CR10607A - Derivado heterociclico fusionado y su uso - Google Patents
Derivado heterociclico fusionado y su usoInfo
- Publication number
- CR10607A CR10607A CR10607A CR10607A CR10607A CR 10607 A CR10607 A CR 10607A CR 10607 A CR10607 A CR 10607A CR 10607 A CR10607 A CR 10607A CR 10607 A CR10607 A CR 10607A
- Authority
- CR
- Costa Rica
- Prior art keywords
- compound
- derivative
- fusioned
- heterociclic
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invencion provee un derivado heterociclico fusionado que tiene una potente actividad inhibidora de quinasa y su uso. Un compuesto de la formula (I): en donde cada simbolo es como se define en la memoria descriptiva, excepto un compuesto particular, o una de sus sales, y un agente farmaceutico que contiene el compuesto o uno de sus profarmacos, que es un inhibidor de quinasa (VEGFR, VEGFR2, PDGFR, Raf), un inhibidor de angiogenesis, un agente para la prevencion o el tratamiento del cancer, un inhibidor del crecimiento del cancer o un supresor de la metastasis del cancer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006213981 | 2006-08-04 | ||
JP2006331230 | 2006-12-07 | ||
JP2007144072 | 2007-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR10607A true CR10607A (es) | 2009-03-12 |
Family
ID=38996616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR10607A CR10607A (es) | 2006-08-04 | 2009-02-09 | Derivado heterociclico fusionado y su uso |
Country Status (18)
Country | Link |
---|---|
US (4) | US8044049B2 (es) |
EP (1) | EP2049541B1 (es) |
JP (1) | JP5238697B2 (es) |
KR (1) | KR20090047509A (es) |
AR (1) | AR062207A1 (es) |
AU (1) | AU2007279595A1 (es) |
BR (1) | BRPI0714665A2 (es) |
CA (1) | CA2659971A1 (es) |
CL (1) | CL2007002261A1 (es) |
CO (1) | CO6150183A2 (es) |
CR (1) | CR10607A (es) |
IL (1) | IL196799A0 (es) |
MA (1) | MA30651B1 (es) |
MX (1) | MX2009001349A (es) |
NO (1) | NO20090986L (es) |
PE (1) | PE20080538A1 (es) |
TW (1) | TW200817409A (es) |
WO (1) | WO2008016192A2 (es) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008150015A1 (en) | 2007-06-05 | 2008-12-11 | Takeda Pharmaceutical Company Limited | Heterobicyclic compounds as kinase inhibitors |
US8431608B2 (en) | 2007-08-17 | 2013-04-30 | Icagen Inc. | Heterocycles as potassium channel modulators |
US8058274B2 (en) * | 2007-08-17 | 2011-11-15 | Icagen, Inc. | Heterocycles as potassium channel modulators |
WO2009025358A1 (ja) | 2007-08-23 | 2009-02-26 | Takeda Pharmaceutical Company Limited | 複素環化合物およびその用途 |
US8389527B2 (en) | 2008-02-06 | 2013-03-05 | Bristol-Myers Squibb Company | Substituted imidazopyridazines useful as kinase inhibitors |
EA201001365A1 (ru) | 2008-02-28 | 2011-04-29 | Новартис Аг | ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-b]ПИРИДАЗИНА, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДУЕМОГО C-МЕТ ТИРОЗИНКИНАЗОЙ |
CN101372475B (zh) * | 2008-03-19 | 2012-01-04 | 南京工业大学 | 芳杂环取代的二苯脲类衍生物及其用途 |
JPWO2009128520A1 (ja) | 2008-04-18 | 2011-08-04 | 塩野義製薬株式会社 | Pi3k阻害活性を有する複素環化合物 |
WO2009136663A1 (en) * | 2008-05-08 | 2009-11-12 | Takeda Pharmaceutical Company Limited | Fused heterocyclic derivatives and use thereof |
WO2010007099A1 (en) * | 2008-07-15 | 2010-01-21 | Cellzome Limited | 2-aminoimidazo[1,2-b]pyridazine derivatives as pi3k inhibitors |
UY32049A (es) | 2008-08-14 | 2010-03-26 | Takeda Pharmaceutical | Inhibidores de cmet |
EA020641B1 (ru) | 2008-10-02 | 2014-12-30 | Респайверт Лимитед | Производные n-(1-фенил-3-алкилпиразол-5-ил)-n'-арилмочевины |
GB0818033D0 (en) | 2008-10-02 | 2008-11-05 | Respivert Ltd | Novel compound |
TWI491610B (zh) * | 2008-10-09 | 2015-07-11 | 必治妥美雅史谷比公司 | 作為激酶抑制劑之咪唑并嗒腈 |
LT3372605T (lt) | 2008-10-22 | 2022-02-10 | Array Biopharma, Inc. | Pakeistieji pirazolo[1,5-a]pirimidino junginiai, kaip trk kinazės inhibitoriai |
US8697874B2 (en) | 2008-12-01 | 2014-04-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
