other protein kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE464303T1 true ATE464303T1 (de) | 2010-04-15 |
Family
ID=34979422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05744555T ATE464303T1 (de) | 2004-04-28 | 2005-04-27 | Als inhibitoren von rock und anderen proteinkinasen geeignete zusammensetzungen |
Country Status (6)
Country | Link |
---|---|
US (1) | US7531556B2 (de) |
EP (1) | EP1751133B1 (de) |
JP (1) | JP2007535551A (de) |
AT (1) | ATE464303T1 (de) |
DE (1) | DE602005020611D1 (de) |
WO (1) | WO2005105780A2 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
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IL169855A (en) * | 2005-07-25 | 2014-05-28 | Elta Systems Ltd | A system and method for locating a receiver location |
DK1907382T3 (en) | 2005-07-26 | 2015-08-31 | Bial Portela & Ca Sa | Nitrocatecholderivater comt inhibitors as |
KR20080040027A (ko) | 2005-09-02 | 2008-05-07 | 아스테라스 세이야쿠 가부시키가이샤 | Rock 억제제로서 아미드 유도체 |
EP1845097A1 (de) * | 2006-04-10 | 2007-10-17 | Portela & Ca., S.A. | Oxadiazolderivate als COMT Inihibitoren |
US20090118336A1 (en) * | 2006-05-03 | 2009-05-07 | Laurent David | Pyrazole derivatives and their use as pi3k inhibitors |
UA95641C2 (en) * | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
EP2044061A2 (de) * | 2006-07-20 | 2009-04-08 | Mehmet Kahraman | Benzothiophen-hemmer der rho-kinase |
US8492378B2 (en) | 2006-08-03 | 2013-07-23 | Takeda Pharmaceutical Company Limited | GSK-3β inhibitor |
US7737149B2 (en) * | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
HUE031317T2 (hu) * | 2007-01-31 | 2017-07-28 | Bial - Portela & Ca S A | Specifikus dózisprotokollal adagolt COMT inhibitor nitrokatechin származékok |
EP2119702A4 (de) | 2007-01-31 | 2010-12-08 | Dainippon Sumitomo Pharma Co | Amidderivat |
EP2259777A2 (de) * | 2008-02-28 | 2010-12-15 | BIAL - Portela & Ca., S.A. | Pharmazeutische zusammensetzung für schwer lösliche arzneimittel |
JP2011514380A (ja) | 2008-03-17 | 2011-05-06 | バイアル−ポルテラ アンド シーエー,エス.エー. | 5−[3−(2,5−ジクロロ−4,6−ジメチル−1−オキシ−ピリジン−3−イル)[1,2,4]オキサジアゾール−5−イル]−3−ニトロベンゼン−1,2−ジオールの結晶形 |
PE20110062A1 (es) * | 2008-06-19 | 2011-03-09 | Astrazeneca Ab | N-(3-(3,5-dimetoxifenetil)-1h-pirazol-5-il)-4-(3,4-dimetilpiperazin-1-il)benzamida y sales del mismo |
TWI461423B (zh) * | 2008-07-02 | 2014-11-21 | Astrazeneca Ab | 用於治療Pim激酶相關病狀及疾病之噻唑啶二酮化合物 |
GB0812648D0 (en) * | 2008-07-10 | 2008-08-20 | Prosidion Ltd | Compounds |
DE102008038220A1 (de) * | 2008-08-18 | 2010-02-25 | Merck Patent Gmbh | Oxadiazolderivate |
WO2010114405A2 (en) * | 2009-04-01 | 2010-10-07 | Bial - Portela & Ca., S.A. | Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making the same |
EP2413912B1 (de) | 2009-04-01 | 2019-03-13 | Bial-Portela & CA, S.A. | Pharmazeutische formulierungen mit nitrocatechol-derivaten und herstellungsverfahren dafür |
US9079859B2 (en) | 2011-01-21 | 2015-07-14 | Auckland Uniservices Limited | Synthetic lethal targeting of glucose transport |
US20140045900A1 (en) | 2011-02-11 | 2014-02-13 | Bial-Portela & Ca, S.A. | Administration regime for nitrocatechols |
FI2694072T4 (fi) | 2011-04-01 | 2024-09-30 | Genentech Inc | Akt-inhibiittoriyhdisteen ja abirateronin yhdistelmä käytettäväksi terapeuttisissa hoidoissa |
EP2694073B1 (de) | 2011-04-01 | 2018-08-08 | Genentech, Inc. | Kombinationen aus akt- und mek-hemmer zur behandlung von krebs |
CA3088684C (en) | 2011-12-13 | 2021-10-26 | Bial - Portela & C.A., S.A. | Compound 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-3-nitrobenzene-1,2-diol in microparticulate form and its use in the treatment of parkinson's disease |
US20140179712A1 (en) | 2012-12-21 | 2014-06-26 | Astrazeneca Ab | Pharmaceutical formulation of n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide |
