AR062207A1 - Derivados de imidazopiridazina inhibidores de quinasas utiles para prevenir y/o tratar el cancer. - Google Patents
Derivados de imidazopiridazina inhibidores de quinasas utiles para prevenir y/o tratar el cancer.Info
- Publication number
- AR062207A1 AR062207A1 ARP070103435A ARP070103435A AR062207A1 AR 062207 A1 AR062207 A1 AR 062207A1 AR P070103435 A ARP070103435 A AR P070103435A AR P070103435 A ARP070103435 A AR P070103435A AR 062207 A1 AR062207 A1 AR 062207A1
- Authority
- AR
- Argentina
- Prior art keywords
- pyridazin
- imidazo
- benzamide
- substituent
- hydrogen atom
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un agente farmacéutico que contiene el compuesto que es un inhibidor de quinasa (VEGFR, VEGFR2, PDGFR, Raf), un inhibidor de angiogénesis, un agente para la prevencion o el tratamiento del cáncer, un inhibidor del crecimiento del cáncer o un supresor de la metástasis cancerosa. Reivindicacion 1: Un compuesto caracterizado por la formula (1) en donde anillo Y es un grupo cíclico opcionalmente sustituido; X es -O-, -S-, -S(O)-, -S(O)2- o -NR- (en donde R es un átomo de hidrogeno o un sustituyente); R1 es un átomo de hidrogeno o un sustituyente; R2 es un átomo de hidrogeno o un sustituyente; R3 es un átomo de hidrogeno o un sustituyente; R4 es un átomo de hidrogeno o un sustituyente; con la condicion de que cuando R1 es distinto de un amino opcionalmente sustituido, anillo Y sea un grupo cíclico sustituido con un amino opcionalmente sustituido, en donde el grupo cíclico también está opcionalmente sustituido, y que se excluyan [6-(feniltio)imidazo(1,2-b]piridazin-2- il]carbamato de metilo, [6-(fenilsulfinil)imidazo[1,2-b]piridazin-2-il]carbamato de metilo, 6-(4-acetamidofenoxi) imidazo[1,2-b]piridazin-2-carboxilato de etilo, 6-[4-(4-acetilpiperazin-1-il)fenoxi]imidazo[1,2- b]piridazin-2-carboxilato de etilo, N- [1-(imidazo[1,2-b]piridazin-6-ilamino)-2,5-dioxo- 1,2, 5, 6,7, 8-hexahidroquinolin-3-il]benzamida, N-[1-(imidazo[1,2-b]piridazin-6-ilamino)-7,7-dimetil-2,5- dioxo-1,2,5,6,7,8-hexahidroquinolin-3-il]benzamida, N-[1-(imidazo[1,2-b]piridazin-6-ilamino)- 2,5-dioxo-2,5,6,7- tetrahidro-1H-ciclopenta[b]piridin-3-il]benzamida, N-[1-(imidazo[1,2-b]piridazin-6-ilamino)-7-metil-2,5-dioxo- 1,2,5,6,7,8-hexahidroquinolin-3-il]benzamida, N-[(5E)-5-(imidazo[1,2-b]piridazin-6-ilhidrazono)-7-metil-2-oxo-4a,5, 6,7,8,8a-hexahidro-2H-cromen-3-il)benzamida, (6R, 7R)-3- (imidazo[1,2-b]piridazin-6-iltio)-8-oxo-7-[(fenilacetil)amino]-5-tia-1-azabiciclo[4,2,0]oct-2-en-2-carboxilato de 4-metoxibencilo, 4-[(3-metoxi-2-fenilimidazo[1,2-b)piridazin-6-il)tio]-N,N- dimetilanilina, 3-metoxi-6-(3-nitrofenoxi)-2-fenilimidazo[1,2-b]piridazina, 3-[(3-metoxi-2-fenilimidazo[1,2-b]piridazin-6-il)oxi)anilina, y 3-[(3-metoxi-2-fenilimidazo[1,2-b]piridazin-6-il)oxi]-N,N-dimetilanilina, o una de sus sales.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006213981 | 2006-08-04 | ||
JP2006331230 | 2006-12-07 | ||
