PE20080893A1 - Triazoles biciclicos como moduladores de la proteina cinasa - Google Patents

Triazoles biciclicos como moduladores de la proteina cinasa

Info

Publication number
PE20080893A1
PE20080893A1 PE2007001437A PE2007001437A PE20080893A1 PE 20080893 A1 PE20080893 A1 PE 20080893A1 PE 2007001437 A PE2007001437 A PE 2007001437A PE 2007001437 A PE2007001437 A PE 2007001437A PE 20080893 A1 PE20080893 A1 PE 20080893A1
Authority
PE
Peru
Prior art keywords
halogen
triazolo
nitro
protein kinase
modulators
Prior art date
Application number
PE2007001437A
Other languages
English (en)
Inventor
Pierre-Yves Bounaud
Christopher Ronald Smith
Elizabeth Anne Jefferson
Original Assignee
Sgx Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sgx Pharmaceuticals Inc filed Critical Sgx Pharmaceuticals Inc
Publication of PE20080893A1 publication Critical patent/PE20080893A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE TRIAZOLES BICICLICOS DE FORMULA (I) DONDE Q ES H, HALOGENO, ALQUILO(C1-C10), CICLOALQUILO(C3-C7), PERFLUOROALQUILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON R22, DONDE R22 ES H, HALOGENO, NITRO, CN, ENTRE OTROS; X ES N O CR2; q ES DE 0 A 2; R1 Y R2 SON CADA UNO H, HALOGENO, NITRO, CN, HIDROXILO, ALQUILO(C1-C10), ENTRE OTROS; R10 ES H, ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS CON R28, DONDE R28 ES UN ENLACE COVALENTE, H, HALOGENO, NITRO, CN, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 6-(6-FENIL-[1,2,4]TRIAZOLO[4,3-b]PIRIDAZIN-3-ILSULFONIL)-QUINOLINA, 6-FENIL-3-([1,2,4]TRIAZOLO[4,3-a]PIRIDIZIN-6-ILSULFONIL)-[1,2,4]TRIAZOLO[4,3-b]PIRIDAZINA, 3-(1H-BENZOTRIAZOL-5-IL-SULFONIL)-6-FENIL[1,2,4]TRIAZOLO[4,3-b]PIRIDAZINA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE PROTEINA CINASA SIENDO UTILES EN EL TRATAMIENTO DE CANCER DE MAMA, MELANOMA, CANCER PANCREATICO, CANCER HEPATICO
PE2007001437A 2006-10-23 2007-10-23 Triazoles biciclicos como moduladores de la proteina cinasa PE20080893A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86255206P 2006-10-23 2006-10-23
US87030906P 2006-12-15 2006-12-15
US91376607P 2007-04-24 2007-04-24
US95284007P 2007-07-30 2007-07-30

Publications (1)

Publication Number Publication Date
PE20080893A1 true PE20080893A1 (es) 2008-08-26

Family

ID=38956385

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001437A PE20080893A1 (es) 2006-10-23 2007-10-23 Triazoles biciclicos como moduladores de la proteina cinasa

Country Status (25)

Country Link
US (1) US8507489B2 (es)
EP (1) EP2084162B1 (es)
JP (1) JP5378222B2 (es)
KR (1) KR20090071612A (es)
AR (1) AR063520A1 (es)
AU (1) AU2007309149C1 (es)
BR (1) BRPI0717320A2 (es)
CA (1) CA2667428A1 (es)
CO (1) CO6190620A2 (es)
CR (1) CR10803A (es)
DK (1) DK2084162T3 (es)
EA (1) EA200970403A1 (es)
ES (1) ES2393130T3 (es)
IL (1) IL197958A0 (es)
MA (1) MA30871B1 (es)
MX (1) MX2009004059A (es)
NO (1) NO20091618L (es)
NZ (1) NZ575336A (es)
PE (1) PE20080893A1 (es)
PL (1) PL2084162T3 (es)
PT (1) PT2084162E (es)
SV (1) SV2009003235A (es)
TN (1) TN2009000142A1 (es)
TW (1) TW200835492A (es)
WO (1) WO2008051808A2 (es)