JO3101B1 (ar) | 2008-12-02 | 2017-09-20 | Takeda Pharmaceuticals Co | مشتقات بنزوثيازول كعوامل مضادة للسرطان |
EP2370429B1 (en) | 2008-12-11 | 2016-04-20 | Respivert Limited | P38 map kinase inhibitors |
BRPI0923401B1 (pt) | 2008-12-24 | 2021-11-23 | Syngenta Limited | Método para o preparo de aril amidas e composto |
ES2427917T3 (es) | 2009-02-10 | 2013-11-04 | Astrazeneca Ab | Derivados de triazolo [4,3-b] piridazina y sus usos para el cáncer de próstata |
GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
JP5583845B2 (ja) | 2010-04-28 | 2014-09-03 | ブリストル−マイヤーズ スクイブ カンパニー | イミダゾピリダジニル化合物および癌に対するそれらの使用 |
PT2694072T (pt) | 2011-04-01 | 2018-02-26 | Genentech Inc | Combinação de composto inibidor de akt e abiraterona para utilização em tratamentos terapêuticos |
EP2788345B1 (en) | 2011-12-09 | 2020-06-10 | Chiesi Farmaceutici S.p.A. | Derivatives of 4-hydroxy-1,2,3,4-tetrahydronaphtalen-1-yl urea and their use in the treatment of, inter alia, diseases of the respiratory tract |
WO2014176259A1 (en) | 2013-04-22 | 2014-10-30 | Icahn School Of Medicine At Mount Sinai | Mutations in pdgfrb and notch3 as causes of autosomal dominant infantile myofibromatosis |
US9988386B2 (en) | 2013-05-30 | 2018-06-05 | Kata Pharmaceuticals, Inc. | Compounds for treatment of diseases of abnormal angiogenesis or aberrant growth factors and uses thereof |
WO2015084384A1 (en) * | 2013-12-06 | 2015-06-11 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
MX2016007734A (es) | 2013-12-13 | 2016-10-14 | Eurochem Agro Gmbh | Mezcla fertilizante que contiene inhibidor de la nitrificacion. |
WO2016086026A1 (en) * | 2014-11-26 | 2016-06-02 | Kala Pharmaceuticals, Inc. | Crystalline forms of a therapeutic compound and uses thereof |
JPWO2016093299A1 (ja) * | 2014-12-10 | 2017-09-21 | 千寿製薬株式会社 | 水性液剤 |
RU2751767C2 (ru) | 2016-04-04 | 2021-07-16 | Локсо Онколоджи, Инк. | Жидкие составы (s)-n-(5-((r)-2-(2,5-дифторфенил)пирролидин-1-ил)пиразоло[1,5-a]пиримидин-3-ил)-3-гидроксипирролидин-1-карбоксамида |
US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
EP3800189B1 (en) | 2016-05-18 | 2023-06-28 | Loxo Oncology, Inc. | Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
EP3478676A1 (en) | 2016-06-29 | 2019-05-08 | Orion Corporation | Benzodioxane derivatives and their pharmaceutical use |
JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
EP3541431B1 (en) * | 2016-11-16 | 2024-04-17 | The General Hospital Corporation | Myeloperoxidase imaging agents |
EA202192575A1 (ru) | 2019-03-21 | 2022-01-14 | Онксео | Соединения dbait в сочетании с ингибиторами киназ для лечения рака |
WO2020245208A1 (en) | 2019-06-04 | 2020-12-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis |
WO2021075477A1 (ja) * | 2019-10-16 | 2021-04-22 | 国立大学法人京都大学 | 運動神経細胞変性阻害剤 |
EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
WO2022192732A1 (en) * | 2021-03-12 | 2022-09-15 | Gt Molecular, Llc | Multiplexed genotyping assays with a single probe using fluorescent amplitude tuning |
CA3237696A1 (en) | 2021-11-08 | 2023-05-11 | Progentos Therapeutics, Inc. | Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof |
WO2024088379A1 (zh) * | 2022-10-27 | 2024-05-02 | 香港科技大学 | 肿瘤的治疗或预防方法 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989001478A1 (en) | 1987-08-07 | 1989-02-23 | The Australian National University | ARYLOXY- AND ARALKYLTHIO-IMIDAZO[1,2-b]PYRIDAZINES |
WO1989001333A1 (en) | 1987-08-07 | 1989-02-23 | The Australian National University | IMIDAZO[1,2-b]PYRIDAZINES |
GB8719368D0 (en) * | 1987-08-15 | 1987-09-23 | Wellcome Found | Heterocyclic compounds |
JPH0820584A (ja) | 1994-07-04 | 1996-01-23 | Takeda Chem Ind Ltd | イミダゾール誘導体及びその用途 |
CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
WO2000042012A1 (en) | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
US6797823B1 (en) | 1999-01-22 | 2004-09-28 | Kirin Beer Kabushiki Kaisha | Quinoline derivatives and quinazoline derivatives |
