EA200901608A1 - Производные хинаксолина в качестве ингибиторов тирозинкиназной активности киназ janus - Google Patents

Производные хинаксолина в качестве ингибиторов тирозинкиназной активности киназ janus

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Publication number
EA200901608A1
EA200901608A1 EA200901608A EA200901608A EA200901608A1 EA 200901608 A1 EA200901608 A1 EA 200901608A1 EA 200901608 A EA200901608 A EA 200901608A EA 200901608 A EA200901608 A EA 200901608A EA 200901608 A1 EA200901608 A1 EA 200901608A1
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EA
Eurasian Patent Office
Prior art keywords
activity
thyrozinkinase
chinaxoline
inhibitors
derivatives
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EA200901608A
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English (en)
Inventor
Марк Гершпахер
Паскаль Фюре
Эрик Вангревелинье
Кароль Писсо-Зольдерманн
Кристоф Гауль
Филипп Хольцер
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Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA200901608A1 publication Critical patent/EA200901608A1/ru

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Health & Medical Sciences (AREA)
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  • Plural Heterocyclic Compounds (AREA)

Abstract

В заявке описаны хиноксалины формулы (I)в которой Rобозначает карбоциклил или гетероциклил, любой из которых необязательно замещен с помощью 1, 2, 3, 4 или 5 R; Rобозначает карбоциклил или гетероциклил, любой из которых необязательно замещен с помощью 1, 2, 3, 4 или 5 R; R, R, Rи R, каждый независимо, обозначает водород или R; и R, Rи R, каждый независимо, выбран из органических и неорганических заместителей, их применение для лечения заболеваний, опосредуемых тирозинкиназной активностью киназ Janus, включая киназы JAK-2 и JAK-3.
EA200901608A 2007-06-08 2008-06-06 Производные хинаксолина в качестве ингибиторов тирозинкиназной активности киназ janus EA200901608A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07109880 2007-06-08
EP07150266 2007-12-20
PCT/EP2008/057058 WO2008148867A2 (en) 2007-06-08 2008-06-06 Quinoxaline derivatives as inhibitors of the tyrosine kinase activity of janus kinases

Publications (1)

Publication Number Publication Date
EA200901608A1 true EA200901608A1 (ru) 2010-06-30

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EA200901608A EA200901608A1 (ru) 2007-06-08 2008-06-06 Производные хинаксолина в качестве ингибиторов тирозинкиназной активности киназ janus

Country Status (17)

Country Link
US (1) US8193189B2 (ru)
EP (1) EP2155201B1 (ru)
JP (1) JP5574957B2 (ru)
KR (1) KR20100020465A (ru)
CN (1) CN101678020B (ru)
AR (1) AR066879A1 (ru)
AU (1) AU2008258486B2 (ru)
BR (1) BRPI0812893A2 (ru)
CA (1) CA2690288A1 (ru)
CL (1) CL2008001659A1 (ru)
EA (1) EA200901608A1 (ru)
ES (1) ES2392570T3 (ru)
MX (1) MX2009013218A (ru)
PA (1) PA8783501A1 (ru)
TW (1) TW200904814A (ru)
UY (1) UY31126A1 (ru)
WO (1) WO2008148867A2 (ru)

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