JP2007144072 | 2007-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR062207A1 true AR062207A1 (es) | 2008-10-22 |
Family
ID=38996616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070103435A AR062207A1 (es) | 2006-08-04 | 2007-08-03 | Derivados de imidazopiridazina inhibidores de quinasas utiles para prevenir y/o tratar el cancer. |
Country Status (18)
Country | Link |
---|---|
US (4) | US8044049B2 (es) |
EP (1) | EP2049541B1 (es) |
JP (1) | JP5238697B2 (es) |
KR (1) | KR20090047509A (es) |
AR (1) | AR062207A1 (es) |
AU (1) | AU2007279595A1 (es) |
BR (1) | BRPI0714665A2 (es) |
CA (1) | CA2659971A1 (es) |
CL (1) | CL2007002261A1 (es) |
CO (1) | CO6150183A2 (es) |
CR (1) | CR10607A (es) |
IL (1) | IL196799A0 (es) |
MA (1) | MA30651B1 (es) |
MX (1) | MX2009001349A (es) |
NO (1) | NO20090986L (es) |
PE (1) | PE20080538A1 (es) |
TW (1) | TW200817409A (es) |
WO (1) | WO2008016192A2 (es) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2008150015A1 (en) | 2007-06-05 | 2008-12-11 | Takeda Pharmaceutical Company Limited | Heterobicyclic compounds as kinase inhibitors |
US8058274B2 (en) * | 2007-08-17 | 2011-11-15 | Icagen, Inc. | Heterocycles as potassium channel modulators |
US8431608B2 (en) | 2007-08-17 | 2013-04-30 | Icagen Inc. | Heterocycles as potassium channel modulators |
JP5270553B2 (ja) | 2007-08-23 | 2013-08-21 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
US8389527B2 (en) | 2008-02-06 | 2013-03-05 | Bristol-Myers Squibb Company | Substituted imidazopyridazines useful as kinase inhibitors |
JP5576802B2 (ja) | 2008-02-28 | 2014-08-20 | ノバルティス アーゲー | C−Metチロシンキナーゼ介在疾患の治療用のイミダゾ[1,2−b]ピリダジン誘導体 |
CN101372475B (zh) * | 2008-03-19 | 2012-01-04 | 南京工业大学 | 芳杂环取代的二苯脲类衍生物及其用途 |
EP2277881A4 (en) | 2008-04-18 | 2011-09-07 | Shionogi & Co | HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON P13K |
US8445509B2 (en) * | 2008-05-08 | 2013-05-21 | Takeda Pharmaceutical Company Limited | Fused heterocyclic derivatives and use thereof |
WO2010007099A1 (en) * | 2008-07-15 | 2010-01-21 | Cellzome Limited | 2-aminoimidazo[1,2-b]pyridazine derivatives as pi3k inhibitors |
UY32049A (es) | 2008-08-14 | 2010-03-26 | Takeda Pharmaceutical | Inhibidores de cmet |
MX2011003553A (es) | 2008-10-02 | 2011-05-25 | Respivert Ltd | Inhibidores de las enzimas de proteina cinasa activadas por mitogeno p38. |
GB0818033D0 (en) | 2008-10-02 | 2008-11-05 | Respivert Ltd | Novel compound |
TWI491610B (zh) * | 2008-10-09 | 2015-07-11 | 必治妥美雅史谷比公司 | 作為激酶抑制劑之咪唑并嗒腈 |
JP5600111B2 (ja) | 2008-10-22 | 2014-10-01 | アレイ バイオファーマ、インコーポレイテッド | TRKキナーゼ阻害剤としての置換ピラゾロ[1,5−a]ピリミジン化合物 |
JP5579619B2 (ja) * | 2008-12-01 | 2014-08-27 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
JO3101B1 (ar) | 2008-12-02 | 2017-09-20 | Takeda Pharmaceuticals Co | مشتقات بنزوثيازول كعوامل مضادة للسرطان |
EP2370428B1 (en) | 2008-12-11 | 2016-08-10 | Respivert Limited | P38 map kinase inhibitors |
WO2010072632A1 (en) | 2008-12-24 | 2010-07-01 | Syngenta Limited | Methods for the preparation of aryl amides |