CA2928568A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
EA201690844A1 (ru) * | 2013-11-06 | 2016-08-31 | Бристол-Маерс Сквибб Компани | Ингибиторы gsk-3 |
ES2693718T3 (es) | 2013-11-06 | 2018-12-13 | Bristol-Myers Squibb Company | Derivados de piridina sustituidos útiles como inhibidores de GSK-3 |
WO2016083863A1 (en) | 2014-11-28 | 2016-06-02 | Bial - Portela & Ca, S.A. | Medicaments for slowing parkinson's disease |
WO2017064119A1 (en) | 2015-10-13 | 2017-04-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of retinal capillary non-perfusion |
EP4088719A1 (de) | 2015-10-13 | 2022-11-16 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Verfahren und pharmazeutische zusammensetzungen zur behandlung von kapillarer nichtperfusion der netzhaut |
CA3008171A1 (en) | 2015-12-22 | 2017-06-29 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
CA3066939A1 (en) | 2017-06-21 | 2018-12-27 | SHY Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
IL294507A (en) * | 2020-01-07 | 2022-09-01 | Disarm Therapeutics Inc | Inhibitors of sarm1 |
EP4192828A1 (de) | 2020-08-04 | 2023-06-14 | Nura Bio, Inc. | Substituierte pyridinderivate als sarm1-inhibitoren |
TWI786777B (zh) | 2020-08-24 | 2022-12-11 | 美商達薩瑪治療公司 | Sarm1之抑制劑 |
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JP2024522192A (ja) | 2021-06-14 | 2024-06-11 | スコーピオン セラピューティクス インコーポレイテッド | がんを処置するために使用され得る尿素誘導体 |
US11629136B1 (en) | 2021-07-28 | 2023-04-18 | Nura Bio, Inc. | Substituted pyridine derivatives as SARM1 inhibitors |
CA3228394A1 (en) * | 2021-08-10 | 2023-02-16 | Avinash BOPPANA | Compositions, formulations, and methods for hair treatment |
WO2024123668A1 (en) * | 2022-12-05 | 2024-06-13 | Oddity Labs, Llc | Compositions, formulations, and methods for hair treatment |
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US20020173507A1 (en) | 2000-08-15 | 2002-11-21 | Vincent Santora | Urea compounds and methods of uses |
AU2002228783A1 (en) * | 2000-12-05 | 2002-06-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
MY130778A (en) * | 2001-02-09 | 2007-07-31 | Vertex Pharma | Heterocyclic inhibitiors of erk2 and uses thereof |
CA2446864C (en) * | 2001-05-16 | 2011-02-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of src and other protein kinases |
KR20040053210A (ko) * | 2001-11-02 | 2004-06-23 | 화이자 프로덕츠 인크. | Pde9 억제제를 사용한 인슐린 저항 증후군 및 2형당뇨병의 치료 |
US7304061B2 (en) * | 2002-04-26 | 2007-12-04 | Vertex Pharmaceuticals Incorporated | Heterocyclic inhibitors of ERK2 and uses thereof |
US7304071B2 (en) | 2002-08-14 | 2007-12-04 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors and uses thereof |
CA2504320A1 (en) * | 2002-10-30 | 2004-05-21 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of rock and other protein kinases |
EP1606284B1 (de) * | 2003-03-13 | 2009-12-02 | Vertex Pharmaceuticals Incorporated | Zusammensetzungen zur verwendung als protein-kinase-inhibitoren |
-
2005
- 2005-04-27 US US11/115,661 patent/US7531556B2/en not_active Expired - Fee Related
- 2005-04-27 AT AT05744555T patent/ATE464303T1/de not_active IP Right Cessation
- 2005-04-27 WO PCT/US2005/014558 patent/WO2005105780A2/en active Application Filing
- 2005-04-27 EP EP05744555A patent/EP1751133B1/de not_active Not-in-force
- 2005-04-27 DE DE602005020611T patent/DE602005020611D1/de active Active
- 2005-04-27 JP JP2007510964A patent/JP2007535551A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1751133B1 (de) | 2010-04-14 |
US7531556B2 (en) | 2009-05-12 |
JP2007535551A (ja) | 2007-12-06 |
US20060019956A1 (en) | 2006-01-26 |
WO2005105780A3 (en) | 2005-12-29 |
DE602005020611D1 (de) | 2010-05-27 |
EP1751133A2 (de) | 2007-02-14 |
WO2005105780A2 (en) | 2005-11-10 |
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