WO2008016192A3 - Fused heterocyclic derivative and use thereof - Google Patents

Fused heterocyclic derivative and use thereof Download PDF

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Publication number
WO2008016192A3
WO2008016192A3 PCT/JP2007/065681 JP2007065681W WO2008016192A3 WO 2008016192 A3 WO2008016192 A3 WO 2008016192A3 JP 2007065681 W JP2007065681 W JP 2007065681W WO 2008016192 A3 WO2008016192 A3 WO 2008016192A3
Authority
WO
WIPO (PCT)
Prior art keywords
fused heterocyclic
heterocyclic derivative
cancer
inhibitor
compound
Prior art date
Application number
PCT/JP2007/065681
Other languages
French (fr)
Other versions
WO2008016192A2 (en
Inventor
Nozomu Sakai
Shinichi Imamura
Naoki Miyamoto
Takaharu Hirayama
Original Assignee
Takeda Pharmaceutical
Nozomu Sakai
Shinichi Imamura
Naoki Miyamoto
Takaharu Hirayama
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2009522492A priority Critical patent/JP5238697B2/en
Priority to MX2009001349A priority patent/MX2009001349A/en
Priority to EP07792327.4A priority patent/EP2049541B1/en
Priority to BRPI0714665-5A priority patent/BRPI0714665A2/en
Priority to AU2007279595A priority patent/AU2007279595A1/en
Priority to US12/064,903 priority patent/US8044049B2/en
Priority to CA002659971A priority patent/CA2659971A1/en
Application filed by Takeda Pharmaceutical, Nozomu Sakai, Shinichi Imamura, Naoki Miyamoto, Takaharu Hirayama filed Critical Takeda Pharmaceutical
Publication of WO2008016192A2 publication Critical patent/WO2008016192A2/en
Publication of WO2008016192A3 publication Critical patent/WO2008016192A3/en
Priority to US12/263,841 priority patent/US20100168424A1/en
Priority to US12/263,884 priority patent/US8034812B2/en
Priority to US12/263,949 priority patent/US8273741B2/en
Priority to IL196799A priority patent/IL196799A0/en
Priority to NO20090986A priority patent/NO20090986L/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The present invention provides a fused heterocyclic derivative having a potent kinase inhibitory activity and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the specification, except a particular compound, or a salt thereof, and a pharmaceutical agent containing the compound or a prodrug thereof, which is a kinase (VEGFR, VEGFR2, PDGFR, Raf) inhibitor, an angiogenesis inhibitor, an agent for the prophylaxis or treatment of cancer, a cancer growth inhibitor or a cancer metastasis suppressor.
PCT/JP2007/065681 2006-08-04 2007-08-03 Fused heterocyclic derivative and use thereof WO2008016192A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
US12/064,903 US8044049B2 (en) 2006-08-04 2007-08-03 Fused heterocyclic derivative and use thereof
MX2009001349A MX2009001349A (en) 2006-08-04 2007-08-03 Fused heterocyclic derivative and use thereof.
EP07792327.4A EP2049541B1 (en) 2006-08-04 2007-08-03 N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1h-pyrazole-5-carboxamide as vegfr inhibitor
BRPI0714665-5A BRPI0714665A2 (en) 2006-08-04 2007-08-03 COMPOSITE, PRODUCT, PHARMACEUTICAL AGENT, AND METHOD FOR CANCER PROPHYLAXY OR TREATMENT
AU2007279595A AU2007279595A1 (en) 2006-08-04 2007-08-03 Fused heterocyclic derivative and use thereof
JP2009522492A JP5238697B2 (en) 2006-08-04 2007-08-03 Fused heterocyclic derivatives and uses thereof
CA002659971A CA2659971A1 (en) 2006-08-04 2007-08-03 Fused heterocyclic derivative and use thereof
US12/263,841 US20100168424A1 (en) 2006-08-04 2008-11-03 Fused heterocyclic derivative and use thereof
US12/263,949 US8273741B2 (en) 2006-08-04 2008-11-03 Imidazo-pyridazinyl compounds and uses thereof
US12/263,884 US8034812B2 (en) 2006-08-04 2008-11-03 Imidazopyridazine derivative having kinase inhibitory activity and pharmaceutical agent thereof
IL196799A IL196799A0 (en) 2006-08-04 2009-01-29 Fused heterocyclic derivative and use thereof
NO20090986A NO20090986L (en) 2006-08-04 2009-03-04 Merged heterocyclic derivative and its use

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2006-213981 2006-08-04
JP2006213981 2006-08-04
JP2006-331230 2006-12-07
JP2006331230 2006-12-07
JP2007144072 2007-05-30
JP2007-144072 2007-05-30

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US12/064,903 A-371-Of-International US8044049B2 (en) 2006-08-04 2007-08-03 Fused heterocyclic derivative and use thereof
US12/263,949 Continuation US8273741B2 (en) 2006-08-04 2008-11-03 Imidazo-pyridazinyl compounds and uses thereof
US12/263,841 Continuation US20100168424A1 (en) 2006-08-04 2008-11-03 Fused heterocyclic derivative and use thereof
US12/263,884 Continuation US8034812B2 (en) 2006-08-04 2008-11-03 Imidazopyridazine derivative having kinase inhibitory activity and pharmaceutical agent thereof

Publications (2)

Publication Number Publication Date
WO2008016192A2 WO2008016192A2 (en) 2008-02-07
WO2008016192A3 true WO2008016192A3 (en) 2008-05-08

Family

ID=38996616

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/065681 WO2008016192A2 (en) 2006-08-04 2007-08-03 Fused heterocyclic derivative and use thereof

Country Status (18)

Country Link
US (4) US8044049B2 (en)
EP (1) EP2049541B1 (en)
JP (1) JP5238697B2 (en)
KR (1) KR20090047509A (en)
AR (1) AR062207A1 (en)
AU (1) AU2007279595A1 (en)
BR (1) BRPI0714665A2 (en)
CA (1) CA2659971A1 (en)
CL (1) CL2007002261A1 (en)
CO (1) CO6150183A2 (en)
CR (1) CR10607A (en)
IL (1) IL196799A0 (en)
MA (1) MA30651B1 (en)
MX (1) MX2009001349A (en)
NO (1) NO20090986L (en)
PE (1) PE20080538A1 (en)
TW (1) TW200817409A (en)
WO (1) WO2008016192A2 (en)

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CN102245609B (en) * 2008-10-09 2016-03-09 百时美施贵宝公司 Can be used as the Imidazopyridazine formonitrile HCN of kinase inhibitor

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AU2008289101A1 (en) * 2007-08-17 2009-02-26 Icagen, Inc. Heterocycles as potassium channel modulators
US8431608B2 (en) * 2007-08-17 2013-04-30 Icagen Inc. Heterocycles as potassium channel modulators
US8324395B2 (en) 2007-08-23 2012-12-04 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
JP5394404B2 (en) * 2008-02-06 2014-01-22 ブリストル−マイヤーズ スクイブ カンパニー Substituted imidazopyridazines useful as kinase inhibitors
KR20100128305A (en) 2008-02-28 2010-12-07 노파르티스 아게 Imidazo[1,2-b]pyridazine derivatives for the treatment of c-met tyrosine kinase mediated disease
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CN102245609B (en) * 2008-10-09 2016-03-09 百时美施贵宝公司 Can be used as the Imidazopyridazine formonitrile HCN of kinase inhibitor

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