JP5059977B2 (ja) | 2009-02-10 | 2012-10-31 | アストラゼネカ アクチボラグ | トリアゾロ[4,3−b]ピリダジン誘導体および前立腺癌のためのそれらの使用 |
GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
JP5583845B2 (ja) | 2010-04-28 | 2014-09-03 | ブリストル−マイヤーズ スクイブ カンパニー | イミダゾピリダジニル化合物および癌に対するそれらの使用 |
ES2620644T3 (es) * | 2011-04-01 | 2017-06-29 | Genentech, Inc. | Combinaciones de compuestos inhibidores de AKT y agentes quimioterapéuticos, y métodos de uso |
KR20140103925A (ko) | 2011-12-09 | 2014-08-27 | 키에시 파르마슈티시 엣스. 피. 에이. | 4-히드록시-1,2,3,4-테트라히드로나프탈렌-1-일 우레아 및 호흡기 질환의 치료에서의 이들의 용도 |
EP2992112B1 (en) | 2013-04-22 | 2020-06-03 | Icahn School of Medicine at Mount Sinai | Mutations in pdgfrb and notch3 as causes of autosomal dominant infantile myofibromatosis |
US9988386B2 (en) | 2013-05-30 | 2018-06-05 | Kata Pharmaceuticals, Inc. | Compounds for treatment of diseases of abnormal angiogenesis or aberrant growth factors and uses thereof |
JP2016540773A (ja) * | 2013-12-06 | 2016-12-28 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用な化合物 |
SI3623362T1 (sl) | 2013-12-13 | 2023-03-31 | Eurochem Agro Gmbh | Gnojilna zmes, ki vsebuje nitrifikacijski inhibitor |
US10253045B2 (en) | 2014-11-26 | 2019-04-09 | Kala Pharmaceuticals, Inc. | Crystalline forms of a therapeutic compound and uses thereof |
JPWO2016093299A1 (ja) * | 2014-12-10 | 2017-09-21 | 千寿製薬株式会社 | 水性液剤 |
US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
TN2018000335A1 (en) | 2016-04-04 | 2020-01-16 | Loxo Oncology Inc | Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
PL3800189T3 (pl) | 2016-05-18 | 2023-10-23 | Loxo Oncology, Inc. | Wytwarzanie (s)-n-(5-((r)-2-(2,5-difluorofenylo)pirolidyn-1-ylo)pirazolo[1,5-a]pirymidyn-3-ylo)-3-hydroksypirolidyno-1-karboksyamidu |
EA201990158A1 (ru) | 2016-06-29 | 2019-05-31 | Орион Корпорейшн | Производные бензодиоксана и их фармацевтическое применение |
JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
WO2018094005A1 (en) * | 2016-11-16 | 2018-05-24 | The General Hospital Corporation | Myeloperoxidase imaging agents |
DE102017201608A1 (de) | 2017-02-01 | 2018-08-02 | Eurochem Agro Gmbh | 3,4-Dimethylpyrazol enthaltende Mischung und ihre Verwendung |
CA3129665A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
WO2020245208A1 (en) | 2019-06-04 | 2020-12-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis |
WO2021075477A1 (ja) * | 2019-10-16 | 2021-04-22 | 国立大学法人京都大学 | 運動神経細胞変性阻害剤 |
CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
CA3210985A1 (en) * | 2021-03-12 | 2022-09-15 | Sarah KANE | Multiplexed genotyping assays with a single probe using fluorescent amplitude tuning |
IL312506A (en) | 2021-11-08 | 2024-07-01 | Progentos Therapeutics Inc | Platelet-based alpha inhibitors and their uses |
WO2024088379A1 (zh) * | 2022-10-27 | 2024-05-02 | 香港科技大学 | 肿瘤的治疗或预防方法 |
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WO1989001478A1 (en) | 1987-08-07 | 1989-02-23 | The Australian National University | ARYLOXY- AND ARALKYLTHIO-IMIDAZO[1,2-b]PYRIDAZINES |
