MA30871B1 - Triazoles bicycliques a titre de modulateurs de proteines kinases - Google Patents
Triazoles bicycliques a titre de modulateurs de proteines kinasesInfo
- Publication number
- MA30871B1 MA30871B1 MA31849A MA31849A MA30871B1 MA 30871 B1 MA30871 B1 MA 30871B1 MA 31849 A MA31849 A MA 31849A MA 31849 A MA31849 A MA 31849A MA 30871 B1 MA30871 B1 MA 30871B1
- Authority
- MA
- Morocco
- Prior art keywords
- modulators
- protein kinases
- bicyclic
- bicyclic triazoles
- triazoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
LA PRÉSENTE INVENTION FOURNIT DES MODULATEURS DE PROTÉINE KINASE DE TRIAZOLE BICYCLIQUE, ET DES PROCÉDÉS POUR UTILISER CES COMPOSÉS POUR TRAITER DES MALADIES FAVORISÉES PAR UNE ACTIVITÉ DE KINASE.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86255206P | 2006-10-23 | 2006-10-23 | |
US87030906P | 2006-12-15 | 2006-12-15 | |
US91376607P | 2007-04-24 | 2007-04-24 | |
US95284007P | 2007-07-30 | 2007-07-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA30871B1 true MA30871B1 (fr) | 2009-11-02 |
Family
ID=38956385
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31849A MA30871B1 (fr) | 2006-10-23 | 2009-05-07 | Triazoles bicycliques a titre de modulateurs de proteines kinases |
Country Status (25)
Country | Link |
---|---|
US (1) | US8507489B2 (fr) |
EP (1) | EP2084162B1 (fr) |
JP (1) | JP5378222B2 (fr) |
KR (1) | KR20090071612A (fr) |
AR (1) | AR063520A1 (fr) |
AU (1) | AU2007309149C1 (fr) |
BR (1) | BRPI0717320A2 (fr) |
CA (1) | CA2667428A1 (fr) |
CO (1) | CO6190620A2 (fr) |
CR (1) | CR10803A (fr) |
DK (1) | DK2084162T3 (fr) |
EA (1) | EA200970403A1 (fr) |
ES (1) | ES2393130T3 (fr) |
IL (1) | IL197958A0 (fr) |
MA (1) | MA30871B1 (fr) |
MX (1) | MX2009004059A (fr) |
NO (1) | NO20091618L (fr) |
NZ (1) | NZ575336A (fr) |
PE (1) | PE20080893A1 (fr) |
PL (1) | PL2084162T3 (fr) |
PT (1) | PT2084162E (fr) |
SV (1) | SV2009003235A (fr) |
TN (1) | TN2009000142A1 (fr) |
TW (1) | TW200835492A (fr) |
WO (1) | WO2008051808A2 (fr) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PA8792501A1 (es) * | 2007-08-09 | 2009-04-23 | Sanofi Aventis | Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met. |
TWI365185B (en) | 2008-07-24 | 2012-06-01 | Lilly Co Eli | Amidophenoxyindazoles useful as inhibitors of c-met |
UY32049A (es) | 2008-08-14 | 2010-03-26 | Takeda Pharmaceutical | Inhibidores de cmet |
EP2165710A1 (fr) * | 2008-09-19 | 2010-03-24 | Institut Curie | Récepteur TYRO3 de la tyrosine kinase en tant que cible thérapeutique dans le traitement d'une tumeur de la vessie |
US8592448B2 (en) | 2008-11-20 | 2013-11-26 | OSI Pharmaceuticals, LLC | Substituted pyrrolo[2,3-b]-pyridines and -pyrazines |
FR2941952B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-substitue-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles et 5-fluoro-benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
FR2941951B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-nh-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
FR2941949B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-cycloalkyl ou 6-nh-cycloalkyl- triazolopyridazine-sulfanyl)benzothiazoles et benzimidazoles preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
FR2941950B1 (fr) * | 2009-02-06 | 2011-04-01 | Sanofi Aventis | Derives de 6-(6-o-substitue-triazolopyridazine-sulfanyl) benzothiazoles et benzimidazoles : preparation, application comme medicaments et utilisation comme inhibiteurs de met. |
MX2012001838A (es) | 2009-08-12 | 2012-02-29 | Novartis Ag | Compuestos de hidrazona heterociclico y sus usos para tratar cancer e inflamacion. |
IN2012DN01453A (fr) | 2009-08-20 | 2015-06-05 | Novartis Ag | |