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JP2012509342A (ja) 2008-11-20 2012-04-19 オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド 置換ピロロ［２，３−ｂ］−ピリジンおよび−ピラジン
FR2941951B1 (fr) * 2009-02-06 2011-04-01 Sanofi Aventis Derives de 6-(6-nh-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met.
FR2941952B1 (fr) * 2009-02-06 2011-04-01 Sanofi Aventis Derives de 6-(6-substitue-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles et 5-fluoro-benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met.
FR2941949B1 (fr) * 2009-02-06 2011-04-01 Sanofi Aventis Derives de 6-(6-o-cycloalkyl ou 6-nh-cycloalkyl- triazolopyridazine-sulfanyl)benzothiazoles et benzimidazoles preparation, application comme medicaments et utilisation comme inhibiteurs de met.
FR2941950B1 (fr) * 2009-02-06 2011-04-01 Sanofi Aventis Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met.
JP5781510B2 (ja) 2009-08-12 2015-09-24 ノバルティス アーゲー ヘテロ環式ヒドラゾン化合物および癌および炎症の処置のためのそれらの使用
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AR085183A1 (es) 2010-07-30 2013-09-18 Lilly Co Eli Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer
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JP2014505088A (ja) 2011-02-10 2014-02-27 ノバルティス アーゲー Ｃ−ＭＥＴチロシンキナーゼ阻害剤としての［１，２，４］トリアゾロ［４，３−ｂ］ピリダジン化合物
CN103459396B (zh) * 2011-02-10 2015-08-19 诺瓦提斯公司 作为c-Met酪氨酸激酶抑制剂的[1,2,4]三唑并[4,3-b]哒嗪化合物
US20140088114A1 (en) 2011-05-16 2014-03-27 OSI Pharmaceuticals ,LLC Fused bicyclic kinase inhibitors
JP5957526B2 (ja) * 2011-09-15 2016-07-27 ノバルティス アーゲー チロシンキナーゼとしての６−置換３−（キノリン−６−イルチオ）−［１，２，４］トリアゾロ［４，３−ａ］ピラジン
CN103958509B (zh) * 2011-09-15 2015-12-23 诺华股份有限公司 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物
EP2833917A1 (en) 2012-04-03 2015-02-11 Novartis AG Tyrosine kinase inhibitor combinations and their use
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CN103122000B (zh) * 2012-09-03 2013-12-25 中美冠科生物技术（太仓）有限公司 用作抗肿瘤药物的高选择性的c-Met激酶抑制剂
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Also Published As

Publication number Publication date
NZ575336A (en) 2012-04-27
EP2084162A2 (en) 2009-08-05
US20090258855A1 (en) 2009-10-15
AU2007309149B2 (en) 2012-09-06
EP2084162B1 (en) 2012-09-12
ES2393130T3 (es) 2012-12-18
BRPI0717320A2 (pt) 2013-10-22
AU2007309149C1 (en) 2013-04-04
MA30871B1 (fr) 2009-11-02
PT2084162E (pt) 2012-10-09
JP2010507578A (ja) 2010-03-11
AU2007309149A1 (en) 2008-05-02
TW200835492A (en) 2008-09-01
CR10803A (es) 2009-06-16
JP5378222B2 (ja) 2013-12-25
SV2009003235A (es) 2009-10-15
TN2009000142A1 (en) 2010-10-18
PL2084162T3 (pl) 2013-01-31
NO20091618L (no) 2009-05-22
AR063520A1 (es) 2009-01-28
IL197958A0 (en) 2009-12-24
DK2084162T3 (da) 2012-10-01
CO6190620A2 (es) 2010-08-19
EA200970403A1 (ru) 2009-10-30
KR20090071612A (ko) 2009-07-01
US8507489B2 (en) 2013-08-13
CA2667428A1 (en) 2008-05-02
MX2009004059A (es) 2009-04-27
WO2008051808A3 (en) 2008-07-24
WO2008051808A2 (en) 2008-05-02

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