WO1989001333A1 (en) | 1987-08-07 | 1989-02-23 | The Australian National University | IMIDAZO[1,2-b]PYRIDAZINES |
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US20070078136A1 (en) * | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
US7723336B2 (en) * | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
EP2058309A4 (en) * | 2006-08-04 | 2010-12-22 | Takeda Pharmaceutical | CONDENSED HETEROCYCLIC COMPOUND |
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2007
- 2007-08-03 AR ARP070103435A patent/AR062207A1/es unknown
- 2007-08-03 JP JP2009522492A patent/JP5238697B2/ja active Active
- 2007-08-03 AU AU2007279595A patent/AU2007279595A1/en not_active Abandoned
- 2007-08-03 US US12/064,903 patent/US8044049B2/en active Active
- 2007-08-03 CA CA002659971A patent/CA2659971A1/en not_active Abandoned
- 2007-08-03 BR BRPI0714665-5A patent/BRPI0714665A2/pt not_active IP Right Cessation
- 2007-08-03 KR KR1020097004527A patent/KR20090047509A/ko not_active Application Discontinuation
- 2007-08-03 EP EP07792327.4A patent/EP2049541B1/en active Active
- 2007-08-03 MX MX2009001349A patent/MX2009001349A/es unknown
- 2007-08-03 WO PCT/JP2007/065681 patent/WO2008016192A2/en active Application Filing
- 2007-08-03 TW TW096128518A patent/TW200817409A/zh unknown
- 2007-08-03 CL CL200702261A patent/CL2007002261A1/es unknown
- 2007-08-03 PE PE2007001018A patent/PE20080538A1/es not_active Application Discontinuation
-
2008
- 2008-11-03 US US12/263,841 patent/US20100168424A1/en not_active Abandoned
- 2008-11-03 US US12/263,949 patent/US8273741B2/en active Active
- 2008-11-03 US US12/263,884 patent/US8034812B2/en active Active
-
2009
- 2009-01-29 IL IL196799A patent/IL196799A0/en unknown
- 2009-02-09 CR CR10607A patent/CR10607A/es not_active Application Discontinuation
- 2009-02-17 MA MA31647A patent/MA30651B1/fr unknown
- 2009-03-04 NO NO20090986A patent/NO20090986L/no not_active Application Discontinuation
- 2009-03-04 CO CO09022290A patent/CO6150183A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20100168424A1 (en) | 2010-07-01 |
JP5238697B2 (ja) | 2013-07-17 |
KR20090047509A (ko) | 2009-05-12 |
EP2049541B1 (en) | 2015-09-23 |
US8034812B2 (en) | 2011-10-11 |
CA2659971A1 (en) | 2008-02-07 |
WO2008016192A2 (en) | 2008-02-07 |
CO6150183A2 (es) | 2010-04-20 |
CR10607A (es) | 2009-03-12 |
WO2008016192A3 (en) | 2008-05-08 |
CL2007002261A1 (es) | 2008-05-02 |
AU2007279595A2 (en) | 2009-03-19 |
IL196799A0 (en) | 2009-11-18 |
MA30651B1 (fr) | 2009-08-03 |
MX2009001349A (es) | 2009-04-17 |
AU2007279595A1 (en) | 2008-02-07 |
PE20080538A1 (es) | 2008-06-18 |
JP2009545583A (ja) | 2009-12-24 |
US8044049B2 (en) | 2011-10-25 |
EP2049541A2 (en) | 2009-04-22 |
US8273741B2 (en) | 2012-09-25 |
TW200817409A (en) | 2008-04-16 |
US20100273788A1 (en) | 2010-10-28 |
NO20090986L (no) | 2009-05-04 |
US20090137595A1 (en) | 2009-05-28 |
BRPI0714665A2 (pt) | 2012-03-13 |
US20090306374A1 (en) | 2009-12-10 |
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