PT3795573T (pt) | 2009-12-31 | 2022-09-15 | Hutchison Medipharma Ltd | Certas triazolopirazinas, suas composições e seus métodos de utilização |
AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
EP2569315A1 (fr) | 2010-05-14 | 2013-03-20 | OSI Pharmaceuticals, LLC | Inhibiteurs de kinases bicycliques fusionnés |
AR085183A1 (es) | 2010-07-30 | 2013-09-18 | Lilly Co Eli | Compuesto 6-(1-metil-1h-pirazol-4-il)-3-(2-metil-2h-indazol-5-iltio)-[1,2,4]triazol[4,3-b]piridazina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar cancer |
UY33549A (es) * | 2010-08-10 | 2012-01-31 | Glaxo Group Ltd | Quinolil aminas como agentes inhibidores de las quinasas |
WO2012042421A1 (fr) | 2010-09-29 | 2012-04-05 | Pfizer Inc. | Procédé de traitement de la croissance cellulaire anormale |
CN102532141A (zh) | 2010-12-08 | 2012-07-04 | 中国科学院上海药物研究所 | [1,2,4]三唑并[4,3-b][1,2,4]三嗪类化合物、其制备方法和用途 |
ES2627788T3 (es) | 2011-01-11 | 2017-07-31 | Sunovion Pharmaceuticals Inc. | Compuestos heteroarilo y procedimientos de uso de los mismos |
EP2673277A1 (fr) | 2011-02-10 | 2013-12-18 | Novartis AG | Composés de [1, 2, 4]triazolo [4, 3 -b]pyridazine en tant qu'inhibiteurs de la tyrosine kinase c-met |
CN103459396B (zh) * | 2011-02-10 | 2015-08-19 | 诺瓦提斯公司 | 作为c-Met酪氨酸激酶抑制剂的[1,2,4]三唑并[4,3-b]哒嗪化合物 |
US20140088114A1 (en) | 2011-05-16 | 2014-03-27 | OSI Pharmaceuticals ,LLC | Fused bicyclic kinase inhibitors |
EP2755976B1 (fr) * | 2011-09-15 | 2018-07-18 | Novartis AG | 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyradines substituées en position 6 à activité tyrosine kinase |
CN103958509B (zh) * | 2011-09-15 | 2015-12-23 | 诺华股份有限公司 | 作为酪氨酸激酶抑制剂的6-取代的3-(喹啉-6-基硫代)-[1,2,4]三唑并[4,3-a]吡啶化合物 |
AU2013243737B2 (en) | 2012-04-03 | 2016-06-30 | Novartis Ag | Tyrosine kinase inhibitor combinations and their use |
CN104245701A (zh) | 2012-04-03 | 2014-12-24 | 诺华有限公司 | 有酪氨酸激酶抑制剂的组合产品和其应用 |
CN103122000B (zh) * | 2012-09-03 | 2013-12-25 | 中美冠科生物技术(太仓)有限公司 | 用作抗肿瘤药物的高选择性的c-Met激酶抑制剂 |
WO2014089904A1 (fr) | 2012-12-10 | 2014-06-19 | Abbvie Inc. | Composés triazinones |
WO2014164200A1 (fr) | 2013-03-13 | 2014-10-09 | Avon Products, Inc | Inhibiteurs de la tyrosinase |
WO2014158943A1 (fr) * | 2013-03-13 | 2014-10-02 | Avon Products, Inc | Inhibiteurs de tyrosinase |
US9364405B2 (en) | 2013-03-13 | 2016-06-14 | Avon Products, Inc. | Tyrosinase inhibitors |
KR101821468B1 (ko) * | 2013-03-13 | 2018-01-23 | 에프. 호프만-라 로슈 아게 | 벤즈옥사제핀 화합물의 제조 방법 |
WO2014174478A1 (fr) | 2013-04-26 | 2014-10-30 | Novartis Ag | Combinaisons pharmaceutiques d'un inhibiteur de la pkc et d'un inhibiteur du récepteur tyrosine-kinase c-met |
CN105143228B (zh) | 2013-05-10 | 2017-07-21 | 江苏豪森药业集团有限公司 | [1,2,4]三唑并[4,3‑a]吡啶类衍生物,其制备方法或其在医药上的应用 |
CN105272995B (zh) | 2015-09-24 | 2017-10-27 | 上海海聚生物科技有限公司 | 喹啉类衍生物、其药物组合物、制备方法及应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5604091A (en) | 1984-03-01 | 1997-02-18 | Microgenics Corporation | Methods for protein binding enzyme complementation |
JPS60194443A (ja) * | 1984-03-16 | 1985-10-02 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
EP0228061A3 (fr) | 1985-12-23 | 1988-12-14 | Takeda Chemical Industries, Ltd. | Composés céphem |
JPS62228086A (ja) * | 1985-12-23 | 1987-10-06 | Takeda Chem Ind Ltd | セフエム化合物 |
GB9918035D0 (en) | 1999-07-30 | 1999-09-29 | Novartis Ag | Organic compounds |
AU2002251266A1 (en) | 2001-04-10 | 2002-10-28 | Merck Sharp And Dohme Limited | Inhibitors of akt activity |
WO2002083139A1 (fr) * | 2001-04-10 | 2002-10-24 | Merck & Co., Inc. | Inhibiteurs de l'activite d'akt |
US20030229453A1 (en) | 2002-04-09 | 2003-12-11 | Antonysamy Stephen Suresh | Crystals and structures of PAK4KD kinase PAK4KD |