NZ518028A (en) | 1999-11-05 | 2004-03-26 | Astrazeneca Ab | Quinazoline derivatives as VEGF inhibitors |
MXPA02008021A (es) | 2000-02-15 | 2004-04-05 | Sugen Inc | Indolinonas sustituidas con pirroles inhibidoras de proteinquinasas. |
EP1777218B1 (en) | 2000-10-20 | 2008-12-31 | Eisai R&D Management Co., Ltd. | Process for the preparation of 4-phenoxy quinoline derivatives |
JP2003137785A (ja) * | 2001-08-23 | 2003-05-14 | Takeda Chem Ind Ltd | Jnk活性化阻害剤 |
CN100582108C (zh) | 2003-12-31 | 2010-01-20 | 先灵-普劳有限公司 | 通过使用咪唑并[1,2-b]哒嗪衍生物控制动物中的寄生虫 |
CA2586259A1 (en) * | 2004-11-08 | 2006-05-11 | Banyu Pharmaceutical Co., Ltd. | Novel fused imidazole derivative |
US20080167314A1 (en) * | 2004-12-28 | 2008-07-10 | Osamu Uchikawa | Condensed Imidazole Compound And Use Thereof |
WO2007013673A1 (en) * | 2005-07-29 | 2007-02-01 | Astellas Pharma Inc. | Fused heterocycles as lck inhibitors |
US20070049591A1 (en) * | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Inhibitors of MAPK/Erk Kinase |
DE102005042742A1 (de) | 2005-09-02 | 2007-03-08 | Schering Ag | Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
US7723336B2 (en) | 2005-09-22 | 2010-05-25 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
US20070078136A1 (en) * | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
WO2008016131A1 (fr) * | 2006-08-04 | 2008-02-07 | Takeda Pharmaceutical Company Limited | Composé hétérocyclique à cycles fusionnés |
-
2007
- 2007-08-03 PE PE2007001018A patent/PE20080538A1/es not_active Application Discontinuation
- 2007-08-03 CL CL200702261A patent/CL2007002261A1/es unknown
- 2007-08-03 MX MX2009001349A patent/MX2009001349A/es unknown
- 2007-08-03 KR KR1020097004527A patent/KR20090047509A/ko not_active Application Discontinuation
- 2007-08-03 US US12/064,903 patent/US8044049B2/en active Active
- 2007-08-03 TW TW096128518A patent/TW200817409A/zh unknown
- 2007-08-03 EP EP07792327.4A patent/EP2049541B1/en active Active
- 2007-08-03 BR BRPI0714665-5A patent/BRPI0714665A2/pt not_active IP Right Cessation
- 2007-08-03 WO PCT/JP2007/065681 patent/WO2008016192A2/en active Application Filing
- 2007-08-03 AR ARP070103435A patent/AR062207A1/es unknown
- 2007-08-03 CA CA002659971A patent/CA2659971A1/en not_active Abandoned
- 2007-08-03 JP JP2009522492A patent/JP5238697B2/ja active Active
- 2007-08-03 AU AU2007279595A patent/AU2007279595A1/en not_active Abandoned
-
2008
- 2008-11-03 US US12/263,884 patent/US8034812B2/en active Active
- 2008-11-03 US US12/263,841 patent/US20100168424A1/en not_active Abandoned
- 2008-11-03 US US12/263,949 patent/US8273741B2/en active Active
-
2009
- 2009-01-29 IL IL196799A patent/IL196799A0/en unknown
- 2009-02-09 CR CR10607A patent/CR10607A/es not_active Application Discontinuation
- 2009-02-17 MA MA31647A patent/MA30651B1/fr unknown
- 2009-03-04 CO CO09022290A patent/CO6150183A2/es unknown
- 2009-03-04 NO NO20090986A patent/NO20090986L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2659971A1 (en) | 2008-02-07 |
CO6150183A2 (es) | 2010-04-20 |
AU2007279595A1 (en) | 2008-02-07 |
JP5238697B2 (ja) | 2013-07-17 |
NO20090986L (no) | 2009-05-04 |
US20100168424A1 (en) | 2010-07-01 |
AR062207A1 (es) | 2008-10-22 |
AU2007279595A2 (en) | 2009-03-19 |
MA30651B1 (fr) | 2009-08-03 |
IL196799A0 (en) | 2009-11-18 |
US8273741B2 (en) | 2012-09-25 |
WO2008016192A3 (en) | 2008-05-08 |
US20090306374A1 (en) | 2009-12-10 |
US8034812B2 (en) | 2011-10-11 |
US20100273788A1 (en) | 2010-10-28 |
TW200817409A (en) | 2008-04-16 |
PE20080538A1 (es) | 2008-06-18 |
KR20090047509A (ko) | 2009-05-12 |
MX2009001349A (es) | 2009-04-17 |
BRPI0714665A2 (pt) | 2012-03-13 |
EP2049541B1 (en) | 2015-09-23 |
CL2007002261A1 (es) | 2008-05-02 |
JP2009545583A (ja) | 2009-12-24 |
US8044049B2 (en) | 2011-10-25 |
US20090137595A1 (en) | 2009-05-28 |
EP2049541A2 (en) | 2009-04-22 |
WO2008016192A2 (en) | 2008-02-07 |
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