AU2003297161B8 (en) * | 2002-12-18 | 2011-03-31 | Vertex Pharmaceuticals Incorporated | Triazolopyridazines as protein kinases inhibitors |
US7122548B2 (en) * | 2003-07-02 | 2006-10-17 | Sugen, Inc. | Triazolotriazine compounds and uses thereof |
SG156685A1 (en) * | 2004-07-27 | 2009-11-26 | Sgx Pharmaceuticals Inc | Fused ring heterocycle kinase modulators |
SI1784396T1 (sl) | 2004-08-26 | 2011-03-31 | Pfizer | S pirazolom substituirane aminoheteroarilne spojine kot zaviralci protein-kinaze |
US20080269249A2 (en) | 2004-12-27 | 2008-10-30 | Alcon, Inc. | Aminopyrazine analogs for treating glaucoma and other rho kinase-mediated diseases and conditions |
-
2007
- 2007-10-18 CA CA002667428A patent/CA2667428A1/fr not_active Abandoned
- 2007-10-18 JP JP2009533541A patent/JP5378222B2/ja not_active Expired - Fee Related
- 2007-10-18 BR BRPI0717320-2A2A patent/BRPI0717320A2/pt not_active IP Right Cessation
- 2007-10-18 US US12/442,566 patent/US8507489B2/en not_active Expired - Fee Related
- 2007-10-18 DK DK07844414.8T patent/DK2084162T3/da active
- 2007-10-18 NZ NZ575336A patent/NZ575336A/en not_active IP Right Cessation
- 2007-10-18 ES ES07844414T patent/ES2393130T3/es active Active
- 2007-10-18 EP EP07844414A patent/EP2084162B1/fr active Active
- 2007-10-18 PT PT07844414T patent/PT2084162E/pt unknown
- 2007-10-18 WO PCT/US2007/081841 patent/WO2008051808A2/fr active Application Filing
- 2007-10-18 AU AU2007309149A patent/AU2007309149C1/en not_active Ceased
- 2007-10-18 PL PL07844414T patent/PL2084162T3/pl unknown
- 2007-10-18 MX MX2009004059A patent/MX2009004059A/es active IP Right Grant
- 2007-10-18 EA EA200970403A patent/EA200970403A1/ru unknown
- 2007-10-18 KR KR1020097008200A patent/KR20090071612A/ko active IP Right Grant
- 2007-10-22 TW TW096139480A patent/TW200835492A/zh unknown
- 2007-10-23 PE PE2007001437A patent/PE20080893A1/es not_active Application Discontinuation
- 2007-10-23 AR ARP070104680A patent/AR063520A1/es not_active Application Discontinuation
-
2009
- 2009-04-05 IL IL197958A patent/IL197958A0/en unknown
- 2009-04-15 TN TNP2009000142A patent/TN2009000142A1/fr unknown
- 2009-04-22 CO CO09040677A patent/CO6190620A2/es not_active Application Discontinuation
- 2009-04-23 SV SV2009003235A patent/SV2009003235A/es not_active Application Discontinuation
- 2009-04-23 NO NO20091618A patent/NO20091618L/no not_active Application Discontinuation
- 2009-05-07 MA MA31849A patent/MA30871B1/fr unknown
- 2009-05-19 CR CR10803A patent/CR10803A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP2084162A2 (fr) | 2009-08-05 |
TW200835492A (en) | 2008-09-01 |
IL197958A0 (en) | 2009-12-24 |
MX2009004059A (es) | 2009-04-27 |
AR063520A1 (es) | 2009-01-28 |
NO20091618L (no) | 2009-05-22 |
US8507489B2 (en) | 2013-08-13 |
CA2667428A1 (fr) | 2008-05-02 |
AU2007309149A1 (en) | 2008-05-02 |
NZ575336A (en) | 2012-04-27 |
PL2084162T3 (pl) | 2013-01-31 |
KR20090071612A (ko) | 2009-07-01 |
CO6190620A2 (es) | 2010-08-19 |
BRPI0717320A2 (pt) | 2013-10-22 |
TN2009000142A1 (en) | 2010-10-18 |
EP2084162B1 (fr) | 2012-09-12 |
JP2010507578A (ja) | 2010-03-11 |
AU2007309149B2 (en) | 2012-09-06 |
WO2008051808A3 (fr) | 2008-07-24 |
US20090258855A1 (en) | 2009-10-15 |
PT2084162E (pt) | 2012-10-09 |
ES2393130T3 (es) | 2012-12-18 |
JP5378222B2 (ja) | 2013-12-25 |
CR10803A (es) | 2009-06-16 |
AU2007309149C1 (en) | 2013-04-04 |
SV2009003235A (es) | 2009-10-15 |
EA200970403A1 (ru) | 2009-10-30 |
PE20080893A1 (es) | 2008-08-26 |
DK2084162T3 (da) | 2012-10-01 |
WO2008051808A2 (fr) | 2008-05-02 |
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